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Infection resisters: targets of new research for uncovering natural protective immunity against Mycobacterium tuberculosis.

Kaipilyawar V, Salgame P.

F1000Res. 2019 Sep 27;8. pii: F1000 Faculty Rev-1698. doi: 10.12688/f1000research.19805.1. eCollection 2019. Review.


Interaction of nutritional status and diabetes on active and latent tuberculosis: a cross-sectional analysis.

Kubiak RW, Sarkar S, Horsburgh CR, Roy G, Kratz M, Reshma A, Knudsen S, Salgame P, Ellner JJ, Drain PK, Hochberg NS.

BMC Infect Dis. 2019 Jul 16;19(1):627. doi: 10.1186/s12879-019-4244-4.


QuantiFERON®-TB Gold In-Tube reliability for immigrants with parasitic infections in Boston, USA.

Epstein RL, Bhagavathula M, Saag LA, Verma S, Kan CK, Mesick J, Kamineni P, White LF, Barnett ED, Salgame P, Hochberg NS.

Int J Tuberc Lung Dis. 2019 Apr 1;23(4):482-490. doi: 10.5588/ijtld.18.0540.


Effect of malnutrition on radiographic findings and mycobacterial burden in pulmonary tuberculosis.

Hoyt KJ, Sarkar S, White L, Joseph NM, Salgame P, Lakshminarayanan S, Muthaiah M, Vinod Kumar S, Ellner JJ, Roy G, Horsburgh CR Jr, Hochberg NS.

PLoS One. 2019 Mar 27;14(3):e0214011. doi: 10.1371/journal.pone.0214011. eCollection 2019.


Transmission phenotype of Mycobacterium tuberculosis strains is mechanistically linked to induction of distinct pulmonary pathology.

Verma S, Bhatt K, Lovey A, Ribeiro-Rodrigues R, Durbin J, Jones-López EC, Palaci M, Vinhas SA, Alland D, Dietze R, Ellner JJ, Salgame P.

PLoS Pathog. 2019 Mar 6;15(3):e1007613. doi: 10.1371/journal.ppat.1007613. eCollection 2019 Mar.


Fluoroquinolone Efficacy against Tuberculosis Is Driven by Penetration into Lesions and Activity against Resident Bacterial Populations.

Sarathy J, Blanc L, Alvarez-Cabrera N, O'Brien P, Dias-Freedman I, Mina M, Zimmerman M, Kaya F, Ho Liang HP, Prideaux B, Dietzold J, Salgame P, Savic RM, Linderman J, Kirschner D, Pienaar E, Dartois V.

Antimicrob Agents Chemother. 2019 Apr 25;63(5). pii: e02516-18. doi: 10.1128/AAC.02516-18. Print 2019 May.


Synergistic Lethality of a Binary Inhibitor of Mycobacterium tuberculosis KasA.

Kumar P, Capodagli GC, Awasthi D, Shrestha R, Maharaja K, Sukheja P, Li SG, Inoyama D, Zimmerman M, Ho Liang HP, Sarathy J, Mina M, Rasic G, Russo R, Perryman AL, Richmann T, Gupta A, Singleton E, Verma S, Husain S, Soteropoulos P, Wang Z, Morris R, Porter G, Agnihotri G, Salgame P, Ekins S, Rhee KY, Connell N, Dartois V, Neiditch MB, Freundlich JS, Alland D.

MBio. 2018 Dec 18;9(6). pii: e02101-17. doi: 10.1128/mBio.02101-17.


Toll-like Receptor 2 Prevents Neutrophil-Driven Immunopathology during Infection with Mycobacterium tuberculosis by Curtailing CXCL5 Production.

Gopalakrishnan A, Dietzold J, Verma S, Bhagavathula M, Salgame P.

Infect Immun. 2019 Feb 21;87(3). pii: e00760-18. doi: 10.1128/IAI.00760-18. Print 2019 Mar.


