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Items: 6


Molecular Determinants of the Differential Modulation of Cav1.2 and Cav1.3 by Nifedipine and FPL 64176.

Wang Y, Tang S, Harvey KE, Salyer AE, Li TA, Rantz EK, Lill MA, Hockerman GH.

Mol Pharmacol. 2018 Sep;94(3):973-983. doi: 10.1124/mol.118.112441. Epub 2018 Jul 6.


Agonists of the γ-aminobutyric acid type B (GABAB) receptor derived from β-hydroxy and β-amino difluoromethyl ketones.

Sowaileh MF, Salyer AE, Roy KK, John JP, Woods JR, Doerksen RJ, Hockerman GH, Colby DA.

Bioorg Med Chem Lett. 2018 Sep 1;28(16):2697-2700. doi: 10.1016/j.bmcl.2018.04.003. Epub 2018 Apr 7.


Ca2+ influx through L-type Ca2+ channels and Ca2+-induced Ca2+ release regulate cAMP accumulation and Epac1-dependent ERK 1/2 activation in INS-1 cells.

Pratt EP, Salyer AE, Guerra ML, Hockerman GH.

Mol Cell Endocrinol. 2016 Jan 5;419:60-71. doi: 10.1016/j.mce.2015.09.034. Epub 2015 Oct 3.


Uncoupling of Cav1.2 from Ca(2+)-induced Ca(2+) release and SK channel regulation in pancreatic β-cells.

Wang Y, Jarrard RE, Pratt EP, Guerra ML, Salyer AE, Lange AM, Soderling IM, Hockerman GH.

Mol Endocrinol. 2014 Apr;28(4):458-76. doi: 10.1210/me.2013-1094. Epub 2014 Feb 7.


Evaluation of difluoromethyl ketones as agonists of the γ-aminobutyric acid type B (GABAB) receptor.

Han C, Salyer AE, Kim EH, Jiang X, Jarrard RE, Powers MS, Kirchhoff AM, Salvador TK, Chester JA, Hockerman GH, Colby DA.

J Med Chem. 2013 Mar 28;56(6):2456-65. doi: 10.1021/jm301805e. Epub 2013 Mar 6.


Potentiation of sulfonylurea action by an EPAC-selective cAMP analog in INS-1 cells: comparison of tolbutamide and gliclazide and a potential role for EPAC activation of a 2-APB-sensitive Ca2+ influx.

Jarrard RE, Wang Y, Salyer AE, Pratt EP, Soderling IM, Guerra ML, Lange AM, Broderick HJ, Hockerman GH.

Mol Pharmacol. 2013 Jan;83(1):191-205. doi: 10.1124/mol.112.081943. Epub 2012 Oct 15.

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