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Items: 30


Aryl-fluorosulfate-based Lysine Covalent Pan-Inhibitors of Apoptosis Protein (IAP) Antagonists with Cellular Efficacy.

Baggio C, Udompholkul P, Gambini L, Salem AF, Jossart J, Perry JJP, Pellecchia M.

J Med Chem. 2019 Oct 24;62(20):9188-9200. doi: 10.1021/acs.jmedchem.9b01108. Epub 2019 Oct 8.


Covalent Inhibitors of Protein-Protein Interactions Targeting Lysine, Tyrosine, or Histidine Residues.

Gambini L, Baggio C, Udompholkul P, Jossart J, Salem AF, Perry JJP, Pellecchia M.

J Med Chem. 2019 Jun 13;62(11):5616-5627. doi: 10.1021/acs.jmedchem.9b00561. Epub 2019 May 29.


Structure-Based Design of Novel EphA2 Agonistic Agents with Nanomolar Affinity in Vitro and in Cell.

Gambini L, Salem AF, Udompholkul P, Tan XF, Baggio C, Shah N, Aronson A, Song J, Pellecchia M.

ACS Chem Biol. 2018 Sep 21;13(9):2633-2644. doi: 10.1021/acschembio.8b00556. Epub 2018 Aug 29.


Design of Potent pan-IAP and Lys-Covalent XIAP Selective Inhibitors Using a Thermodynamics Driven Approach.

Baggio C, Gambini L, Udompholkul P, Salem AF, Aronson A, Dona A, Troadec E, Pichiorri F, Pellecchia M.

J Med Chem. 2018 Jul 26;61(14):6350-6363. doi: 10.1021/acs.jmedchem.8b00810. Epub 2018 Jul 9.


Reduction of Circulating Cancer Cells and Metastases in Breast-Cancer Models by a Potent EphA2-Agonistic Peptide-Drug Conjugate.

Salem AF, Wang S, Billet S, Chen JF, Udompholkul P, Gambini L, Baggio C, Tseng HR, Posadas EM, Bhowmick NA, Pellecchia M.

J Med Chem. 2018 Mar 8;61(5):2052-2061. doi: 10.1021/acs.jmedchem.7b01837. Epub 2018 Feb 27.


Potent and Selective EphA4 Agonists for the Treatment of ALS.

Wu B, De SK, Kulinich A, Salem AF, Koeppen J, Wang R, Barile E, Wang S, Zhang D, Ethell I, Pellecchia M.

Cell Chem Biol. 2017 Mar 16;24(3):293-305. doi: 10.1016/j.chembiol.2017.01.006. Epub 2017 Feb 9.


hBfl-1/hNOXA Interaction Studies Provide New Insights on the Role of Bfl-1 in Cancer Cell Resistance and for the Design of Novel Anticancer Agents.

Barile E, Marconi GD, De SK, Baggio C, Gambini L, Salem AF, Kashyap MK, Castro JE, Kipps TJ, Pellecchia M.

ACS Chem Biol. 2017 Feb 17;12(2):444-455. doi: 10.1021/acschembio.6b00962. Epub 2016 Dec 27.


Effects of exogenous enzymes and application method on nutrient intake, digestibility and growth performance of Pelibuey lambs.

López-Aguirre D, Hernández-Meléndez J, Rojo R, Sánchez-Dávila F, López-Villalobos N, Salem AF, Martínez-González JC, Vázquez-Armijo JF, Ruíz S.

Springerplus. 2016 Aug 23;5(1):1399. doi: 10.1186/s40064-016-3075-7. eCollection 2016.


Risk of recurrent laryngeal nerve palsy in patients undergoing thyroidectomy with and without intraoperative nerve monitoring.

Bergenfelz A, Salem AF, Jacobsson H, Nordenström E, Almquist M; Steering Committee for the Scandinavian Quality Register for Thyroid, Parathyroid and Adrenal Surgery (SQRTPA).

Br J Surg. 2016 Dec;103(13):1828-1838. doi: 10.1002/bjs.10276. Epub 2016 Aug 18.


