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Selective inhibition of matrix metalloproteinase 10 (MMP10) with a single-domain antibody.

Razai AS, Eckelman BP, Salvesen GS.

J Biol Chem. 2020 Jan 17. pii: jbc.RA119.011712. doi: 10.1074/jbc.RA119.011712. [Epub ahead of print]


Cytosolic Gram-negative bacteria prevent apoptosis by inhibition of effector caspases through lipopolysaccharide.

Günther SD, Fritsch M, Seeger JM, Schiffmann LM, Snipas SJ, Coutelle M, Kufer TA, Higgins PG, Hornung V, Bernardini ML, Höning S, Krönke M, Salvesen GS, Kashkar H.

Nat Microbiol. 2019 Dec 23. doi: 10.1038/s41564-019-0620-5. [Epub ahead of print]


Fluorescent probes towards selective cathepsin B detection and visualization in cancer cells and patient samples.

Poreba M, Groborz K, Vizovisek M, Maruggi M, Turk D, Turk B, Powis G, Drag M, Salvesen GS.

Chem Sci. 2019 Jul 31;10(36):8461-8477. doi: 10.1039/c9sc00997c. eCollection 2019 Sep 28.


The Proteasome as a Drug Target in the Metazoan Pathogen, Schistosoma mansoni.

Bibo-Verdugo B, Wang SC, Almaliti J, Ta AP, Jiang Z, Wong DA, Lietz CB, Suzuki BM, El-Sakkary N, Hook V, Salvesen GS, Gerwick WH, Caffrey CR, O'Donoghue AJ.

ACS Infect Dis. 2019 Oct 11;5(10):1802-1812. doi: 10.1021/acsinfecdis.9b00237. Epub 2019 Aug 12.


Cathepsin G Inhibition by Serpinb1 and Serpinb6 Prevents Programmed Necrosis in Neutrophils and Monocytes and Reduces GSDMD-Driven Inflammation.

Burgener SS, Leborgne NGF, Snipas SJ, Salvesen GS, Bird PI, Benarafa C.

Cell Rep. 2019 Jun 18;27(12):3646-3656.e5. doi: 10.1016/j.celrep.2019.05.065.


Exploring the prime site in caspases as a novel chemical strategy for understanding the mechanisms of cell death: a proof of concept study on necroptosis in cancer cells.

Groborz K, Gonzalez Ramirez ML, Snipas SJ, Salvesen GS, Drąg M, Poręba M.

Cell Death Differ. 2020 Feb;27(2):451-465. doi: 10.1038/s41418-019-0364-z. Epub 2019 Jun 17.


The Pyroptotic Cell Death Effector Gasdermin D Is Activated by Gout-Associated Uric Acid Crystals but Is Dispensable for Cell Death and IL-1β Release.

Rashidi M, Simpson DS, Hempel A, Frank D, Petrie E, Vince A, Feltham R, Murphy J, Chatfield SM, Salvesen GS, Murphy JM, Wicks IP, Vince JE.

J Immunol. 2019 Aug 1;203(3):736-748. doi: 10.4049/jimmunol.1900228. Epub 2019 Jun 17.


Potent and selective caspase-2 inhibitor prevents MDM-2 cleavage in reversine-treated colon cancer cells.

Poreba M, Rut W, Groborz K, Snipas SJ, Salvesen GS, Drag M.

Cell Death Differ. 2019 Dec;26(12):2695-2709. doi: 10.1038/s41418-019-0329-2. Epub 2019 Apr 11.


Development of an advanced nanoformulation for the intracellular delivery of a caspase-3 selective activity-based probe.

Cogo F, Poreba M, Rut W, Groborz K, Smyth P, Johnston MC, Williams R, Longley DB, Burden RE, Salvesen GS, Drag M, Scott CJ.

Nanoscale. 2019 Jan 3;11(2):742-751. doi: 10.1039/c8nr07859a.


Determination of extended substrate specificity of the MALT1 as a strategy for the design of potent substrates and activity-based probes.

Kasperkiewicz P, Kołt S, Janiszewski T, Groborz K, Poręba M, Snipas SJ, Salvesen GS, Drąg M.

Sci Rep. 2018 Oct 30;8(1):15998. doi: 10.1038/s41598-018-34476-7.


Protease Specificity: Towards In Vivo Imaging Applications and Biomarker Discovery.

Vizovišek M, Vidmar R, Drag M, Fonović M, Salvesen GS, Turk B.

