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Silver nanoparticle-adjuvanted vaccine protects against lethal influenza infection through inducing BALT and IgA-mediated mucosal immunity.

Sanchez-Guzman D, Le Guen P, Villeret B, Sola N, Le Borgne R, Guyard A, Kemmel A, Crestani B, Sallenave JM, Garcia-Verdugo I.

Biomaterials. 2019 Oct;217:119308. doi: 10.1016/j.biomaterials.2019.119308. Epub 2019 Jun 26.


Airway surface liquid acidification initiates host defense abnormalities in Cystic Fibrosis.

Simonin J, Bille E, Crambert G, Noel S, Dreano E, Edwards A, Hatton A, Pranke I, Villeret B, Cottart CH, Vrel JP, Urbach V, Baatallah N, Hinzpeter A, Golec A, Touqui L, Nassif X, Galietta LJV, Planelles G, Sallenave JM, Edelman A, Sermet-Gaudelus I.

Sci Rep. 2019 Apr 24;9(1):6516. doi: 10.1038/s41598-019-42751-4.


Pseudomonas aeruginosa LasB Subverts Alveolar Macrophage Activity by Interfering With Bacterial Killing Through Downregulation of Innate Immune Defense, Reactive Oxygen Species Generation, and Complement Activation.

Bastaert F, Kheir S, Saint-Criq V, Villeret B, Dang PM, El-Benna J, Sirard JC, Voulhoux R, Sallenave JM.

Front Immunol. 2018 Jul 23;9:1675. doi: 10.3389/fimmu.2018.01675. eCollection 2018.


Silver Nanoparticles Impair Retinoic Acid-Inducible Gene I-Mediated Mitochondrial Antiviral Immunity by Blocking the Autophagic Flux in Lung Epithelial Cells.

Villeret B, Dieu A, Straube M, Solhonne B, Miklavc P, Hamadi S, Le Borgne R, Mailleux A, Norel X, Aerts J, Diallo D, Rouzet F, Dietl P, Sallenave JM, Garcia-Verdugo I.

ACS Nano. 2018 Feb 27;12(2):1188-1202. doi: 10.1021/acsnano.7b06934. Epub 2018 Jan 30.


Human airway trypsin-like protease exerts potent, antifibrotic action in pulmonary fibrosis.

Menou A, Flajolet P, Duitman J, Justet A, Moog S, Jaillet M, Tabèze L, Solhonne B, Garnier M, Mal H, Mordant P, Castier Y, Cazes A, Sallenave JM, Mailleux AA, Crestani B.

FASEB J. 2018 Mar;32(3):1250-1264. doi: 10.1096/fj.201700583R. Epub 2018 Jan 3.


Pseudomonas aeruginosa LasB protease impairs innate immunity in mice and humans by targeting a lung epithelial cystic fibrosis transmembrane regulator-IL-6-antimicrobial-repair pathway.

Saint-Criq V, Villeret B, Bastaert F, Kheir S, Hatton A, Cazes A, Xing Z, Sermet-Gaudelus I, Garcia-Verdugo I, Edelman A, Sallenave JM.

Thorax. 2018 Jan;73(1):49-61. doi: 10.1136/thoraxjnl-2017-210298. Epub 2017 Aug 8.


FGF9 prevents pleural fibrosis induced by intrapleural adenovirus injection in mice.

Justet A, Joannes A, Besnard V, Marchal-Sommé J, Jaillet M, Bonniaud P, Sallenave JM, Solhonne B, Castier Y, Mordant P, Mal H, Cazes A, Borie R, Mailleux AA, Crestani B.

Am J Physiol Lung Cell Mol Physiol. 2017 Nov 1;313(5):L781-L795. doi: 10.1152/ajplung.00508.2016. Epub 2017 Jul 20.


Systemic Human ILC Precursors Provide a Substrate for Tissue ILC Differentiation.

Lim AI, Li Y, Lopez-Lastra S, Stadhouders R, Paul F, Casrouge A, Serafini N, Puel A, Bustamante J, Surace L, Masse-Ranson G, David E, Strick-Marchand H, Le Bourhis L, Cocchi R, Topazio D, Graziano P, Muscarella LA, Rogge L, Norel X, Sallenave JM, Allez M, Graf T, Hendriks RW, Casanova JL, Amit I, Yssel H, Di Santo JP.

