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Is Rapamycin a Dietary Restriction Mimetic?

Unnikrishnan A, Kurup K, Salmon AB, Richardson A.

J Gerontol A Biol Sci Med Sci. 2019 Mar 11. pii: glz060. doi: 10.1093/gerona/glz060. [Epub ahead of print]


Long-term treatment with the mTOR inhibitor rapamycin has minor effect on clinical laboratory markers in middle-aged marmosets.

Sills AM, Artavia JM, DeRosa BD, Ross CN, Salmon AB.

Am J Primatol. 2019 Feb;81(2):e22927. doi: 10.1002/ajp.22927. Epub 2018 Oct 12.


Maternal nutrient restriction in baboon programs later-life cellular growth and respiration of cultured skin fibroblasts: a potential model for the study of aging-programming interactions.

Salmon AB, Dorigatti J, Huber HF, Li C, Nathanielsz PW.

Geroscience. 2018 Jun;40(3):269-278. doi: 10.1007/s11357-018-0024-0. Epub 2018 May 25.


Metformin reduces glucose intolerance caused by rapamycin treatment in genetically heterogeneous female mice.

Weiss R, Fernandez E, Liu Y, Strong R, Salmon AB.

Aging (Albany NY). 2018 Mar 22;10(3):386-401. doi: 10.18632/aging.101401.


Changes in macroautophagy, chaperone-mediated autophagy, and mitochondrial metabolism in murine skeletal and cardiac muscle during aging.

Zhou J, Chong SY, Lim A, Singh BK, Sinha RA, Salmon AB, Yen PM.

Aging (Albany NY). 2017 Feb 26;9(2):583-599. doi: 10.18632/aging.101181.


Effects of transgenic methionine sulfoxide reductase A (MsrA) expression on lifespan and age-dependent changes in metabolic function in mice.

Salmon AB, Kim G, Liu C, Wren JD, Georgescu C, Richardson A, Levine RL.

Redox Biol. 2016 Dec;10:251-256. doi: 10.1016/j.redox.2016.10.012. Epub 2016 Oct 25.


Moving toward 'common' use of the marmoset as a non-human primate aging model.

Salmon AB.

Pathobiol Aging Age Relat Dis. 2016 Jul 22;6:32758. doi: 10.3402/pba.v6.32758. eCollection 2016. No abstract available.


Beyond Diabetes: Does Obesity-Induced Oxidative Stress Drive the Aging Process?

Salmon AB.

Antioxidants (Basel). 2016 Jul 18;5(3). pii: E24. doi: 10.3390/antiox5030024. Review.


Pharmaceutical inhibition of mTOR in the common marmoset: effect of rapamycin on regulators of proteostasis in a non-human primate.

Lelegren M, Liu Y, Ross C, Tardif S, Salmon AB.

Pathobiol Aging Age Relat Dis. 2016 Jun 23;6:31793. doi: 10.3402/pba.v6.31793. eCollection 2016.


Longer lifespan in male mice treated with a weakly estrogenic agonist, an antioxidant, an α-glucosidase inhibitor or a Nrf2-inducer.

Strong R, Miller RA, Antebi A, Astle CM, Bogue M, Denzel MS, Fernandez E, Flurkey K, Hamilton KL, Lamming DW, Javors MA, de Magalhães JP, Martinez PA, McCord JM, Miller BF, Müller M, Nelson JF, Ndukum J, Rainger GE, Richardson A, Sabatini DM, Salmon AB, Simpkins JW, Steegenga WT, Nadon NL, Harrison DE.

Aging Cell. 2016 Oct;15(5):872-84. doi: 10.1111/acel.12496. Epub 2016 Jun 16.


MsrA Overexpression Targeted to the Mitochondria, but Not Cytosol, Preserves Insulin Sensitivity in Diet-Induced Obese Mice.

Hunnicut J, Liu Y, Richardson A, Salmon AB.

PLoS One. 2015 Oct 8;10(10):e0139844. doi: 10.1371/journal.pone.0139844. eCollection 2015.


Dynamic differences in oxidative stress and the regulation of metabolism with age in visceral versus subcutaneous adipose.

Liu R, Pulliam DA, Liu Y, Salmon AB.

Redox Biol. 2015 Dec;6:401-408. doi: 10.1016/j.redox.2015.07.014. Epub 2015 Sep 3.


Nox2 mediates skeletal muscle insulin resistance induced by a high fat diet.