Undernutrition and Tuberculosis: Public Health Implications.

Sinha P, Davis J, Saag L, Wanke C, Salgame P, Mesick J, Horsburgh CR, Hochberg NS.

J Infect Dis. 2019 Apr 16;219(9):1356-1363. doi: 10.1093/infdis/jiy675.


Moving toward Tuberculosis Elimination. Critical Issues for Research in Diagnostics and Therapeutics for Tuberculosis Infection.

Keshavjee S, Amanullah F, Cattamanchi A, Chaisson R, Dobos KM, Fox GJ, Gendelman HE, Gordon R, Hesseling A, Le Van H, Kampmann B, Kana B, Khuller G, Lewinsohn DM, Lewinsohn DA, Lin PL, Lu LL, Maartens G, Owen A, Protopopova M, Rengarajan J, Rubin E, Salgame P, Schurr E, Seddon JA, Swindells S, Tobin DM, Udwadia Z, Walzl G, Srinivasan S, Rustomjee R, Nahid P.

Am J Respir Crit Care Med. 2019 Mar 1;199(5):564-571. doi: 10.1164/rccm.201806-1053PP. No abstract available.


Ambroxol Induces Autophagy and Potentiates Rifampin Antimycobacterial Activity.

Choi SW, Gu Y, Peters RS, Salgame P, Ellner JJ, Timmins GS, Deretic V.

Antimicrob Agents Chemother. 2018 Aug 27;62(9). pii: e01019-18. doi: 10.1128/AAC.01019-18. Print 2018 Sep.


"Tuberculosis in advanced HIV infection is associated with increased expression of IFNγ and its downstream targets".

Verma S, Du P, Nakanjako D, Hermans S, Briggs J, Nakiyingi L, Ellner JJ, Manabe YC, Salgame P.

BMC Infect Dis. 2018 May 15;18(1):220. doi: 10.1186/s12879-018-3127-4.


Existing blood transcriptional classifiers accurately discriminate active tuberculosis from latent infection in individuals from south India.

Leong S, Zhao Y, Joseph NM, Hochberg NS, Sarkar S, Pleskunas J, Hom D, Lakshminarayanan S, Horsburgh CR Jr, Roy G, Ellner JJ, Johnson WE, Salgame P.

Tuberculosis (Edinb). 2018 Mar;109:41-51. doi: 10.1016/ Epub 2018 Jan 31.


Intensity of exposure to pulmonary tuberculosis determines risk of tuberculosis infection and disease.

Acuña-Villaorduña C, Jones-López EC, Fregona G, Marques-Rodrigues P, Gaeddert M, Geadas C, Hadad DJ, White LF, Pereira Dutra Molina L, Vinhas S, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

Eur Respir J. 2018 Jan 18;51(1). pii: 1701578. doi: 10.1183/13993003.01578-2017. Print 2018 Jan.


Comorbidities in pulmonary tuberculosis cases in Puducherry and Tamil Nadu, India: Opportunities for intervention.

Hochberg NS, Sarkar S, Horsburgh CR Jr, Knudsen S, Pleskunas J, Sahu S, Kubiak RW, Govindarajan S, Salgame P, Lakshminarayanan S, Sivaprakasam A, White LF, Joseph NM, Ellner JJ, Roy G.

PLoS One. 2017 Aug 23;12(8):e0183195. doi: 10.1371/journal.pone.0183195. eCollection 2017.


Incident Mycobacterium tuberculosis infection in household contacts of infectious tuberculosis patients in Brazil.

Jones-López EC, Acuña-Villaorduña C, Fregona G, Marques-Rodrigues P, White LF, Hadad DJ, Dutra-Molina LP, Vinhas S, McIntosh AI, Gaeddert M, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

BMC Infect Dis. 2017 Aug 18;17(1):576. doi: 10.1186/s12879-017-2675-3.


