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Toll-like Receptor 2 Facilitates Oxidative Damage-Induced Retinal Degeneration.

Mulfaul K, Ozaki E, Fernando N, Brennan K, Chirco KR, Connolly E, Greene C, Maminishkis A, Salomon RG, Linetsky M, Natoli R, Mullins RF, Campbell M, Doyle SL.

Cell Rep. 2020 Feb 18;30(7):2209-2224.e5. doi: 10.1016/j.celrep.2020.01.064.


4-Hydroxy-7-oxo-5-heptenoic acid lactone is a potent inducer of brain cancer cell invasiveness that may contribute to the failure of anti-angiogenic therapies.

Tomko N, Kluever M, Wu C, Zhu J, Wang Y, Salomon RG.

Free Radic Biol Med. 2020 Jan;146:234-256. doi: 10.1016/j.freeradbiomed.2019.11.009. Epub 2019 Nov 9.


The Adductomics of Isolevuglandins: Oxidation of IsoLG Pyrrole Intermediates Generates Pyrrole⁻Pyrrole Crosslinks and Lactams.

Bi W, Jang GF, Zhang L, Crabb JW, Laird J, Linetsky M, Salomon RG.

High Throughput. 2019 May 10;8(2). pii: E12. doi: 10.3390/ht8020012.


Light-induced generation and toxicity of docosahexaenoate-derived oxidation products in retinal pigmented epithelial cells.

Cheng YS, Linetsky M, Gu X, Ayyash N, Gardella A, Salomon RG.

Exp Eye Res. 2019 Apr;181:325-345. doi: 10.1016/j.exer.2018.09.012. Epub 2018 Oct 5.


4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Is a Potent Inducer of the Complement Pathway in Human Retinal Pigmented Epithelial Cells.

Linetsky M, Bondelid KS, Losovskiy S, Gabyak V, Rullo MJ, Stiadle TI, Munjapara V, Saxena P, Ma D, Cheng YS, Howes AM, Udeigwe E, Salomon RG.

Chem Res Toxicol. 2018 Aug 20;31(8):666-679. doi: 10.1021/acs.chemrestox.8b00028. Epub 2018 Jul 9.


Oxidative modifications of extracellular matrix promote the second wave of inflammation via β2 integrins.

Yakubenko VP, Cui K, Ardell CL, Brown KE, West XZ, Gao D, Stefl S, Salomon RG, Podrez EA, Byzova TV.

Blood. 2018 Jul 5;132(1):78-88. doi: 10.1182/blood-2017-10-810176. Epub 2018 May 3.


High-resolution dynamic oxygen-17 MR imaging of mouse brain with golden-ratio-based radial sampling and k-space-weighted image reconstruction.

Liu Y, Zhang Y, Wu C, Zhu J, Wang C, Tomko N, Linetsky MD, Salomon RG, Ramos-Estebanez C, Wang Y, Yu X.

Magn Reson Med. 2018 Jan;79(1):256-263. doi: 10.1002/mrm.26669. Epub 2017 Mar 13.


Total Synthesis Confirms the Molecular Structure Proposed for Oxidized Levuglandin D2.

Cheng YS, Yu W, Xu Y, Salomon RG.

J Nat Prod. 2017 Feb 24;80(2):488-498. doi: 10.1021/acs.jnatprod.6b01048. Epub 2017 Feb 14.


4-Hydroxy-7-oxo-5-heptenoic Acid Lactone Induces Angiogenesis through Several Different Molecular Pathways.

Guo J, Linetsky M, Yu AO, Zhang L, Howell SJ, Folkwein HJ, Wang H, Salomon RG.

Chem Res Toxicol. 2016 Dec 19;29(12):2125-2135. Epub 2016 Nov 11.


Carboxyethylpyrroles: From Hypothesis to the Discovery of Biologically Active Natural Products.

Salomon RG.

