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Items: 49

1.

Genetic and Cytological Methods to Study ESCRT Cell Cycle Function in Fission Yeast.

Rezig IM, Bremner SK, Bhutta MS, Salt IP, Gould GW, McInerny CJ.

Methods Mol Biol. 2019;1998:239-250. doi: 10.1007/978-1-4939-9492-2_18.

PMID:
31250307
2.

AMP-activated protein kinase complexes containing the β2 regulatory subunit are up-regulated during and contribute to adipogenesis.

Katwan OJ, Alghamdi F, Almabrouk TA, Mancini SJ, Kennedy S, Oakhill JS, Scott JW, Salt IP.

Biochem J. 2019 Jun 26;476(12):1725-1740. doi: 10.1042/BCJ20180714.

3.

A769662 Inhibits Insulin-Stimulated Akt Activation in Human Macrovascular Endothelial Cells Independent of AMP-Activated Protein Kinase.

Strembitska A, Mancini SJ, Gamwell JM, Palmer TM, Baillie GS, Salt IP.

Int J Mol Sci. 2018 Dec 5;19(12). pii: E3886. doi: 10.3390/ijms19123886.

4.

Canagliflozin inhibits interleukin-1β-stimulated cytokine and chemokine secretion in vascular endothelial cells by AMP-activated protein kinase-dependent and -independent mechanisms.

Mancini SJ, Boyd D, Katwan OJ, Strembitska A, Almabrouk TA, Kennedy S, Palmer TM, Salt IP.

Sci Rep. 2018 Mar 27;8(1):5276. doi: 10.1038/s41598-018-23420-4.

5.

Investigating the Role of AMPK in Inflammation.

Mancini SJ, Salt IP.

Methods Mol Biol. 2018;1732:307-319. doi: 10.1007/978-1-4939-7598-3_20.

PMID:
29480484
6.

High Fat Diet Attenuates the Anticontractile Activity of Aortic PVAT via a Mechanism Involving AMPK and Reduced Adiponectin Secretion.

Almabrouk TAM, White AD, Ugusman AB, Skiba DS, Katwan OJ, Alganga H, Guzik TJ, Touyz RM, Salt IP, Kennedy S.

Front Physiol. 2018 Feb 9;9:51. doi: 10.3389/fphys.2018.00051. eCollection 2018.

7.

Linking energy sensing to suppression of JAK-STAT signalling: A potential route for repurposing AMPK activators?

Speirs C, Williams JJL, Riches K, Salt IP, Palmer TM.

Pharmacol Res. 2018 Feb;128:88-100. doi: 10.1016/j.phrs.2017.10.001. Epub 2017 Oct 13. Review.

PMID:
29037480
8.

Molecular mechanisms regulating perivascular adipose tissue - potential pharmacological targets?

Kennedy S, Salt IP.

Br J Pharmacol. 2017 Oct;174(20):3385-3387. doi: 10.1111/bph.13969.

9.

AMP-Activated Protein Kinase: An Ubiquitous Signaling Pathway With Key Roles in the Cardiovascular System.

Salt IP, Hardie DG.

Circ Res. 2017 May 26;120(11):1825-1841. doi: 10.1161/CIRCRESAHA.117.309633. Review.

10.

Corrigendum to "Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms" [Mol. Cell. Endocrinol. 440 15 January 2017 57-68].

Chen SC, Brooks R, Houskeeper J, Bremner SK, Dunlop J, Viollet B, Logan PJ, Salt IP, Ahmed SF, Yarwood SJ.

Mol Cell Endocrinol. 2017 Mar 5;443:176. doi: 10.1016/j.mce.2017.01.049. No abstract available.

PMID:
28183460
11.

Phosphorylation of Janus kinase 1 (JAK1) by AMP-activated protein kinase (AMPK) links energy sensing to anti-inflammatory signaling.

Rutherford C, Speirs C, Williams JJ, Ewart MA, Mancini SJ, Hawley SA, Delles C, Viollet B, Costa-Pereira AP, Baillie GS, Salt IP, Palmer TM.

Sci Signal. 2016 Nov 8;9(453):ra109.

12.

Metformin suppresses adipogenesis through both AMP-activated protein kinase (AMPK)-dependent and AMPK-independent mechanisms.

Chen SC, Brooks R, Houskeeper J, Bremner SK, Dunlop J, Viollet B, Logan PJ, Salt IP, Ahmed SF, Yarwood SJ.

Mol Cell Endocrinol. 2017 Jan 15;440:57-68. doi: 10.1016/j.mce.2016.11.011. Epub 2016 Nov 14. Erratum in: Mol Cell Endocrinol. 2017 Mar 5;443:176.

13.

Activation of AMP-activated protein kinase rapidly suppresses multiple pro-inflammatory pathways in adipocytes including IL-1 receptor-associated kinase-4 phosphorylation.

Mancini SJ, White AD, Bijland S, Rutherford C, Graham D, Richter EA, Viollet B, Touyz RM, Palmer TM, Salt IP.

