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Dosage compensation plans: protein aggregation provides additional insurance against aneuploidy.

Samant RS, Masto VB, Frydman J.

Genes Dev. 2019 Aug 1;33(15-16):1027-1030. doi: 10.1101/gad.329383.119. Review.


The nucleolus: a central response hub for the stressors that drive cancer progression.

Weeks SE, Metge BJ, Samant RS.

Cell Mol Life Sci. 2019 Jul 23. doi: 10.1007/s00018-019-03231-0. [Epub ahead of print] Review.


Methods for measuring misfolded protein clearance in the budding yeast Saccharomyces cerevisiae.

Samant RS, Frydman J.

Methods Enzymol. 2019;619:27-45. doi: 10.1016/bs.mie.2018.12.039. Epub 2019 Feb 8.


Inhibition of Hedgehog signaling reprograms the dysfunctional immune microenvironment in breast cancer.

Hanna A, Metge BJ, Bailey SK, Chen D, Chandrashekar DS, Varambally S, Samant RS, Shevde LA.

Oncoimmunology. 2018 Dec 12;8(3):1548241. doi: 10.1080/2162402X.2018.1548241. eCollection 2019.


Phage Ligands for Identification of Mesenchymal-Like Breast Cancer Cells and Cancer-Associated Fibroblasts.

Jones KM, Karanam B, Jones-Triche J, Sandey M, Henderson HJ, Samant RS, Temesgen S, Yates C, Bedi D.

Front Oncol. 2018 Dec 17;8:625. doi: 10.3389/fonc.2018.00625. eCollection 2018.


Distinct proteostasis circuits cooperate in nuclear and cytoplasmic protein quality control.

Samant RS, Livingston CM, Sontag EM, Frydman J.

Nature. 2018 Nov;563(7731):407-411. doi: 10.1038/s41586-018-0678-x. Epub 2018 Oct 31.


O-GlcNAcylation of GLI transcription factors in hyperglycemic conditions augments Hedgehog activity.

Das S, Bailey SK, Metge BJ, Hanna A, Hinshaw DC, Mota M, Forero-Torres A, Chatham JC, Samant RS, Shevde LA.

Lab Invest. 2019 Feb;99(2):260-270. doi: 10.1038/s41374-018-0122-8. Epub 2018 Nov 12.


Deficiency of tumor suppressor Merlin facilitates metabolic adaptation by co-operative engagement of SMAD-Hippo signaling in breast cancer.

Mota MSV, Jackson WP, Bailey SK, Vayalil P, Landar A, Rostas JW 3rd, Mulekar MS, Samant RS, Shevde LA.

Carcinogenesis. 2018 Sep 21;39(9):1165-1175. doi: 10.1093/carcin/bgy078.


The presence of large focal lesions is a strong independent prognostic factor in multiple myeloma.

Rasche L, Angtuaco EJ, Alpe TL, Gershner GH, McDonald JE, Samant RS, Kumar M, Van Hemert R, Epstein J, Deshpande S, Tytarenko R, Yaccoby S, Hillengass J, Thanendrarajan S, Schinke C, van Rhee F, Zangari M, Walker BA, Barlogie B, Morgan GJ, Davies FE, Weinhold N.

Blood. 2018 Jul 5;132(1):59-66. doi: 10.1182/blood-2018-04-842880. Epub 2018 May 21.


Correction: Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.

Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ.

Oncotarget. 2018 Apr 10;9(27):19459. doi: 10.18632/oncotarget.25151. eCollection 2018 Apr 10.


Conditional knockout of N-Myc and STAT interactor disrupts normal mammary development and enhances metastatic ability of mammary tumors.

Pruitt HC, Metge BJ, Weeks SE, Chen D, Wei S, Kesterson RA, Shevde LA, Samant RS.

Oncogene. 2018 Mar;37(12):1610-1623. doi: 10.1038/s41388-017-0037-7. Epub 2018 Jan 12.


Methods to Evaluate Cell Growth, Viability, and Response to Treatment in a Tissue Engineered Breast Cancer Model.

Goliwas KF, Richter JR, Pruitt HC, Araysi LM, Anderson NR, Samant RS, Lobo-Ruppert SM, Berry JL, Frost AR.

Sci Rep. 2017 Oct 26;7(1):14167. doi: 10.1038/s41598-017-14326-8.


Developing Cures: Targeting Ontogenesis in Cancer.

Lin VTG, Pruitt HC, Samant RS, Shevde LA.

Trends Cancer. 2017 Feb;3(2):126-136. doi: 10.1016/j.trecan.2016.12.007. Epub 2017 Jan 27. Review.