Chem Res Toxicol. 2017 Jan 17;30(1):105-113. doi: 10.1021/acs.chemrestox.6b00304. Epub 2016 Nov 2.


2-(ω-Carboxyethyl)pyrrole Antibody as a New Inhibitor of Tumor Angiogenesis and Growth.

Wu C, Wang X, Tomko N, Zhu J, Wang WR, Zhu J, Wangf B, Wang Y, Salomon RG.

Anticancer Agents Med Chem. 2017;17(6):813-820. doi: 10.2174/1871520616666160923093959.


Bioactive 4-Oxoheptanedioic Monoamide Derivatives of Proteins and Ethanolaminephospholipids: Products of Docosahexaenoate Oxidation.

Guo J, Hong L, West XZ, Wang H, Salomon RG.

Chem Res Toxicol. 2016 Oct 17;29(10):1706-1719. Epub 2016 Sep 26.


Molecular Structures of Isolevuglandin-Protein Cross-Links.

Bi W, Jang GF, Zhang L, Crabb JW, Laird J, Linetsky M, Salomon RG.

Chem Res Toxicol. 2016 Oct 17;29(10):1628-1640. Epub 2016 Sep 21.


Metabolism of 4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone by Retinal Pigmented Epithelial Cells.

Wang H, Linetsky M, Guo J, Yu AO, Salomon RG.

Chem Res Toxicol. 2016 Jul 18;29(7):1198-210. doi: 10.1021/acs.chemrestox.6b00153. Epub 2016 Jul 7.


Efficient Quantitative Analysis of Carboxyalkylpyrrole Ethanolamine Phospholipids: Elevated Levels in Sickle Cell Disease Blood.

Guo J, Wang H, Hrinczenko B, Salomon RG.

Chem Res Toxicol. 2016 Jul 18;29(7):1187-97. doi: 10.1021/acs.chemrestox.6b00152. Epub 2016 Jun 24.


Novel phosphatidylethanolamine derivatives accumulate in circulation in hyperlipidemic ApoE-/- mice and activate platelets via TLR2.

Biswas S, Xin L, Panigrahi S, Zimman A, Wang H, Yakubenko VP, Byzova TV, Salomon RG, Podrez EA.

Blood. 2016 May 26;127(21):2618-29. doi: 10.1182/blood-2015-08-664300. Epub 2016 Mar 25.


Receptor-Mediated Mechanism Controlling Tissue Levels of Bioactive Lipid Oxidation Products.

Kim YW, Yakubenko VP, West XZ, Gugiu GB, Renganathan K, Biswas S, Gao D, Crabb JW, Salomon RG, Podrez EA, Byzova TV.

Circ Res. 2015 Jul 31;117(4):321-32. doi: 10.1161/CIRCRESAHA.117.305925. Epub 2015 May 12.


4-Hydroxy-7-oxo-5-heptenoic Acid (HOHA) Lactone is a Biologically Active Precursor for the Generation of 2-(ω-Carboxyethyl)pyrrole (CEP) Derivatives of Proteins and Ethanolamine Phospholipids.

Wang H, Linetsky M, Guo J, Choi J, Hong L, Chamberlain AS, Howell SJ, Howes AM, Salomon RG.

Chem Res Toxicol. 2015 May 18;28(5):967-77. doi: 10.1021/acs.chemrestox.5b00001. Epub 2015 Apr 2.


Isolevuglandin adducts in disease.

Salomon RG, Bi W.

Antioxid Redox Signal. 2015 Jun 20;22(18):1703-18. doi: 10.1089/ars.2014.6154. Epub 2015 Feb 18. Review.


Detection and biological activities of carboxyethylpyrrole ethanolamine phospholipids (CEP-EPs).

Wang H, Guo J, West XZ, Bid HK, Lu L, Hong L, Jang GF, Zhang L, Crabb JW; Clinical Genomic and Proteomic AMD Study Group, Linetsky M, Salomon RG.