Characterization of Cardiac Glycoside Natural Products as Potent Inhibitors of DNA Double-Strand Break Repair by a Whole-Cell Double Immunofluorescence Assay.

Surovtseva YV, Jairam V, Salem AF, Sundaram RK, Bindra RS, Herzon SB.

J Am Chem Soc. 2016 Mar 23;138(11):3844-55. doi: 10.1021/jacs.6b00162. Epub 2016 Mar 9.


WNT/β-catenin signaling mediates human neural crest induction via a pre-neural border intermediate.

Leung AW, Murdoch B, Salem AF, Prasad MS, Gomez GA, García-Castro MI.

Development. 2016 Feb 1;143(3):398-410. doi: 10.1242/dev.130849.


Combined photon-electron beams in the treatment of the supraclavicular lymph nodes in breast cancer: A novel technique that achieves adequate coverage while reducing lung dose.

Salem A, Mohamad I, Dayyat A, Kanaa'n H, Sarhan N, Roujob I, Salem AF, Afifi S, Jaradat I, Mubiden R, Almousa A.

Med Dosim. 2015 Autumn;40(3):210-7. doi: 10.1016/j.meddos.2014.12.001. Epub 2015 Jan 13.


Development of a novel method to create double-strand break repair fingerprints using next-generation sequencing.

Soong CP, Breuer GA, Hannon RA, Kim SD, Salem AF, Wang G, Yu R, Carriero NJ, Bjornson R, Sundaram RK, Bindra RS.

DNA Repair (Amst). 2015 Feb;26:44-53. doi: 10.1016/j.dnarep.2014.12.002. Epub 2014 Dec 19.


Identification of novel radiosensitizers in a high-throughput, cell-based screen for DSB repair inhibitors.

Goglia AG, Delsite R, Luz AN, Shahbazian D, Salem AF, Sundaram RK, Chiaravalli J, Hendrikx PJ, Wilshire JA, Jasin M, Kluger HM, Glickman JF, Powell SN, Bindra RS.

Mol Cancer Ther. 2015 Feb;14(2):326-42. doi: 10.1158/1535-7163.MCT-14-0765. Epub 2014 Dec 15.


Breaking bad news: current prospective and practical guideline for Muslim countries.

Salem A, Salem AF.

J Cancer Educ. 2013 Dec;28(4):790-4. doi: 10.1007/s13187-013-0523-8.


Cigarette smoke metabolically promotes cancer, via autophagy and premature aging in the host stromal microenvironment.

Salem AF, Al-Zoubi MS, Whitaker-Menezes D, Martinez-Outschoorn UE, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Galbiati F, Bevilacqua G, Sotgia F, Lisanti MP.

Cell Cycle. 2013 Mar 1;12(5):818-25. doi: 10.4161/cc.23722. Epub 2013 Feb 6.


Creating a tumor-resistant microenvironment: cell-mediated delivery of TNFα completely prevents breast cancer tumor formation in vivo.

Al-Zoubi M, Salem AF, Martinez-Outschoorn UE, Whitaker-Menezes D, Lamb R, Hulit J, Howell A, Gandara R, Sartini M, Arafat H, Bevilacqua G, Sotgia F, Lisanti MP.

Cell Cycle. 2013 Feb 1;12(3):480-90. doi: 10.4161/cc.23370. Epub 2012 Feb 1.


Mitochondria "fuel" breast cancer metabolism: fifteen markers of mitochondrial biogenesis label epithelial cancer cells, but are excluded from adjacent stromal cells.

Sotgia F, Whitaker-Menezes D, Martinez-Outschoorn UE, Salem AF, Tsirigos A, Lamb R, Sneddon S, Hulit J, Howell A, Lisanti MP.

Cell Cycle. 2012 Dec 1;11(23):4390-401. doi: 10.4161/cc.22777. Epub 2012 Nov 21.


Mitochondrial biogenesis in epithelial cancer cells promotes breast cancer tumor growth and confers autophagy resistance.