Trends Biochem Sci. 2018 Oct;43(10):829-844. doi: 10.1016/j.tibs.2018.07.003. Epub 2018 Aug 7. Review.


Caspase selective reagents for diagnosing apoptotic mechanisms.

Poreba M, Groborz K, Navarro M, Snipas SJ, Drag M, Salvesen GS.

Cell Death Differ. 2019 Feb;26(2):229-244. doi: 10.1038/s41418-018-0110-y. Epub 2018 May 10.


Selective imaging of cathepsin L in breast cancer by fluorescent activity-based probes.

Poreba M, Rut W, Vizovisek M, Groborz K, Kasperkiewicz P, Finlay D, Vuori K, Turk D, Turk B, Salvesen GS, Drag M.

Chem Sci. 2018 Jan 16;9(8):2113-2129. doi: 10.1039/c7sc04303a. eCollection 2018 Feb 28.


Extensive peptide and natural protein substrate screens reveal that mouse caspase-11 has much narrower substrate specificity than caspase-1.

Ramirez MLG, Poreba M, Snipas SJ, Groborz K, Drag M, Salvesen GS.

J Biol Chem. 2018 May 4;293(18):7058-7067. doi: 10.1074/jbc.RA117.001329. Epub 2018 Feb 6.


A primer on caspase mechanisms.

Ramirez MLG, Salvesen GS.

Semin Cell Dev Biol. 2018 Oct;82:79-85. doi: 10.1016/j.semcdb.2018.01.002. Epub 2018 Jan 12. Review.


Hyperbaric oxygen treatment did not significantly affect radiation injury in the mandibular area of rats.

Sønstevold T, Johannessen AC, Reed RK, Salvesen GS, Stuhr L.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Feb;125(2):112-119. doi: 10.1016/j.oooo.2017.10.014. Epub 2017 Nov 2.


Synthesis of a HyCoSuL peptide substrate library to dissect protease substrate specificity.

Poreba M, Salvesen GS, Drag M.

Nat Protoc. 2017 Oct;12(10):2189-2214. doi: 10.1038/nprot.2017.091. Epub 2017 Sep 21.


Toolbox of Fluorescent Probes for Parallel Imaging Reveals Uneven Location of Serine Proteases in Neutrophils.

Kasperkiewicz P, Altman Y, D'Angelo M, Salvesen GS, Drag M.

J Am Chem Soc. 2017 Jul 26;139(29):10115-10125. doi: 10.1021/jacs.7b04394. Epub 2017 Jul 18.


Highly sensitive and adaptable fluorescence-quenched pair discloses the substrate specificity profiles in diverse protease families.

Poreba M, Szalek A, Rut W, Kasperkiewicz P, Rutkowska-Wlodarczyk I, Snipas SJ, Itoh Y, Turk D, Turk B, Overall CM, Kaczmarek L, Salvesen GS, Drag M.

Sci Rep. 2017 Feb 23;7:43135. doi: 10.1038/srep43135.


Counter Selection Substrate Library Strategy for Developing Specific Protease Substrates and Probes.

Poreba M, Solberg R, Rut W, Lunde NN, Kasperkiewicz P, Snipas SJ, Mihelic M, Turk D, Turk B, Salvesen GS, Drag M.

Cell Chem Biol. 2016 Aug 18;23(8):1023-35. doi: 10.1016/j.chembiol.2016.05.020. Epub 2016 Jul 28.


Protease signaling in animal and plant-regulated cell death.

Salvesen GS, Hempel A, Coll NS.

FEBS J. 2016 Jul;283(14):2577-98. doi: 10.1111/febs.13616. Epub 2015 Dec 31. Review.


Small Molecule Active Site Directed Tools for Studying Human Caspases.

Poreba M, Szalek A, Kasperkiewicz P, Rut W, Salvesen GS, Drag M.

Chem Rev. 2015 Nov 25;115(22):12546-629. doi: 10.1021/acs.chemrev.5b00434. Epub 2015 Nov 9. Review.


The Paracaspase MALT1.

Hachmann J, Salvesen GS.

Biochimie. 2016 Mar;122:324-38. doi: 10.1016/j.biochi.2015.09.018. Epub 2015 Sep 16. Review.


Caspase-11 cleaves gasdermin D for non-canonical inflammasome signalling.