Souto Padron de Figueiredo A, Salmon AB, Bruno F, Jimenez F, Martinez HG, Halade GV, Ahuja SS, Clark RA, DeFronzo RA, Abboud HE, El Jamali A.

J Biol Chem. 2015 May 22;290(21):13427-39. doi: 10.1074/jbc.M114.626077. Epub 2015 Mar 30.


The paradoxical role of thioredoxin on oxidative stress and aging.

Cunningham GM, Roman MG, Flores LC, Hubbard GB, Salmon AB, Zhang Y, Gelfond J, Ikeno Y.

Arch Biochem Biophys. 2015 Jun 15;576:32-8. doi: 10.1016/ Epub 2015 Feb 26. Review.


About-face on the metabolic side effects of rapamycin.

Salmon AB.

Oncotarget. 2015 Feb 20;6(5):2585-6. No abstract available.


Altered metabolism and resistance to obesity in long-lived mice producing reduced levels of IGF-I.

Salmon AB, Lerner C, Ikeno Y, Motch Perrine SM, McCarter R, Sell C.

Am J Physiol Endocrinol Metab. 2015 Apr 1;308(7):E545-53. doi: 10.1152/ajpendo.00558.2014. Epub 2015 Feb 3.


Obesity-induced oxidative stress, accelerated functional decline with age and increased mortality in mice.

Zhang Y, Fischer KE, Soto V, Liu Y, Sosnowska D, Richardson A, Salmon AB.

Arch Biochem Biophys. 2015 Jun 15;576:39-48. doi: 10.1016/ Epub 2015 Jan 3.


Rapamycin-induced metabolic defects are reversible in both lean and obese mice.

Liu Y, Diaz V, Fernandez E, Strong R, Ye L, Baur JA, Lamming DW, Richardson A, Salmon AB.

Aging (Albany NY). 2014 Sep;6(9):742-54.


Rapamycin and dietary restriction induce metabolically distinctive changes in mouse liver.

Yu Z, Wang R, Fok WC, Coles A, Salmon AB, Pérez VI.

J Gerontol A Biol Sci Med Sci. 2015 Apr;70(4):410-20. doi: 10.1093/gerona/glu053. Epub 2014 Apr 22.


Revisiting an age-old question regarding oxidative stress.

Edrey YH, Salmon AB.

Free Radic Biol Med. 2014 Jun;71:368-78. doi: 10.1016/j.freeradbiomed.2014.03.038. Epub 2014 Apr 4. Review.


Mice fed rapamycin have an increase in lifespan associated with major changes in the liver transcriptome.

Fok WC, Chen Y, Bokov A, Zhang Y, Salmon AB, Diaz V, Javors M, Wood WH 3rd, Zhang Y, Becker KG, Pérez VI, Richardson A.

PLoS One. 2014 Jan 7;9(1):e83988. doi: 10.1371/journal.pone.0083988. eCollection 2014. Erratum in: PLoS One. 2014;9(4):e92346.


Rapamycin-mediated lifespan increase in mice is dose and sex dependent and metabolically distinct from dietary restriction.

Miller RA, Harrison DE, Astle CM, Fernandez E, Flurkey K, Han M, Javors MA, Li X, Nadon NL, Nelson JF, Pletcher S, Salmon AB, Sharp ZD, Van Roekel S, Winkleman L, Strong R.

Aging Cell. 2014 Jun;13(3):468-77. doi: 10.1111/acel.12194. Epub 2014 Feb 9.


Genetic disruption of SOD1 gene causes glucose intolerance and impairs β-cell function.

Muscogiuri G, Salmon AB, Aguayo-Mazzucato C, Li M, Balas B, Guardado-Mendoza R, Giaccari A, Reddick RL, Reyna SM, Weir G, Defronzo RA, Van Remmen H, Musi N.

Diabetes. 2013 Dec;62(12):4201-7. doi: 10.2337/db13-0314. Epub 2013 Sep 5.


Mice producing reduced levels of insulin-like growth factor type 1 display an increase in maximum, but not mean, life span.

Lorenzini A, Salmon AB, Lerner C, Torres C, Ikeno Y, Motch S, McCarter R, Sell C.

J Gerontol A Biol Sci Med Sci. 2014 Apr;69(4):410-9. doi: 10.1093/gerona/glt108. Epub 2013 Jul 20.


Oxidative damage associated with obesity is prevented by overexpression of CuZn- or Mn-superoxide dismutase.