Cell. 2017 Mar 9;168(6):1086-1100.e10. doi: 10.1016/j.cell.2017.02.021.


Human airway trypsin-like protease, a serine protease involved in respiratory diseases.

Menou A, Duitman J, Flajolet P, Sallenave JM, Mailleux AA, Crestani B.

Am J Physiol Lung Cell Mol Physiol. 2017 May 1;312(5):L657-L668. doi: 10.1152/ajplung.00509.2016. Epub 2017 Feb 24. Review.


The antimicrobial molecule trappin-2/elafin has anti-parasitic properties and is protective in vivo in a murine model of cerebral malaria.

Roussilhon C, Bang G, Bastaert F, Solhonne B, Garcia-Verdugo I, Peronet R, Druilhe P, Sakuntabhai A, Mecheri S, Sallenave JM.

Sci Rep. 2017 Feb 9;7:42243. doi: 10.1038/srep42243.


Editorial: Neutrophil elastase and the lung: is it degradation, repair, emphysema, or fibrosis? What tilts it left or right?

Sallenave JM.

J Leukoc Biol. 2015 Aug;98(2):137-9. doi: 10.1189/jlb.3CE0215-057R. No abstract available.


Serine protease inhibitors protect better than IL-10 and TGF-β anti-inflammatory cytokines against mouse colitis when delivered by recombinant lactococci.

Bermúdez-Humarán LG, Motta JP, Aubry C, Kharrat P, Rous-Martin L, Sallenave JM, Deraison C, Vergnolle N, Langella P.

Microb Cell Fact. 2015 Feb 26;14:26. doi: 10.1186/s12934-015-0198-4.


Cyclosporine Does Not Prevent Microvascular Loss in Transplantation but Can Synergize With a Neutrophil Elastase Inhibitor, Elafin, to Maintain Graft Perfusion During Acute Rejection.

Jiang X, Nguyen TT, Tian W, Sung YK, Yuan K, Qian J, Rajadas J, Sallenave JM, Nickel NP, de Jesus Perez V, Rabinovitch M, Nicolls MR.

Am J Transplant. 2015 Jul;15(7):1768-81. doi: 10.1111/ajt.13189. Epub 2015 Feb 27.


Acute exposure to silica nanoparticles enhances mortality and increases lung permeability in a mouse model of Pseudomonas aeruginosa pneumonia.

Delaval M, Boland S, Solhonne B, Nicola MA, Mornet S, Baeza-Squiban A, Sallenave JM, Garcia-Verdugo I.

Part Fibre Toxicol. 2015 Jan 21;12:1. doi: 10.1186/s12989-014-0078-9.


Sheep lung segmental delivery strategy demonstrates adenovirus priming of local lung responses to bacterial LPS and the role of elafin as a response modulator.

Brown TI, Collie DS, Shaw DJ, Rzechorzek NM, Sallenave JM.

PLoS One. 2014 Sep 12;9(9):e107590. doi: 10.1371/journal.pone.0107590. eCollection 2014.


Cystic fibrosis, a multi-systemic mucosal disease: 25 years after the discovery of CFTR.

Edelman A, Sallenave JM.

Int J Biochem Cell Biol. 2014 Jul;52:2-4. doi: 10.1016/j.biocel.2014.04.006. Epub 2014 Apr 13. No abstract available.


Phagocytic and signaling innate immune receptors: are they dysregulated in cystic fibrosis in the fight against Pseudomonas aeruginosa?

Sallenave JM.

Int J Biochem Cell Biol. 2014 Jul;52:103-7. doi: 10.1016/j.biocel.2014.01.013. Epub 2014 Feb 5. Review.


Antiviral activity of trappin-2 and elafin in vitro and in vivo against genital herpes.

Drannik AG, Nag K, Sallenave JM, Rosenthal KL.

J Virol. 2013 Jul;87(13):7526-38. doi: 10.1128/JVI.02243-12. Epub 2013 May 1.


Internalization of SiO₂ nanoparticles by alveolar macrophages and lung epithelial cells and its modulation by the lung surfactant substitute Curosurf.

Vranic S, Garcia-Verdugo I, Darnis C, Sallenave JM, Boggetto N, Marano F, Boland S, Baeza-Squiban A.

Environ Sci Pollut Res Int. 2013 May;20(5):2761-70. doi: 10.1007/s11356-012-1436-5. Epub 2013 Jan 5.


