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Progenitor-derived human endothelial cells evade alloimmunity by CRISPR/Cas9-mediated complete ablation of MHC expression.

Merola J, Reschke M, Pierce RW, Qin L, Spindler S, Baltazar T, Manes TD, Lopez-Giraldez F, Li G, Bracaglia LG, Xie C, Kirkiles-Smith N, Saltzman WM, Tietjen GT, Tellides G, Pober JS.

JCI Insight. 2019 Oct 17;4(20). pii: 129739. doi: 10.1172/jci.insight.129739.


Fas ligand and nitric oxide combination to control smooth muscle growth while sparing endothelium.

Kural MH, Wang J, Gui L, Yuan Y, Li G, Leiby KL, Quijano E, Tellides G, Saltzman WM, Niklason LE.

Biomaterials. 2019 Aug;212:28-38. doi: 10.1016/j.biomaterials.2019.05.011. Epub 2019 May 7.


Poly(amine-co-ester) nanoparticles for effective Nogo-B knockdown in the liver.

Cui J, Piotrowski-Daspit AS, Zhang J, Shao M, Bracaglia LG, Utsumi T, Seo YE, DiRito J, Song E, Wu C, Inada A, Tietjen GT, Pober JS, Iwakiri Y, Saltzman WM.

J Control Release. 2019 Jun 28;304:259-267. doi: 10.1016/j.jconrel.2019.04.044. Epub 2019 May 1.


Structural and pharmacological evaluation of a novel non-nucleoside reverse transcriptase inhibitor as a promising long acting nanoformulation for treating HIV.

Kudalkar SN, Ullah I, Bertoletti N, Mandl HK, Cisneros JA, Beloor J, Chan AH, Quijano E, Saltzman WM, Jorgensen WL, Kumar P, Anderson KS.

Antiviral Res. 2019 Jul;167:110-116. doi: 10.1016/j.antiviral.2019.04.010. Epub 2019 Apr 26.


Debugging the genetic code: non-viral in vivo delivery of therapeutic genome editing technologies.

Piotrowski-Daspit AS, Glaze PM, Saltzman WM.

Curr Opin Biomed Eng. 2018 Sep;7:24-32. doi: 10.1016/j.cobme.2018.08.002. Epub 2018 Aug 21.


Nanoparticle-mediated intratumoral inhibition of miR-21 for improved survival in glioblastoma.

Seo YE, Suh HW, Bahal R, Josowitz A, Zhang J, Song E, Cui J, Noorbakhsh S, Jackson C, Bu T, Piotrowski-Daspit A, Bindra R, Saltzman WM.

Biomaterials. 2019 May;201:87-98. doi: 10.1016/j.biomaterials.2019.02.016. Epub 2019 Feb 14.


Biodegradable bioadhesive nanoparticle incorporation of broad-spectrum organic sunscreen agents.

Suh HW, Lewis J, Fong L, Ramseier JY, Carlson K, Peng ZH, Yin ES, Saltzman WM, Girardi M.

Bioeng Transl Med. 2018 Jul 6;4(1):129-140. doi: 10.1002/btm2.10092. eCollection 2019 Jan.


The Yale Center for Biomedical Innovation and Technology (CBIT): One Model to Accelerate Impact From Academic Health Care Innovation.

Siefert AL, Cartiera MS, Khalid AN, Nantel MC, Loose CR, Schulam PG, Saltzman WM, Dempsey MK.

Acad Med. 2019 Apr;94(4):528-534. doi: 10.1097/ACM.0000000000002542.


Alginate microparticles loaded with basic fibroblast growth factor induce tissue coverage in a rat model of myelomeningocele.

Farrelly JS, Bianchi AH, Ricciardi AS, Buzzelli GL, Ahle SL, Freedman-Weiss MR, Luks VL, Saltzman WM, Stitelman DH.

J Pediatr Surg. 2019 Jan;54(1):80-85. doi: 10.1016/j.jpedsurg.2018.10.031. Epub 2018 Oct 5.