Salem AF, Whitaker-Menezes D, Howell A, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Nov 15;11(22):4174-80. doi: 10.4161/cc.22376. Epub 2012 Oct 15.


Downregulation of stromal BRCA1 drives breast cancer tumor growth via upregulation of HIF-1α, autophagy and ketone body production.

Salem AF, Howell A, Sartini M, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Nov 15;11(22):4167-73. doi: 10.4161/cc.22316. Epub 2012 Oct 9.


Milk yield and composition of crossbred Sahelian × Anglo-Nubian goats in the semi-intensive system in Mali during the preweaning period.

Sanogo S, Shaker MM, Nantoumé H, Salem AF.

Trop Anim Health Prod. 2013 Jan;45(1):305-10. doi: 10.1007/s11250-012-0219-9. Epub 2012 Jul 13.


Two-compartment tumor metabolism: autophagy in the tumor microenvironment and oxidative mitochondrial metabolism (OXPHOS) in cancer cells.

Salem AF, Whitaker-Menezes D, Lin Z, Martinez-Outschoorn UE, Tanowitz HB, Al-Zoubi MS, Howell A, Pestell RG, Sotgia F, Lisanti MP.

Cell Cycle. 2012 Jul 1;11(13):2545-56. doi: 10.4161/cc.20920. Epub 2012 Jul 1.


Evidence for the use PET for radiation therapy planning in patients with cervical cancer: a systematic review.

Salem A, Salem AF, Al-Ibraheem A, Lataifeh I, Almousa A, Jaradat I.

Hematol Oncol Stem Cell Ther. 2011;4(4):173-81. doi: 10.5144/1658-3876.2011.173. Review.


Caveolin-1 promotes pancreatic cancer cell differentiation and restores membranous E-cadherin via suppression of the epithelial-mesenchymal transition.

Salem AF, Bonuccelli G, Bevilacqua G, Arafat H, Pestell RG, Sotgia F, Lisanti MP.

Cell Cycle. 2011 Nov 1;10(21):3692-700. doi: 10.4161/cc.10.21.17895. Epub 2011 Nov 1.


In vitro gas production and dry matter degradability of diets consumed by goats with or without copper and zinc supplementation.

Vázquez-Armijo JF, Martínez-Tinajero JJ, López D, Salem AF, Rojo R.

Biol Trace Elem Res. 2011 Dec;144(1-3):580-7. doi: 10.1007/s12011-011-9113-y. Epub 2011 Jun 21.


Effects of Cu-doping on the magnetic state of Zn(0.9-x)Fe0.1Cu(x)O.

Ziq KhA, Ismail A, Salem AF, Ahmed S, Ghannam A.

J Nanosci Nanotechnol. 2011 Mar;11(3):2579-82.


Involvement of osteopontin in the matrix-degrading and proangiogenic changes mediated by nicotine in pancreatic cancer cells.

Lazar M, Sullivan J, Chipitsyna G, Gong Q, Ng CY, Salem AF, Aziz T, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA.

J Gastrointest Surg. 2010 Oct;14(10):1566-77. doi: 10.1007/s11605-010-1338-0. Epub 2010 Sep 8.


Induction of monocyte chemoattractant protein-1 by nicotine in pancreatic ductal adenocarcinoma cells: role of osteopontin.

Lazar M, Sullivan J, Chipitsyna G, Aziz T, Salem AF, Gong Q, Witkiewicz A, Denhardt DT, Yeo CJ, Arafat HA.

Surgery. 2010 Aug;148(2):298-309. doi: 10.1016/j.surg.2010.05.002. Epub 2010 Jun 25.


The effects of acetyl-L-carnitine and sorbinil on peripheral nerve structure, chemistry, and function in experimental diabetes.

Malone JI, Lowitt S, Salem AF, Miranda C, Korthals JK, Carver J.

Metabolism. 1996 Jul;45(7):902-7.


Acetyl-L-carnitine corrects the altered peripheral nerve function of experimental diabetes.

Lowitt S, Malone JI, Salem AF, Korthals J, Benford S.

Metabolism. 1995 May;44(5):677-80.


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