Neutrophil elastase degrades cystic fibrosis transmembrane conductance regulator via calpains and disables channel function in vitro and in vivo.

Le Gars M, Descamps D, Roussel D, Saussereau E, Guillot L, Ruffin M, Tabary O, Hong SS, Boulanger P, Paulais M, Malleret L, Belaaouaj A, Edelman A, Huerre M, Chignard M, Sallenave JM.

Am J Respir Crit Care Med. 2013 Jan 15;187(2):170-9. doi: 10.1164/rccm.201205-0875OC. Epub 2012 Dec 6.


Food-grade bacteria expressing elafin protect against inflammation and restore colon homeostasis.

Motta JP, Bermúdez-Humarán LG, Deraison C, Martin L, Rolland C, Rousset P, Boue J, Dietrich G, Chapman K, Kharrat P, Vinel JP, Alric L, Mas E, Sallenave JM, Langella P, Vergnolle N.

Sci Transl Med. 2012 Oct 31;4(158):158ra144. doi: 10.1126/scitranslmed.3004212.


Overexpressing mouse model demonstrates the protective role of Muc5ac in the lungs.

Ehre C, Worthington EN, Liesman RM, Grubb BR, Barbier D, O'Neal WK, Sallenave JM, Pickles RJ, Boucher RC.

Proc Natl Acad Sci U S A. 2012 Oct 9;109(41):16528-33. doi: 10.1073/pnas.1206552109. Epub 2012 Sep 24. Erratum in: Proc Natl Acad Sci U S A. 2014 Apr 15;111(15):5753.


Ventilator-associated pneumonia is characterized by excessive release of neutrophil proteases in the lung.

Wilkinson TS, Conway Morris A, Kefala K, O'Kane CM, Moore NR, Booth NA, McAuley DF, Dhaliwal K, Walsh TS, Haslett C, Sallenave JM, Simpson AJ.

Chest. 2012 Dec;142(6):1425-1432. doi: 10.1378/chest.11-3273.


Anti-tumor effect of SLPI on mammary but not colon tumor growth.

Amiano NO, Costa MJ, Reiteri RM, Payés C, Guerrieri D, Tateosian NL, Sánchez ML, Maffia PC, Diament M, Karas R, Orqueda A, Rizzo M, Alaniz L, Mazzolini G, Klein S, Sallenave JM, Chuluyan HE.

J Cell Physiol. 2013 Feb;228(2):469-75. doi: 10.1002/jcp.24153.


The WAP protein Trappin-2/Elafin: a handyman in the regulation of inflammatory and immune responses.

Verrier T, Solhonne B, Sallenave JM, Garcia-Verdugo I.

Int J Biochem Cell Biol. 2012 Aug;44(8):1377-80. doi: 10.1016/j.biocel.2012.05.007. Epub 2012 May 23. Review.


Trappin-2/elafin modulate innate immune responses of human endometrial epithelial cells to PolyI:C.

Drannik AG, Nag K, Yao XD, Henrick BM, Sallenave JM, Rosenthal KL.

PLoS One. 2012;7(4):e35866. doi: 10.1371/journal.pone.0035866. Epub 2012 Apr 24.


Influenza A induces the major secreted airway mucin MUC5AC in a protease-EGFR-extracellular regulated kinase-Sp1-dependent pathway.

Barbier D, Garcia-Verdugo I, Pothlichet J, Khazen R, Descamps D, Rousseau K, Thornton D, Si-Tahar M, Touqui L, Chignard M, Sallenave JM.

Am J Respir Cell Mol Biol. 2012 Aug;47(2):149-57. doi: 10.1165/rcmb.2011-0405OC. Epub 2012 Mar 1.


Toll-like receptor 5 (TLR5), IL-1β secretion, and asparagine endopeptidase are critical factors for alveolar macrophage phagocytosis and bacterial killing.

Descamps D, Le Gars M, Balloy V, Barbier D, Maschalidi S, Tohme M, Chignard M, Ramphal R, Manoury B, Sallenave JM.

Proc Natl Acad Sci U S A. 2012 Jan 31;109(5):1619-24. doi: 10.1073/pnas.1108464109. Epub 2012 Jan 17.


WAP domain proteins as modulators of mucosal immunity.

Wilkinson TS, Roghanian A, Simpson AJ, Sallenave JM.

