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2001 2
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2013 1
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39 results

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Page 1
Macrophage SAMSN1 protects against sepsis-induced acute lung injury in mice.
Jiang W, Ma C, Bai J, Du X. Jiang W, et al. Redox Biol. 2022 Oct;56:102432. doi: 10.1016/j.redox.2022.102432. Epub 2022 Aug 13. Redox Biol. 2022. PMID: 35981417 Free PMC article.
The present study generates macrophage-specific SAMSN1-knockout (Samsn1(MKO)) and SAMSN1-transgenic (Samsn1(MTG)) mice to investigate its role and mechanism in sepsis-induced ALI. ...Bone marrow transplantation, cellular depletion and non-invasive adop …
The present study generates macrophage-specific SAMSN1-knockout (Samsn1(MKO)) and SAMSN1-transgenic (Samsn1(MTG) …
Suppression of SAMSN1 contributes to neuroprotection in neonatal rats suffering from hypoxic-ischemic encephalopathy injury.
Wang YB, Gan ZJ, Zhang JY, Wanchana S, Guo XL. Wang YB, et al. Ibrain. 2022 Nov 12;9(1):3-12. doi: 10.1002/ibra.12078. eCollection 2023 Spring. Ibrain. 2022. PMID: 37786523 Free PMC article.
Obviously, Zea-longa scores increased in rats with HI insult. Subsequently, SAMSN1 was screened out, and it was found that SAMSN1 was strikingly upregulated in SY5Y cells and fetal neurons post-OGD. Interestingly, we found that SAMSN1 silencing could markedly …
Obviously, Zea-longa scores increased in rats with HI insult. Subsequently, SAMSN1 was screened out, and it was found that SAMSN1 …
Differentiation-related genes in tumor-associated macrophages as potential prognostic biomarkers in non-small cell lung cancer.
Li Z, Zhou B, Zhu X, Yang F, Jin K, Dai J, Zhu Y, Song X, Jiang G. Li Z, et al. Front Immunol. 2023 Mar 9;14:1123840. doi: 10.3389/fimmu.2023.1123840. eCollection 2023. Front Immunol. 2023. PMID: 36969247 Free PMC article.
C1QB, CD84, FGL2, MS4A6A, NLRP3, PLEK, SAMSN1, SPN, and ZEB2 were downregulated in NSCLC compared to non-cancer tissue. ...Meanwhile, immunohistochemical staining showed that C1QB, CCL4, SPN, CD14, NLRP3, SAMSN1, MS4A6A, TMEM176B were expressed in different degrees …
C1QB, CD84, FGL2, MS4A6A, NLRP3, PLEK, SAMSN1, SPN, and ZEB2 were downregulated in NSCLC compared to non-cancer tissue. ...Meanwhile, …
Characterization of the role of Samsn1 loss in multiple myeloma development.
Friend NL, Hewett DR, Panagopoulos V, Noll JE, Vandyke K, Mrozik KM, Fitter S, Zannettino ACW. Friend NL, et al. FASEB Bioadv. 2020 Aug 5;2(9):554-572. doi: 10.1096/fba.2020-00027. eCollection 2020 Sep. FASEB Bioadv. 2020. PMID: 32923989 Free PMC article.
Crucially, the growth of Samsn1-expressing 5TGM1 cells was limited in C57BL/6/Samsn1(-/-) mice but not in C57BL/6 Samsn1(+/+) mice. We conclude that the reported potent in vivo tumor suppressor activity of Samsn1 can be attributed, in large part, to gr …
Crucially, the growth of Samsn1-expressing 5TGM1 cells was limited in C57BL/6/Samsn1(-/-) mice but not in C57BL/6 Samsn1 …
SAMSN1 is highly expressed and associated with a poor survival in glioblastoma multiforme.
Yan Y, Zhang L, Xu T, Zhou J, Qin R, Chen C, Zou Y, Fu D, Hu G, Chen J, Lu Y. Yan Y, et al. PLoS One. 2013 Nov 22;8(11):e81905. doi: 10.1371/journal.pone.0081905. eCollection 2013. PLoS One. 2013. PMID: 24278465 Free PMC article.
Multivariate survival analysis with Cox proportional hazards regression models confirmed that high expression of SAMSN1 was a strong risk factor for PFS and OS of GBM patients. CONCLUSION: SAMSN1 is over-expressed in glioma as compared with that found in normal brai …
Multivariate survival analysis with Cox proportional hazards regression models confirmed that high expression of SAMSN1 was a strong …
Prognostic relevance of SAMSN1 expression in gastric cancer.