Chem Res Toxicol. 2014 Dec 15;27(12):2015-22. doi: 10.1021/tx500216a. Epub 2014 Nov 19.


The oxidative stress product carboxyethylpyrrole potentiates TLR2/TLR1 inflammatory signaling in macrophages.

Saeed AM, Duffort S, Ivanov D, Wang H, Laird JM, Salomon RG, Cruz-Guilloty F, Perez VL.

PLoS One. 2014 Sep 3;9(9):e106421. doi: 10.1371/journal.pone.0106421. eCollection 2014.


Protective role of HO-1 and carbon monoxide in ethanol-induced hepatocyte cell death and liver injury in mice.

Bakhautdin B, Das D, Mandal P, Roychowdhury S, Danner J, Bush K, Pollard K, Kaspar JW, Li W, Salomon RG, McMullen MR, Nagy LE.

J Hepatol. 2014 Nov;61(5):1029-37. doi: 10.1016/j.jhep.2014.06.007. Epub 2014 Jun 16.


T cells and macrophages responding to oxidative damage cooperate in pathogenesis of a mouse model of age-related macular degeneration.

Cruz-Guilloty F, Saeed AM, Duffort S, Cano M, Ebrahimi KB, Ballmick A, Tan Y, Wang H, Laird JM, Salomon RG, Handa JT, Perez VL.

PLoS One. 2014 Feb 19;9(2):e88201. doi: 10.1371/journal.pone.0088201. eCollection 2014.


CEP biomarkers as potential tools for monitoring therapeutics.

Renganathan K, Gu J, Rayborn ME, Crabb JS, Salomon RG, Collier RJ, Kapin MA, Romano C, Hollyfield JG, Crabb JW.

PLoS One. 2013 Oct 1;8(10):e76325. doi: 10.1371/journal.pone.0076325. eCollection 2013.


Pretreatment with pyridoxamine mitigates isolevuglandin-associated retinal effects in mice exposed to bright light.

Charvet CD, Saadane A, Wang M, Salomon RG, Brunengraber H, Turko IV, Pikuleva IA.

J Biol Chem. 2013 Oct 11;288(41):29267-80. doi: 10.1074/jbc.M113.498832. Epub 2013 Aug 22. Erratum in: J Biol Chem. 2013 Nov 22;288(47):34054. Dosage error in article text.


Infiltration of proinflammatory m1 macrophages into the outer retina precedes damage in a mouse model of age-related macular degeneration.

Cruz-Guilloty F, Saeed AM, Echegaray JJ, Duffort S, Ballmick A, Tan Y, Betancourt M, Viteri E, Ramkhellawan GC, Ewald E, Feuer W, Huang D, Wen R, Hong L, Wang H, Laird JM, Sene A, Apte RS, Salomon RG, Hollyfield JG, Perez VL.

Int J Inflam. 2013;2013:503725. doi: 10.1155/2013/503725. Epub 2013 Mar 7.


Posttranslational modification by an isolevuglandin diminishes activity of the mitochondrial cytochrome P450 27A1.

Charvet CD, Laird J, Xu Y, Salomon RG, Pikuleva IA.

J Lipid Res. 2013 May;54(5):1421-9. doi: 10.1194/jlr.M035790. Epub 2013 Mar 11.


Metabolomics and mass isotopomer analysis as a strategy for pathway discovery: pyrrolyl and cyclopentenyl derivatives of the pro-drug of abuse, levulinate.

Harris SR, Zhang GF, Sadhukhan S, Wang H, Shi C, Puchowicz MA, Anderson VE, Salomon RG, Tochtrop GP, Brunengraber H.

Chem Res Toxicol. 2013 Feb 18;26(2):213-20. doi: 10.1021/tx3003643. Epub 2012 Dec 6.


Engagement of platelet toll-like receptor 9 by novel endogenous ligands promotes platelet hyperreactivity and thrombosis.

Panigrahi S, Ma Y, Hong L, Gao D, West XZ, Salomon RG, Byzova TV, Podrez EA.