Mol Cell Endocrinol. 2017 Jan 15;440:44-56. doi: 10.1016/j.mce.2016.11.010. Epub 2016 Nov 11.

14.

Protein kinase C phosphorylates AMP-activated protein kinase α1 Ser487.

Heathcote HR, Mancini SJ, Strembitska A, Jamal K, Reihill JA, Palmer TM, Gould GW, Salt IP.

Biochem J. 2016 Dec 15;473(24):4681-4697. Epub 2016 Oct 26.

15.

Deletion of AMPKα1 attenuates the anticontractile effect of perivascular adipose tissue (PVAT) and reduces adiponectin release.

Almabrouk TAM, Ugusman AB, Katwan OJ, Salt IP, Kennedy S.

Br J Pharmacol. 2017 Oct;174(20):3398-3410. doi: 10.1111/bph.13633. Epub 2016 Oct 23.

16.

The Na+/Glucose Cotransporter Inhibitor Canagliflozin Activates AMPK by Inhibiting Mitochondrial Function and Increasing Cellular AMP Levels.

Hawley SA, Ford RJ, Smith BK, Gowans GJ, Mancini SJ, Pitt RD, Day EA, Salt IP, Steinberg GR, Hardie DG.

Diabetes. 2016 Sep;65(9):2784-94. doi: 10.2337/db16-0058. Epub 2016 Jul 5.

17.

Metformin Reverses Development of Pulmonary Hypertension via Aromatase Inhibition.

Dean A, Nilsen M, Loughlin L, Salt IP, MacLean MR.

Hypertension. 2016 Aug;68(2):446-54. doi: 10.1161/HYPERTENSIONAHA.116.07353. Epub 2016 Jun 13.

PMID:
27296990
18.

Lin28A induces energetic switching to glycolytic metabolism in human embryonic kidney cells.

Docherty CK, Salt IP, Mercer JR.

Stem Cell Res Ther. 2016 May 26;7(1):78. doi: 10.1186/s13287-016-0323-2.

19.

AMPK-friend or foe for targeted therapy?

Choudhury Y, Salt IP, Leung HY.

Cell Cycle. 2015;14(12):1761-2. doi: 10.1080/15384101.2015.1022066. No abstract available.

20.

AMP-activated protein kinase (AMPK) as a potential therapeutic target independent of PI3K/Akt signaling in prostate cancer.

Choudhury Y, Yang Z, Ahmad I, Nixon C, Salt IP, Leung HY.

Oncoscience. 2014 Jun 4;1(6):446-56. eCollection 2014.

21.

Perivascular fat, AMP-activated protein kinase and vascular diseases.

Almabrouk TA, Ewart MA, Salt IP, Kennedy S.

Br J Pharmacol. 2014 Feb;171(3):595-617. doi: 10.1111/bph.12479. Review.

22.

Role of AMP-activated protein kinase in adipose tissue metabolism and inflammation.

Bijland S, Mancini SJ, Salt IP.

Clin Sci (Lond). 2013 Apr;124(8):491-507. doi: 10.1042/CS20120536. Review.

PMID:
23298225
23.

Examining the role of insulin in the regulation of cardiovascular health.

Salt IP.

Future Cardiol. 2013 Jan;9(1):39-52. doi: 10.2217/fca.12.77. Review.

PMID:
23259474
24.

Mitochondrial reactive oxygen species enhance AMP-activated protein kinase activation in the endothelium of patients with coronary artery disease and diabetes.

Mackenzie RM, Salt IP, Miller WH, Logan A, Ibrahim HA, Degasperi A, Dymott JA, Hamilton CA, Murphy MP, Delles C, Dominiczak AF.

Clin Sci (Lond). 2013 Mar;124(6):403-11. doi: 10.1042/CS20120239.

25.

Exploiting the anti-inflammatory effects of AMP-activated protein kinase activation.

Salt IP, Palmer TM.

Expert Opin Investig Drugs. 2012 Aug;21(8):1155-67. doi: 10.1517/13543784.2012.696609. Epub 2012 Jun 14. Review.

PMID:
22694351
26.

Insulin rapidly stimulates L-arginine transport in human aortic endothelial cells via Akt.

Kohlhaas CF, Morrow VA, Jhakra N, Patil V, Connell JM, Petrie JR, Salt IP.

Biochem Biophys Res Commun. 2011 Sep 9;412(4):747-51. doi: 10.1016/j.bbrc.2011.08.048. Epub 2011 Aug 17.

27.
28.

AMP-activated protein kinase is activated in adipose tissue of individuals with type 2 diabetes treated with metformin: a randomised glycaemia-controlled crossover study.

Boyle JG, Logan PJ, Jones GC, Small M, Sattar N, Connell JM, Cleland SJ, Salt IP.

Diabetologia. 2011 Jul;54(7):1799-809. doi: 10.1007/s00125-011-2126-4. Epub 2011 Apr 1.

PMID:
21455728
29.

Fat oxidation, fitness and skeletal muscle expression of oxidative/lipid metabolism genes in South Asians: implications for insulin resistance?