Glycoprotein-130 Expression Is Associated with Aggressive Bladder Cancer and Is a Potential Therapeutic Target.

Martin DT, Shen H, Steinbach-Rankins JM, Zhu X, Johnson KK, Syed J, Saltzman WM, Weiss RM.

Mol Cancer Ther. 2019 Feb;18(2):413-420. doi: 10.1158/1535-7163.MCT-17-1079. Epub 2018 Oct 31.


Tunability of Biodegradable Poly(amine- co-ester) Polymers for Customized Nucleic Acid Delivery and Other Biomedical Applications.

Kauffman AC, Piotrowski-Daspit AS, Nakazawa KH, Jiang Y, Datye A, Saltzman WM.

Biomacromolecules. 2018 Sep 10;19(9):3861-3873. doi: 10.1021/acs.biomac.8b00997. Epub 2018 Aug 28.


Reply to Pandey et al.: Understanding the efficacy of a potential antiretroviral drug candidate in humanized mouse model of HIV infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Aug 28;115(35):E8114-E8115. doi: 10.1073/pnas.1810136115. Epub 2018 Aug 10. No abstract available.


Oligosaccharyltransferase Inhibition Overcomes Therapeutic Resistance to EGFR Tyrosine Kinase Inhibitors.

Lopez Sambrooks C, Baro M, Quijano A, Narayan A, Cui W, Greninger P, Egan R, Patel A, Benes CH, Saltzman WM, Contessa JN.

Cancer Res. 2018 Sep 1;78(17):5094-5106. doi: 10.1158/0008-5472.CAN-18-0505. Epub 2018 Jul 19.


Oligosaccharyltransferase Inhibition Reduces Receptor Tyrosine Kinase Activation and Enhances Glioma Radiosensitivity.

Baro M, Lopez Sambrooks C, Quijano A, Saltzman WM, Contessa J.

Clin Cancer Res. 2019 Jan 15;25(2):784-795. doi: 10.1158/1078-0432.CCR-18-0792. Epub 2018 Jul 2.


In utero nanoparticle delivery for site-specific genome editing.

Ricciardi AS, Bahal R, Farrelly JS, Quijano E, Bianchi AH, Luks VL, Putman R, López-Giráldez F, Coşkun S, Song E, Liu Y, Hsieh WC, Ly DH, Stitelman DH, Glazer PM, Saltzman WM.

Nat Commun. 2018 Jun 26;9(1):2481. doi: 10.1038/s41467-018-04894-2.


Biodegradable PEG-poly(ω-pentadecalactone-co-p-dioxanone) nanoparticles for enhanced and sustained drug delivery to treat brain tumors.

Chen EM, Quijano AR, Seo YE, Jackson C, Josowitz AD, Noorbakhsh S, Merlettini A, Sundaram RK, Focarete ML, Jiang Z, Bindra RS, Saltzman WM.

Biomaterials. 2018 Sep;178:193-203. doi: 10.1016/j.biomaterials.2018.06.024. Epub 2018 Jun 18.


Focus on Fundamentals: Achieving Effective Nanoparticle Targeting.

Tietjen GT, Bracaglia LG, Saltzman WM, Pober JS.

Trends Mol Med. 2018 Jul;24(7):598-606. doi: 10.1016/j.molmed.2018.05.003. Epub 2018 Jun 5. Review.


A "top-down" approach to actuate poly(amine-co-ester) terpolymers for potent and safe mRNA delivery.

Jiang Y, Gaudin A, Zhang J, Agarwal T, Song E, Kauffman AC, Tietjen GT, Wang Y, Jiang Z, Cheng CJ, Saltzman WM.

Biomaterials. 2018 Sep;176:122-130. doi: 10.1016/j.biomaterials.2018.05.043. Epub 2018 May 25.


Peptide Nucleic Acids as a Tool for Site-Specific Gene Editing.

Ricciardi AS, Quijano E, Putman R, Saltzman WM, Glazer PM.

Molecules. 2018 Mar 11;23(3). pii: E632. doi: 10.3390/molecules23030632. Review.