Current practice in total-body irradiation: results of a Canada-wide survey.

Studinski RCN, Fraser DJ, Samant RS, MacPherson MS.

Curr Oncol. 2017 Jun;24(3):181-186. doi: 10.3747/co.24.3484. Epub 2017 Jun 27.


Mechanisms and Functions of Spatial Protein Quality Control.

Sontag EM, Samant RS, Frydman J.

Annu Rev Biochem. 2017 Jun 20;86:97-122. doi: 10.1146/annurev-biochem-060815-014616. Epub 2017 May 10. Review.


PRES and Epilepsy: A Potential Long-Term Consequence of a "Reversible" Syndrome.

Fitzgerald RT, Santoro J, Hinduja A, Samant RS, Kumar M, Angtuaco EJ.

Neurologist. 2017 Mar;22(2):41-43. doi: 10.1097/NRL.0000000000000103.


Extensive Remineralization of Large Pelvic Lytic Lesions Following Total Therapy Treatment in Patients With Multiple Myeloma.

Mohan M, Samant RS, Yoon D, Buros AF, Branca A, Montgomery CO, Nicholas R, Suva LJ, Morello R, Thanendrarajan S, Schinke C, Yaccoby S, van Rhee F, Davies FE, Morgan GJ, Zangari M.

J Bone Miner Res. 2017 Jun;32(6):1261-1266. doi: 10.1002/jbmr.3111. Epub 2017 Mar 27.


Loss of Merlin induces metabolomic adaptation that engages dependence on Hedgehog signaling.

Das S, Jackson WP, Prasain JK, Hanna A, Bailey SK, Tucker JA, Bae S, Wilson LS, Samant RS, Barnes S, Shevde LA.

Sci Rep. 2017 Jan 23;7:40773. doi: 10.1038/srep40773.


Niclosamide and its analogs are potent inhibitors of Wnt/β-catenin, mTOR and STAT3 signaling in ovarian cancer.

Arend RC, Londoño-Joshi AI, Gangrade A, Katre AA, Kurpad C, Li Y, Samant RS, Li PK, Landen CN, Yang ES, Hidalgo B, Alvarez RD, Straughn JM, Forero A, Buchsbaum DJ.

Oncotarget. 2016 Dec 27;7(52):86803-86815. doi: 10.18632/oncotarget.13466. Erratum in: Oncotarget. 2018 Apr 10;9(27):19459.


Root Cause Analysis: An Examination of Odontogenic Origins of Acute Maxillary Sinusitis in Both Immunocompetent & Immunocompromised Patients.

McCarty JL, David RM, Lensing SY, Samant RS, Kumar M, Van Hemert RL, Angtuaco EJC, Fitzgerald RT.

J Comput Assist Tomogr. 2017 May/Jun;41(3):484-488. doi: 10.1097/RCT.0000000000000522.


Characterization of Thyroid Nodules by 4-Dimensional Computed Tomography: Initial Experience.

Fitzgerald RT, Kuruva M, David R, Samant RS, Kumar M, Van Hemert R, Angtuaco EJ, Bodenner D, Stack BC Jr.

J Comput Assist Tomogr. 2017 Mar/Apr;41(2):195-198. doi: 10.1097/RCT.0000000000000495.


Emerging roles and underlying molecular mechanisms of DNAJB6 in cancer.

Meng E, Shevde LA, Samant RS.

Oncotarget. 2016 Aug 16;7(33):53984-53996. doi: 10.18632/oncotarget.9803. Review.


Loss of tumor suppressor Merlin results in aberrant activation of Wnt/β-catenin signaling in cancer.

Morrow KA, Das S, Meng E, Menezes ME, Bailey SK, Metge BJ, Buchsbaum DJ, Samant RS, Shevde LA.

Oncotarget. 2016 Apr 5;7(14):17991-8005. doi: 10.18632/oncotarget.7494.


Roles of N-Myc and STAT interactor in cancer: From initiation to dissemination.

Pruitt HC, Devine DJ, Samant RS.

Int J Cancer. 2016 Aug 1;139(3):491-500. doi: 10.1002/ijc.30043. Epub 2016 Mar 11. Review.


A selective chemical probe for exploring the role of CDK8 and CDK19 in human disease.

Dale T, Clarke PA, Esdar C, Waalboer D, Adeniji-Popoola O, Ortiz-Ruiz MJ, Mallinger A, Samant RS, Czodrowski P, Musil D, Schwarz D, Schneider K, Stubbs M, Ewan K, Fraser E, TePoele R, Court W, Box G, Valenti M, de Haven Brandon A, Gowan S, Rohdich F, Raynaud F, Schneider R, Poeschke O, Blaukat A, Workman P, Schiemann K, Eccles SA, Wienke D, Blagg J.