Liu Y, Qi W, Richardson A, Van Remmen H, Ikeno Y, Salmon AB.

Biochem Biophys Res Commun. 2013 Aug 16;438(1):78-83. doi: 10.1016/j.bbrc.2013.07.029. Epub 2013 Jul 18.


Methionine sulfoxide reductase A affects insulin resistance by protecting insulin receptor function.

Styskal J, Nwagwu FA, Watkins YN, Liang H, Richardson A, Musi N, Salmon AB.

Free Radic Biol Med. 2013 Mar;56:123-32. doi: 10.1016/j.freeradbiomed.2012.10.544. Epub 2012 Oct 23.


Reduction of glucose intolerance with high fat feeding is associated with anti-inflammatory effects of thioredoxin 1 overexpression in mice.

Salmon AB, Flores LC, Li Y, Van Remmen H, Richardson A, Ikeno Y.

Pathobiol Aging Age Relat Dis. 2012;2. doi: 10.3402/pba.v2i0.17101. Epub 2012 May 17.


Short-term treatment with rapamycin and dietary restriction have overlapping and distinctive effects in young mice.

Fok WC, Zhang Y, Salmon AB, Bhattacharya A, Gunda R, Jones D, Ward W, Fisher K, Richardson A, Pérez VI.

J Gerontol A Biol Sci Med Sci. 2013 Feb;68(2):108-16. doi: 10.1093/gerona/gls127. Epub 2012 May 8.


Rapamycin-induced insulin resistance is mediated by mTORC2 loss and uncoupled from longevity.

Lamming DW, Ye L, Katajisto P, Goncalves MD, Saitoh M, Stevens DM, Davis JG, Salmon AB, Richardson A, Ahima RS, Guertin DA, Sabatini DM, Baur JA.

Science. 2012 Mar 30;335(6076):1638-43. doi: 10.1126/science.1215135.


Oxidative stress in the etiology of age-associated decline in glucose metabolism.

Salmon AB.

Longev Healthspan. 2012 Nov 1;1:7. doi: 10.1186/2046-2395-1-7. eCollection 2012. Review.


Oxidative stress and diabetes: what can we learn about insulin resistance from antioxidant mutant mouse models?

Styskal J, Van Remmen H, Richardson A, Salmon AB.

Free Radic Biol Med. 2012 Jan 1;52(1):46-58. doi: 10.1016/j.freeradbiomed.2011.10.441. Epub 2011 Oct 20. Review.


Metabolic effects of intra-abdominal fat in GHRKO mice.

Masternak MM, Bartke A, Wang F, Spong A, Gesing A, Fang Y, Salmon AB, Hughes LF, Liberati T, Boparai R, Kopchick JJ, Westbrook R.

Aging Cell. 2012 Feb;11(1):73-81. doi: 10.1111/j.1474-9726.2011.00763.x. Epub 2011 Nov 28.


Heightened induction of proapoptotic signals in response to endoplasmic reticulum stress in primary fibroblasts from a mouse model of longevity.

Sadighi Akha AA, Harper JM, Salmon AB, Schroeder BA, Tyra HM, Rutkowski DT, Miller RA.

J Biol Chem. 2011 Sep 2;286(35):30344-51. doi: 10.1074/jbc.M111.220541. Epub 2011 Jul 12.


Increased superoxide in vivo accelerates age-associated muscle atrophy through mitochondrial dysfunction and neuromuscular junction degeneration.

Jang YC, Lustgarten MS, Liu Y, Muller FL, Bhattacharya A, Liang H, Salmon AB, Brooks SV, Larkin L, Hayworth CR, Richardson A, Van Remmen H.

FASEB J. 2010 May;24(5):1376-90. doi: 10.1096/fj.09-146308. Epub 2009 Dec 29.


Update on the oxidative stress theory of aging: does oxidative stress play a role in aging or healthy aging?

Salmon AB, Richardson A, Pérez VI.

Free Radic Biol Med. 2010 Mar 1;48(5):642-55. doi: 10.1016/j.freeradbiomed.2009.12.015. Epub 2009 Dec 28. Review.


Insulin resistance is a cellular antioxidant defense mechanism.

Hoehn KL, Salmon AB, Hohnen-Behrens C, Turner N, Hoy AJ, Maghzal GJ, Stocker R, Van Remmen H, Kraegen EW, Cooney GJ, Richardson AR, James DE.

