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Alkyladenine DNA glycosylase associates with transcription elongation to coordinate DNA repair with gene expression.

Montaldo NP, Bordin DL, Brambilla A, Rösinger M, Fordyce Martin SL, Bjørås KØ, Bradamante S, Aas PA, Furrer A, Olsen LC, Kunath N, Otterlei M, Sætrom P, Bjørås M, Samson LD, van Loon B.

Nat Commun. 2019 Nov 29;10(1):5460. doi: 10.1038/s41467-019-13394-w.


Donor T-cell-derived GM-CSF drives alloantigen presentation by dendritic cells in the gastrointestinal tract.

Gartlan KH, Koyama M, Lineburg KE, Chang K, Ensbey KS, Kuns RD, Henden AS, Samson LD, Clouston AD, Lopez AF, MacDonald KPA, Hill GR.

Blood Adv. 2019 Oct 8;3(19):2859-2865. doi: 10.1182/bloodadvances.2019000053.


Correction to: Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study.

Navasumrit P, Chaisatra K, Promvijit J, Parnlob V, Waraprasit S, Chompoobut C, Binh TT, Hai DN, Bao ND, Hai NK, Kim KW, Samson LD, Graziano JH, Mahidol C, Ruchirawat M.

Environ Health. 2019 Jul 24;18(1):68. doi: 10.1186/s12940-019-0504-4.


Frailty is associated with elevated CRP trajectories and higher numbers of neutrophils and monocytes.

Samson LD, Boots AMH, Verschuren WMM, Picavet HSJ, Engelfriet P, Buisman AM.

Exp Gerontol. 2019 Oct 1;125:110674. doi: 10.1016/j.exger.2019.110674. Epub 2019 Jul 20.


Exposure to arsenic in utero is associated with various types of DNA damage and micronuclei in newborns: a birth cohort study.

Navasumrit P, Chaisatra K, Promvijit J, Parnlob V, Waraprasit S, Chompoobut C, Binh TT, Hai DN, Bao ND, Hai NK, Kim KW, Samson LD, Graziano JH, Mahidol C, Ruchirawat M.

Environ Health. 2019 Jun 7;18(1):51. doi: 10.1186/s12940-019-0481-7. Erratum in: Environ Health. 2019 Jul 24;18(1):68.


Expansion of IL-17A-secreting CD8+ mucosa-associated invariant T cells in peripheral blood following stem cell mobilization.

Varelias A, Gartlan KH, Wilkinson AN, Olver SD, Samson LD, Tey SK, MacDonald KPA, Hill GR.

Blood Adv. 2019 Mar 12;3(5):718-723. doi: 10.1182/bloodadvances.2018025601. No abstract available.


Fluorescent reporter assays provide direct, accurate, quantitative measurements of MGMT status in human cells.

Nagel ZD, Beharry AA, Mazzucato P, Kitange GJ, Sarkaria JN, Kool ET, Samson LD.

PLoS One. 2019 Feb 27;14(2):e0208341. doi: 10.1371/journal.pone.0208341. eCollection 2019.


The human gut bacterial genotoxin colibactin alkylates DNA.

Wilson MR, Jiang Y, Villalta PW, Stornetta A, Boudreau PD, Carrá A, Brennan CA, Chun E, Ngo L, Samson LD, Engelward BP, Garrett WS, Balbo S, Balskus EP.

Science. 2019 Feb 15;363(6428). pii: eaar7785. doi: 10.1126/science.aar7785.


Phase I Trial of Inducible Caspase 9 T Cells in Adult Stem Cell Transplant Demonstrates Massive Clonotypic Proliferative Potential and Long-term Persistence of Transgenic T Cells.

Zhang P, Raju J, Ullah MA, Au R, Varelias A, Gartlan KH, Olver SD, Samson LD, Sturgeon E, Zomerdijk N, Avery J, Gargett T, Brown MP, Coin LJ, Ganesamoorthy D, Hutchins C, Pratt GR, Kennedy GA, Morton AJ, Curley CI, Hill GR, Tey SK.

