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YIPF6 controls sorting of FGF21 into COPII vesicles and promotes obesity.

Wang L, Mazagova M, Pan C, Yang S, Brandl K, Liu J, Reilly SM, Wang Y, Miao Z, Loomba R, Lu N, Guo Q, Liu J, Yu RT, Downes M, Evans RM, Brenner DA, Saltiel AR, Beutler B, Schnabl B.

Proc Natl Acad Sci U S A. 2019 Jul 9. pii: 201904360. doi: 10.1073/pnas.1904360116. [Epub ahead of print]


Synthesis of deuterium-labelled amlexanox and its metabolic stability against mouse, rat, and human microsomes.

Gan X, Wilson MW, Beyett TS, Wen B, Sun D, Larsen SD, Tesmer JJG, Saltiel AR, Showalter HD.

J Labelled Comp Radiopharm. 2019 May 15;62(5):202-208. doi: 10.1002/jlcr.3716. Epub 2019 Apr 3.


Design, synthesis, and biological activity of substituted 2-amino-5-oxo-5H-chromeno[2,3-b]pyridine-3-carboxylic acid derivatives as inhibitors of the inflammatory kinases TBK1 and IKKε for the treatment of obesity.

Beyett TS, Gan X, Reilly SM, Gomez AV, Chang L, Tesmer JJG, Saltiel AR, Showalter HD.

Bioorg Med Chem. 2018 Nov 1;26(20):5443-5461. doi: 10.1016/j.bmc.2018.09.020. Epub 2018 Sep 20.


ER Stress Drives Lipogenesis and Steatohepatitis via Caspase-2 Activation of S1P.

Kim JY, Garcia-Carbonell R, Yamachika S, Zhao P, Dhar D, Loomba R, Kaufman RJ, Saltiel AR, Karin M.

Cell. 2018 Sep 20;175(1):133-145.e15. doi: 10.1016/j.cell.2018.08.020. Epub 2018 Sep 13.


Carboxylic Acid Derivatives of Amlexanox Display Enhanced Potency toward TBK1 and IKKε and Reveal Mechanisms for Selective Inhibition.

Beyett TS, Gan X, Reilly SM, Chang L, Gomez AV, Saltiel AR, Showalter HD, Tesmer JJG.

Mol Pharmacol. 2018 Oct;94(4):1210-1219. doi: 10.1124/mol.118.112185. Epub 2018 Aug 6.


RalA controls glucose homeostasis by regulating glucose uptake in brown fat.

Skorobogatko Y, Dragan M, Cordon C, Reilly SM, Hung CW, Xia W, Zhao P, Wallace M, Lackey DE, Chen XW, Osborn O, Bogner-Strauss JG, Theodorescu D, Metallo CM, Olefsky JM, Saltiel AR.

Proc Natl Acad Sci U S A. 2018 Jul 24;115(30):7819-7824. doi: 10.1073/pnas.1801050115. Epub 2018 Jun 18.


ERRγ Preserves Brown Fat Innate Thermogenic Activity.

Ahmadian M, Liu S, Reilly SM, Hah N, Fan W, Yoshihara E, Jha P, De Magalhaes Filho CD, Jacinto S, Gomez AV, Dai Y, Yu RT, Liddle C, Atkins AR, Auwerx J, Saltiel AR, Downes M, Evans RM.

Cell Rep. 2018 Mar 13;22(11):2849-2859. doi: 10.1016/j.celrep.2018.02.061.


TBK1 at the Crossroads of Inflammation and Energy Homeostasis in Adipose Tissue.

Zhao P, Wong KI, Sun X, Reilly SM, Uhm M, Liao Z, Skorobogatko Y, Saltiel AR.

Cell. 2018 Feb 8;172(4):731-743.e12. doi: 10.1016/j.cell.2018.01.007.


Lipotoxicity induces hepatic protein inclusions through TANK binding kinase 1-mediated p62/sequestosome 1 phosphorylation.

Cho CS, Park HW, Ho A, Semple IA, Kim B, Jang I, Park H, Reilly S, Saltiel AR, Lee JH.

Hepatology. 2018 Oct;68(4):1331-1346. doi: 10.1002/hep.29742. Epub 2018 May 21.


Vinexin family (SORBS) proteins play different roles in stiffness-sensing and contractile force generation.

Ichikawa T, Kita M, Matsui TS, Nagasato AI, Araki T, Chiang SH, Sezaki T, Kimura Y, Ueda K, Deguchi S, Saltiel AR, Kioka N.

J Cell Sci. 2017 Oct 15;130(20):3517-3531. doi: 10.1242/jcs.200691. Epub 2017 Sep 1.