Ethambutol Partitioning in Tuberculous Pulmonary Lesions Explains Its Clinical Efficacy.

Zimmerman M, Lestner J, Prideaux B, O'Brien P, Dias-Freedman I, Chen C, Dietzold J, Daudelin I, Kaya F, Blanc L, Chen PY, Park S, Salgame P, Sarathy J, Dartois V.

Antimicrob Agents Chemother. 2017 Aug 24;61(9). pii: e00924-17. doi: 10.1128/AAC.00924-17. Print 2017 Sep.


Strains of Mycobacterium tuberculosis transmitting infection in Brazilian households and those associated with community transmission of tuberculosis.

Vinhas SA, Jones-López EC, Ribeiro Rodrigues R, Gaeddert M, Peres RL, Marques-Rodrigues P, de Aguiar PPL, White LF, Alland D, Salgame P, Hom D, Ellner JJ, Dietze R, Collins LF, Shashkina E, Kreiswirth B, Palaci M.

Tuberculosis (Edinb). 2017 May;104:79-86. doi: 10.1016/ Epub 2017 Mar 16.


Divergent Functions of TLR2 on Hematopoietic and Nonhematopoietic Cells during Chronic Mycobacterium tuberculosis Infection.

Konowich J, Gopalakrishnan A, Dietzold J, Verma S, Bhatt K, Rafi W, Salgame P.

J Immunol. 2017 Jan 15;198(2):741-748. doi: 10.4049/jimmunol.1601651. Epub 2016 Dec 5.


Toll-like receptor 2 in host defense against Mycobacterium tuberculosis: to be or not to be-that is the question.

Gopalakrishnan A, Salgame P.

Curr Opin Immunol. 2016 Oct;42:76-82. doi: 10.1016/j.coi.2016.06.003. Epub 2016 Jun 18. Review.


1,25 (OH)2D3 treatment alters the granulomatous response in M. tuberculosis infected mice.

Bhatt K, Rafi W, Shah N, Christakos S, Salgame P.

Sci Rep. 2016 Oct 4;6:34469. doi: 10.1038/srep34469.


Vaccine-mediated immunity to experimental Mycobacterium tuberculosis is not impaired in the absence of Toll-like receptor 9.

Gopalakrishnan A, Dietzold J, Salgame P.

Cell Immunol. 2016 Apr;302:11-18. doi: 10.1016/j.cellimm.2015.12.009. Epub 2015 Dec 30.


Latent tuberculosis infection--Revisiting and revising concepts.

Salgame P, Geadas C, Collins L, Jones-López E, Ellner JJ.

Tuberculosis (Edinb). 2015 Jul;95(4):373-84. doi: 10.1016/ Epub 2015 May 15. Review.


Duality of lipid mediators in host response against Mycobacterium tuberculosis: good cop, bad cop.

Dietzold J, Gopalakrishnan A, Salgame P.

F1000Prime Rep. 2015 Mar 3;7:29. doi: 10.12703/P7-29. eCollection 2015. Review.


Disruption of an M. tuberculosis membrane protein causes a magnesium-dependent cell division defect and failure to persist in mice.

Goodsmith N, Guo XV, Vandal OH, Vaubourgeix J, Wang R, Botella H, Song S, Bhatt K, Liba A, Salgame P, Schnappinger D, Ehrt S.

PLoS Pathog. 2015 Feb 6;11(2):e1004645. doi: 10.1371/journal.ppat.1004645. eCollection 2015 Feb.


Neither primary nor memory immunity to Mycobacterium tuberculosis infection is compromised in mice with chronic enteric helminth infection.

Rafi W, Bhatt K, Gause WC, Salgame P.

Infect Immun. 2015 Mar;83(3):1217-23. doi: 10.1128/IAI.03004-14. Epub 2015 Jan 20.


Quest for correlates of protection against tuberculosis.

Bhatt K, Verma S, Ellner JJ, Salgame P.