Nanomaterials for convection-enhanced delivery of agents to treat brain tumors.

Seo YE, Bu T, Saltzman WM.

Curr Opin Biomed Eng. 2017 Dec;4:1-12. doi: 10.1016/j.cobme.2017.09.002. Epub 2017 Sep 22.


From in silico hit to long-acting late-stage preclinical candidate to combat HIV-1 infection.

Kudalkar SN, Beloor J, Quijano E, Spasov KA, Lee WG, Cisneros JA, Saltzman WM, Kumar P, Jorgensen WL, Anderson KS.

Proc Natl Acad Sci U S A. 2018 Jan 23;115(4):E802-E811. doi: 10.1073/pnas.1717932115. Epub 2017 Dec 26. Erratum in: Proc Natl Acad Sci U S A. 2018 Mar 12;:.


Therapeutic Peptide Nucleic Acids: Principles, Limitations, and Opportunities.

Quijano E, Bahal R, Ricciardi A, Saltzman WM, Glazer PM.

Yale J Biol Med. 2017 Dec 19;90(4):583-598. eCollection 2017 Dec. Review.


Anti-tumor Activity of miniPEG-γ-Modified PNAs to Inhibit MicroRNA-210 for Cancer Therapy.

Gupta A, Quijano E, Liu Y, Bahal R, Scanlon SE, Song E, Hsieh WC, Braddock DE, Ly DH, Saltzman WM, Glazer PM.

Mol Ther Nucleic Acids. 2017 Dec 15;9:111-119. doi: 10.1016/j.omtn.2017.09.001. Epub 2017 Sep 12.


Nanoparticle targeting to the endothelium during normothermic machine perfusion of human kidneys.

Tietjen GT, Hosgood SA, DiRito J, Cui J, Deep D, Song E, Kraehling JR, Piotrowski-Daspit AS, Kirkiles-Smith NC, Al-Lamki R, Thiru S, Bradley JA, Saeb-Parsy K, Bradley JR, Nicholson ML, Saltzman WM, Pober JS.

Sci Transl Med. 2017 Nov 29;9(418). pii: eaam6764. doi: 10.1126/scitranslmed.aam6764.


Improved threshold selection for the determination of volume of distribution of nanoparticles administered by convection-enhanced delivery.

Chi DL, Song E, Gaudin A, Saltzman WM.

Comput Med Imaging Graph. 2017 Dec;62:34-40. doi: 10.1016/j.compmedimag.2017.08.001. Epub 2017 Aug 24.


Degradable bioadhesive nanoparticles for prolonged intravaginal delivery and retention of elvitegravir.

Mohideen M, Quijano E, Song E, Deng Y, Panse G, Zhang W, Clark MR, Saltzman WM.

Biomaterials. 2017 Nov;144:144-154. doi: 10.1016/j.biomaterials.2017.08.029. Epub 2017 Aug 15.


Multifunctional Poly(amine-co-ester-co-ortho ester) for Efficient and Safe Gene Delivery.

Zhang J, Cui J, Deng Y, Jiang Z, Saltzman WM.

ACS Biomater Sci Eng. 2016 Nov 14;2(11):2080-2089. doi: 10.1021/acsbiomaterials.6b00502. Epub 2016 Sep 26.


Local DNA Repair Inhibition for Sustained Radiosensitization of High-Grade Gliomas.

King AR, Corso CD, Chen EM, Song E, Bongiorni P, Chen Z, Sundaram RK, Bindra RS, Saltzman WM.

Mol Cancer Ther. 2017 Aug;16(8):1456-1469. doi: 10.1158/1535-7163.MCT-16-0788. Epub 2017 May 31.


Surface chemistry governs cellular tropism of nanoparticles in the brain.

Song E, Gaudin A, King AR, Seo YE, Suh HW, Deng Y, Cui J, Tietjen GT, Huttner A, Saltzman WM.

Nat Commun. 2017 May 19;8:15322. doi: 10.1038/ncomms15322.


Quantitative microscopy-based measurements of circulating nanoparticle concentration using microliter blood volumes.

