Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 85

1.

Ibogaine Administration Modifies GDNF and BDNF Expression in Brain Regions Involved in Mesocorticolimbic and Nigral Dopaminergic Circuits.

Marton S, González B, Rodríguez-Bottero S, Miquel E, Martínez-Palma L, Pazos M, Prieto JP, Rodríguez P, Sames D, Seoane G, Scorza C, Cassina P, Carrera I.

Front Pharmacol. 2019 Mar 5;10:193. doi: 10.3389/fphar.2019.00193. eCollection 2019.

2.

Evoked transients of pH-sensitive fluorescent false neurotransmitter reveal dopamine hot spots in the globus pallidus.

Meszaros J, Cheung T, Erler MM, Kang UJ, Sames D, Kellendonk C, Sulzer D.

Elife. 2018 Dec 19;7. pii: e42383. doi: 10.7554/eLife.42383.

3.

Designing a norepinephrine optical tracer for imaging individual noradrenergic synapses and their activity in vivo.

Dunn M, Henke A, Clark S, Kovalyova Y, Kempadoo KA, Karpowicz RJ Jr, Kandel ER, Sulzer D, Sames D.

Nat Commun. 2018 Jul 19;9(1):2838. doi: 10.1038/s41467-018-05075-x.

4.

Toward Serotonin Fluorescent False Neurotransmitters: Development of Fluorescent Dual Serotonin and Vesicular Monoamine Transporter Substrates for Visualizing Serotonin Neurons.

Henke A, Kovalyova Y, Dunn M, Dreier D, Gubernator NG, Dincheva I, Hwu C, Šebej P, Ansorge MS, Sulzer D, Sames D.

ACS Chem Neurosci. 2018 May 16;9(5):925-934. doi: 10.1021/acschemneuro.7b00320. Epub 2018 Feb 2.

5.

Identification of Fluorescent Small Molecule Compounds for Synaptic Labeling by Image-Based, High-Content Screening.

Dunn M, Boltaev U, Beskow A, Pampou S, Realubit R, Meira T, Silva JV, Reeb R, Karan C, Jockusch S, Sulzer D, Chang YT, Sames D, Waites CL.

ACS Chem Neurosci. 2018 Apr 18;9(4):673-683. doi: 10.1021/acschemneuro.7b00263. Epub 2017 Dec 18.

PMID:
29215865
6.

Multiplex quantitative assays indicate a need for reevaluating reported small-molecule TrkB agonists.

Boltaev U, Meyer Y, Tolibzoda F, Jacques T, Gassaway M, Xu Q, Wagner F, Zhang YL, Palmer M, Holson E, Sames D.

Sci Signal. 2017 Aug 22;10(493). pii: eaal1670. doi: 10.1126/scisignal.aal1670.

PMID:
28831019
7.

Neuronal Depolarization Drives Increased Dopamine Synaptic Vesicle Loading via VGLUT.

Aguilar JI, Dunn M, Mingote S, Karam CS, Farino ZJ, Sonders MS, Choi SJ, Grygoruk A, Zhang Y, Cela C, Choi BJ, Flores J, Freyberg RJ, McCabe BD, Mosharov EV, Krantz DE, Javitch JA, Sulzer D, Sames D, Rayport S, Freyberg Z.

Neuron. 2017 Aug 30;95(5):1074-1088.e7. doi: 10.1016/j.neuron.2017.07.038. Epub 2017 Aug 17.

8.

The Behavioral Effects of the Antidepressant Tianeptine Require the Mu-Opioid Receptor.

Samuels BA, Nautiyal KM, Kruegel AC, Levinstein MR, Magalong VM, Gassaway MM, Grinnell SG, Han J, Ansonoff MA, Pintar JE, Javitch JA, Sames D, Hen R.

Neuropsychopharmacology. 2017 Sep;42(10):2052-2063. doi: 10.1038/npp.2017.60. Epub 2017 Mar 17.

9.

Accessing Drug Metabolites via Transition-Metal Catalyzed C-H Oxidation: The Liver as Synthetic Inspiration.