Creatine Fuels the Thermic Effect of Feeding.

Saltiel AR.

Cell Metab. 2017 Oct 3;26(4):594-595. doi: 10.1016/j.cmet.2017.08.010. Epub 2017 Aug 24.


Adapting to obesity with adipose tissue inflammation.

Reilly SM, Saltiel AR.

Nat Rev Endocrinol. 2017 Nov;13(11):633-643. doi: 10.1038/nrendo.2017.90. Epub 2017 Aug 11. Review.


Inhibition of IKKɛ and TBK1 Improves Glucose Control in a Subset of Patients with Type 2 Diabetes.

Oral EA, Reilly SM, Gomez AV, Meral R, Butz L, Ajluni N, Chenevert TL, Korytnaya E, Neidert AH, Hench R, Rus D, Horowitz JF, Poirier B, Zhao P, Lehmann K, Jain M, Yu R, Liddle C, Ahmadian M, Downes M, Evans RM, Saltiel AR.

Cell Metab. 2017 Jul 5;26(1):157-170.e7. doi: 10.1016/j.cmet.2017.06.006.


Phosphorylation of the exocyst protein Exo84 by TBK1 promotes insulin-stimulated GLUT4 trafficking.

Uhm M, Bazuine M, Zhao P, Chiang SH, Xiong T, Karunanithi S, Chang L, Saltiel AR.

Sci Signal. 2017 Mar 21;10(471). pii: eaah5085. doi: 10.1126/scisignal.aah5085.


Inflammatory mechanisms linking obesity and metabolic disease.

Saltiel AR, Olefsky JM.

J Clin Invest. 2017 Jan 3;127(1):1-4. doi: 10.1172/JCI92035. Epub 2017 Jan 3. Review.


Adipose tissue glycogen accumulation is associated with obesity-linked inflammation in humans.

Ceperuelo-Mallafré V, Ejarque M, Serena C, Duran X, Montori-Grau M, Rodríguez MA, Yanes O, Núñez-Roa C, Roche K, Puthanveetil P, Garrido-Sánchez L, Saez E, Tinahones FJ, Garcia-Roves PM, Gómez-Foix AM, Saltiel AR, Vendrell J, Fernández-Veledo S.

Mol Metab. 2015 Oct 16;5(1):5-18. doi: 10.1016/j.molmet.2015.10.001. eCollection 2016 Jan.


New therapeutic approaches for the treatment of obesity.

Saltiel AR.

Sci Transl Med. 2016 Jan 27;8(323):323rv2. doi: 10.1126/scitranslmed.aad1811. Review.


p75 Neurotrophin Receptor Regulates Energy Balance in Obesity.

Baeza-Raja B, Sachs BD, Li P, Christian F, Vagena E, Davalos D, Le Moan N, Ryu JK, Sikorski SL, Chan JP, Scadeng M, Taylor SS, Houslay MD, Baillie GS, Saltiel AR, Olefsky JM, Akassoglou K.

Cell Rep. 2016 Jan 12;14(2):255-68. doi: 10.1016/j.celrep.2015.12.028. Epub 2015 Dec 31.


Insulin Signaling in the Control of Glucose and Lipid Homeostasis.

Saltiel AR.

Handb Exp Pharmacol. 2016;233:51-71. doi: 10.1007/164_2015_14. Review.


Metabolism: Inflammation keeps old mice healthy.

Maillard I, Saltiel AR.

Nature. 2015 Dec 3;528(7580):44-6. doi: 10.1038/nature15648. Epub 2015 Nov 18. No abstract available.


A futile approach to fighting obesity?

Reilly SM, Saltiel AR.

Cell. 2015 Oct 22;163(3):539-40. doi: 10.1016/j.cell.2015.10.006. Epub 2015 Oct 22.


Gene expression changes in subcutaneous adipose tissue due to Cushing's disease.

Hochberg I, Harvey I, Tran QT, Stephenson EJ, Barkan AL, Saltiel AR, Chandler WF, Bridges D.

J Mol Endocrinol. 2015 Oct;55(2):81-94. doi: 10.1530/JME-15-0119. Epub 2015 Jul 6.


Gene Expression Signature in Adipose Tissue of Acromegaly Patients.

Hochberg I, Tran QT, Barkan AL, Saltiel AR, Chandler WF, Bridges D.

PLoS One. 2015 Jun 18;10(6):e0129359. doi: 10.1371/journal.pone.0129359. eCollection 2015.


White, brown, and beige; type 2 immunity gets hot.

Uhm M, Saltiel AR.

Immunity. 2015 Jan 20;42(1):15-7. doi: 10.1016/j.immuni.2015.01.001.


