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Items: 45


Voltage-clamp recordings of light responses from wild-type and mutant mouse cone photoreceptors.

Ingram NT, Sampath AP, Fain GL.

J Gen Physiol. 2019 Sep 27. pii: jgp.201912419. doi: 10.1085/jgp.201912419. [Epub ahead of print]


Activation of Rod Input in a Model of Retinal Degeneration Reverses Retinal Remodeling and Induces Formation of Functional Synapses and Recovery of Visual Signaling in the Adult Retina.

Wang T, Pahlberg J, Cafaro J, Frederiksen R, Cooper AJ, Sampath AP, Field GD, Chen J.

J Neurosci. 2019 Aug 21;39(34):6798-6810. doi: 10.1523/JNEUROSCI.2902-18.2019. Epub 2019 Jul 8.


Light-Driven Regeneration of Cone Visual Pigments through a Mechanism Involving RGR Opsin in Müller Glial Cells.

Morshedian A, Kaylor JJ, Ng SY, Tsan A, Frederiksen R, Xu T, Yuan L, Sampath AP, Radu RA, Fain GL, Travis GH.

Neuron. 2019 Jun 19;102(6):1172-1183.e5. doi: 10.1016/j.neuron.2019.04.004. Epub 2019 May 2.


Rod and cone interactions in the retina.

Fain G, Sampath AP.

F1000Res. 2018 May 23;7. pii: F1000 Faculty Rev-657. doi: 10.12688/f1000research.14412.1. eCollection 2018. Review.


LRIT1 Modulates Adaptive Changes in Synaptic Communication of Cone Photoreceptors.

Sarria I, Cao Y, Wang Y, Ingram NT, Orlandi C, Kamasawa N, Kolesnikov AV, Pahlberg J, Kefalov VJ, Sampath AP, Martemyanov KA.

Cell Rep. 2018 Mar 27;22(13):3562-3573. doi: 10.1016/j.celrep.2018.03.008.


The Transduction Cascade in Retinal ON-Bipolar Cells: Signal Processing and Disease.

Martemyanov KA, Sampath AP.

Annu Rev Vis Sci. 2017 Sep 15;3:25-51. doi: 10.1146/annurev-vision-102016-061338. Epub 2017 Jul 17. Review.


The Auxiliary Calcium Channel Subunit α2δ4 Is Required for Axonal Elaboration, Synaptic Transmission, and Wiring of Rod Photoreceptors.

Wang Y, Fehlhaber KE, Sarria I, Cao Y, Ingram NT, Guerrero-Given D, Throesch B, Baldwin K, Kamasawa N, Ohtsuka T, Sampath AP, Martemyanov KA.

Neuron. 2017 Mar 22;93(6):1359-1374.e6. doi: 10.1016/j.neuron.2017.02.021. Epub 2017 Mar 2.


Behavioural and physiological limits to vision in mammals.

Field GD, Sampath AP.

Philos Trans R Soc Lond B Biol Sci. 2017 Apr 5;372(1717). pii: 20160072. doi: 10.1098/rstb.2016.0072. Review.


Voltage-sensitive conductances increase the sensitivity of rod photoresponses following pigment bleaching.

Pahlberg J, Frederiksen R, Pollock GE, Miyagishima KJ, Sampath AP, Cornwall MC.

J Physiol. 2017 Jun 1;595(11):3459-3469. doi: 10.1113/JP273398. Epub 2017 Mar 22.


Why are rods more sensitive than cones?

Ingram NT, Sampath AP, Fain GL.

J Physiol. 2016 Oct 1;594(19):5415-26. doi: 10.1113/JP272556. Epub 2016 Jul 21. Review.


Mechanism for Selective Synaptic Wiring of Rod Photoreceptors into the Retinal Circuitry and Its Role in Vision.

Cao Y, Sarria I, Fehlhaber KE, Kamasawa N, Orlandi C, James KN, Hazen JL, Gardner MR, Farzan M, Lee A, Baker S, Baldwin K, Sampath AP, Martemyanov KA.

Neuron. 2015 Sep 23;87(6):1248-1260. doi: 10.1016/j.neuron.2015.09.002.


Exchange of Cone for Rod Phosphodiesterase 6 Catalytic Subunits in Rod Photoreceptors Mimics in Part Features of Light Adaptation.

Majumder A, Pahlberg J, Muradov H, Boyd KK, Sampath AP, Artemyev NO.

J Neurosci. 2015 Jun 17;35(24):9225-35. doi: 10.1523/JNEUROSCI.3563-14.2015.


Sensitivity and kinetics of signal transmission at the first visual synapse differentially impact visually-guided behavior.

Sarria I, Pahlberg J, Cao Y, Kolesnikov AV, Kefalov VJ, Sampath AP, Martemyanov KA.