Tietjen GT, DiRito J, Pober JS, Saltzman WM.

Nanomedicine. 2017 Aug;13(6):1863-1867. doi: 10.1016/j.nano.2017.04.003. Epub 2017 Apr 13.


Dual-Targeting Nanoparticles for In Vivo Delivery of Suicide Genes to Chemotherapy-Resistant Ovarian Cancer Cells.

Cocco E, Deng Y, Shapiro EM, Bortolomai I, Lopez S, Lin K, Bellone S, Cui J, Menderes G, Black JD, Schwab CL, Bonazzoli E, Yang F, Predolini F, Zammataro L, Altwerger G, de Haydu C, Clark M, Alvarenga J, Ratner E, Azodi M, Silasi DA, Schwartz PE, Litkouhi B, Saltzman WM, Santin AD.

Mol Cancer Ther. 2017 Feb;16(2):323-333. doi: 10.1158/1535-7163.MCT-16-0501. Epub 2016 Dec 12.


Improved i.p. drug delivery with bioadhesive nanoparticles.

Deng Y, Yang F, Cocco E, Song E, Zhang J, Cui J, Mohideen M, Bellone S, Santin AD, Saltzman WM.

Proc Natl Acad Sci U S A. 2016 Oct 11;113(41):11453-11458. Epub 2016 Sep 23.


PEGylated squalenoyl-gemcitabine nanoparticles for the treatment of glioblastoma.

Gaudin A, Song E, King AR, Saucier-Sawyer JK, Bindra R, Desmaële D, Couvreur P, Saltzman WM.

Biomaterials. 2016 Oct;105:136-144. doi: 10.1016/j.biomaterials.2016.07.037. Epub 2016 Aug 4.


Pigment epithelium-derived factor restoration increases bone mass and improves bone plasticity in a model of osteogenesis imperfecta type VI via Wnt3a blockade.

Belinsky GS, Sreekumar B, Andrejecsk JW, Saltzman WM, Gong J, Herzog RI, Lin S, Horsley V, Carpenter TO, Chung C.

FASEB J. 2016 Aug;30(8):2837-48. doi: 10.1096/fj.201500027R. Epub 2016 Apr 28.


Distribution of polymer nanoparticles by convection-enhanced delivery to brain tumors.

Saucier-Sawyer JK, Seo YE, Gaudin A, Quijano E, Song E, Sawyer AJ, Deng Y, Huttner A, Saltzman WM.

J Control Release. 2016 Jun 28;232:103-12. doi: 10.1016/j.jconrel.2016.04.006. Epub 2016 Apr 8.


Nanoparticle delivery of miR-223 to attenuate macrophage fusion.

Moore LB, Sawyer AJ, Saucier-Sawyer J, Saltzman WM, Kyriakides TR.

Biomaterials. 2016 May;89:127-35. doi: 10.1016/j.biomaterials.2016.02.036. Epub 2016 Feb 26.


Cellular distribution of injected PLGA-nanoparticles in the liver.

Park JK, Utsumi T, Seo YE, Deng Y, Satoh A, Saltzman WM, Iwakiri Y.

Nanomedicine. 2016 Jul;12(5):1365-74. doi: 10.1016/j.nano.2016.01.013. Epub 2016 Mar 4.


Blocking MHC class II on human endothelium mitigates acute rejection.

Abrahimi P, Qin L, Chang WG, Bothwell AL, Tellides G, Saltzman WM, Pober JS.

JCI Insight. 2016;1(1). pii: e85293. Epub 2016 Jan 21.


Nanotechnology for delivery of peptide nucleic acids (PNAs).

Gupta A, Bahal R, Gupta M, Glazer PM, Saltzman WM.

J Control Release. 2016 Oct 28;240:302-311. doi: 10.1016/j.jconrel.2016.01.005. Epub 2016 Jan 8. Review.


miR-34a Silences c-SRC to Attenuate Tumor Growth in Triple-Negative Breast Cancer.