Proc Natl Acad Sci U S A. 2009 Oct 20;106(42):17787-92. doi: 10.1073/pnas.0902380106. Epub 2009 Sep 30.


Overexpression of Mn superoxide dismutase does not increase life span in mice.

Jang YC, Pérez VI, Song W, Lustgarten MS, Salmon AB, Mele J, Qi W, Liu Y, Liang H, Chaudhuri A, Ikeno Y, Epstein CJ, Van Remmen H, Richardson A.

J Gerontol A Biol Sci Med Sci. 2009 Nov;64(11):1114-25. doi: 10.1093/gerona/glp100. Epub 2009 Jul 24.


Lack of methionine sulfoxide reductase A in mice increases sensitivity to oxidative stress but does not diminish life span.

Salmon AB, Pérez VI, Bokov A, Jernigan A, Kim G, Zhao H, Levine RL, Richardson A.

FASEB J. 2009 Oct;23(10):3601-8. doi: 10.1096/fj.08-127415. Epub 2009 Jun 1.


Mechanisms of stress resistance in Snell dwarf mouse fibroblasts: enhanced antioxidant and DNA base excision repair capacity, but no differences in mitochondrial metabolism.

Page MM, Salmon AB, Leiser SF, Robb EL, Brown MF, Miller RA, Stuart JA.

Free Radic Biol Med. 2009 Apr 15;46(8):1109-18. doi: 10.1016/j.freeradbiomed.2009.01.014. Epub 2009 Jan 23.


The long lifespan of two bat species is correlated with resistance to protein oxidation and enhanced protein homeostasis.

Salmon AB, Leonard S, Masamsetti V, Pierce A, Podlutsky AJ, Podlutskaya N, Richardson A, Austad SN, Chaudhuri AR.

FASEB J. 2009 Jul;23(7):2317-26. doi: 10.1096/fj.08-122523. Epub 2009 Feb 24.


Protein stability and resistance to oxidative stress are determinants of longevity in the longest-living rodent, the naked mole-rat.

Pérez VI, Buffenstein R, Masamsetti V, Leonard S, Salmon AB, Mele J, Andziak B, Yang T, Edrey Y, Friguet B, Ward W, Richardson A, Chaudhuri A.

Proc Natl Acad Sci U S A. 2009 Mar 3;106(9):3059-64. doi: 10.1073/pnas.0809620106. Epub 2009 Feb 17.


Reduction of mitochondrial H2O2 by overexpressing peroxiredoxin 3 improves glucose tolerance in mice.

Chen L, Na R, Gu M, Salmon AB, Liu Y, Liang H, Qi W, Van Remmen H, Richardson A, Ran Q.

Aging Cell. 2008 Dec;7(6):866-78. doi: 10.1111/j.1474-9726.2008.00432.x. Epub 2008 Sep 5.


Cells from long-lived mutant mice exhibit enhanced repair of ultraviolet lesions.

Salmon AB, Ljungman M, Miller RA.

J Gerontol A Biol Sci Med Sci. 2008 Mar;63(3):219-31.


Skin-derived fibroblasts from long-lived species are resistant to some, but not all, lethal stresses and to the mitochondrial inhibitor rotenone.

Harper JM, Salmon AB, Leiser SF, Galecki AT, Miller RA.

Aging Cell. 2007 Feb;6(1):1-13. Epub 2006 Dec 5.


Correlated resistance to glucose deprivation and cytotoxic agents in fibroblast cell lines from long-lived pituitary dwarf mice.

Leiser SF, Salmon AB, Miller RA.

Mech Ageing Dev. 2006 Nov;127(11):821-9. Epub 2006 Sep 18.


Stress resistance and aging: influence of genes and nutrition.

Harper JM, Salmon AB, Chang Y, Bonkowski M, Bartke A, Miller RA.

Mech Ageing Dev. 2006 Aug;127(8):687-94. Epub 2006 May 19.


Fibroblast cell lines from young adult mice of long-lived mutant strains are resistant to multiple forms of stress.

Salmon AB, Murakami S, Bartke A, Kopchick J, Yasumura K, Miller RA.

Am J Physiol Endocrinol Metab. 2005 Jul;289(1):E23-9. Epub 2005 Feb 8.


A cost of reproduction in Drosophila melanogaster: stress susceptibility.

Salmon AB, Marx DB, Harshman LG.

Evolution. 2001 Aug;55(8):1600-8.


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