Nat Chem Biol. 2015 Dec;11(12):973-980. doi: 10.1038/nchembio.1952. Epub 2015 Oct 26.


Nuclear Localization of DNAJB6 Is Associated With Survival of Patients With Esophageal Cancer and Reduces AKT Signaling and Proliferation of Cancer Cells.

Yu VZ, Wong VC, Dai W, Ko JM, Lam AK, Chan KW, Samant RS, Lung HL, Shuen WH, Law S, Chan YP, Lee NP, Tong DK, Law TT, Lee VH, Lung ML.

Gastroenterology. 2015 Dec;149(7):1825-1836.e5. doi: 10.1053/j.gastro.2015.08.025. Epub 2015 Aug 22.


The Impact of Hedgehog Signaling Pathway on DNA Repair Mechanisms in Human Cancer.

Meng E, Hanna A, Samant RS, Shevde LA.

Cancers (Basel). 2015 Jul 21;7(3):1333-48. doi: 10.3390/cancers7030839. Review.


N-Myc and STAT Interactor regulates autophagy and chemosensitivity in breast cancer cells.

Metge BJ, Mitra A, Chen D, Shevde LA, Samant RS.

Sci Rep. 2015 Jul 6;5:11995. doi: 10.1038/srep11995.


Features of infratentorial-predominant posterior reversible encephalopathy syndrome.

Fitzgerald RT, Samant RS, Kumar M, Van Hemert R, Angtuaco EJ.

Acta Neurol Belg. 2015 Dec;115(4):629-34. doi: 10.1007/s13760-015-0431-2. Epub 2015 Jan 21.


NMI and EMT.

Samant RS, Shevde LA.

Oncoscience. 2014 Jun 19;1(7):476-7. eCollection 2014. No abstract available.


microRNA-29 negatively regulates EMT regulator N-myc interactor in breast cancer.

Rostas JW 3rd, Pruitt HC, Metge BJ, Mitra A, Bailey SK, Bae S, Singh KP, Devine DJ, Dyess DL, Richards WO, Tucker JA, Shevde LA, Samant RS.

Mol Cancer. 2014 Aug 29;13:200. doi: 10.1186/1476-4598-13-200.


Spinal bone marrow necrosis with vertebral compression fracture: differentiation of BMN from AVN.

Nix JS, Fitzgerald RT, Samant RS, Harrison M, Angtuaco EJ.

Skeletal Radiol. 2014 Sep;43(9):1337-40. doi: 10.1007/s00256-014-1906-6. Epub 2014 May 22.


Pulsatile Tinnitus Secondary to a Dural Arteriovenous Fistula.

Fitzgerald RT, Pollitzer R, Samant RS, Kumar M, Ramakrishnaiah RH, Amole A, Akdol MS, Angtuaco EJ.

Otol Neurotol. 2015 Aug;36(7):e115-6. doi: 10.1097/MAO.0000000000000410. No abstract available.


Elevation of serum lactate dehydrogenase at posterior reversible encephalopathy syndrome onset in chemotherapy-treated cancer patients.

Fitzgerald RT, Wright SM, Samant RS, Kumar M, Ramakrishnaiah RH, Van Hemert R, Brown AT, Angtuaco EJ.

J Clin Neurosci. 2014 Sep;21(9):1575-8. doi: 10.1016/j.jocn.2014.03.004. Epub 2014 Apr 26.


E3 ubiquitin ligase Cullin-5 modulates multiple molecular and cellular responses to heat shock protein 90 inhibition in human cancer cells.

Samant RS, Clarke PA, Workman P.

Proc Natl Acad Sci U S A. 2014 May 6;111(18):6834-9. doi: 10.1073/pnas.1322412111. Epub 2014 Apr 23.


Inhibition of Wnt/β-catenin pathway by niclosamide: a therapeutic target for ovarian cancer.

Arend RC, Londoño-Joshi AI, Samant RS, Li Y, Conner M, Hidalgo B, Alvarez RD, Landen CN, Straughn JM, Buchsbaum DJ.

Gynecol Oncol. 2014 Jul;134(1):112-20. doi: 10.1016/j.ygyno.2014.04.005. Epub 2014 Apr 13.


Multi-targeted therapy of cancer by niclosamide: A new application for an old drug.

Li Y, Li PK, Roberts MJ, Arend RC, Samant RS, Buchsbaum DJ.