Clin Cancer Res. 2019 Mar 15;25(6):1749-1755. doi: 10.1158/1078-0432.CCR-18-3069. Epub 2019 Feb 14.


Inflammation, necrosis, and the kinase RIP3 are key mediators of AAG-dependent alkylation-induced retinal degeneration.

Allocca M, Corrigan JJ, Mazumder A, Fake KR, Samson LD.

Sci Signal. 2019 Feb 12;12(568). pii: eaau9216. doi: 10.1126/scisignal.aau9216.


Microcolony Size Distribution Assay Enables High-Throughput Cell Survival Quantitation.

Ngo LP, Chan TK, Ge J, Samson LD, Engelward BP.

Cell Rep. 2019 Feb 5;26(6):1668-1678.e4. doi: 10.1016/j.celrep.2019.01.053.


A target to suppress inflammation.

Samson LD.

Science. 2018 Nov 16;362(6416):748-749. doi: 10.1126/science.aav4744. No abstract available.


Nitric oxide induced S-nitrosation causes base excision repair imbalance.

Parrish MC, Chaim IA, Nagel ZD, Tannenbaum SR, Samson LD, Engelward BP.

DNA Repair (Amst). 2018 Aug;68:25-33. doi: 10.1016/j.dnarep.2018.04.008. Epub 2018 May 5.


ARID1A deficiency promotes mutability and potentiates therapeutic antitumor immunity unleashed by immune checkpoint blockade.

Shen J, Ju Z, Zhao W, Wang L, Peng Y, Ge Z, Nagel ZD, Zou J, Wang C, Kapoor P, Ma X, Ma D, Liang J, Song S, Liu J, Samson LD, Ajani JA, Li GM, Liang H, Shen X, Mills GB, Peng G.

Nat Med. 2018 May;24(5):556-562. doi: 10.1038/s41591-018-0012-z. Epub 2018 May 7.


Granulocytes Are Unresponsive to IL-6 Due to an Absence of gp130.

Wilkinson AN, Gartlan KH, Kelly G, Samson LD, Olver SD, Avery J, Zomerdijk N, Tey SK, Lee JS, Vuckovic S, Hill GR.

J Immunol. 2018 May 15;200(10):3547-3555. doi: 10.4049/jimmunol.1701191. Epub 2018 Apr 6.


In vivo measurements of interindividual differences in DNA glycosylases and APE1 activities.

Chaim IA, Nagel ZD, Jordan JJ, Mazzucato P, Ngo LP, Samson LD.

Proc Natl Acad Sci U S A. 2017 Nov 28;114(48):E10379-E10388. doi: 10.1073/pnas.1712032114. Epub 2017 Nov 9.


The Lancet Commission on pollution and health.

Landrigan PJ, Fuller R, Acosta NJR, Adeyi O, Arnold R, Basu NN, Baldé AB, Bertollini R, Bose-O'Reilly S, Boufford JI, Breysse PN, Chiles T, Mahidol C, Coll-Seck AM, Cropper ML, Fobil J, Fuster V, Greenstone M, Haines A, Hanrahan D, Hunter D, Khare M, Krupnick A, Lanphear B, Lohani B, Martin K, Mathiasen KV, McTeer MA, Murray CJL, Ndahimananjara JD, Perera F, Potočnik J, Preker AS, Ramesh J, Rockström J, Salinas C, Samson LD, Sandilya K, Sly PD, Smith KR, Steiner A, Stewart RB, Suk WA, van Schayck OCP, Yadama GN, Yumkella K, Zhong M.

Lancet. 2018 Feb 3;391(10119):462-512. doi: 10.1016/S0140-6736(17)32345-0. Epub 2017 Oct 19. Review. No abstract available. Erratum in: Lancet. 2018 Feb 3;391(10119):430.


PARP inhibitors protect against sex- and AAG-dependent alkylation-induced neural degeneration.

