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Items: 1 to 50 of 196

1.

Timed Regulation of 3BP2 Induction Is Critical for Sustaining CD8+ T Cell Expansion and Differentiation.

Dimitriou ID, Lee K, Akpan I, Lind EF, Barr VA, Ohashi PS, Samelson LE, Rottapel R.

Cell Rep. 2018 Jul 31;24(5):1123-1135. doi: 10.1016/j.celrep.2018.06.075.

2.

Plasma membrane LAT activation precedes vesicular recruitment defining two phases of early T-cell activation.

Balagopalan L, Yi J, Nguyen T, McIntire KM, Harned AS, Narayan K, Samelson LE.

Nat Commun. 2018 May 22;9(1):2013. doi: 10.1038/s41467-018-04419-x.

3.

The Cish SH2 domain is essential for PLC-γ1 regulation in TCR stimulated CD8+ T cells.

Guittard G, Dios-Esponera A, Palmer DC, Akpan I, Barr VA, Manna A, Restifo NP, Samelson LE.

Sci Rep. 2018 Mar 28;8(1):5336. doi: 10.1038/s41598-018-23549-2.

4.

Intensity and duration of TCR signaling is limited by p38 phosphorylation of ZAP-70T293 and destabilization of the signalosome.

Giardino Torchia ML, Dutta D, Mittelstadt PR, Guha J, Gaida MM, Fish K, Barr VA, Akpan IO, Samelson LE, Tagad HD, Debnath S, Miller Jenkins LM, Appella E, Ashwell JD.

Proc Natl Acad Sci U S A. 2018 Feb 27;115(9):2174-2179. doi: 10.1073/pnas.1713301115. Epub 2018 Feb 12.

5.

Highly Multiplexed, Super-resolution Imaging of T Cells Using madSTORM.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

J Vis Exp. 2017 Jun 24;(124). doi: 10.3791/55997.

6.

Unexpected Cartilage Phenotype in CD4-Cre-Conditional SOS-Deficient Mice.

Guittard G, Gallardo DL, Li W, Melis N, Lui JC, Kortum RL, Shakarishvili NG, Huh S, Baron J, Weigert R, Kramer JA, Samelson LE, Sommers CL.

Front Immunol. 2017 Mar 23;8:343. doi: 10.3389/fimmu.2017.00343. eCollection 2017.

7.

Super-resolution Analysis of TCR-Dependent Signaling: Single-Molecule Localization Microscopy.

Barr VA, Yi J, Samelson LE.

Methods Mol Biol. 2017;1584:183-206. doi: 10.1007/978-1-4939-6881-7_13.

PMID:
28255704
8.

Recruitment of calcineurin to the TCR positively regulates T cell activation.

Dutta D, Barr VA, Akpan I, Mittelstadt PR, Singha LI, Samelson LE, Ashwell JD.

Nat Immunol. 2017 Feb;18(2):196-204. doi: 10.1038/ni.3640. Epub 2016 Dec 12.

PMID:
27941787
9.

Development of nanoscale structure in LAT-based signaling complexes.

Barr VA, Sherman E, Yi J, Akpan I, Rouquette-Jazdanian AK, Samelson LE.

J Cell Sci. 2016 Dec 15;129(24):4548-4562. Epub 2016 Nov 10.

10.

madSTORM: a superresolution technique for large-scale multiplexing at single-molecule accuracy.

Yi J, Manna A, Barr VA, Hong J, Neuman KC, Samelson LE.

Mol Biol Cell. 2016 Nov 7;27(22):3591-3600. Epub 2016 Oct 5.

11.

Microvilli set the stage for T-cell activation.

Yi JC, Samelson LE.

Proc Natl Acad Sci U S A. 2016 Oct 4;113(40):11061-11062. Epub 2016 Sep 23. No abstract available.

12.

Hierarchical nanostructure and synergy of multimolecular signalling complexes.

Sherman E, Barr VA, Merrill RK, Regan CK, Sommers CL, Samelson LE.

Nat Commun. 2016 Jul 11;7:12161. doi: 10.1038/ncomms12161.

13.

William E. Paul, MD (1936-2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Trends Immunol. 2015 Dec;36(12):751-3. No abstract available.

PMID:
27064162
14.

William E. Paul, M.D. (1936–2015).

Germain RN, Fowlkes BJ, Samelson LE, Leonard WJ.

Immunity. 2015 Oct 20;43(4):617-9. No abstract available.

15.

Cish actively silences TCR signaling in CD8+ T cells to maintain tumor tolerance.

