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Items: 9


Isolating pulmonary microvascular endothelial cells ex vivo: Implications for pulmonary arterial hypertension, and a caution on the use of commercial biomaterials.

Wertheim BM, Lin YD, Zhang YY, Samokhin AO, Alba GA, Arons E, Yu PB, Maron BA.

PLoS One. 2019 Feb 27;14(2):e0211909. doi: 10.1371/journal.pone.0211909. eCollection 2019.


NEDD9 targets COL3A1 to promote endothelial fibrosis and pulmonary arterial hypertension.

Samokhin AO, Stephens T, Wertheim BM, Wang RS, Vargas SO, Yung LM, Cao M, Brown M, Arons E, Dieffenbach PB, Fewell JG, Matar M, Bowman FP, Haley KJ, Alba GA, Marino SM, Kumar R, Rosas IO, Waxman AB, Oldham WM, Khanna D, Graham BB, Seo S, Gladyshev VN, Yu PB, Fredenburgh LE, Loscalzo J, Leopold JA, Maron BA.

Sci Transl Med. 2018 Jun 13;10(445). pii: eaap7294. doi: 10.1126/scitranslmed.aap7294.


The IL-1RI Co-Receptor TILRR (FREM1 Isoform 2) Controls Aberrant Inflammatory Responses and Development of Vascular Disease.

Smith SA, Samokhin AO, Alfadi M, Murphy EC, Rhodes D, Holcombe WML, Kiss-Toth E, Storey RF, Yee SP, Francis SE, Qwarnstrom EE.

JACC Basic Transl Sci. 2017 Aug 28;2(4):398-414. doi: 10.1016/j.jacbts.2017.03.014. eCollection 2017 Aug.


Lack of cathepsin activities alter or prevent the development of lung granulomas in a mouse model of sarcoidosis.

Samokhin AO, Gauthier JY, Percival MD, Brömme D.

Respir Res. 2011 Jan 20;12:13. doi: 10.1186/1465-9921-12-13.


Pharmacological inhibition of cathepsin S decreases atherosclerotic lesions in Apoe-/- mice.

Samokhin AO, Lythgo PA, Gauthier JY, Percival MD, Brömme D.

J Cardiovasc Pharmacol. 2010 Jul;56(1):98-105. doi: 10.1097/FJC.0b013e3181e23e10.


Cholate-containing high-fat diet induces the formation of multinucleated giant cells in atherosclerotic plaques of apolipoprotein E-/- mice.

Samokhin AO, Wilson S, Nho B, Lizame ML, Musenden OE, Brömme D.

Arterioscler Thromb Vasc Biol. 2010 Jun;30(6):1166-73. doi: 10.1161/ATVBAHA.110.203976. Epub 2010 Mar 4.


ApoE-deficient mice on cholate-containing high-fat diet reveal a pathology similar to lung sarcoidosis.

Samokhin AO, Bühling F, Theissig F, Brömme D.

Am J Pathol. 2010 Mar;176(3):1148-56. doi: 10.2353/ajpath.2010.090857. Epub 2010 Jan 21.


Free cholesterol accumulation in macrophage membranes activates Toll-like receptors and p38 mitogen-activated protein kinase and induces cathepsin K.

Sun Y, Ishibashi M, Seimon T, Lee M, Sharma SM, Fitzgerald KA, Samokhin AO, Wang Y, Sayers S, Aikawa M, Jerome WG, Ostrowski MC, Bromme D, Libby P, Tabas IA, Welch CL, Tall AR.

Circ Res. 2009 Feb 27;104(4):455-65. doi: 10.1161/CIRCRESAHA.108.182568. Epub 2009 Jan 2.


Role of cathepsin K in structural changes in brachiocephalic artery during progression of atherosclerosis in apoE-deficient mice.

Samokhin AO, Wong A, Saftig P, Brömme D.

Atherosclerosis. 2008 Sep;200(1):58-68. doi: 10.1016/j.atherosclerosis.2007.12.047. Epub 2008 Mar 4.


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