Allocca M, Corrigan JJ, Fake KR, Calvo JA, Samson LD.

Oncotarget. 2017 Aug 3;8(40):68707-68720. doi: 10.18632/oncotarget.19844. eCollection 2017 Sep 15.


Alkylation induced cerebellar degeneration dependent on Aag and Parp1 does not occur via previously established cell death mechanisms.

Margulies CM, Chaim IA, Mazumder A, Criscione J, Samson LD.

PLoS One. 2017 Sep 8;12(9):e0184619. doi: 10.1371/journal.pone.0184619. eCollection 2017.


Eomesodermin promotes the development of type 1 regulatory T (TR1) cells.

Zhang P, Lee JS, Gartlan KH, Schuster IS, Comerford I, Varelias A, Ullah MA, Vuckovic S, Koyama M, Kuns RD, Locke KR, Beckett KJ, Olver SD, Samson LD, Montes de Oca M, de Labastida Rivera F, Clouston AD, Belz GT, Blazar BR, MacDonald KP, McColl SR, Thomas R, Engwerda CR, Degli-Esposti MA, Kallies A, Tey SK, Hill GR.

Sci Immunol. 2017 Apr 7;2(10). pii: eaah7152. doi: 10.1126/sciimmunol.aah7152.


ALKBH7 drives a tissue and sex-specific necrotic cell death response following alkylation-induced damage.

Jordan JJ, Chhim S, Margulies CM, Allocca M, Bronson RT, Klungland A, Samson LD, Fu D.

Cell Death Dis. 2017 Jul 20;8(7):e2947. doi: 10.1038/cddis.2017.343.


A novel role for transcription-coupled nucleotide excision repair for the in vivo repair of 3,N4-ethenocytosine.

Chaim IA, Gardner A, Wu J, Iyama T, Wilson DM 3rd, Samson LD.

Nucleic Acids Res. 2017 Apr 7;45(6):3242-3252. doi: 10.1093/nar/gkx015.


DNA Repair Capacity in Multiple Pathways Predicts Chemoresistance in Glioblastoma Multiforme.

Nagel ZD, Kitange GJ, Gupta SK, Joughin BA, Chaim IA, Mazzucato P, Lauffenburger DA, Sarkaria JN, Samson LD.

Cancer Res. 2017 Jan 1;77(1):198-206. doi: 10.1158/0008-5472.CAN-16-1151. Epub 2016 Oct 28.


Parp1 protects against Aag-dependent alkylation-induced nephrotoxicity in a sex-dependent manner.

Calvo JA, Allocca M, Fake KR, Muthupalani S, Corrigan JJ, Bronson RT, Samson LD.

Oncotarget. 2016 Jul 19;7(29):44950-44965. doi: 10.18632/oncotarget.10440.


The Mbd4 DNA glycosylase protects mice from inflammation-driven colon cancer and tissue injury.

Yu AM, Calvo JA, Muthupalani S, Samson LD.

Oncotarget. 2016 May 10;7(19):28624-36. doi: 10.18632/oncotarget.8721.


Fluorogenic Real-Time Reporters of DNA Repair by MGMT, a Clinical Predictor of Antitumor Drug Response.

Beharry AA, Nagel ZD, Samson LD, Kool ET.

PLoS One. 2016 Apr 1;11(4):e0152684. doi: 10.1371/journal.pone.0152684. eCollection 2016.


The interaction between ALKBH2 DNA repair enzyme and PCNA is direct, mediated by the hydrophobic pocket of PCNA and perturbed in naturally-occurring ALKBH2 variants.

Fu D, Samson LD, Hübscher U, van Loon B.

DNA Repair (Amst). 2015 Nov;35:13-8. doi: 10.1016/j.dnarep.2015.09.008. Epub 2015 Sep 14.


Minor Changes in Expression of the Mismatch Repair Protein MSH2 Exert a Major Impact on Glioblastoma Response to Temozolomide.