Palmer DC, Guittard GC, Franco Z, Crompton JG, Eil RL, Patel SJ, Ji Y, Van Panhuys N, Klebanoff CA, Sukumar M, Clever D, Chichura A, Roychoudhuri R, Varma R, Wang E, Gattinoni L, Marincola FM, Balagopalan L, Samelson LE, Restifo NP.

J Exp Med. 2015 Nov 16;212(12):2095-113. doi: 10.1084/jem.20150304. Epub 2015 Nov 2.

16.

The linker for activation of T cells (LAT) signaling hub: from signaling complexes to microclusters.

Balagopalan L, Kortum RL, Coussens NP, Barr VA, Samelson LE.

J Biol Chem. 2015 Oct 30;290(44):26422-9. doi: 10.1074/jbc.R115.665869. Epub 2015 Sep 9. Review.

17.

miR-155 Controls Lymphoproliferation in LAT Mutant Mice by Restraining T-Cell Apoptosis via SHIP-1/mTOR and PAK1/FOXO3/BIM Pathways.

Rouquette-Jazdanian AK, Kortum RL, Li W, Merrill RK, Nguyen PH, Samelson LE, Sommers CL.

PLoS One. 2015 Jun 29;10(6):e0131823. doi: 10.1371/journal.pone.0131823. eCollection 2015.

18.

Enhanced T-cell activation and differentiation in lymphocytes from transgenic mice expressing ubiquitination-resistant 2KR LAT molecules.

Rodriguez-Peña AB, Gomez-Rodriguez J, Kortum RL, Palmer DC, Yu Z, Guittard GC, Wohlfert EA, Silver PB, Misplon JA, Sommers CL, Feigenbaum L, Epstein SL, Caspi RR, Belkaid Y, Restifo NP, Samelson LE, Balagopalan L.

Gene Ther. 2015 Oct;22(10):781-92. doi: 10.1038/gt.2015.48. Epub 2015 Jun 18.

PMID:
26018935
19.

Absence of both Sos-1 and Sos-2 in peripheral CD4(+) T cells leads to PI3K pathway activation and defects in migration.

Guittard G, Kortum RL, Balagopalan L, Çuburu N, Nguyen P, Sommers CL, Samelson LE.

Eur J Immunol. 2015 Aug;45(8):2389-95. doi: 10.1002/eji.201445226. Epub 2015 Jun 5.

20.

Cytoskeletal forces during signaling activation in Jurkat T-cells.

Hui KL, Balagopalan L, Samelson LE, Upadhyaya A.

Mol Biol Cell. 2015 Feb 15;26(4):685-95. doi: 10.1091/mbc.E14-03-0830. Epub 2014 Dec 17.

21.

The ability of Sos1 to oligomerize the adaptor protein LAT is separable from its guanine nucleotide exchange activity in vivo.

Kortum RL, Balagopalan L, Alexander CP, Garcia J, Pinski JM, Merrill RK, Nguyen PH, Li W, Agarwal I, Akpan IO, Sommers CL, Samelson LE.

Sci Signal. 2013 Nov 12;6(301):ra99. doi: 10.1126/scisignal.2004494.

22.

Functional redundancy of Sos1 and Sos2 for lymphopoiesis and organismal homeostasis and survival.

Baltanás FC, Pérez-Andrés M, Ginel-Picardo A, Diaz D, Jimeno D, Liceras-Boillos P, Kortum RL, Samelson LE, Orfao A, Santos E.

Mol Cell Biol. 2013 Nov;33(22):4562-78. doi: 10.1128/MCB.01026-13. Epub 2013 Sep 16.

23.

Automatic sorting of point pattern sets using Minkowski functionals.

Parker J, Sherman E, van de Raa M, van der Meer D, Samelson LE, Losert W.

Phys Rev E Stat Nonlin Soft Matter Phys. 2013 Aug;88(2):022720. Epub 2013 Aug 29.

PMID:
24032877
24.

Multipoint binding of the SLP-76 SH2 domain to ADAP is critical for oligomerization of SLP-76 signaling complexes in stimulated T cells.

Coussens NP, Hayashi R, Brown PH, Balagopalan L, Balbo A, Akpan I, Houtman JC, Barr VA, Schuck P, Appella E, Samelson LE.

Mol Cell Biol. 2013 Nov;33(21):4140-51. doi: 10.1128/MCB.00410-13. Epub 2013 Aug 26.

25.

miRNA signature of mouse helper T cell hyper-proliferation.