Biochem Soc Trans. 2011 Oct;39(5):1409-15. doi: 10.1042/BST0391409. Review.


Transcriptomic analysis of host immune and cell death responses associated with the influenza A virus PB1-F2 protein.

Le Goffic R, Leymarie O, Chevalier C, Rebours E, Da Costa B, Vidic J, Descamps D, Sallenave JM, Rauch M, Samson M, Delmas B.

PLoS Pathog. 2011 Aug;7(8):e1002202. doi: 10.1371/journal.ppat.1002202. Epub 2011 Aug 25.


Serine leucocyte proteinase inhibitor-treated monocyte inhibits human CD4(+) lymphocyte proliferation.

Guerrieri D, Tateosian NL, Maffía PC, Reiteri RM, Amiano NO, Costa MJ, Villalonga X, Sanchez ML, Estein SM, Garcia VE, Sallenave JM, Chuluyan HE.

Immunology. 2011 Aug;133(4):434-41. doi: 10.1111/j.1365-2567.2011.03451.x. Epub 2011 May 17.


Deletion of Serpina1a, a murine α1-antitrypsin ortholog, results in embryonic lethality.

Wang D, Wang W, Dawkins P, Paterson T, Kalsheker N, Sallenave JM, Houghton AM.

Exp Lung Res. 2011 Jun;37(5):291-300. doi: 10.3109/01902148.2011.554599. Epub 2011 May 16.


Modifying the protease, antiprotease pattern by elafin overexpression protects mice from colitis.

Motta JP, Magne L, Descamps D, Rolland C, Squarzoni-Dale C, Rousset P, Martin L, Cenac N, Balloy V, Huerre M, Fröhlich LF, Jenne D, Wartelle J, Belaaouaj A, Mas E, Vinel JP, Alric L, Chignard M, Vergnolle N, Sallenave JM.

Gastroenterology. 2011 Apr;140(4):1272-82. doi: 10.1053/j.gastro.2010.12.050. Epub 2011 Jan 1.


CXCL10 reduces melanoma proliferation and invasiveness in vitro and in vivo.

Antonicelli F, Lorin J, Kurdykowski S, Gangloff SC, Le Naour R, Sallenave JM, Hornebeck W, Grange F, Bernard P.

Br J Dermatol. 2011 Apr;164(4):720-8. doi: 10.1111/j.1365-2133.2010.10176.x. Epub 2011 Mar 16.


Lung protease/anti-protease network and modulation of mucus production and surfactant activity.

Garcia-Verdugo I, Descamps D, Chignard M, Touqui L, Sallenave JM.

Biochimie. 2010 Nov;92(11):1608-17. doi: 10.1016/j.biochi.2010.05.010. Epub 2010 May 21. Review.


Secretory leukocyte protease inhibitor and elafin/trappin-2: versatile mucosal antimicrobials and regulators of immunity.

Sallenave JM.

Am J Respir Cell Mol Biol. 2010 Jun;42(6):635-43. doi: 10.1165/rcmb.2010-0095RT. Epub 2010 Apr 15. Review.


An additive interaction between the NFkappaB and estrogen receptor signalling pathways in human endometrial epithelial cells.

King AE, Collins F, Klonisch T, Sallenave JM, Critchley HO, Saunders PT.

Hum Reprod. 2010 Feb;25(2):510-8. doi: 10.1093/humrep/dep421. Epub 2009 Dec 2.


Diagnostic importance of pulmonary interleukin-1beta and interleukin-8 in ventilator-associated pneumonia.

Conway Morris A, Kefala K, Wilkinson TS, Moncayo-Nieto OL, Dhaliwal K, Farrell L, Walsh TS, Mackenzie SJ, Swann DG, Andrews PJ, Anderson N, Govan JR, Laurenson IF, Reid H, Davidson DJ, Haslett C, Sallenave JM, Simpson AJ.

Thorax. 2010 Mar;65(3):201-7. doi: 10.1136/thx.2009.122291. Epub 2009 Oct 12. Erratum in: Thorax. 2010 Sep;65(9):844.


IL-33 enhances lipopolysaccharide-induced inflammatory cytokine production from mouse macrophages by regulating lipopolysaccharide receptor complex.

Espinassous Q, Garcia-de-Paco E, Garcia-Verdugo I, Synguelakis M, von Aulock S, Sallenave JM, McKenzie AN, Kanellopoulos J.