McFaline-Figueroa JL, Braun CJ, Stanciu M, Nagel ZD, Mazzucato P, Sangaraju D, Cerniauskas E, Barford K, Vargas A, Chen Y, Tretyakova N, Lees JA, Hemann MT, White FM, Samson LD.

Cancer Res. 2015 Aug 1;75(15):3127-38. doi: 10.1158/0008-5472.CAN-14-3616. Epub 2015 May 29.


Aag-initiated base excision repair promotes ischemia reperfusion injury in liver, brain, and kidney.

Ebrahimkhani MR, Daneshmand A, Mazumder A, Allocca M, Calvo JA, Abolhassani N, Jhun I, Muthupalani S, Ayata C, Samson LD.

Proc Natl Acad Sci U S A. 2014 Nov 11;111(45):E4878-86. doi: 10.1073/pnas.1413582111. Epub 2014 Oct 27.


DNA glycosylase activity and cell proliferation are key factors in modulating homologous recombination in vivo.

Kiraly O, Gong G, Roytman MD, Yamada Y, Samson LD, Engelward BP.

Carcinogenesis. 2014 Nov;35(11):2495-502. doi: 10.1093/carcin/bgu177. Epub 2014 Aug 25.


Repair of endogenous DNA base lesions modulate lifespan in mice.

Meira LB, Calvo JA, Shah D, Klapacz J, Moroski-Erkul CA, Bronson RT, Samson LD.

DNA Repair (Amst). 2014 Sep;21:78-86. doi: 10.1016/j.dnarep.2014.05.012. Epub 2014 Jun 30.


Inter-individual variation in DNA repair capacity: a need for multi-pathway functional assays to promote translational DNA repair research.

Nagel ZD, Chaim IA, Samson LD.

DNA Repair (Amst). 2014 Jul;19:199-213. doi: 10.1016/j.dnarep.2014.03.009. Epub 2014 Apr 26.


Multiplexed DNA repair assays for multiple lesions and multiple doses via transcription inhibition and transcriptional mutagenesis.

Nagel ZD, Margulies CM, Chaim IA, McRee SK, Mazzucato P, Ahmad A, Abo RP, Butty VL, Forget AL, Samson LD.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):E1823-32. doi: 10.1073/pnas.1401182111. Epub 2014 Apr 22.


Genomic phenotyping by barcode sequencing broadly distinguishes between alkylating agents, oxidizing agents, and non-genotoxic agents, and reveals a role for aromatic amino acids in cellular recovery after quinone exposure.

Svensson JP, Quirós Pesudo L, McRee SK, Adeleye Y, Carmichael P, Samson LD.

PLoS One. 2013 Sep 9;8(9):e73736. doi: 10.1371/journal.pone.0073736. eCollection 2013.


Genome-wide single-cell-level screen for protein abundance and localization changes in response to DNA damage in S. cerevisiae.

Mazumder A, Pesudo LQ, McRee S, Bathe M, Samson LD.

Nucleic Acids Res. 2013 Nov;41(20):9310-24. doi: 10.1093/nar/gkt715. Epub 2013 Aug 9.


Human ALKBH7 is required for alkylation and oxidation-induced programmed necrosis.

Fu D, Jordan JJ, Samson LD.

Genes Dev. 2013 May 15;27(10):1089-100. doi: 10.1101/gad.215533.113. Epub 2013 May 10.


Microfluidic genome-wide profiling of intrinsic electrical properties in Saccharomyces cerevisiae.

Vahey MD, Quiros Pesudo L, Svensson JP, Samson LD, Voldman J.

Lab Chip. 2013 Jul 21;13(14):2754-63. doi: 10.1039/c3lc50162k.


Aag DNA glycosylase promotes alkylation-induced tissue damage mediated by Parp1.

Calvo JA, Moroski-Erkul CA, Lake A, Eichinger LW, Shah D, Jhun I, Limsirichai P, Bronson RT, Christiani DC, Meira LB, Samson LD.

