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Haemophagocytic lymphohistiocytosis complicating visceral leishmaniasis in the UK: a case for detailed travel history, a high index of suspicion and timely diagnostics.

Johnson SM, Gilmour K, Samarasinghe S, Bamford A.

BMJ Case Rep. 2019 Jul 10;12(7). pii: e228307. doi: 10.1136/bcr-2018-228307.


The incidence of invasive fungal infections in children, adolescents and young adults with acute lymphoblastic leukaemia/lymphoma treated with the UKALL2011 protocol: a multicentre retrospective study.

O'Reilly MA, Govender D, Kirkwood AA, Vora A, Samarasinghe S, Khwaja A, Grandage V, Rao A, Ancliff P, Pavasovic V, Cheng D, Carpenter B, Daw S, Hough R, O'Connor D.

Br J Haematol. 2019 Jul;186(2):327-329. doi: 10.1111/bjh.15798. Epub 2019 Feb 15. No abstract available.


Management of hypertriglyceridaemic pancreatitis in the acute setting and review of literature.

Samarasinghe S, Avari P, Meeran K, Cegla J.

BMJ Case Rep. 2018 Nov 28;11(1). pii: e227594. doi: 10.1136/bcr-2018-227594. Review.


Boolean Calcium Signalling Model Predicts Calcium Role in Acceleration and Stability of Abscisic Acid-Mediated Stomatal Closure.

Waidyarathne P, Samarasinghe S.

Sci Rep. 2018 Dec 5;8(1):17635. doi: 10.1038/s41598-018-35872-9.


Genomic insights into virulence mechanisms of Leishmania donovani: evidence from an atypical strain.

Samarasinghe SR, Samaranayake N, Kariyawasam UL, Siriwardana YD, Imamura H, Karunaweera ND.

BMC Genomics. 2018 Nov 28;19(1):843. doi: 10.1186/s12864-018-5271-z.


Trypsin-encoding PRSS1-PRSS2 variations influence the risk of asparaginase-associated pancreatitis in children with acute lymphoblastic leukemia: a Ponte di Legno toxicity working group report.

Wolthers BO, Frandsen TL, Patel CJ, Abaji R, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grosjean M, Krajinovic M, Larsen E, Liang DC, Möricke A, Rasmussen KK, Samarasinghe S, Silverman LB, van der Sluis IM, Stanulla M, Tulstrup M, Yadav R, Yang W, Zapotocka E, Gupta R, Schmiegelow K; Ponte di Legno toxicity working group.

Haematologica. 2019 Mar;104(3):556-563. doi: 10.3324/haematol.2018.199356. Epub 2018 Nov 22.


Mathematical modelling of core regulatory mechanism in p53 protein that activates apoptotic switch.

Chong KH, Samarasinghe S, Kulasiri D, Zheng J.

J Theor Biol. 2019 Feb 7;462:134-147. doi: 10.1016/j.jtbi.2018.11.008. Epub 2018 Nov 12.


Impact of T-cell depletion strategies on outcomes following hematopoietic stem cell transplantation for idiopathic aplastic anemia: A study on behalf of the European blood and marrow transplant severe aplastic anemia working party.

Samarasinghe S, Clesham K, Iacobelli S, Sbianchi G, Knol C, Hamladji RM, Socié G, Aljurf M, Koh M, Sengeloev H, Dalle JH, Robinson S, Van Lint MT, Halkes CJM, Beelen D, Mufti GJ, Snowden J, Blaise D, de Latour RP, Marsh J, Dufour C, Risitano AM; Severe Aplastic Anaemia Working Party of the EBMT.

Am J Hematol. 2019 Jan;94(1):80-86. doi: 10.1002/ajh.25314. Epub 2018 Nov 25.


A Novel Data-Driven Boolean Model for Genetic Regulatory Networks.

Chen L, Kulasiri D, Samarasinghe S.

Front Physiol. 2018 Sep 25;9:1328. doi: 10.3389/fphys.2018.01328. eCollection 2018.


Upfront Matched Unrelated Donor Transplantation in Aplastic Anemia.

Clesham K, Dowse R, Samarasinghe S.

Hematol Oncol Clin North Am. 2018 Aug;32(4):619-628. doi: 10.1016/j.hoc.2018.03.004. Epub 2018 May 28. Review.


Galactose protects against cell damage in mouse models of acute pancreatitis.