J Immunol. 2009 Jul 15;183(2):1446-55. doi: 10.4049/jimmunol.0803067. Epub 2009 Jun 24.


Intranasal mucosal boosting with an adenovirus-vectored vaccine markedly enhances the protection of BCG-primed guinea pigs against pulmonary tuberculosis.

Xing Z, McFarland CT, Sallenave JM, Izzo A, Wang J, McMurray DN.

PLoS One. 2009 Jun 10;4(6):e5856. doi: 10.1371/journal.pone.0005856.


C5a mediates peripheral blood neutrophil dysfunction in critically ill patients.

Conway Morris A, Kefala K, Wilkinson TS, Dhaliwal K, Farrell L, Walsh T, Mackenzie SJ, Reid H, Davidson DJ, Haslett C, Rossi AG, Sallenave JM, Simpson AJ.

Am J Respir Crit Care Med. 2009 Jul 1;180(1):19-28. doi: 10.1164/rccm.200812-1928OC. Epub 2009 Mar 26.


Trappin-2 promotes early clearance of Pseudomonas aeruginosa through CD14-dependent macrophage activation and neutrophil recruitment.

Wilkinson TS, Dhaliwal K, Hamilton TW, Lipka AF, Farrell L, Davidson DJ, Duffin R, Morris AC, Haslett C, Govan JR, Gregory CD, Sallenave JM, Simpson AJ.

Am J Pathol. 2009 Apr;174(4):1338-46. doi: 10.2353/ajpath.2009.080746. Epub 2009 Mar 5.


Aspergillus fumigatus-induced interleukin-8 synthesis by respiratory epithelial cells is controlled by the phosphatidylinositol 3-kinase, p38 MAPK, and ERK1/2 pathways and not by the toll-like receptor-MyD88 pathway.

Balloy V, Sallenave JM, Wu Y, Touqui L, Latgé JP, Si-Tahar M, Chignard M.

J Biol Chem. 2008 Nov 7;283(45):30513-21. doi: 10.1074/jbc.M803149200. Epub 2008 Aug 14.


Neutrophil elastase (NE) and NE inhibitors: canonical and noncanonical functions in lung chronic inflammatory diseases (cystic fibrosis and chronic obstructive pulmonary disease).

Roghanian A, Sallenave JM.

J Aerosol Med Pulm Drug Deliv. 2008 Mar;21(1):125-44. doi: 10.1089/jamp.2007.0653. Review.


Altered secretory leukocyte protease inhibitor expression in the uterine decidua of tubal compared with intrauterine pregnancy.

Dalgetty DM, Sallenave JM, Critchley HO, Williams AR, Tham WY, King AE, Horne AW.

Hum Reprod. 2008 Jul;23(7):1485-90. doi: 10.1093/humrep/den130. Epub 2008 May 2.


Proteases and antiproteases in development, homeostasis and disease: The old, the new, and the unknown...

Sallenave JM, Shapiro S.

Int J Biochem Cell Biol. 2008;40(6-7):1066-7. doi: 10.1016/j.biocel.2008.03.011. Epub 2008 Mar 22. No abstract available.


Human neutrophil elastase: mediator and therapeutic target in atherosclerosis.

Henriksen PA, Sallenave JM.

Int J Biochem Cell Biol. 2008;40(6-7):1095-100. doi: 10.1016/j.biocel.2008.01.004. Epub 2008 Jan 11. Review.


Local lung responses following endobronchial elastase and lipopolysaccharide instillation in sheep.

Collie DD, McLean N, Sallenave JM, Baker A, Blundell R, Milne E, Rhind S, Woodall C.

Int J Chron Obstruct Pulmon Dis. 2006;1(2):189-99.


Innate immune defences in the human uterus during pregnancy.

King AE, Kelly RW, Sallenave JM, Bocking AD, Challis JR.

Placenta. 2007 Nov-Dec;28(11-12):1099-106. Epub 2007 Jul 30. Review.


Role of Toll-like receptors in lung innate defense against invasive aspergillosis. Distinct impact in immunocompetent and immunocompromized hosts.

Chignard M, Balloy V, Sallenave JM, Si-Tahar M.

Clin Immunol. 2007 Sep;124(3):238-43. Epub 2007 Jul 2. Review.

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