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Items: 32


The TGF-β1/p53/PAI-1 Signaling Axis in Vascular Senescence: Role of Caveolin-1.

Samarakoon R, Higgins SP, Higgins CE, Higgins PJ.

Biomolecules. 2019 Aug 3;9(8). pii: E341. doi: 10.3390/biom9080341. Review.


TGF-β1-p53 cooperativity regulates a profibrotic genomic program in the kidney: molecular mechanisms and clinical implications.

Higgins CE, Tang J, Mian BM, Higgins SP, Gifford CC, Conti DJ, Meldrum KK, Samarakoon R, Higgins PJ.

FASEB J. 2019 Oct;33(10):10596-10606. doi: 10.1096/fj.201900943R. Epub 2019 Jul 6.


Oligogenic inheritance of a human heart disease involving a genetic modifier.

Gifford CA, Ranade SS, Samarakoon R, Salunga HT, de Soysa TY, Huang Y, Zhou P, Elfenbein A, Wyman SK, Bui YK, Cordes Metzler KR, Ursell P, Ivey KN, Srivastava D.

Science. 2019 May 31;364(6443):865-870. doi: 10.1126/science.aat5056. Epub 2019 May 30.


Rac-GTPase promotes fibrotic TGF-β1 signaling and chronic kidney disease via EGFR, p53, and Hippo/YAP/TAZ pathways.

Patel S, Tang J, Overstreet JM, Anorga S, Lian F, Arnouk A, Goldschmeding R, Higgins PJ, Samarakoon R.

FASEB J. 2019 Sep;33(9):9797-9810. doi: 10.1096/fj.201802489RR. Epub 2019 May 16.


Deregulation of Negative Controls on TGF-β1 Signaling in Tumor Progression.

Tang J, Gifford CC, Samarakoon R, Higgins PJ.

Cancers (Basel). 2018 May 25;10(6). pii: E159. doi: 10.3390/cancers10060159. Review.


The Cytoskeletal Network Regulates Expression of the Profibrotic Genes PAI-1 and CTGF in Vascular Smooth Muscle Cells.

Samarakoon R, Higgins PJ.

Adv Pharmacol. 2018;81:79-94. doi: 10.1016/bs.apha.2017.08.006. Epub 2017 Oct 31. Review.


Deregulation of Hippo-TAZ pathway during renal injury confers a fibrotic maladaptive phenotype.

Anorga S, Overstreet JM, Falke LL, Tang J, Goldschmeding RG, Higgins PJ, Samarakoon R.

FASEB J. 2018 May;32(5):2644-2657. doi: 10.1096/fj.201700722R. Epub 2018 Jan 3.


TGF-β1/p53 signaling in renal fibrogenesis.

Higgins SP, Tang Y, Higgins CE, Mian B, Zhang W, Czekay RP, Samarakoon R, Conti DJ, Higgins PJ.

Cell Signal. 2018 Mar;43:1-10. doi: 10.1016/j.cellsig.2017.11.005. Epub 2017 Nov 28. Review.


Loss of expression of protein phosphatase magnesium-dependent 1A during kidney injury promotes fibrotic maladaptive repair.

Samarakoon R, Rehfuss A, Khakoo NS, Falke LL, Dobberfuhl AD, Helo S, Overstreet JM, Goldschmeding R, Higgins PJ.

FASEB J. 2016 Oct;30(10):3308-3320. Epub 2016 Jun 21.


Loss of tumour suppressor PTEN expression in renal injury initiates SMAD3- and p53-dependent fibrotic responses.

Samarakoon R, Helo S, Dobberfuhl AD, Khakoo NS, Falke L, Overstreet JM, Goldschmeding R, Higgins PJ.

J Pathol. 2015 Aug;236(4):421-32. doi: 10.1002/path.4538. Epub 2015 Apr 27.


Tumor suppressor ataxia telangiectasia mutated functions downstream of TGF-β1 in orchestrating profibrotic responses.

Overstreet JM, Samarakoon R, Cardona-Grau D, Goldschmeding R, Higgins PJ.

FASEB J. 2015 Apr;29(4):1258-68. doi: 10.1096/fj.14-262527. Epub 2014 Dec 5.


Redox control of p53 in the transcriptional regulation of TGF-β1 target genes through SMAD cooperativity.

Overstreet JM, Samarakoon R, Meldrum KK, Higgins PJ.

Cell Signal. 2014 Jul;26(7):1427-36. doi: 10.1016/j.cellsig.2014.02.017. Epub 2014 Mar 5.


Induction of renal fibrotic genes by TGF-β1 requires EGFR activation, p53 and reactive oxygen species.

Samarakoon R, Dobberfuhl AD, Cooley C, Overstreet JM, Patel S, Goldschmeding R, Meldrum KK, Higgins PJ.

Cell Signal. 2013 Nov;25(11):2198-209. doi: 10.1016/j.cellsig.2013.07.007. Epub 2013 Jul 18.


Ureteral Obstruction-Induced Renal Fibrosis: An In Vivo Platform for Mechanistic Discovery and Therapeutic Intervention.

Dobberfuhl AD, Samarakoon R, Higgins CE, Mian BM, Overstreet JM, Higgins SP, Kogan BA, Higgins PJ.

Cell Dev Biol. 2012;1(3). pii: e107. Epub 2012 Jul 3. No abstract available.


TGF-β signaling in tissue fibrosis: redox controls, target genes and therapeutic opportunities.