Sommers CL, Rouquette-Jazdanian AK, Robles AI, Kortum RL, Merrill RK, Li W, Nath N, Wohlfert E, Sixt KM, Belkaid Y, Samelson LE.

PLoS One. 2013 Jun 25;8(6):e66709. doi: 10.1371/journal.pone.0066709. Print 2013.

26.

Ras and extracellular signal-regulated kinase signaling in thymocytes and T cells.

Kortum RL, Rouquette-Jazdanian AK, Samelson LE.

Trends Immunol. 2013 Jun;34(6):259-68. doi: 10.1016/j.it.2013.02.004. Epub 2013 Mar 15. Review.

27.

Cutting edge: cell surface linker for activation of T cells is recruited to microclusters and is active in signaling.

Balagopalan L, Barr VA, Kortum RL, Park AK, Samelson LE.

J Immunol. 2013 Apr 15;190(8):3849-53. doi: 10.4049/jimmunol.1202760. Epub 2013 Mar 13.

28.

Super-resolution characterization of TCR-dependent signaling clusters.

Sherman E, Barr V, Samelson LE.

Immunol Rev. 2013 Jan;251(1):21-35. doi: 10.1111/imr.12010. Review.

29.

Resolving multi-molecular protein interactions by photoactivated localization microscopy.

Sherman E, Barr VA, Samelson LE.

Methods. 2013 Mar;59(3):261-9. doi: 10.1016/j.ymeth.2012.12.002. Epub 2012 Dec 22.

30.

A phospholipase C-γ1-independent, RasGRP1-ERK-dependent pathway drives lymphoproliferative disease in linker for activation of T cells-Y136F mutant mice.

Kortum RL, Rouquette-Jazdanian AK, Miyaji M, Merrill RK, Markegard E, Pinski JM, Wesselink A, Nath NN, Alexander CP, Li W, Kedei N, Roose JP, Blumberg PM, Samelson LE, Sommers CL.

J Immunol. 2013 Jan 1;190(1):147-58. doi: 10.4049/jimmunol.1201458. Epub 2012 Dec 3.

31.

Enhanced function of redirected human T cells expressing linker for activation of T cells that is resistant to ubiquitylation.

Kunii N, Zhao Y, Jiang S, Liu X, Scholler J, Balagopalan L, Samelson LE, Milone MC, June CH.

Hum Gene Ther. 2013 Jan;24(1):27-37. doi: 10.1089/hum.2012.130. Epub 2012 Nov 6.

32.

LAT-independent Erk activation via Bam32-PLC-γ1-Pak1 complexes: GTPase-independent Pak1 activation.

Rouquette-Jazdanian AK, Sommers CL, Kortum RL, Morrison DK, Samelson LE.

Mol Cell. 2012 Oct 26;48(2):298-312. doi: 10.1016/j.molcel.2012.08.011. Epub 2012 Sep 13.

33.

Interchangeability of Themis1 and Themis2 in thymocyte development reveals two related proteins with conserved molecular function.

Lesourne R, Zvezdova E, Song KD, El-Khoury D, Uehara S, Barr VA, Samelson LE, Love PE.

J Immunol. 2012 Aug 1;189(3):1154-61. doi: 10.4049/jimmunol.1200123. Epub 2012 Jun 25.

34.

Deconstructing Ras signaling in the thymus.

Kortum RL, Sommers CL, Pinski JM, Alexander CP, Merrill RK, Li W, Love PE, Samelson LE.

Mol Cell Biol. 2012 Jul;32(14):2748-59. doi: 10.1128/MCB.00317-12. Epub 2012 May 14.

35.

Immunoreceptor signaling.

Samelson LE.

Cold Spring Harb Perspect Biol. 2011 Dec 1;3(12). pii: a011510. doi: 10.1101/cshperspect.a011510. Review. No abstract available.

36.

Functional nanoscale organization of signaling molecules downstream of the T cell antigen receptor.

Sherman E, Barr V, Manley S, Patterson G, Balagopalan L, Akpan I, Regan CK, Merrill RK, Sommers CL, Lippincott-Schwartz J, Samelson LE.

Immunity. 2011 Nov 23;35(5):705-20. doi: 10.1016/j.immuni.2011.10.004. Epub 2011 Nov 4.

37.

Targeted Sos1 deletion reveals its critical role in early T-cell development.

Kortum RL, Sommers CL, Alexander CP, Pinski JM, Li W, Grinberg A, Lee J, Love PE, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Jul 26;108(30):12407-12. doi: 10.1073/pnas.1104295108. Epub 2011 Jul 11.