Kayagaki N, Stowe IB, Lee BL, O'Rourke K, Anderson K, Warming S, Cuellar T, Haley B, Roose-Girma M, Phung QT, Liu PS, Lill JR, Li H, Wu J, Kummerfeld S, Zhang J, Lee WP, Snipas SJ, Salvesen GS, Morris LX, Fitzgerald L, Zhang Y, Bertram EM, Goodnow CC, Dixit VM.

Nature. 2015 Oct 29;526(7575):666-71. doi: 10.1038/nature15541. Epub 2015 Sep 16.


Design of a Selective Substrate and Activity Based Probe for Human Neutrophil Serine Protease 4.

Kasperkiewicz P, Poreba M, Snipas SJ, Lin SJ, Kirchhofer D, Salvesen GS, Drag M.

PLoS One. 2015 Jul 14;10(7):e0132818. doi: 10.1371/journal.pone.0132818. eCollection 2015.


SUMO deconjugation is required for arsenic-triggered ubiquitylation of PML.

Fasci D, Anania VG, Lill JR, Salvesen GS.

Sci Signal. 2015 Jun 9;8(380):ra56. doi: 10.1126/scisignal.aaa3929.


Probes to monitor activity of the paracaspase MALT1.

Hachmann J, Edgington-Mitchell LE, Poreba M, Sanman LE, Drag M, Bogyo M, Salvesen GS.

Chem Biol. 2015 Jan 22;22(1):139-47. doi: 10.1016/j.chembiol.2014.11.011. Epub 2014 Dec 31.


Caspase cleavage sites in the human proteome: CaspDB, a database of predicted substrates.

Kumar S, van Raam BJ, Salvesen GS, Cieplak P.

PLoS One. 2014 Oct 17;9(10):e110539. doi: 10.1371/journal.pone.0110539. eCollection 2014.


Caspase enzymology and activation mechanisms.

Mace PD, Riedl SJ, Salvesen GS.

Methods Enzymol. 2014;544:161-78. doi: 10.1016/B978-0-12-417158-9.00007-8.


Functions of caspase 8: the identified and the mysterious.

Salvesen GS, Walsh CM.

Semin Immunol. 2014 Jun;26(3):246-52. doi: 10.1016/j.smim.2014.03.005. Epub 2014 May 21. Review.


Unnatural amino acids increase sensitivity and provide for the design of highly selective caspase substrates.

Poreba M, Kasperkiewicz P, Snipas SJ, Fasci D, Salvesen GS, Drag M.

Cell Death Differ. 2014 Sep;21(9):1482-92. doi: 10.1038/cdd.2014.64. Epub 2014 May 16.


Staphylococcal SplB serine protease utilizes a novel molecular mechanism of activation.

Pustelny K, Zdzalik M, Stach N, Stec-Niemczyk J, Cichon P, Czarna A, Popowicz G, Mak P, Drag M, Salvesen GS, Wladyka B, Potempa J, Dubin A, Dubin G.

J Biol Chem. 2014 May 30;289(22):15544-53. doi: 10.1074/jbc.M113.507616. Epub 2014 Apr 8.


A remarkable activity of human leukotriene A4 hydrolase (LTA4H) toward unnatural amino acids.

Byzia A, Haeggström JZ, Salvesen GS, Drag M.

Amino Acids. 2014 May;46(5):1313-20. doi: 10.1007/s00726-014-1694-2. Epub 2014 Feb 27.


Design of ultrasensitive probes for human neutrophil elastase through hybrid combinatorial substrate library profiling.

Kasperkiewicz P, Poreba M, Snipas SJ, Parker H, Winterbourn CC, Salvesen GS, Drag M.

Proc Natl Acad Sci U S A. 2014 Feb 18;111(7):2518-23. doi: 10.1073/pnas.1318548111. Epub 2014 Feb 3.


Dying from within: granzyme B converts entosis to emperitosis.

Salvesen GS.

Cell Death Differ. 2014 Jan;21(1):3-4. doi: 10.1038/cdd.2013.157. No abstract available.


Caspase substrates and inhibitors.

Poreba M, Strózyk A, Salvesen GS, Drag M.

Cold Spring Harb Perspect Biol. 2013 Aug 1;5(8):a008680. doi: 10.1101/cshperspect.a008680. Review.


Expedient synthesis of highly potent antagonists of inhibitor of apoptosis proteins (IAPs) with unique selectivity for ML-IAP.

Vamos M, Welsh K, Finlay D, Lee PS, Mace PD, Snipas SJ, Gonzalez ML, Ganji SR, Ardecky RJ, Riedl SJ, Salvesen GS, Vuori K, Reed JC, Cosford ND.