Samarakoon R, Overstreet JM, Higgins PJ.

Cell Signal. 2013 Jan;25(1):264-8. doi: 10.1016/j.cellsig.2012.10.003. Epub 2012 Oct 11. Review.


PAI-1: An Integrator of Cell Signaling and Migration.

Czekay RP, Wilkins-Port CE, Higgins SP, Freytag J, Overstreet JM, Klein RM, Higgins CE, Samarakoon R, Higgins PJ.

Int J Cell Biol. 2011;2011:562481. doi: 10.1155/2011/562481. Epub 2011 Aug 3.


Redox-induced Src kinase and caveolin-1 signaling in TGF-β1-initiated SMAD2/3 activation and PAI-1 expression.

Samarakoon R, Chitnis SS, Higgins SP, Higgins CE, Krepinsky JC, Higgins PJ.

PLoS One. 2011;6(7):e22896. doi: 10.1371/journal.pone.0022896. Epub 2011 Jul 28.


TGF-β1 → SMAD/p53/USF2 → PAI-1 transcriptional axis in ureteral obstruction-induced renal fibrosis.

Samarakoon R, Overstreet JM, Higgins SP, Higgins PJ.

Cell Tissue Res. 2012 Jan;347(1):117-28. doi: 10.1007/s00441-011-1181-y. Epub 2011 Jun 4. Review.


PAI-1 mediates the TGF-beta1+EGF-induced "scatter" response in transformed human keratinocytes.

Freytag J, Wilkins-Port CE, Higgins CE, Higgins SP, Samarakoon R, Higgins PJ.

J Invest Dermatol. 2010 Sep;130(9):2179-90. doi: 10.1038/jid.2010.106. Epub 2010 Apr 29.


Linking cell structure to gene regulation: signaling events and expression controls on the model genes PAI-1 and CTGF.

Samarakoon R, Goppelt-Struebe M, Higgins PJ.

Cell Signal. 2010 Oct;22(10):1413-9. doi: 10.1016/j.cellsig.2010.03.020. Epub 2010 Apr 2. Review.


TGF-beta1-Induced Expression of the Poor Prognosis SERPINE1/PAI-1 Gene Requires EGFR Signaling: A New Target for Anti-EGFR Therapy.

Samarakoon R, Higgins CE, Higgins SP, Higgins PJ.

J Oncol. 2009;2009:342391. doi: 10.1155/2009/342391. Epub 2009 Apr 9.


Differential requirement for MEK/ERK and SMAD signaling in PAI-1 and CTGF expression in response to microtubule disruption.

Samarakoon R, Higgins CE, Higgins SP, Higgins PJ.

Cell Signal. 2009 Jun;21(6):986-95. doi: 10.1016/j.cellsig.2009.02.007. Epub 2009 Feb 25.


TGF-β1-Induced Expression of the Anti-Apoptotic PAI-1 Protein Requires EGFR Signaling.

Higgins SP, Samarakoon R, Higgins CE, Freytag J, Wilkins-Port CE, Higgins PJ.

Cell Commun Insights. 2009;2:1-11.


PAI-1 Regulates the Invasive Phenotype in Human Cutaneous Squamous Cell Carcinoma.

Freytag J, Wilkins-Port CE, Higgins CE, Carlson JA, Noel A, Foidart JM, Higgins SP, Samarakoon R, Higgins PJ.

J Oncol. 2009;2009:963209. doi: 10.1155/2009/963209. Epub 2010 Mar 1.


SERPINE1 (PAI-1) is deposited into keratinocyte migration "trails" and required for optimal monolayer wound repair.

Providence KM, Higgins SP, Mullen A, Battista A, Samarakoon R, Higgins CE, Wilkins-Port CE, Higgins PJ.

Arch Dermatol Res. 2008 Jul;300(6):303-10. doi: 10.1007/s00403-008-0845-2. Epub 2008 Apr 2.


TGF-beta1-induced plasminogen activator inhibitor-1 expression in vascular smooth muscle cells requires pp60(c-src)/EGFR(Y845) and Rho/ROCK signaling.

Samarakoon R, Higgins SP, Higgins CE, Higgins PJ.

J Mol Cell Cardiol. 2008 Mar;44(3):527-38. doi: 10.1016/j.yjmcc.2007.12.006. Epub 2008 Jan 3.


SERPINE1 (PAI-1) is a prominent member of the early G0 --> G1 transition "wound repair" transcriptome in p53 mutant human keratinocytes.

Qi L, Higgins SP, Lu Q, Samarakoon R, Wilkins-Port CE, Ye Q, Higgins CE, Staiano-Coico L, Higgins PJ.

J Invest Dermatol. 2008 Mar;128(3):749-53. Epub 2007 Sep 20. No abstract available.


TGF-beta 1-induced PAI-1 expression is E box/USF-dependent and requires EGFR signaling.

Kutz SM, Higgins CE, Samarakoon R, Higgins SP, Allen RR, Qi L, Higgins PJ.

Exp Cell Res. 2006 Apr 15;312(7):1093-105. Epub 2006 Feb 7.


Plasminogen activator inhibitor type-1 gene expression and induced migration in TGF-beta1-stimulated smooth muscle cells is pp60(c-src)/MEK-dependent.

Samarakoon R, Higgins CE, Higgins SP, Kutz SM, Higgins PJ.

J Cell Physiol. 2005 Jul;204(1):236-46.


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