Elife. 2015 Apr 16;4:e06358. doi: 10.7554/eLife.06358.


Detection of single photons by toad and mouse rods.

Reingruber J, Pahlberg J, Woodruff ML, Sampath AP, Fain GL, Holcman D.

Proc Natl Acad Sci U S A. 2013 Nov 26;110(48):19378-83. doi: 10.1073/pnas.1314030110. Epub 2013 Nov 8.


Transducin translocation contributes to rod survival and enhances synaptic transmission from rods to rod bipolar cells.

Majumder A, Pahlberg J, Boyd KK, Kerov V, Kolandaivelu S, Ramamurthy V, Sampath AP, Artemyev NO.

Proc Natl Acad Sci U S A. 2013 Jul 23;110(30):12468-73. doi: 10.1073/pnas.1222666110. Epub 2013 Jul 8.


Apoptosis regulates ipRGC spacing necessary for rods and cones to drive circadian photoentrainment.

Chen SK, Chew KS, McNeill DS, Keeley PW, Ecker JL, Mao BQ, Pahlberg J, Kim B, Lee SC, Fox MA, Guido W, Wong KY, Sampath AP, Reese BE, Kuruvilla R, Hattar S.

Neuron. 2013 Feb 6;77(3):503-15. doi: 10.1016/j.neuron.2012.11.028.


Physiological response of normal and RD mouse retinal ganglion cells to electrical stimulation.

Cho AK, Sampath AP, Weiland JD.

Conf Proc IEEE Eng Med Biol Soc. 2012;2012:2985-8. doi: 10.1109/EMBC.2012.6346591.


Functional comparison of rod and cone Gα(t) on the regulation of light sensitivity.

Mao W, Miyagishima KJ, Yao Y, Soreghan B, Sampath AP, Chen J.

J Biol Chem. 2013 Feb 22;288(8):5257-67. doi: 10.1074/jbc.M112.430058. Epub 2013 Jan 3.


Regulators of G protein signaling RGS7 and RGS11 determine the onset of the light response in ON bipolar neurons.

Cao Y, Pahlberg J, Sarria I, Kamasawa N, Sampath AP, Martemyanov KA.

Proc Natl Acad Sci U S A. 2012 May 15;109(20):7905-10. doi: 10.1073/pnas.1202332109. Epub 2012 Apr 30.


Dark-adapted response threshold of OFF ganglion cells is not set by OFF bipolar cells in the mouse retina.

Arman AC, Sampath AP.

J Neurophysiol. 2012 May;107(10):2649-59. doi: 10.1152/jn.01202.2011. Epub 2012 Feb 15.


Physiological response of mouse retinal ganglion cells to electrical stimulation: effect of soma size.

Cho AK, Sampath AP, Weiland JD.

Conf Proc IEEE Eng Med Biol Soc. 2011;2011:1081-4. doi: 10.1109/IEMBS.2011.6090252.


Perspectives on: information coding in mammalian sensory physiology.

Farley RA, Sampath AP.

J Gen Physiol. 2011 Sep;138(3):281-2. doi: 10.1085/jgp.201110666. No abstract available.


Virally delivered channelrhodopsin-2 safely and effectively restores visual function in multiple mouse models of blindness.

Doroudchi MM, Greenberg KP, Liu J, Silka KA, Boyden ES, Lockridge JA, Arman AC, Janani R, Boye SE, Boye SL, Gordon GM, Matteo BC, Sampath AP, Hauswirth WW, Horsager A.

Mol Ther. 2011 Jul;19(7):1220-9. doi: 10.1038/mt.2011.69. Epub 2011 Apr 19.


Patch clamp recordings from mouse retinal neurons in a dark-adapted slice preparation.

Arman AC, Sampath AP.

J Vis Exp. 2010 Sep 12;(43). pii: 2107. doi: 10.3791/2107.


Coordinated control of sensitivity by two splice variants of Gα(o) in retinal ON bipolar cells.

Okawa H, Pahlberg J, Rieke F, Birnbaumer L, Sampath AP.

J Gen Physiol. 2010 Oct;136(4):443-54. doi: 10.1085/jgp.201010477. Epub 2010 Sep 13.


Rod photoreceptors drive circadian photoentrainment across a wide range of light intensities.

Altimus CM, Güler AD, Alam NM, Arman AC, Prusky GT, Sampath AP, Hattar S.

Nat Neurosci. 2010 Sep;13(9):1107-12. doi: 10.1038/nn.2617. Epub 2010 Aug 15.


Setting the absolute threshold of vision.

Sampath AP, Fain GL.

F1000 Biol Rep. 2009 Aug 26;1:66. doi: 10.3410/B1-66.


Flow of energy in the outer retina in darkness and in light.