Adams BD, Wali VB, Cheng CJ, Inukai S, Booth CJ, Agarwal S, Rimm DL, Győrffy B, Santarpia L, Pusztai L, Saltzman WM, Slack FJ.

Cancer Res. 2016 Feb 15;76(4):927-39. doi: 10.1158/0008-5472.CAN-15-2321. Epub 2015 Dec 16.


Enhancing potency of siRNA targeting fusion genes by optimization outside of target sequence.

Gavrilov K, Seo YE, Tietjen GT, Cui J, Cheng CJ, Saltzman WM.

Proc Natl Acad Sci U S A. 2015 Dec 1;112(48):E6597-605. doi: 10.1073/pnas.1517039112. Epub 2015 Nov 16.


Cell penetrating peptide-modified poly(lactic-co-glycolic acid) nanoparticles with enhanced cell internalization.

Steinbach JM, Seo YE, Saltzman WM.

Acta Biomater. 2016 Jan;30:49-61. doi: 10.1016/j.actbio.2015.11.029. Epub 2015 Nov 18.


Nanomedicine gets personal.

Tietjen GT, Saltzman WM.

Sci Transl Med. 2015 Nov 18;7(314):314fs47. doi: 10.1126/scitranslmed.aad6645.


Systemic delivery of blood-brain barrier-targeted polymeric nanoparticles enhances delivery to brain tissue.

Saucier-Sawyer JK, Deng Y, Seo YE, Cheng CJ, Zhang J, Quijano E, Saltzman WM.

J Drug Target. 2015;23(7-8):736-49. doi: 10.3109/1061186X.2015.1065833.


Tissue-Engineered Microvasculature to Reperfuse Isolated Renal Glomeruli.

Chang WG, Fornoni A, Tietjen G, Mendez JJ, Niklason LE, Saltzman WM, Pober JS.

Tissue Eng Part A. 2015 Nov;21(21-22):2673-9. doi: 10.1089/ten.TEA.2015.0060. Epub 2015 Oct 1.


A sunblock based on bioadhesive nanoparticles.

Deng Y, Ediriwickrema A, Yang F, Lewis J, Girardi M, Saltzman WM.

Nat Mater. 2015 Dec;14(12):1278-85. doi: 10.1038/nmat4422. Epub 2015 Sep 28.


Clostridium perfringens enterotoxin C-terminal domain labeled to fluorescent dyes for in vivo visualization of micrometastatic chemotherapy-resistant ovarian cancer.

Cocco E, Shapiro EM, Gasparrini S, Lopez S, Schwab CL, Bellone S, Bortolomai I, Sumi NJ, Bonazzoli E, Nicoletti R, Deng Y, Saltzman WM, Zeiss CJ, Centritto F, Black JD, Silasi DA, Ratner E, Azodi M, Rutherford TJ, Schwartz PE, Pecorelli S, Santin AD.

Int J Cancer. 2015 Dec 1;137(11):2618-29. doi: 10.1002/ijc.29632. Epub 2015 Aug 18.


Nanotherapy for Cancer: Targeting and Multifunctionality in the Future of Cancer Therapies.

Ediriwickrema A, Saltzman WM.

ACS Biomater Sci Eng. 2015 Feb 9;1(2):64-78. Epub 2015 Jan 13. Review.


Efficient gene disruption in cultured primary human endothelial cells by CRISPR/Cas9.

Abrahimi P, Chang WG, Kluger MS, Qyang Y, Tellides G, Saltzman WM, Pober JS.

Circ Res. 2015 Jul 3;117(2):121-8. doi: 10.1161/CIRCRESAHA.117.306290. Epub 2015 May 4.


Nanoparticles that deliver triplex-forming peptide nucleic acid molecules correct F508del CFTR in airway epithelium.

McNeer NA, Anandalingam K, Fields RJ, Caputo C, Kopic S, Gupta A, Quijano E, Polikoff L, Kong Y, Bahal R, Geibel JP, Glazer PM, Saltzman WM, Egan ME.

Nat Commun. 2015 Apr 27;6:6952. doi: 10.1038/ncomms7952.

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