Hall LM, Moran CN, Milne GR, Wilson J, MacFarlane NG, Forouhi NG, Hariharan N, Salt IP, Sattar N, Gill JM.

PLoS One. 2010 Dec 1;5(12):e14197. doi: 10.1371/journal.pone.0014197.

30.

Metformin action on AMP-activated protein kinase: a translational research approach to understanding a potential new therapeutic target.

Boyle JG, Salt IP, McKay GA.

Diabet Med. 2010 Oct;27(10):1097-106. doi: 10.1111/j.1464-5491.2010.03098.x. Review.

PMID:
20854376
31.

Insulin-stimulated phosphorylation of endothelial nitric oxide synthase at serine-615 contributes to nitric oxide synthesis.

Ritchie SA, Kohlhaas CF, Boyd AR, Yalla KC, Walsh K, Connell JM, Salt IP.

Biochem J. 2010 Jan 27;426(1):85-90. doi: 10.1042/BJ20091580.

PMID:
19925457
32.

Inhibition of tumor necrosis factor alpha-stimulated monocyte adhesion to human aortic endothelial cells by AMP-activated protein kinase.

Ewart MA, Kohlhaas CF, Salt IP.

Arterioscler Thromb Vasc Biol. 2008 Dec;28(12):2255-7. doi: 10.1161/ATVBAHA.108.175919. Epub 2008 Sep 18.

PMID:
18802013
33.

Rosiglitazone stimulates nitric oxide synthesis in human aortic endothelial cells via AMP-activated protein kinase.

Boyle JG, Logan PJ, Ewart MA, Reihill JA, Ritchie SA, Connell JM, Cleland SJ, Salt IP.

J Biol Chem. 2008 Apr 25;283(17):11210-7. doi: 10.1074/jbc.M710048200. Epub 2008 Feb 26.

34.

AMP-activated protein kinase mediates VEGF-stimulated endothelial NO production.

Reihill JA, Ewart MA, Hardie DG, Salt IP.

Biochem Biophys Res Commun. 2007 Mar 23;354(4):1084-8. Epub 2007 Jan 29.

35.

Reduced insulin-stimulated GLUT4 bioavailability in stroke-prone spontaneously hypertensive rats.

Collison M, James DJ, Graham D, Holman GD, Connell JM, Dominiczak AF, Gould GW, Salt IP.

Diabetologia. 2005 Mar;48(3):539-46. Epub 2005 Feb 24.

PMID:
15729573
36.

The role of insulin and the adipocytokines in regulation of vascular endothelial function.

Ritchie SA, Ewart MA, Perry CG, Connell JM, Salt IP.

Clin Sci (Lond). 2004 Dec;107(6):519-32. Review.

PMID:
15324298
37.

Direct activation of AMP-activated protein kinase stimulates nitric-oxide synthesis in human aortic endothelial cells.

Morrow VA, Foufelle F, Connell JM, Petrie JR, Gould GW, Salt IP.

J Biol Chem. 2003 Aug 22;278(34):31629-39. Epub 2003 Jun 4.

38.

Decreased insulin sensitivity during dietary sodium restriction is not mediated by effects of angiotensin II on insulin action.

Perry CG, Palmer T, Cleland SJ, Morton IJ, Salt IP, Petrie JR, Gould GW, Connell JM.

Clin Sci (Lond). 2003 Aug;105(2):187-94.

PMID:
12691602
39.
40.
41.

Sex hormones induce insulin resistance in 3T3-L1 adipocytes by reducing cellular content of IRS proteins.

Collison M, Campbell IW, Salt IP, Dominiczak AF, Connell JM, Lyall H, Gould GW.

Diabetologia. 2000 Nov;43(11):1374-80.

PMID:
11126405
42.

Activation of glucose transport by AMP-activated protein kinase via stimulation of nitric oxide synthase.

Fryer LG, Hajduch E, Rencurel F, Salt IP, Hundal HS, Hardie DG, Carling D.

Diabetes. 2000 Dec;49(12):1978-85.

PMID:
11117997
43.
44.

Analysis of the role of the AMP-activated protein kinase in the response to cellular stress.

Hardie DG, Salt IP, Davies SP.

Methods Mol Biol. 2000;99:63-74. Review. No abstract available.

PMID:
10909077
45.
46.

Role of AMP-activated protein kinase in the regulation by glucose of islet beta cell gene expression.

da Silva Xavier G, Leclerc I, Salt IP, Doiron B, Hardie DG, Kahn A, Rutter GA.

Proc Natl Acad Sci U S A. 2000 Apr 11;97(8):4023-8.

47.

Characterization of AMP-activated protein kinase gamma-subunit isoforms and their role in AMP binding.

Cheung PC, Salt IP, Davies SP, Hardie DG, Carling D.

Biochem J. 2000 Mar 15;346 Pt 3:659-69.

48.

AMP-activated protein kinase: an ultrasensitive system for monitoring cellular energy charge.

Hardie DG, Salt IP, Hawley SA, Davies SP.

Biochem J. 1999 Mar 15;338 ( Pt 3):717-22.

49.

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