Circ Res. 2013 Jan 4;112(1):103-12. doi: 10.1161/CIRCRESAHA.112.274241. Epub 2012 Oct 15.


Structural identification and cardiovascular activities of oxidized phospholipids.

Salomon RG.

Circ Res. 2012 Sep 14;111(7):930-46. doi: 10.1161/CIRCRESAHA.112.275388. Review.


NLRP3 has a protective role in age-related macular degeneration through the induction of IL-18 by drusen components.

Doyle SL, Campbell M, Ozaki E, Salomon RG, Mori A, Kenna PF, Farrar GJ, Kiang AS, Humphries MM, Lavelle EC, O'Neill LA, Hollyfield JG, Humphries P.

Nat Med. 2012 May;18(5):791-8. doi: 10.1038/nm.2717.


Fragmentation of β-hydroxy hydroperoxides.

Gu X, Zhang W, Salomon RG.

J Org Chem. 2012 Feb 3;77(3):1554-9. doi: 10.1021/jo201910g. Epub 2012 Jan 24.


The mechanism of fenretinide (4-HPR) inhibition of β-carotene monooxygenase 1. New suspect for the visual side effects of fenretinide.

Poliakov E, Gubin A, Laird J, Gentleman S, Salomon RG, Redmond TM.

Adv Exp Med Biol. 2012;723:167-74. doi: 10.1007/978-1-4614-0631-0_23. No abstract available.


Fragmentation of a linoleate-derived γ-hydroperoxy-α,β-unsaturated epoxide to γ-hydroxy- and γ-oxo-alkenals involves a unique pseudo-symmetrical diepoxycarbinyl radical.

Gu X, Salomon RG.

Free Radic Biol Med. 2012 Feb 1;52(3):601-606. doi: 10.1016/j.freeradbiomed.2011.11.013. Epub 2011 Dec 1.


Discovery of carboxyethylpyrroles (CEPs): critical insights into AMD, autism, cancer, and wound healing from basic research on the chemistry of oxidized phospholipids.

Salomon RG, Hong L, Hollyfield JG.

Chem Res Toxicol. 2011 Nov 21;24(11):1803-16. doi: 10.1021/tx200206v. Epub 2011 Oct 3. Review.


Critical insights into cardiovascular disease from basic research on the oxidation of phospholipids: the γ-hydroxyalkenal phospholipid hypothesis.

Salomon RG, Gu X.

Chem Res Toxicol. 2011 Nov 21;24(11):1791-802. doi: 10.1021/tx200207z. Epub 2011 Sep 30. Review.


An (1)O2 route to γ-hydroxyalkenal phospholipids by vitamin E-induced fragmentation of hydroperoxydiene-derived endoperoxides.

Gu X, Zhang W, Choi J, Li W, Chen X, Laird JM, Salomon RG.

Chem Res Toxicol. 2011 Jul 18;24(7):1080-93. doi: 10.1021/tx200093m. Epub 2011 May 31.


Isolevuglandins and mitochondrial enzymes in the retina: mass spectrometry detection of post-translational modification of sterol-metabolizing CYP27A1.

Charvet C, Liao WL, Heo GY, Laird J, Salomon RG, Turko IV, Pikuleva IA.

J Biol Chem. 2011 Jun 10;286(23):20413-22. doi: 10.1074/jbc.M111.232546. Epub 2011 Apr 15.


An efficient synthesis of γ-hydroxy-α,β-unsaturated aldehydic esters of 2-lysophosphatidylcholine.

Choi J, Laird JM, Salomon RG.

Bioorg Med Chem. 2011 Jan 1;19(1):580-7. doi: 10.1016/j.bmc.2010.10.058. Epub 2010 Oct 31.


Lysophosphatidylcholine is generated by spontaneous deacylation of oxidized phospholipids.

Choi J, Zhang W, Gu X, Chen X, Hong L, Laird JM, Salomon RG.