Zinc finger protein 407 (ZFP407) regulates insulin-stimulated glucose uptake and glucose transporter 4 (Glut4) mRNA.

Buchner DA, Charrier A, Srinivasan E, Wang L, Paulsen MT, Ljungman M, Bridges D, Saltiel AR.

J Biol Chem. 2015 Mar 6;290(10):6376-86. doi: 10.1074/jbc.M114.623736. Epub 2015 Jan 16.


A subcutaneous adipose tissue-liver signalling axis controls hepatic gluconeogenesis.

Reilly SM, Ahmadian M, Zamarron BF, Chang L, Uhm M, Poirier B, Peng X, Krause DM, Korytnaya E, Neidert A, Liddle C, Yu RT, Lumeng CN, Oral EA, Downes M, Evans RM, Saltiel AR.

Nat Commun. 2015 Jan 12;6:6047. doi: 10.1038/ncomms7047.


Intestinal FXR agonism promotes adipose tissue browning and reduces obesity and insulin resistance.

Fang S, Suh JM, Reilly SM, Yu E, Osborn O, Lackey D, Yoshihara E, Perino A, Jacinto S, Lukasheva Y, Atkins AR, Khvat A, Schnabl B, Yu RT, Brenner DA, Coulter S, Liddle C, Schoonjans K, Olefsky JM, Saltiel AR, Downes M, Evans RM.

Nat Med. 2015 Feb;21(2):159-65. doi: 10.1038/nm.3760. Epub 2015 Jan 5.


Phosphoinositides: Key modulators of energy metabolism.

Bridges D, Saltiel AR.

Biochim Biophys Acta. 2015 Jun;1851(6):857-66. doi: 10.1016/j.bbalip.2014.11.008. Epub 2014 Nov 20. Review.


A Rab10:RalA G protein cascade regulates insulin-stimulated glucose uptake in adipocytes.

Karunanithi S, Xiong T, Uhm M, Leto D, Sun J, Chen XW, Saltiel AR.

Mol Biol Cell. 2014 Oct 1;25(19):3059-69. doi: 10.1091/mbc.E14-06-1060. Epub 2014 Aug 7.


The lipid kinase PI4KIIIβ is highly expressed in breast tumors and activates Akt in cooperation with Rab11a.

Morrow AA, Alipour MA, Bridges D, Yao Z, Saltiel AR, Lee JM.

Mol Cancer Res. 2014 Oct;12(10):1492-508. doi: 10.1158/1541-7786.MCR-13-0604. Epub 2014 Jun 24.


Countering inflammatory signals in obesity.

Reilly SM, Saltiel AR.

Nat Immunol. 2014 May;15(5):410-1. doi: 10.1038/ni.2874. No abstract available.


SRA regulates adipogenesis by modulating p38/JNK phosphorylation and stimulating insulin receptor gene expression and downstream signaling.

Liu S, Xu R, Gerin I, Cawthorn WP, Macdougald OA, Chen XW, Saltiel AR, Koenig RJ, Xu B.

PLoS One. 2014 Apr 17;9(4):e95416. doi: 10.1371/journal.pone.0095416. eCollection 2014.


Metabolic crosstalk: molecular links between glycogen and lipid metabolism in obesity.

Lu B, Bridges D, Yang Y, Fisher K, Cheng A, Chang L, Meng ZX, Lin JD, Downes M, Yu RT, Liddle C, Evans RM, Saltiel AR.

Diabetes. 2014 Sep;63(9):2935-48. doi: 10.2337/db13-1531. Epub 2014 Apr 10.


Obesity: A complex role for adipose tissue macrophages.

Reilly SM, Saltiel AR.

Nat Rev Endocrinol. 2014 Apr;10(4):193-4. doi: 10.1038/nrendo.2014.12. Epub 2014 Feb 4. No abstract available.


Roles for PI(3,5)P2 in nutrient sensing through TORC1.

Jin N, Mao K, Jin Y, Tevzadze G, Kauffman EJ, Park S, Bridges D, Loewith R, Saltiel AR, Klionsky DJ, Weisman LS.

Mol Biol Cell. 2014 Apr;25(7):1171-85. doi: 10.1091/mbc.E14-01-0021. Epub 2014 Jan 29.


Ral and Rheb GTPase activating proteins integrate mTOR and GTPase signaling in aging, autophagy, and tumor cell invasion.

Martin TD, Chen XW, Kaplan RE, Saltiel AR, Walker CL, Reiner DJ, Der CJ.

Mol Cell. 2014 Jan 23;53(2):209-20. doi: 10.1016/j.molcel.2013.12.004. Epub 2014 Jan 2.


Otopetrin 1 protects mice from obesity-associated metabolic dysfunction through attenuating adipose tissue inflammation.