Genovino J, Sames D, Hamann LG, Touré BB.

Angew Chem Int Ed Engl. 2016 Nov 7;55(46):14218-14238. doi: 10.1002/anie.201602644. Epub 2016 Oct 10. Review.

PMID:
27723189
10.

Synthetic and Receptor Signaling Explorations of the Mitragyna Alkaloids: Mitragynine as an Atypical Molecular Framework for Opioid Receptor Modulators.

Kruegel AC, Gassaway MM, Kapoor A, Váradi A, Majumdar S, Filizola M, Javitch JA, Sames D.

J Am Chem Soc. 2016 Jun 1;138(21):6754-64. doi: 10.1021/jacs.6b00360. Epub 2016 May 18.

11.

Fluorescent false neurotransmitter reveals functionally silent dopamine vesicle clusters in the striatum.

Pereira DB, Schmitz Y, Mészáros J, Merchant P, Hu G, Li S, Henke A, Lizardi-Ortiz JE, Karpowicz RJ Jr, Morgenstern TJ, Sonders MS, Kanter E, Rodriguez PC, Mosharov EV, Sames D, Sulzer D.

Nat Neurosci. 2016 Apr;19(4):578-86. doi: 10.1038/nn.4252. Epub 2016 Feb 22.

12.

Mechanisms of amphetamine action illuminated through optical monitoring of dopamine synaptic vesicles in Drosophila brain.

Freyberg Z, Sonders MS, Aguilar JI, Hiranita T, Karam CS, Flores J, Pizzo AB, Zhang Y, Farino ZJ, Chen A, Martin CA, Kopajtic TA, Fei H, Hu G, Lin YY, Mosharov EV, McCabe BD, Freyberg R, Wimalasena K, Hsin LW, Sames D, Krantz DE, Katz JL, Sulzer D, Javitch JA.

Nat Commun. 2016 Feb 16;7:10652. doi: 10.1038/ncomms10652.

13.

Deconstructing the Iboga Alkaloid Skeleton: Potentiation of FGF2-induced Glial Cell Line-Derived Neurotrophic Factor Release by a Novel Compound.

Gassaway MM, Jacques TL, Kruegel AC, Karpowicz RJ Jr, Li X, Li S, Myer Y, Sames D.

ACS Chem Biol. 2016 Jan 15;11(1):77-87. doi: 10.1021/acschembio.5b00678. Epub 2015 Oct 30.

PMID:
26517751
14.

Synaptic optical imaging platforms: Examining pharmacological modulation of neurotransmitter release at discrete synapses.

Merchant P, Sulzer D, Sames D.

Neuropharmacology. 2015 Nov;98:90-4. doi: 10.1016/j.neuropharm.2015.03.013. Epub 2015 Mar 30. Review.

15.

Constructing Iboga alkaloids via C-H bond functionalization: examination of the direct and catalytic union of heteroarenes and isoquinuclidine alkenes.

Kruegel AC, Rakshit S, Li X, Sames D.

J Org Chem. 2015 Feb 20;80(4):2062-71. doi: 10.1021/jo5018102. Epub 2015 Jan 29.

PMID:
25633249
16.

NeuO: a fluorescent chemical probe for live neuron labeling.

Er JC, Leong C, Teoh CL, Yuan Q, Merchant P, Dunn M, Sulzer D, Sames D, Bhinge A, Kim D, Kim SM, Yoon MH, Stanton LW, Je SH, Yun SW, Chang YT.

Angew Chem Int Ed Engl. 2015 Feb 16;54(8):2442-6. doi: 10.1002/anie.201408614. Epub 2015 Jan 7.

PMID:
25565332
17.

The atypical antidepressant and neurorestorative agent tianeptine is a μ-opioid receptor agonist.

Gassaway MM, Rives ML, Kruegel AC, Javitch JA, Sames D.

Transl Psychiatry. 2014 Jul 15;4:e411. doi: 10.1038/tp.2014.30.