PLoS Genet. 2013 Apr;9(4):e1003413. doi: 10.1371/journal.pgen.1003413. Epub 2013 Apr 4.


Alkyladenine DNA glycosylase (AAG) localizes to mitochondria and interacts with mitochondrial single-stranded binding protein (mtSSB).

van Loon B, Samson LD.

DNA Repair (Amst). 2013 Mar 1;12(3):177-87. doi: 10.1016/j.dnarep.2012.11.009. Epub 2013 Jan 3.


Single-cell analysis of ribonucleotide reductase transcriptional and translational response to DNA damage.

Mazumder A, Tummler K, Bathe M, Samson LD.

Mol Cell Biol. 2013 Feb;33(3):635-42. doi: 10.1128/MCB.01020-12. Epub 2012 Nov 26.


DNA repair is indispensable for survival after acute inflammation.

Calvo JA, Meira LB, Lee CY, Moroski-Erkul CA, Abolhassani N, Taghizadeh K, Eichinger LW, Muthupalani S, Nordstrand LM, Klungland A, Samson LD.

J Clin Invest. 2012 Jul;122(7):2680-9. doi: 10.1172/JCI63338. Epub 2012 Jun 11.


Identification of novel human damage response proteins targeted through yeast orthology.

Svensson JP, Fry RC, Wang E, Somoza LA, Samson LD.

PLoS One. 2012;7(5):e37368. doi: 10.1371/journal.pone.0037368. Epub 2012 May 16.


Integrated molecular analysis indicates undetectable change in DNA damage in mice after continuous irradiation at ~ 400-fold natural background radiation.

Olipitz W, Wiktor-Brown D, Shuga J, Pang B, McFaline J, Lonkar P, Thomas A, Mutamba JT, Greenberger JS, Samson LD, Dedon PC, Yanch JC, Engelward BP.

Environ Health Perspect. 2012 Aug;120(8):1130-6. doi: 10.1289/ehp.1104294. Epub 2012 Apr 26.


Combined experimental and computational analysis of DNA damage signaling reveals context-dependent roles for Erk in apoptosis and G1/S arrest after genotoxic stress.

Tentner AR, Lee MJ, Ostheimer GJ, Samson LD, Lauffenburger DA, Yaffe MB.

Mol Syst Biol. 2012 Jan 31;8:568. doi: 10.1038/msb.2012.1.


Balancing repair and tolerance of DNA damage caused by alkylating agents.

Fu D, Calvo JA, Samson LD.

Nat Rev Cancer. 2012 Jan 12;12(2):104-20. doi: 10.1038/nrc3185. Review.


Searching for DNA lesions: structural evidence for lower- and higher-affinity DNA binding conformations of human alkyladenine DNA glycosylase.

Setser JW, Lingaraju GM, Davis CA, Samson LD, Drennan CL.

Biochemistry. 2012 Jan 10;51(1):382-90. doi: 10.1021/bi201484k. Epub 2011 Dec 20.


A rapid survival assay to measure drug-induced cytotoxicity and cell cycle effects.

Valiathan C, McFaline JL, Samson LD.

DNA Repair (Amst). 2012 Jan 2;11(1):92-8. doi: 10.1016/j.dnarep.2011.11.002. Epub 2011 Nov 30.


Direct repair of 3,N(4)-ethenocytosine by the human ALKBH2 dioxygenase is blocked by the AAG/MPG glycosylase.

Fu D, Samson LD.

DNA Repair (Amst). 2012 Jan 2;11(1):46-52. doi: 10.1016/j.dnarep.2011.10.004. Epub 2011 Nov 11.


Genomic phenotyping of the essential and non-essential yeast genome detects novel pathways for alkylation resistance.

Svensson JP, Pesudo LQ, Fry RC, Adeleye YA, Carmichael P, Samson LD.

BMC Syst Biol. 2011 Oct 6;5:157. doi: 10.1186/1752-0509-5-157.

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