Wang GX, Cho KW, Uhm M, Hu CR, Li S, Cozacov Z, Xu AE, Cheng JX, Saltiel AR, Lumeng CN, Lin JD.

Diabetes. 2014 Apr;63(4):1340-52. doi: 10.2337/db13-1139. Epub 2013 Dec 30.


Inflammation produces catecholamine resistance in obesity via activation of PDE3B by the protein kinases IKKε and TBK1.

Mowers J, Uhm M, Reilly SM, Simon J, Leto D, Chiang SH, Chang L, Saltiel AR.

Elife. 2013 Dec 24;2:e01119. doi: 10.7554/eLife.01119.


Inhibition of AMPK catabolic action by GSK3.

Suzuki T, Bridges D, Nakada D, Skiniotis G, Morrison SJ, Lin JD, Saltiel AR, Inoki K.

Mol Cell. 2013 May 9;50(3):407-19. doi: 10.1016/j.molcel.2013.03.022. Epub 2013 Apr 25.


An inhibitor of the protein kinases TBK1 and IKK-ɛ improves obesity-related metabolic dysfunctions in mice.

Reilly SM, Chiang SH, Decker SJ, Chang L, Uhm M, Larsen MJ, Rubin JR, Mowers J, White NM, Hochberg I, Downes M, Yu RT, Liddle C, Evans RM, Oh D, Li P, Olefsky JM, Saltiel AR.

Nat Med. 2013 Mar;19(3):313-21. doi: 10.1038/nm.3082. Epub 2013 Feb 10.


Negative regulation of the RalGAP complex by 14-3-3.

Leto D, Uhm M, Williams A, Chen XW, Saltiel AR.

J Biol Chem. 2013 Mar 29;288(13):9272-83. doi: 10.1074/jbc.M112.426106. Epub 2013 Feb 5.


Phosphoinositides in insulin action and diabetes.

Bridges D, Saltiel AR.

Curr Top Microbiol Immunol. 2012;362:61-85. doi: 10.1007/978-94-007-5025-8_3. Review.


In vivo, Pikfyve generates PI(3,5)P2, which serves as both a signaling lipid and the major precursor for PI5P.

Zolov SN, Bridges D, Zhang Y, Lee WW, Riehle E, Verma R, Lenk GM, Converso-Baran K, Weide T, Albin RL, Saltiel AR, Meisler MH, Russell MW, Weisman LS.

Proc Natl Acad Sci U S A. 2012 Oct 23;109(43):17472-7. doi: 10.1073/pnas.1203106109. Epub 2012 Oct 9.


TC10 is regulated by caveolin in 3T3-L1 adipocytes.

Bridges D, Chang L, Lodhi IJ, Clark NA, Saltiel AR.

PLoS One. 2012;7(8):e42451. doi: 10.1371/journal.pone.0042451. Epub 2012 Aug 10.


Phosphatidylinositol 3,5-bisphosphate plays a role in the activation and subcellular localization of mechanistic target of rapamycin 1.

Bridges D, Ma JT, Park S, Inoki K, Weisman LS, Saltiel AR.

Mol Biol Cell. 2012 Aug;23(15):2955-62. doi: 10.1091/mbc.E11-12-1034. Epub 2012 Jun 13.


Insulin resistance in the defense against obesity.

Saltiel AR.

Cell Metab. 2012 Jun 6;15(6):798-804. doi: 10.1016/j.cmet.2012.03.001.


Regulation of glucose transport by insulin: traffic control of GLUT4.

Leto D, Saltiel AR.

Nat Rev Mol Cell Biol. 2012 May 23;13(6):383-96. doi: 10.1038/nrm3351. Review.


Rab5 proteins regulate activation and localization of target of rapamycin complex 1.

Bridges D, Fisher K, Zolov SN, Xiong T, Inoki K, Weisman LS, Saltiel AR.

J Biol Chem. 2012 Jun 15;287(25):20913-21. doi: 10.1074/jbc.M111.334060. Epub 2012 Apr 30.


p75 neurotrophin receptor regulates glucose homeostasis and insulin sensitivity.

Baeza-Raja B, Li P, Le Moan N, Sachs BD, Schachtrup C, Davalos D, Vagena E, Bridges D, Kim C, Saltiel AR, Olefsky JM, Akassoglou K.

Proc Natl Acad Sci U S A. 2012 Apr 10;109(15):5838-43. doi: 10.1073/pnas.1103638109. Epub 2012 Mar 28.


Autophagy works out.

Klionsky DJ, Saltiel AR.

Cell Metab. 2012 Mar 7;15(3):273-4. doi: 10.1016/j.cmet.2012.02.008.

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