18.

Paradoxical abatement of striatal dopaminergic transmission by cocaine and methylphenidate.

Federici M, Latagliata EC, Ledonne A, Rizzo FR, Feligioni M, Sulzer D, Dunn M, Sames D, Gu H, Nisticò R, Puglisi-Allegra S, Mercuri NB.

J Biol Chem. 2014 Jan 3;289(1):264-74. doi: 10.1074/jbc.M113.495499. Epub 2013 Nov 26.

19.

Complementation of biotransformations with chemical C-H oxidation: copper-catalyzed oxidation of tertiary amines in complex pharmaceuticals.

Genovino J, Lütz S, Sames D, Touré BB.

J Am Chem Soc. 2013 Aug 21;135(33):12346-52. doi: 10.1021/ja405471h. Epub 2013 Aug 12.

PMID:
23875728
20.

Visualizing neurotransmitter secretion at individual synapses.

Sames D, Dunn M, Karpowicz RJ Jr, Sulzer D.

ACS Chem Neurosci. 2013 May 15;4(5):648-51. doi: 10.1021/cn4000956.

21.

New fluorescent substrate enables quantitative and high-throughput examination of vesicular monoamine transporter 2 (VMAT2).

Hu G, Henke A, Karpowicz RJ Jr, Sonders MS, Farrimond F, Edwards R, Sulzer D, Sames D.

ACS Chem Biol. 2013 Sep 20;8(9):1947-54. doi: 10.1021/cb400259n. Epub 2013 Jul 16.

22.

APP+, a fluorescent analogue of the neurotoxin MPP+, is a marker of catecholamine neurons in brain tissue, but not a fluorescent false neurotransmitter.

Karpowicz RJ Jr, Dunn M, Sulzer D, Sames D.

ACS Chem Neurosci. 2013 May 15;4(5):858-69. doi: 10.1021/cn400038u. Epub 2013 May 6.

23.

Fluorescent dopamine tracer resolves individual dopaminergic synapses and their activity in the brain.

Rodriguez PC, Pereira DB, Borgkvist A, Wong MY, Barnard C, Sonders MS, Zhang H, Sames D, Sulzer D.

Proc Natl Acad Sci U S A. 2013 Jan 15;110(3):870-5. doi: 10.1073/pnas.1213569110. Epub 2012 Dec 31.

24.

C-H bonds as ubiquitous functionality: preparation of multiple regioisomers of arylated 1,2,4-triazoles via C-H arylation.

Joo JM, Guo P, Sames D.

J Org Chem. 2013 Jan 18;78(2):738-43. doi: 10.1021/jo3021677. Epub 2012 Dec 31.

26.
27.

C-H arylation of pyridines: high regioselectivity as a consequence of the electronic character of C-H bonds and heteroarene ring.

Guo P, Joo JM, Rakshit S, Sames D.

J Am Chem Soc. 2011 Oct 19;133(41):16338-41. doi: 10.1021/ja206022p. Epub 2011 Sep 22.

28.

Intermolecular energy transfer from Tb3+ to Eu3+ in aqueous aggregates and on the surface of human cells.

Lee M, Tremblay MS, Jockusch S, Turro NJ, Sames D.

Org Lett. 2011 Jun 3;13(11):2802-5. doi: 10.1021/ol200328p. Epub 2011 May 12.

PMID:
21563789
29.
30.

(-)-CHANA, a fluorogenic probe for detecting amyloid binding alcohol dehydrogenase HSD10 activity in living cells.

Muirhead KE, Froemming M, Li X, Musilek K, Conway SJ, Sames D, Gunn-Moore FJ.

ACS Chem Biol. 2010 Dec 17;5(12):1105-14. doi: 10.1021/cb100199m. Epub 2010 Oct 8.

PMID:
20836522
32.

Development of pH-responsive fluorescent false neurotransmitters.

Lee M, Gubernator NG, Sulzer D, Sames D.

J Am Chem Soc. 2010 Jul 7;132(26):8828-30. doi: 10.1021/ja101740k.

