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Items: 5


Tissue-specific regulation of p53 by PKM2 is redox dependent and provides a therapeutic target for anthracycline-induced cardiotoxicity.

Saleme B, Gurtu V, Zhang Y, Kinnaird A, Boukouris AE, Gopal K, Ussher JR, Sutendra G.

Sci Transl Med. 2019 Feb 6;11(478). pii: eaau8866. doi: 10.1126/scitranslmed.aau8866.


The antianginal ranolazine mitigates obesity-induced nonalcoholic fatty liver disease and increases hepatic pyruvate dehydrogenase activity.

Al Batran R, Gopal K, Aburasayn H, Eshreif A, Almutairi M, Greenwell AA, Campbell SA, Saleme B, Court EA, Eaton F, Light PE, Sutendra G, Ussher JR.

JCI Insight. 2019 Jan 10;4(1). pii: 124643. doi: 10.1172/jci.insight.124643. [Epub ahead of print]


A Similar Metabolic Profile Between the Failing Myocardium and Tumor Could Provide Alternative Therapeutic Targets in Chemotherapy-Induced Cardiotoxicity.

Saleme B, Sutendra G.

Front Cardiovasc Med. 2018 Jun 11;5:61. doi: 10.3389/fcvm.2018.00061. eCollection 2018. No abstract available.


FoxO1 regulates myocardial glucose oxidation rates via transcriptional control of pyruvate dehydrogenase kinase 4 expression.

Gopal K, Saleme B, Al Batran R, Aburasayn H, Eshreif A, Ho KL, Ma WK, Almutairi M, Eaton F, Gandhi M, Park EA, Sutendra G, Ussher JR.

Am J Physiol Heart Circ Physiol. 2017 Sep 1;313(3):H479-H490. doi: 10.1152/ajpheart.00191.2017. Epub 2017 Jul 7.


Metabolic Modulation of Clear-cell Renal Cell Carcinoma with Dichloroacetate, an Inhibitor of Pyruvate Dehydrogenase Kinase.

Kinnaird A, Dromparis P, Saleme B, Gurtu V, Watson K, Paulin R, Zervopoulos S, Stenson T, Sutendra G, Pink DB, Carmine-Simmen K, Moore R, Lewis JD, Michelakis ED.

Eur Urol. 2016 Apr;69(4):734-744. doi: 10.1016/j.eururo.2015.09.014. Epub 2016 Feb 18.


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