Peng S, Gerasimenko JV, Tsugorka TM, Gryshchenko O, Samarasinghe S, Petersen OH, Gerasimenko OV.

J Clin Invest. 2018 Aug 31;128(9):3769-3778. doi: 10.1172/JCI94714. Epub 2018 Jul 30.


Parabens generate reactive oxygen species in human spermatozoa.

Samarasinghe SVAC, Krishnan K, Naidu R, Megharaj M, Miller K, Fraser B, Aitken RJ.

Andrology. 2018 Jul;6(4):532-541. doi: 10.1111/andr.12499. Epub 2018 May 2.


Prognostic impact of the absence of biallelic deletion at the TRG locus for pediatric patients with T-cell acute lymphoblastic leukemia treated on the Medical Research Council UK Acute Lymphoblastic Leukemia 2003 trial.

Farah N, Kirkwood AA, Rahman S, Leon T, Jenkinson S, Gale RE, Patrick K, Hancock J, Samarasinghe S, Linch DC, Moorman AV, Goulden N, Vora A, Mansour MR.

Haematologica. 2018 Jul;103(7):e288-e292. doi: 10.3324/haematol.2017.185801. Epub 2018 Mar 8. No abstract available.


Early morphological response is significantly associated with, but does not accurately predict, relapse in teenagers and young adults aged 10-24 years with acute lymphoblastic leukaemia (ALL): results from UKALL2003.

Furness CL, Kirkwood A, Rowntree C, Vora A, Mitchell C, Samarasinghe S, Goulden N, Moorman A, Hough R.

Br J Haematol. 2019 Feb;184(4):663-666. doi: 10.1111/bjh.15150. Epub 2018 Feb 22. No abstract available.


iPSC modeling of severe aplastic anemia reveals impaired differentiation and telomere shortening in blood progenitors.

Melguizo-Sanchis D, Xu Y, Taheem D, Yu M, Tilgner K, Barta T, Gassner K, Anyfantis G, Wan T, Elango R, Alharthi S, El-Harouni AA, Przyborski S, Adam S, Saretzki G, Samarasinghe S, Armstrong L, Lako M.

Cell Death Dis. 2018 Jan 26;9(2):128. doi: 10.1038/s41419-017-0141-1.


Paediatric amendment to adult BSH Guidelines for aplastic anaemia.

Samarasinghe S, Veys P, Vora A, Wynn R.

Br J Haematol. 2018 Jan;180(2):201-205. doi: 10.1111/bjh.15066. Epub 2017 Dec 28. No abstract available.


Genotype-Specific Minimal Residual Disease Interpretation Improves Stratification in Pediatric Acute Lymphoblastic Leukemia.

O'Connor D, Enshaei A, Bartram J, Hancock J, Harrison CJ, Hough R, Samarasinghe S, Schwab C, Vora A, Wade R, Moppett J, Moorman AV, Goulden N.

J Clin Oncol. 2018 Jan 1;36(1):34-43. doi: 10.1200/JCO.2017.74.0449. Epub 2017 Nov 13.


Targeting acute myeloid leukemia by drug-induced c-MYB degradation.

Walf-Vorderwülbecke V, Pearce K, Brooks T, Hubank M, van den Heuvel-Eibrink MM, Zwaan CM, Adams S, Edwards D, Bartram J, Samarasinghe S, Ancliff P, Khwaja A, Goulden N, Williams G, de Boer J, Williams O.

Leukemia. 2018 Apr;32(4):882-889. doi: 10.1038/leu.2017.317. Epub 2017 Nov 1.


Biotin Interference in Clinical Immunoassays: A Cause for Concern.

Holmes EW, Samarasinghe S, Emanuele MA, Meah F.

Arch Pathol Lab Med. 2017 Nov;141(11):1459-1460. doi: 10.5858/arpa.2017-0107-LE. No abstract available. Erratum in: Arch Pathol Lab Med. 2018 Jan;142(1):10.


An upper and lower bound of the Medication Possession Ratio.

Sperber CM, Samarasinghe SR, Lomax GP.

Patient Prefer Adherence. 2017 Aug 30;11:1469-1478. doi: 10.2147/PPA.S136890. eCollection 2017.


Computational investigation of Amyloid-β-induced location- and subunit-specific disturbances of NMDAR at hippocampal dendritic spine in Alzheimer's disease.

Liang J, Kulasiri D, Samarasinghe S.