Clin Vaccine Immunol. 2015 Mar;22(3):258-66. doi: 10.1128/CVI.00721-14. Epub 2015 Jan 14. Review.


Importance of cough and M. tuberculosis strain type as risks for increased transmission within households.

Jones-López EC, Kim S, Fregona G, Marques-Rodrigues P, Hadad DJ, Molina LP, Vinhas S, Reilly N, Moine S, Chakravorty S, Gaeddert M, Ribeiro-Rodrigues R, Salgame P, Palaci M, Alland D, Ellner JJ, Dietze R.

PLoS One. 2014 Jul 2;9(7):e100984. doi: 10.1371/journal.pone.0100984. eCollection 2014.


Discordance of tuberculin skin test and interferon gamma release assay in recently exposed household contacts of pulmonary TB cases in Brazil.

Ribeiro-Rodrigues R, Kim S, Coelho da Silva FD, Uzelac A, Collins L, Palaci M, Alland D, Dietze R, Ellner JJ, Jones-López E, Salgame P.

PLoS One. 2014 May 12;9(5):e96564. doi: 10.1371/journal.pone.0096564. eCollection 2014.


Increased cellular activity in thoracic lymph nodes in early human latent tuberculosis infection.

Ghesani N, Patrawalla A, Lardizabal A, Salgame P, Fennelly KP.

Am J Respir Crit Care Med. 2014 Mar 15;189(6):748-50. doi: 10.1164/rccm.201311-1976LE. No abstract available.


Effect of helminth-induced immunity on infections with microbial pathogens.

Salgame P, Yap GS, Gause WC.

Nat Immunol. 2013 Nov;14(11):1118-1126. doi: 10.1038/ni.2736. Review.


Equivalent functions for B7.1 and B7.2 costimulation in mediating host resistance to Mycobacterium tuberculosis.

Bhatt K, Kim A, Kim A, Mathur S, Salgame P.

Cell Immunol. 2013 Sep-Oct;285(1-2):69-75. doi: 10.1016/j.cellimm.2013.09.004. Epub 2013 Sep 23.


Host defense and recruitment of Foxp3⁺ T regulatory cells to the lungs in chronic Mycobacterium tuberculosis infection requires toll-like receptor 2.

McBride A, Konowich J, Salgame P.

PLoS Pathog. 2013;9(6):e1003397. doi: 10.1371/journal.ppat.1003397. Epub 2013 Jun 13.


Sustained generation of nitric oxide and control of mycobacterial infection requires argininosuccinate synthase 1.

Qualls JE, Subramanian C, Rafi W, Smith AM, Balouzian L, DeFreitas AA, Shirey KA, Reutterer B, Kernbauer E, Stockinger S, Decker T, Miyairi I, Vogel SN, Salgame P, Rock CO, Murray PJ.

Cell Host Microbe. 2012 Sep 13;12(3):313-23. doi: 10.1016/j.chom.2012.07.012.


'Coinfection-helminthes and tuberculosis'.

Rafi W, Ribeiro-Rodrigues R, Ellner JJ, Salgame P.

Curr Opin HIV AIDS. 2012 May;7(3):239-44. doi: 10.1097/COH.0b013e3283524dc5. Review.


Imatinib-sensitive tyrosine kinases regulate mycobacterial pathogenesis and represent therapeutic targets against tuberculosis.

Napier RJ, Rafi W, Cheruvu M, Powell KR, Zaunbrecher MA, Bornmann W, Salgame P, Shinnick TM, Kalman D.

Cell Host Microbe. 2011 Nov 17;10(5):475-85. doi: 10.1016/j.chom.2011.09.010. Erratum in: Cell Host Microbe. 2011 Dec 15;10(6):635.


Preexisting helminth infection induces inhibition of innate pulmonary anti-tuberculosis defense by engaging the IL-4 receptor pathway.

Potian JA, Rafi W, Bhatt K, McBride A, Gause WC, Salgame P.

