Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 14

1.

MEK1/2 inhibitor withdrawal reverses acquired resistance driven by BRAFV600E amplification whereas KRASG13D amplification promotes EMT-chemoresistance.

Sale MJ, Balmanno K, Saxena J, Ozono E, Wojdyla K, McIntyre RE, Gilley R, Woroniuk A, Howarth KD, Hughes G, Dry JR, Arends MJ, Caro P, Oxley D, Ashton S, Adams DJ, Saez-Rodriguez J, Smith PD, Cook SJ.

Nat Commun. 2019 May 2;10(1):2030. doi: 10.1038/s41467-019-09438-w.

2.

Control of cell death and mitochondrial fission by ERK1/2 MAP kinase signalling.

Cook SJ, Stuart K, Gilley R, Sale MJ.

FEBS J. 2017 Dec;284(24):4177-4195. doi: 10.1111/febs.14122. Epub 2017 Jun 18. Review.

3.

MEK1 and MEK2 inhibitors and cancer therapy: the long and winding road.

Caunt CJ, Sale MJ, Smith PD, Cook SJ.

Nat Rev Cancer. 2015 Oct;15(10):577-92. doi: 10.1038/nrc4000. Review.

PMID:
26399658
4.

Lysine acetylation controls local protein conformation by influencing proline isomerization.

Howe FS, Boubriak I, Sale MJ, Nair A, Clynes D, Grijzenhout A, Murray SC, Woloszczuk R, Mellor J.

Mol Cell. 2014 Sep 4;55(5):733-44. doi: 10.1016/j.molcel.2014.07.004. Epub 2014 Aug 7.

5.

Intrinsic and acquired resistance to MEK1/2 inhibitors in cancer.

Sale MJ, Cook SJ.

Biochem Soc Trans. 2014 Aug;42(4):776-83. doi: 10.1042/BST20140129. Review.

PMID:
25109957
7.

Adaptation to mTOR kinase inhibitors by amplification of eIF4E to maintain cap-dependent translation.

Cope CL, Gilley R, Balmanno K, Sale MJ, Howarth KD, Hampson M, Smith PD, Guichard SM, Cook SJ.

J Cell Sci. 2014 Feb 15;127(Pt 4):788-800. doi: 10.1242/jcs.137588. Epub 2013 Dec 20.

8.
9.
10.

Tumour cell responses to MEK1/2 inhibitors: acquired resistance and pathway remodelling.

Little AS, Balmanno K, Sale MJ, Smith PD, Cook SJ.

Biochem Soc Trans. 2012 Feb;40(1):73-8. doi: 10.1042/BST20110647.

PMID:
22260668
12.

Amplification of the driving oncogene, KRAS or BRAF, underpins acquired resistance to MEK1/2 inhibitors in colorectal cancer cells.

Little AS, Balmanno K, Sale MJ, Newman S, Dry JR, Hampson M, Edwards PA, Smith PD, Cook SJ.

Sci Signal. 2011 Mar 29;4(166):ra17. doi: 10.1126/scisignal.2001752. Erratum in: Sci Signal. 2011;4(170). doi:10.1126/scisignal.4170er2. Corrected and republished in: Sci Signal. 2011;4(170):er2.

13.

Sensitivity to change for low-ANC eastern US lakes and streams and brook trout populations under alternative sulfate deposition scenarios.

Turner RS, Ryan PF, Marmorek DR, Thornton KW, Sullivan TJ, Baker JP, Christensen SW, Sale MJ.

Environ Pollut. 1992;77(2-3):269-77.

PMID:
15091968
14.

Habitat shifts in rainbow trout: competitive influences of brown trout.

Gatz AJ Jr, Sale MJ, Loar JM.

Oecologia. 1987 Nov;74(1):7-19. doi: 10.1007/BF00377339.

PMID:
28310408

Supplemental Content

Support Center