PLoS One. 2017 Aug 24;12(8):e0182743. doi: 10.1371/journal.pone.0182743. eCollection 2017.


Asparaginase-associated pancreatitis in childhood acute lymphoblastic leukaemia: an observational Ponte di Legno Toxicity Working Group study.

Wolthers BO, Frandsen TL, Baruchel A, Attarbaschi A, Barzilai S, Colombini A, Escherich G, Grell K, Inaba H, Kovacs G, Liang DC, Mateos M, Mondelaers V, Möricke A, Ociepa T, Samarasinghe S, Silverman LB, van der Sluis IM, Stanulla M, Vrooman LM, Yano M, Zapotocka E, Schmiegelow K; Ponte di Legno Toxicity Working Group.

Lancet Oncol. 2017 Sep;18(9):1238-1248. doi: 10.1016/S1470-2045(17)30424-2. Epub 2017 Jul 20.


A comprehensive complex systems approach to the study and analysis of mammalian cell cycle control system in the presence of DNA damage stress.

Abroudi A, Samarasinghe S, Kulasiri D.

J Theor Biol. 2017 Sep 21;429:204-228. doi: 10.1016/j.jtbi.2017.06.018. Epub 2017 Jun 22.


British Committee for Standards in Haematology guidelines for aplastic anemia: Single centre retrospective review finds no compelling evidence for the recommended higher platelet count threshold of 20 × 109 /L - RESPONSE to Yan et al.

Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A, Marsh JCW; British Society for Standards in Haematology AA Guidelines Committee.

Br J Haematol. 2018 Jul;182(2):286-287. doi: 10.1111/bjh.14766. Epub 2017 May 23. No abstract available.



Samarasinghe S, Meah F, Singh V, Basit A, Emanuele N, Emanuele MA, Mazhari A, Holmes EW.

Endocr Pract. 2017 Aug;23(8):989-998. doi: 10.4158/EP171761.RA. Epub 2017 May 23. Review.


Global sensitivity analysis of a model related to memory formation in synapses: Model reduction based on epistemic parameter uncertainties and related issues.

Kulasiri D, Liang J, He Y, Samarasinghe S.

J Theor Biol. 2017 Apr 21;419:116-136. doi: 10.1016/j.jtbi.2017.02.003. Epub 2017 Feb 9.


A system of recurrent neural networks for modularising, parameterising and dynamic analysis of cell signalling networks.

Samarasinghe S, Ling H.

Biosystems. 2017 Mar - Apr;153-154:6-25. doi: 10.1016/j.biosystems.2017.01.001. Epub 2017 Feb 4.


Molecular remission of infant B-ALL after infusion of universal TALEN gene-edited CAR T cells.

Qasim W, Zhan H, Samarasinghe S, Adams S, Amrolia P, Stafford S, Butler K, Rivat C, Wright G, Somana K, Ghorashian S, Pinner D, Ahsan G, Gilmour K, Lucchini G, Inglott S, Mifsud W, Chiesa R, Peggs KS, Chan L, Farzeneh F, Thrasher AJ, Vora A, Pule M, Veys P.

Sci Transl Med. 2017 Jan 25;9(374). pii: eaaj2013. doi: 10.1126/scitranslmed.aaj2013. Erratum in: Sci Transl Med. 2017 Feb 15;9(377):null.


Use of Minimal Residual Disease Assessment to Redefine Induction Failure in Pediatric Acute Lymphoblastic Leukemia.

O'Connor D, Moorman AV, Wade R, Hancock J, Tan RM, Bartram J, Moppett J, Schwab C, Patrick K, Harrison CJ, Hough R, Goulden N, Vora A, Samarasinghe S.

J Clin Oncol. 2017 Feb 20;35(6):660-667. doi: 10.1200/JCO.2016.69.6278. Epub 2017 Jan 3.


Impact of Conditioning Regimen on Outcomes for Children with Acute Myeloid Leukemia Undergoing Transplantation in First Complete Remission. An Analysis on Behalf of the Pediatric Disease Working Party of the European Group for Blood and Marrow Transplantation.

Lucchini G, Labopin M, Beohou E, Dalissier A, Dalle JH, Cornish J, Zecca M, Samarasinghe S, Gibson B, Locatelli F, Bertrand Y, Abdel-Rahman F, Socie G, Sundin M, Lankester A, Sedlacek P, Hamladji RM, Heilmann C, Afanasyev B, Hough R, Peters C, Bader P, Veys P.