J Exp Med. 2011 Aug 29;208(9):1863-74. doi: 10.1084/jem.20091473. Epub 2011 Aug 8.


MMPs in tuberculosis: granuloma creators and tissue destroyers.

Salgame P.

J Clin Invest. 2011 May;121(5):1686-8. doi: 10.1172/JCI57423. Epub 2011 Apr 25.


Development of a secondary immune response to Mycobacterium tuberculosis is independent of Toll-like receptor 2.

McBride A, Bhatt K, Salgame P.

Infect Immun. 2011 Mar;79(3):1118-23. doi: 10.1128/IAI.01076-10. Epub 2010 Dec 20.


Human breast tumor cells express IL-10 and IL-12p40 transcripts and proteins, but do not produce IL-12p70.

Heckel MC, Wolfson A, Slachta CA, Schwarting R, Salgame P, Katsetos CD, Platsoucas CD.

Cell Immunol. 2011;266(2):143-53. doi: 10.1016/j.cellimm.2010.09.010. Epub 2010 Oct 1.


Regulation of type 1 diabetes, tuberculosis, and asthma by parasites.

Liu Z, Liu Q, Bleich D, Salgame P, Gause WC.

J Mol Med (Berl). 2010 Jan;88(1):27-38. doi: 10.1007/s00109-009-0546-0. Epub 2009 Oct 21. Review.


B7 costimulation is critical for host control of chronic Mycobacterium tuberculosis infection.

Bhatt K, Uzelac A, Mathur S, McBride A, Potian J, Salgame P.

J Immunol. 2009 Mar 15;182(6):3793-800. doi: 10.4049/jimmunol.0802996.


The multifunctional histone-like protein Lsr2 protects mycobacteria against reactive oxygen intermediates.

Colangeli R, Haq A, Arcus VL, Summers E, Magliozzo RS, McBride A, Mitra AK, Radjainia M, Khajo A, Jacobs WR Jr, Salgame P, Alland D.

Proc Natl Acad Sci U S A. 2009 Mar 17;106(11):4414-8. doi: 10.1073/pnas.0810126106. Epub 2009 Feb 23.


Comparative evaluation of cytokines, T-cell apoptosis, and costimulatory molecule expression in tuberculous and nontuberculous pleurisy.

Rajavelu P, Pokkali S, P U, Bhatt K, Narayanan PR, Salgame P, Das SD.

Clin Transl Sci. 2008 Dec;1(3):209-14. doi: 10.1111/j.1752-8062.2008.00057.x.


PUPylation provides the punch as Mycobacterium tuberculosis battles the host macrophage.

Salgame P.

Cell Host Microbe. 2008 Nov 13;4(5):415-6. doi: 10.1016/j.chom.2008.10.009.


Distinct chemokine and cytokine gene expression pattern of murine dendritic cells and macrophages in response to Mycobacterium tuberculosis infection.

Jang S, Uzelac A, Salgame P.

J Leukoc Biol. 2008 Nov;84(5):1264-70. doi: 10.1189/jlb.1107742. Epub 2008 Aug 14.


Nucleotide-binding oligomerization domain protein 2-deficient mice control infection with Mycobacterium tuberculosis.

Gandotra S, Jang S, Murray PJ, Salgame P, Ehrt S.

Infect Immun. 2007 Nov;75(11):5127-34. Epub 2007 Aug 20.


Disparity in IL-12 release in dendritic cells and macrophages in response to Mycobacterium tuberculosis is due to use of distinct TLRs.

Pompei L, Jang S, Zamlynny B, Ravikumar S, McBride A, Hickman SP, Salgame P.

J Immunol. 2007 Apr 15;178(8):5192-9.


Host innate immune response to Mycobacterium tuberculosis.

Bhatt K, Salgame P.

J Clin Immunol. 2007 Jul;27(4):347-62. Epub 2007 Mar 16. Review.


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