38.

Enhanced T-cell signaling in cells bearing linker for activation of T-cell (LAT) molecules resistant to ubiquitylation.

Balagopalan L, Ashwell BA, Bernot KM, Akpan IO, Quasba N, Barr VA, Samelson LE.

Proc Natl Acad Sci U S A. 2011 Feb 15;108(7):2885-90. doi: 10.1073/pnas.1007098108. Epub 2011 Jan 31.

39.

Imaging techniques for assaying lymphocyte activation in action.

Balagopalan L, Sherman E, Barr VA, Samelson LE.

Nat Rev Immunol. 2011 Jan;11(1):21-33. doi: 10.1038/nri2903. Review.

40.

The LAT story: a tale of cooperativity, coordination, and choreography.

Balagopalan L, Coussens NP, Sherman E, Samelson LE, Sommers CL.

Cold Spring Harb Perspect Biol. 2010 Aug;2(8):a005512. doi: 10.1101/cshperspect.a005512. Epub 2010 Jul 7. Review.

41.

Cooperative interactions at the SLP-76 complex are critical for actin polymerization.

Barda-Saad M, Shirasu N, Pauker MH, Hassan N, Perl O, Balbo A, Yamaguchi H, Houtman JC, Appella E, Schuck P, Samelson LE.

EMBO J. 2010 Jul 21;29(14):2315-28. doi: 10.1038/emboj.2010.133. Epub 2010 Jun 18.

42.

Endocytic events in TCR signaling: focus on adapters in microclusters.

Balagopalan L, Barr VA, Samelson LE.

Immunol Rev. 2009 Nov;232(1):84-98. doi: 10.1111/j.1600-065X.2009.00840.x. Review.

43.

Formation of STIM and Orai complexes: puncta and distal caps.

Barr VA, Bernot KM, Shaffer MH, Burkhardt JK, Samelson LE.

Immunol Rev. 2009 Sep;231(1):148-59. doi: 10.1111/j.1600-065X.2009.00812.x. Review.

44.

Genetic evidence for the role of Erk activation in a lymphoproliferative disease of mice.

Miyaji M, Kortum RL, Surana R, Li W, Woolard KD, Simpson RM, Samelson LE, Sommers CL.

Proc Natl Acad Sci U S A. 2009 Aug 25;106(34):14502-7. doi: 10.1073/pnas.0903894106. Epub 2009 Aug 10.

45.

Priming the pump: adhesion enhances T cell antigen receptor-induced signaling.

Kortum RL, Samelson LE.

Immunity. 2009 Jan 16;30(1):3-5. doi: 10.1016/j.immuni.2008.12.007.

46.

Rab35 and its GAP EPI64C in T cells regulate receptor recycling and immunological synapse formation.

Patino-Lopez G, Dong X, Ben-Aissa K, Bernot KM, Itoh T, Fukuda M, Kruhlak MJ, Samelson LE, Shaw S.

J Biol Chem. 2008 Jun 27;283(26):18323-30. doi: 10.1074/jbc.M800056200. Epub 2008 Apr 30.

47.

Dynamic movement of the calcium sensor STIM1 and the calcium channel Orai1 in activated T-cells: puncta and distal caps.

Barr VA, Bernot KM, Srikanth S, Gwack Y, Balagopalan L, Regan CK, Helman DJ, Sommers CL, Oh-Hora M, Rao A, Samelson LE.

Mol Biol Cell. 2008 Jul;19(7):2802-17. doi: 10.1091/mbc.E08-02-0146. Epub 2008 Apr 30.

48.

Bam32: a novel mediator of Erk activation in T cells.

Sommers CL, Gurson JM, Surana R, Barda-Saad M, Lee J, Kishor A, Li W, Gasser AJ, Barr VA, Miyaji M, Love PE, Samelson LE.

Int Immunol. 2008 Jul;20(7):811-8. doi: 10.1093/intimm/dxn039. Epub 2008 Apr 29.

49.

Diagonal gel electrophoresis.

Samelson LE.

Curr Protoc Immunol. 2001 May;Chapter 8:Unit 8.6. doi: 10.1002/0471142735.im0806s02.

PMID:
18432859
50.

Iodination of soluble and membrane-bound proteins.

Samelson LE.

Curr Protoc Immunol. 2001 May;Chapter 8:Unit 8.11. doi: 10.1002/0471142735.im0811s11.

PMID:
18432851

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