Biol Blood Marrow Transplant. 2017 Mar;23(3):467-474. doi: 10.1016/j.bbmt.2016.11.022. Epub 2016 Dec 1.


Concise Review: Getting to the Core of Inherited Bone Marrow Failures.

Adam S, Melguizo Sanchis D, El-Kamah G, Samarasinghe S, Alharthi S, Armstrong L, Lako M.

Stem Cells. 2017 Feb;35(2):284-298. doi: 10.1002/stem.2543. Epub 2016 Dec 4. Review.


Fabrication of Bacteria Environment Cubes with Dry Lift-Off Fabrication Process for Enhanced Nitrification.

Samarasinghe SA, Shao Y, Huang PJ, Pishko M, Chu KH, Kameoka J.

PLoS One. 2016 Nov 3;11(11):e0165839. doi: 10.1371/journal.pone.0165839. eCollection 2016.


Calcium and adenosine triphosphate control of cellular pathology: asparaginase-induced pancreatitis elicited via protease-activated receptor 2.

Peng S, Gerasimenko JV, Tsugorka T, Gryshchenko O, Samarasinghe S, Petersen OH, Gerasimenko OV.

Philos Trans R Soc Lond B Biol Sci. 2016 Aug 5;371(1700). pii: 20150423. doi: 10.1098/rstb.2015.0423.


Central nervous system aspergillosis resembling haemorrhagic brain infarct in a paediatric leukaemia patient.

Tan RMR, Ganau M, Jeelani NUO, Tahir Z, Mankad K, Kachramanoglou C, Prabhakar P, Goulden N, Samarasinghe S.

Br J Haematol. 2017 Aug;178(4):642-645. doi: 10.1111/bjh.14161. Epub 2016 Jun 29. No abstract available.


Natural curcuminoids encapsulated in layered double hydroxides: a novel antimicrobial nanohybrid.

Megalathan A, Kumarage S, Dilhari A, Weerasekera MM, Samarasinghe S, Kottegoda N.

Chem Cent J. 2016 May 31;10:35. doi: 10.1186/s13065-016-0179-7. eCollection 2016.


Modelling bidirectional modulations in synaptic plasticity: A biochemical pathway model to understand the emergence of long term potentiation (LTP) and long term depression (LTD).

He Y, Kulasiri D, Samarasinghe S.

J Theor Biol. 2016 Aug 21;403:159-177. doi: 10.1016/j.jtbi.2016.05.015. Epub 2016 May 13.


Classification of treatment-related mortality in children with cancer: a systematic assessment.

Alexander S, Pole JD, Gibson P, Lee M, Hesser T, Chi SN, Dvorak CC, Fisher B, Hasle H, Kanerva J, Möricke A, Phillips B, Raetz E, Rodriguez-Galindo C, Samarasinghe S, Schmiegelow K, Tissing W, Lehrnbecher T, Sung L; International Pediatric Oncology Mortality Classification Group.

Lancet Oncol. 2015 Dec;16(16):e604-10. doi: 10.1016/S1470-2045(15)00197-7. Review.


Evolving hematopoietic stem cell transplantation strategies in severe aplastic anemia.

Dietz AC, Lucchini G, Samarasinghe S, Pulsipher MA.

Curr Opin Pediatr. 2016 Feb;28(1):3-11. doi: 10.1097/MOP.0000000000000299. Review.


Guidelines for the diagnosis and management of adult aplastic anaemia.

Killick SB, Bown N, Cavenagh J, Dokal I, Foukaneli T, Hill A, Hillmen P, Ireland R, Kulasekararaj A, Mufti G, Snowden JA, Samarasinghe S, Wood A, Marsh JC; British Society for Standards in Haematology.

Br J Haematol. 2016 Jan;172(2):187-207. doi: 10.1111/bjh.13853. Epub 2015 Nov 16. No abstract available. Erratum in: Br J Haematol. 2016 Nov;175(3):546.


Similar outcome of upfront-unrelated and matched sibling stem cell transplantation in idiopathic paediatric aplastic anaemia. A study on behalf of the UK Paediatric BMT Working Party, Paediatric Diseases Working Party and Severe Aplastic Anaemia Working Party of EBMT.