33.
34.

Dopamine release at individual presynaptic terminals visualized with FFNs.

Zhang H, Gubernator NG, Yue M, Staal RG, Mosharov EV, Pereira D, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D.

J Vis Exp. 2009 Aug 31;(30). pii: 1562. doi: 10.3791/1562.

35.

C-H bond functionalization via hydride transfer: synthesis of dihydrobenzopyrans from ortho-vinylaryl akyl ethers.

McQuaid KM, Long JZ, Sames D.

Org Lett. 2009 Jul 16;11(14):2972-5. doi: 10.1021/ol900915p.

36.

Fluorescent false neurotransmitters visualize dopamine release from individual presynaptic terminals.

Gubernator NG, Zhang H, Staal RG, Mosharov EV, Pereira DB, Yue M, Balsanek V, Vadola PA, Mukherjee B, Edwards RH, Sulzer D, Sames D.

Science. 2009 Jun 12;324(5933):1441-4. doi: 10.1126/science.1172278. Epub 2009 May 7.

39.
40.

A luminescent sensor for tyrosine phosphorylation.

Tremblay MS, Lee M, Sames D.

Org Lett. 2008 Jan 3;10(1):5-8. Epub 2007 Dec 11.

PMID:
18069839
41.
42.

Ruthenium catalyzed decarbonylative arylation at sp3 carbon centers in pyrrolidine and piperidine heterocycles.

Gribkov DV, Pastine SJ, Schnürch M, Sames D.

J Am Chem Soc. 2007 Sep 26;129(38):11750-5. Epub 2007 Sep 6.

43.

Transposing molecular fluorescent switches into the near-IR: development of luminogenic reporter substrates for redox metabolism.

Halim M, Tremblay MS, Jockusch S, Turro NJ, Sames D.

J Am Chem Soc. 2007 Jun 27;129(25):7704-5. Epub 2007 Jun 2. No abstract available.

PMID:
17542585
44.

Cocktails of Tb(3+) and Eu(3+) complexes: a general platform for the design of ratiometric optical probes.

Tremblay MS, Halim M, Sames D.

J Am Chem Soc. 2007 Jun 20;129(24):7570-7. Epub 2007 May 23.

PMID:
17518468
45.

Phosphine-free palladium-catalyzed C-H bond arylation of free (N-H)-indoles and pyrroles.

Wang X, Gribkov DV, Sames D.

J Org Chem. 2007 Feb 16;72(4):1476-9.

46.

sp3 C-H bond arylation directed by amidine protecting group: alpha-arylation of pyrrolidines and piperidines.

Pastine SJ, Gribkov DV, Sames D.

J Am Chem Soc. 2006 Nov 8;128(44):14220-1.

PMID:
17076471
47.

Synthesis of luminescent heterometallic bis-lanthanide complexes via selective, sequential metallation.

Tremblay MS, Sames D.

Chem Commun (Camb). 2006 Oct 21;(39):4116-8. Epub 2006 Sep 13.

PMID:
17024267
48.

Fluorogenic metabolic probes for direct activity readout of redox enzymes: Selective measurement of human AKR1C2 in living cells.

Yee DJ, Balsanek V, Bauman DR, Penning TM, Sames D.

Proc Natl Acad Sci U S A. 2006 Sep 5;103(36):13304-9. Epub 2006 Aug 28.

49.

Phosphorylation state-responsive lanthanide peptide conjugates: a luminescence switch based on reversible complex reorganization.

Tremblay MS, Zhu Q, Martí AA, Dyer J, Halim M, Jockusch S, Turro NJ, Sames D.

Org Lett. 2006 Jun 22;8(13):2723-6.

PMID:
16774241
50.

Catalytic C-H arylation of SEM-protected azoles with palladium complexes of NHCs and phosphines.

Touré BB, Lane BS, Sames D.

Org Lett. 2006 May 11;8(10):1979-82.

PMID:
16671761

Supplemental Content

Support Center