Chem Res Toxicol. 2011 Jan 14;24(1):111-8. doi: 10.1021/tx100305b. Epub 2010 Oct 25.


Oxidative stress induces angiogenesis by activating TLR2 with novel endogenous ligands.

West XZ, Malinin NL, Merkulova AA, Tischenko M, Kerr BA, Borden EC, Podrez EA, Salomon RG, Byzova TV.

Nature. 2010 Oct 21;467(7318):972-6. doi: 10.1038/nature09421. Epub 2010 Oct 3.


Cardiolipin: characterization of distinct oxidized molecular species.

Kim J, Minkler PE, Salomon RG, Anderson VE, Hoppel CL.

J Lipid Res. 2011 Jan;52(1):125-35. doi: 10.1194/jlr.M010520. Epub 2010 Sep 20.


Proteomic and genomic biomarkers for age-related macular degeneration.

Gu J, Pauer GJ, Yue X, Narendra U, Sturgill GM, Bena J, Gu X, Peachey NS, Salomon RG, Hagstrom SA, Crabb JW; Clinical Genomic and Proteomic AMD Study Group.

Adv Exp Med Biol. 2010;664:411-7. doi: 10.1007/978-1-4419-1399-9_47.


A hapten generated from an oxidation fragment of docosahexaenoic acid is sufficient to initiate age-related macular degeneration.

Hollyfield JG, Perez VL, Salomon RG.

Mol Neurobiol. 2010 Jun;41(2-3):290-8. doi: 10.1007/s12035-010-8110-z. Epub 2010 Mar 12.


A 13-Oxo-9,10-epoxytridecenoate phospholipid analogue of the genotoxic 4,5-epoxy-2E-decenal: detection in vivo, chemical synthesis, and adduction with DNA.

Mesaros C, Gugiu BG, Zhou R, Lee SH, Choi J, Laird J, Blair IA, Salomon RG.

Chem Res Toxicol. 2010 Mar 15;23(3):516-27. doi: 10.1021/tx9002484.


Synthesis and structural characterization of carboxyethylpyrrole-modified proteins: mediators of age-related macular degeneration.

Lu L, Gu X, Hong L, Laird J, Jaffe K, Choi J, Crabb J, Salomon RG.

Bioorg Med Chem. 2009 Nov 1;17(21):7548-61. doi: 10.1016/j.bmc.2009.09.009. Epub 2009 Sep 13.


Isolevuglandins covalently modify phosphatidylethanolamines in vivo: detection and quantitative analysis of hydroxylactam adducts.

Li W, Laird JM, Lu L, Roychowdhury S, Nagy LE, Zhou R, Crabb JW, Salomon RG.

Free Radic Biol Med. 2009 Dec 1;47(11):1539-52. doi: 10.1016/j.freeradbiomed.2009.09.003. Epub 2009 Sep 12.


Formation of gamma-ketoaldehyde-protein adducts during ethanol-induced liver injury in mice.

Roychowdhury S, McMullen MR, Pritchard MT, Li W, Salomon RG, Nagy LE.

Free Radic Biol Med. 2009 Dec 1;47(11):1526-38. doi: 10.1016/j.freeradbiomed.2009.07.015. Epub 2009 Jul 17.


Increased isolevuglandin-modified proteins in glaucomatous astrocytes.

Govindarajan B, Junk A, Algeciras M, Salomon RG, Bhattacharya SK.

Mol Vis. 2009 Jun 1;15:1079-91.


Assessing susceptibility to age-related macular degeneration with proteomic and genomic biomarkers.

Gu J, Pauer GJ, Yue X, Narendra U, Sturgill GM, Bena J, Gu X, Peachey NS, Salomon RG, Hagstrom SA, Crabb JW; Clinical Genomic and Proteomic AMD Study Group.

Mol Cell Proteomics. 2009 Jun;8(6):1338-49. doi: 10.1074/mcp.M800453-MCP200. Epub 2009 Feb 6.

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