Dufour C, Veys P, Carraro E, Bhatnagar N, Pillon M, Wynn R, Gibson B, Vora AJ, Steward CG, Ewins AM, Hough RE, de la Fuente J, Velangi M, Amrolia PJ, Skinner R, Bacigalupo A, Risitano AM, Socie G, Peffault de Latour R, Passweg J, Rovo A, Tichelli A, Schrezenmeier H, Hochsmann B, Bader P, van Biezen A, Aljurf MD, Kulasekararaj A, Marsh JC, Samarasinghe S.

Br J Haematol. 2015 Nov;171(4):585-94. doi: 10.1111/bjh.13614. Epub 2015 Jul 28.


Recommendations on hematopoietic stem cell transplantation for inherited bone marrow failure syndromes.

Peffault de Latour R, Peters C, Gibson B, Strahm B, Lankester A, de Heredia CD, Longoni D, Fioredda F, Locatelli F, Yaniv I, Wachowiak J, Donadieu J, Lawitschka A, Bierings M, Wlodarski M, Corbacioglu S, Bonanomi S, Samarasinghe S, Leblanc T, Dufour C, Dalle JH; Pediatric Working Party of the European Group for Blood and Marrow Transplantation; Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation.

Bone Marrow Transplant. 2015 Sep;50(9):1168-72. doi: 10.1038/bmt.2015.117. Epub 2015 Jun 8. Review.


Ca2+ dysregulation in the endoplasmic reticulum related to Alzheimer's disease: A review on experimental progress and computational modeling.

Liang J, Kulasiri D, Samarasinghe S.

Biosystems. 2015 Aug;134:1-15. doi: 10.1016/j.biosystems.2015.05.003. Epub 2015 May 19. Review.


Outcome of aplastic anaemia in children. A study by the severe aplastic anaemia and paediatric disease working parties of the European group blood and bone marrow transplant.

Dufour C, Pillon M, Sociè G, Rovò A, Carraro E, Bacigalupo A, Oneto R, Passweg J, Risitano A, Tichelli A, Peffault de Latour R, Schrezenmeier H, Hocshmann B, Peters C, Kulasekararaj A, Van Biezen A, Samarasinghe S, Hussein AA, Ayas M, Aljurf M, Marsh J.

Br J Haematol. 2015 May;169(4):565-73. doi: 10.1111/bjh.13297. Epub 2015 Feb 14.


Computational modeling and experimental validation of odor detection behaviors of classically conditioned parasitic wasp, Microplitis croceipes.

Zhou Z, Kulasiri D, Samarasinghe S, Rains G, Olson DM.

Biotechnol Prog. 2015 Mar-Apr;31(2):596-606. doi: 10.1002/btpr.2025. Epub 2014 Dec 20.


Modelling the dynamics of CaMKII-NMDAR complex related to memory formation in synapses: the possible roles of threonine 286 autophosphorylation of CaMKII in long term potentiation.

He Y, Kulasiri D, Samarasinghe S.

J Theor Biol. 2015 Jan 21;365:403-19. doi: 10.1016/j.jtbi.2014.11.001. Epub 2014 Nov 11.


Mathematical modelling of p53 basal dynamics and DNA damage response.

Chong KH, Samarasinghe S, Kulasiri D.

Math Biosci. 2015 Jan;259:27-42. doi: 10.1016/j.mbs.2014.10.010. Epub 2014 Nov 26.


The meiotic-mitotic initiation switch in budding yeast maintains its function robustly against sensitive parameter perturbations.

Wannige CT, Kulasiri D, Samarasinghe S.

Biosystems. 2014 Oct;124:61-74. doi: 10.1016/j.biosystems.2014.09.003. Epub 2014 Sep 4.


Outcome of aplastic anemia in adolescence: a survey of the Severe Aplastic Anemia Working Party of the European Group for Blood and Marrow Transplantation.

Dufour C, Pillon M, Passweg J, Socié G, Bacigalupo A, Franceschetto G, Carraro E, Oneto R, Risitano AM, Peffault de Latour R, Tichelli A, Rovo A, Peters C, Hoechsmann B, Samarasinghe S, Kulasekararaj AG, Schrezenmeier H, Aljurf M, Marsh J.

Haematologica. 2014 Oct;99(10):1574-81. doi: 10.3324/haematol.2014.106096. Epub 2014 Aug 1.


A case of Hymenolepis diminuta (rat tape worm) infestation in a child.

Sinhabahu VP, Perera TM, Samarasinghe S, Nanayakkara N.

Ceylon Med J. 2014 Jun;59(2):70-1. doi: 10.4038/cmj.v59i2.7070. No abstract available.

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