ACS Chem Biol. 2013 Apr 19;8(4):725-32. doi: 10.1021/cb3005512. Epub 2013 Feb 5.


Activity, specificity, and probe design for the smallpox virus protease K7L.

Aleshin AE, Drag M, Gombosuren N, Wei G, Mikolajczyk J, Satterthwait AC, Strongin AY, Liddington RC, Salvesen GS.

J Biol Chem. 2012 Nov 16;287(47):39470-9. doi: 10.1074/jbc.M112.388678. Epub 2012 Sep 25.


Highlight: the universe of proteolytic networks and mechanisms.

Salvesen GS, Bogyo M.

Biol Chem. 2012 Sep;393(9):841. doi: 10.1515/hsz-2012-0262. No abstract available.


Intrinsic cleavage of receptor-interacting protein kinase-1 by caspase-6.

van Raam BJ, Ehrnhoefer DE, Hayden MR, Salvesen GS.

Cell Death Differ. 2013 Jan;20(1):86-96. doi: 10.1038/cdd.2012.98. Epub 2012 Aug 3.


Cathepsin D primes caspase-8 activation by multiple intra-chain proteolysis.

Conus S, Pop C, Snipas SJ, Salvesen GS, Simon HU.

J Biol Chem. 2012 Jun 15;287(25):21142-51. doi: 10.1074/jbc.M111.306399. Epub 2012 Apr 23.


Mousing around with caspases and IAPs.

Rickert RC, Salvesen GS, Ware CF.

Biochem J. 2012 Apr 15;443(2):e1-2. doi: 10.1042/BJ20120402.


An optimized activity-based probe for the study of caspase-6 activation.

Edgington LE, van Raam BJ, Verdoes M, Wierschem C, Salvesen GS, Bogyo M.

Chem Biol. 2012 Mar 23;19(3):340-52. doi: 10.1016/j.chembiol.2011.12.021.


Mitochondrial pathway of apoptosis is ancestral in metazoans.

Bender CE, Fitzgerald P, Tait SW, Llambi F, McStay GP, Tupper DO, Pellettieri J, Sánchez Alvarado A, Salvesen GS, Green DR.

Proc Natl Acad Sci U S A. 2012 Mar 27;109(13):4904-9. doi: 10.1073/pnas.1120680109. Epub 2012 Mar 13.


Fingerprinting the substrate specificity of M1 and M17 aminopeptidases of human malaria, Plasmodium falciparum.

Poreba M, McGowan S, Skinner-Adams TS, Trenholme KR, Gardiner DL, Whisstock JC, To J, Salvesen GS, Dalton JP, Drag M.

PLoS One. 2012;7(2):e31938. doi: 10.1371/journal.pone.0031938. Epub 2012 Feb 16.


Mechanism and specificity of the human paracaspase MALT1.

Hachmann J, Snipas SJ, van Raam BJ, Cancino EM, Houlihan EJ, Poreba M, Kasperkiewicz P, Drag M, Salvesen GS.

Biochem J. 2012 Apr 1;443(1):287-95. doi: 10.1042/BJ20120035.


Glycine fluoromethylketones as SENP-specific activity based probes.

Dobrotă C, Fasci D, Hădade ND, Roiban GD, Pop C, Meier VM, Dumitru I, Matache M, Salvesen GS, Funeriu DP.

Chembiochem. 2012 Jan 2;13(1):80-4. doi: 10.1002/cbic.201100645. Epub 2011 Dec 1.


S1 pocket fingerprints of human and bacterial methionine aminopeptidases determined using fluorogenic libraries of substrates and phosphorus based inhibitors.

Poreba M, Gajda A, Picha J, Jiracek J, Marschner A, Klein CD, Salvesen GS, Drag M.

Biochimie. 2012 Mar;94(3):704-10. doi: 10.1016/j.biochi.2011.10.014. Epub 2011 Nov 7.


Snapshot: caspases.

Salvesen GS, Ashkenazi A.

Cell. 2011 Oct 14;147(2):476-476.e1. doi: 10.1016/j.cell.2011.09.030. No abstract available.


RIPK-dependent necrosis and its regulation by caspases: a mystery in five acts.

Green DR, Oberst A, Dillon CP, Weinlich R, Salvesen GS.

Mol Cell. 2011 Oct 7;44(1):9-16. doi: 10.1016/j.molcel.2011.09.003. Review.

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