Linton JD, Holzhausen LC, Babai N, Song H, Miyagishima KJ, Stearns GW, Lindsay K, Wei J, Chertov AO, Peters TA, Caffe R, Pluk H, Seeliger MW, Tanimoto N, Fong K, Bolton L, Kuok DL, Sweet IR, Bartoletti TM, Radu RA, Travis GH, Zagotta WN, Townes-Anderson E, Parker E, Van der Zee CE, Sampath AP, Sokolov M, Thoreson WB, Hurley JB.

Proc Natl Acad Sci U S A. 2010 May 11;107(19):8599-604. doi: 10.1073/pnas.1002471107. Epub 2010 May 5.


Optimal processing of photoreceptor signals is required to maximize behavioural sensitivity.

Okawa H, Miyagishima KJ, Arman AC, Hurley JB, Field GD, Sampath AP.

J Physiol. 2010 Jun 1;588(Pt 11):1947-60. doi: 10.1113/jphysiol.2010.188573. Epub 2010 Apr 19.


Photopigment quenching is Ca2+ dependent and controls response duration in salamander L-cone photoreceptors.

Matthews HR, Sampath AP.

J Gen Physiol. 2010 Apr;135(4):355-66. doi: 10.1085/jgp.200910394. Epub 2010 Mar 15.


Functional properties of synaptic transmission in primary sense organs.

Singer JH, Glowatzki E, Moser T, Strowbridge BW, Bhandawat V, Sampath AP.

J Neurosci. 2009 Oct 14;29(41):12802-6. doi: 10.1523/JNEUROSCI.3346-09.2009. Review.


Metabolic constraints on the recovery of sensitivity after visual pigment bleaching in retinal rods.

Miyagishima KJ, Cornwall MC, Sampath AP.

J Gen Physiol. 2009 Sep;134(3):165-75. doi: 10.1085/jgp.200910267. Epub 2009 Aug 17.


Retina-specific GTPase accelerator RGS11/G beta 5S/R9AP is a constitutive heterotrimer selectively targeted to mGluR6 in ON-bipolar neurons.

Cao Y, Masuho I, Okawa H, Xie K, Asami J, Kammermeier PJ, Maddox DM, Furukawa T, Inoue T, Sampath AP, Martemyanov KA.

J Neurosci. 2009 Jul 22;29(29):9301-13. doi: 10.1523/JNEUROSCI.1367-09.2009.


ATP consumption by mammalian rod photoreceptors in darkness and in light.

Okawa H, Sampath AP, Laughlin SB, Fain GL.

Curr Biol. 2008 Dec 23;18(24):1917-21. doi: 10.1016/j.cub.2008.10.029. Epub 2008 Dec 11.


Targeting of RGS7/Gbeta5 to the dendritic tips of ON-bipolar cells is independent of its association with membrane anchor R7BP.

Cao Y, Song H, Okawa H, Sampath AP, Sokolov M, Martemyanov KA.

J Neurosci. 2008 Oct 8;28(41):10443-9. doi: 10.1523/JNEUROSCI.3282-08.2008.


Optimization of single-photon response transmission at the rod-to-rod bipolar synapse.

Okawa H, Sampath AP.

Physiology (Bethesda). 2007 Aug;22:279-86. Review.


Controlling the gain of rod-mediated signals in the Mammalian retina.

Dunn FA, Doan T, Sampath AP, Rieke F.

J Neurosci. 2006 Apr 12;26(15):3959-70.


Recoverin improves rod-mediated vision by enhancing signal transmission in the mouse retina.

Sampath AP, Strissel KJ, Elias R, Arshavsky VY, McGinnis JF, Chen J, Kawamura S, Rieke F, Hurley JB.

Neuron. 2005 May 5;46(3):413-20.


Retinal processing near absolute threshold: from behavior to mechanism.

Field GD, Sampath AP, Rieke F.

Annu Rev Physiol. 2005;67:491-514. Review.


Measurement of cytoplasmic calcium concentration in the rods of wild-type and transducin knock-out mice.

Woodruff ML, Sampath AP, Matthews HR, Krasnoperova NV, Lem J, Fain GL.

J Physiol. 2002 Aug 1;542(Pt 3):843-54.


Molecular mechanism of spontaneous pigment activation in retinal cones.

Sampath AP, Baylor DA.

Biophys J. 2002 Jul;83(1):184-93.


Light-dependent changes in outer segment free-Ca2+ concentration in salamander cone photoreceptors.

Sampath AP, Matthews HR, Cornwall MC, Bandarchi J, Fain GL.

J Gen Physiol. 1999 Feb;113(2):267-77.


Bleached pigment produces a maintained decrease in outer segment Ca2+ in salamander rods.

Sampath AP, Matthews HR, Cornwall MC, Fain GL.

J Gen Physiol. 1998 Jan;111(1):53-64.

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