Kanda M, Shimizu D, Sueoka S, Nomoto S, Oya H, Takami H, Ezaka K, Hashimoto R, Tanaka Y, Kobayashi D, Tanaka C, Yamada S, Fujii T, Nakayama G, Sugimoto H, Koike M, Fujiwara M, Kodera Y. Kanda M, et al. Oncol Lett. 2016 Dec;12(6):4708-4716. doi: 10.3892/ol.2016.5233. Epub 2016 Oct 6. Oncol Lett. 2016. PMID: 28105178 Free PMC article.
Immunohistochemical staining was performed to determine the pattern of SAMSN1 protein expression in gastric tissues. The prognostic impact of SAMSN1 expression was determined by analyzing 175 pairs of surgically resected gastric tissues. ...The pattern of SAMSN1 …
Immunohistochemical staining was performed to determine the pattern of SAMSN1 protein expression in gastric tissues. The prognostic i …
Lama2 And Samsn1 Mediate the Effects of Brn4 on Hippocampal Neural Stem Cell Proliferation and Differentiation.
Zhang L, Zhang X, Ji R, Ji Y, Wu Y, Ding X, Shang Z, Liu X, Li W, Guo J, Wang J, Cheng X, Qin J, Tian M, Jin G, Zhang X. Zhang L, et al. Stem Cells Int. 2023 Apr 13;2023:7284986. doi: 10.1155/2023/7284986. eCollection 2023. Stem Cells Int. 2023. PMID: 37091532 Free PMC article.
EdU incorporation, cell cycle analysis, and CCK-8 assay indicated that Lama2 and Samsn1 mediated the inhibitory effect of Brn4 on the proliferation of hippocampal NSCs. Immunofluorescence staining, RT-qPCR, and Western blot suggested that Lama2 and Samsn1 mediated t …
EdU incorporation, cell cycle analysis, and CCK-8 assay indicated that Lama2 and Samsn1 mediated the inhibitory effect of Brn4 on the …
Suppression of SAMSN1 Expression is Associated with the Malignant Phenotype of Hepatocellular Carcinoma.
Sueoka S, Kanda M, Sugimoto H, Shimizu D, Nomoto S, Oya H, Takami H, Ezaka K, Hashimoto R, Tanaka Y, Okamura Y, Yamada S, Fujii T, Nakayama G, Koike M, Fujiwara M, Kodera Y. Sueoka S, et al. Ann Surg Oncol. 2015 Dec;22 Suppl 3:S1453-60. doi: 10.1245/s10434-015-4524-1. Epub 2015 Mar 25. Ann Surg Oncol. 2015. PMID: 25805236
Analysis of HCC cell lines revealed that hypermethylation of the SAMSN1 promoter correlated with decreased expression of SAMSN1 mRNA. ...Moreover, multivariate analysis identified SAMSN1 as an independent prognostic factor of HCC progression. The expression p …
Analysis of HCC cell lines revealed that hypermethylation of the SAMSN1 promoter correlated with decreased expression of SAMSN1 …
SAMSN1 is a tumor suppressor gene in multiple myeloma.
Noll JE, Hewett DR, Williams SA, Vandyke K, Kok C, To LB, Zannettino AC. Noll JE, et al. Neoplasia. 2014 Jul;16(7):572-85. doi: 10.1016/j.neo.2014.07.002. Neoplasia. 2014. PMID: 25117979 Free PMC article.
In addition, SAMSN1 expression is reduced in the malignant CD138+ PCs of patients with MM and this reduced expression correlates to total PC burden. We identify promoter methylation as a potential mechanism through which SAMSN1 expression is modulated in human myelo …
In addition, SAMSN1 expression is reduced in the malignant CD138+ PCs of patients with MM and this reduced expression correlates to t …
Novel Alzheimer risk genes determine the microglia response to amyloid-β but not to TAU pathology.
Sierksma A, Lu A, Mancuso R, Fattorelli N, Thrupp N, Salta E, Zoco J, Blum D, Buée L, De Strooper B, Fiers M. Sierksma A, et al. EMBO Mol Med. 2020 Mar 6;12(3):e10606. doi: 10.15252/emmm.201910606. Epub 2020 Jan 17. EMBO Mol Med. 2020. PMID: 31951107 Free PMC article.
We identify in this module 7 established AD risk genes (APOE, CLU, INPP5D, CD33, PLCG2, SPI1, and FCER1G) and 11 AD GWAS genes below the genome-wide significance threshold (GPC2, TREML2, SYK, GRN, SLC2A5, SAMSN1, PYDC1, HEXB, RRBP1, LYN, and BLNK), that become significantl …
We identify in this module 7 established AD risk genes (APOE, CLU, INPP5D, CD33, PLCG2, SPI1, and FCER1G) and 11 AD GWAS genes below the gen …
39 results