Cancer Lett. 2014 Jul 10;349(1):8-14. doi: 10.1016/j.canlet.2014.04.003. Epub 2014 Apr 13. Review.


Role of osteopontin in the pathophysiology of cancer.

Shevde LA, Samant RS.

Matrix Biol. 2014 Jul;37:131-41. doi: 10.1016/j.matbio.2014.03.001. Epub 2014 Mar 19. Review.


Lithium toxicity and PRES: a novel association.

Fitzgerald RT, Fitzgerald CT, Samant RS, Kumar M, Ramakrishniah R, Van Hemert R, Angtuaco EJ.

J Neuroimaging. 2015 Jan-Feb;25(1):147-9. doi: 10.1111/jon.12094. Epub 2014 Feb 26.


Effect of niclosamide on basal-like breast cancers.

Londoño-Joshi AI, Arend RC, Aristizabal L, Lu W, Samant RS, Metge BJ, Hidalgo B, Grizzle WE, Conner M, Forero-Torres A, Lobuglio AF, Li Y, Buchsbaum DJ.

Mol Cancer Ther. 2014 Apr;13(4):800-11. doi: 10.1158/1535-7163.MCT-13-0555. Epub 2014 Feb 19.


Nonclassical hedgehog-GLI signaling and its clinical implications.

Shevde LA, Samant RS.

Int J Cancer. 2014 Jul 1;135(1):1-6. doi: 10.1002/ijc.28424. Epub 2013 Sep 11. Review.


Loss of N-Myc interactor promotes epithelial-mesenchymal transition by activation of TGF-β/SMAD signaling.

Devine DJ, Rostas JW, Metge BJ, Das S, Mulekar MS, Tucker JA, Grizzle WE, Buchsbaum DJ, Shevde LA, Samant RS.

Oncogene. 2014 May 15;33(20):2620-8. doi: 10.1038/onc.2013.215. Epub 2013 Jun 17.


Nonclassical activation of Hedgehog signaling enhances multidrug resistance and makes cancer cells refractory to Smoothened-targeting Hedgehog inhibition.

Das S, Samant RS, Shevde LA.

J Biol Chem. 2013 Apr 26;288(17):11824-33. doi: 10.1074/jbc.M112.432302. Epub 2013 Mar 18.


ATP-competitive inhibitors block protein kinase recruitment to the Hsp90-Cdc37 system.

Polier S, Samant RS, Clarke PA, Workman P, Prodromou C, Pearl LH.

Nat Chem Biol. 2013 May;9(5):307-12. doi: 10.1038/nchembio.1212. Epub 2013 Mar 17. Erratum in: Nat Chem Biol. 2013 Jun;9(6):406.


Molecular biology: Choose your protein partners.

Samant RS, Workman P.

Nature. 2012 Oct 18;490(7420):351-2. doi: 10.1038/490351a. No abstract available.


Cytoplasmic translocation of p21 mediates NUPR1-induced chemoresistance: NUPR1 and p21 in chemoresistance.

Vincent AJ, Ren S, Harris LG, Devine DJ, Samant RS, Fodstad O, Shevde LA.

FEBS Lett. 2012 Sep 21;586(19):3429-34. doi: 10.1016/j.febslet.2012.07.063. Epub 2012 Jul 31.


Micro-RNA-632 downregulates DNAJB6 in breast cancer.

Mitra A, Rostas JW, Dyess DL, Shevde LA, Samant RS.

Lab Invest. 2012 Sep;92(9):1310-7. doi: 10.1038/labinvest.2012.87. Epub 2012 Jun 18.


The influence of the cancer microenvironment on the process of metastasis.

Frost AR, Hurst DR, Shevde LA, Samant RS.

Int J Breast Cancer. 2012;2012:756257. doi: 10.1155/2012/756257. Epub 2012 Apr 18. No abstract available.


Cellular stress stimulates nuclear localization signal (NLS) independent nuclear transport of MRJ.

Andrews JF, Sykora LJ, Letostak TB, Menezes ME, Mitra A, Barik S, Shevde LA, Samant RS.

Exp Cell Res. 2012 Jun 10;318(10):1086-93. doi: 10.1016/j.yexcr.2012.03.024. Epub 2012 Apr 3.


Hedgehog signaling in tumor cells facilitates osteoblast-enhanced osteolytic metastases.

Das S, Tucker JA, Khullar S, Samant RS, Shevde LA.

PLoS One. 2012;7(3):e34374. doi: 10.1371/journal.pone.0034374. Epub 2012 Mar 29.

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