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Multiple simultaneous fractures are associated with higher all-cause mortality: results from a province-wide fracture liaison service.

Sujic R, Luo J, Beaton DE, Bogoch ER, Sale JEM, Jaglal S, Jain R, Mamdani M; Ontario Osteoporosis Strategy Fracture Screening and Prevention Program Evaluation Team.

Osteoporos Int. 2019 Nov 13. doi: 10.1007/s00198-019-05207-z. [Epub ahead of print]


PRIMPOL-Mediated Adaptive Response Suppresses Replication Fork Reversal in BRCA-Deficient Cells.

Quinet A, Tirman S, Jackson J, Šviković S, Lemaçon D, Carvajal-Maldonado D, González-Acosta D, Vessoni AT, Cybulla E, Wood M, Tavis S, Batista LFZ, Méndez J, Sale JE, Vindigni A.

Mol Cell. 2019 Oct 23. pii: S1097-2765(19)30768-3. doi: 10.1016/j.molcel.2019.10.008. [Epub ahead of print]


"I don't have to think about watching the ground": a qualitative study exploring the concept of vigilance as an important outcome for ankle reconstruction.

Pinsker EB, Sale JEM, Gignac MAM, Daniels TR, Beaton DE.

Arthritis Care Res (Hoboken). 2019 Aug 2. doi: 10.1002/acr.24039. [Epub ahead of print]


Five-year refracture rates of a province-wide fracture liaison service.

Sujic R, Beaton DE, Mamdani M, Cadarette SM, Luo J, Jaglal S, Sale JEM, Jain R, Bogoch E; Ontario Osteoporosis Strategy Fracture Screening and Prevention Program Evaluation Team.

Osteoporos Int. 2019 Aug;30(8):1671-1677. doi: 10.1007/s00198-019-05017-3. Epub 2019 May 31.


Men's perceptions of living with osteoporosis: a systematic review of qualitative studies.

Compton M, Ben Mortenson W, Sale J, Crossman A, Ashe MC.

Int J Orthop Trauma Nurs. 2019 May;33:11-17. doi: 10.1016/j.ijotn.2018.11.007. Epub 2018 Dec 3. Review.


Evidence of patient beliefs, values, and preferences is not provided in osteoporosis clinical practice guidelines.

Sale JEM, Marwah A, Naeem F, Yu W, Meadows L.

Osteoporos Int. 2019 Jul;30(7):1325-1337. doi: 10.1007/s00198-019-04913-y. Epub 2019 Mar 11. Review.


Replication of G Quadruplex DNA.

Lerner LK, Sale JE.

Genes (Basel). 2019 Jan 29;10(2). pii: E95. doi: 10.3390/genes10020095. Review.


Development process and patient usability preferences for a touch screen tablet-based questionnaire.

Lam Shin Cheung V, Kastner M, Sale JE, Straus S, Kaplan A, Boulet LP, Gupta S.

Health Informatics J. 2019 Jan 23:1460458218824749. doi: 10.1177/1460458218824749. [Epub ahead of print]


CtIP-BRCA1 complex and MRE11 maintain replication forks in the presence of chain terminating nucleoside analogs.

Mohiuddin M, Rahman MM, Sale JE, Pearson CE.

Nucleic Acids Res. 2019 Apr 8;47(6):2966-2980. doi: 10.1093/nar/gkz009.


R-loop formation during S phase is restricted by PrimPol-mediated repriming.

Šviković S, Crisp A, Tan-Wong SM, Guilliam TA, Doherty AJ, Proudfoot NJ, Guilbaud G, Sale JE.

EMBO J. 2019 Feb 1;38(3). pii: e99793. doi: 10.15252/embj.201899793. Epub 2018 Nov 26.


Treatment recommendations based on fracture risk status are not consistently provided in osteoporosis guidelines.

Sale JEM, Gray M, Mancuso D, Inrig T, Boire G, Beaulieu MC, Funnell L, Bogoch E.

Rheumatol Int. 2018 Dec;38(12):2193-2208. doi: 10.1007/s00296-018-4181-3. Epub 2018 Oct 26. Review.


Perceived Significance of Engagement in Research Prioritization Among Chronic Kidney Disease Patients, Caregivers, and Health Care Professionals: A Qualitative Study.

Elliott MJ, Goodarzi Z, Sale JEM, Wilhelm LA, Laupacis A, Hemmelgarn BR, Straus SE.

Can J Kidney Health Dis. 2018 Oct 19;5:2054358118807480. doi: 10.1177/2054358118807480. eCollection 2018.


Identifying and Addressing Barriers to Osteoporosis Treatment Associated with Improved Outcomes: An Observational Cohort Study.

Rotondi NK, Beaton DE, Sujic R, Sale JEM, Ansari H, Elliot-Gibson V, Bogoch ER, Cullen J, Jain R, Slater M; Ontario Osteoporosis Strategy Fracture Clinic Screening Program Evaluation Team.

J Rheumatol. 2018 Nov;45(11):1594-1601. doi: 10.3899/jrheum.170915. Epub 2018 Sep 1.


Long-term views on chronic kidney disease research priorities among stakeholders engaged in a priority-setting partnership: A qualitative study.

Elliott MJ, Sale JEM, Goodarzi Z, Wilhelm L, Laupacis A, Hemmelgarn BR, Straus SE.

Health Expect. 2018 Dec;21(6):1142-1149. doi: 10.1111/hex.12818. Epub 2018 Aug 15.


Patient preferences for a touch screen tablet-based asthma questionnaire.

Gupta S, Lam Shin Cheung V, Kastner M, Straus S, Kaplan A, Boulet LP, Sale JEM.

J Asthma. 2019 Jul;56(7):771-781. doi: 10.1080/02770903.2018.1490750. Epub 2018 Sep 28.


Qualitative research is a fundamental scientific process.

Sale JEM, Thielke S.

J Clin Epidemiol. 2018 Oct;102:129-133. doi: 10.1016/j.jclinepi.2018.04.024. Epub 2018 May 21.


A NuRD Complex from Xenopus laevis Eggs Is Essential for DNA Replication during Early Embryogenesis.

Christov CP, Dingwell KS, Skehel M, Wilkes HS, Sale JE, Smith JC, Krude T.

Cell Rep. 2018 Feb 27;22(9):2265-2278. doi: 10.1016/j.celrep.2018.02.015.


Long-term experiences of pain after a fragility fracture.

Gheorghita A, Webster F, Thielke S, Sale JEM.

Osteoporos Int. 2018 May;29(5):1093-1104. doi: 10.1007/s00198-018-4399-7. Epub 2018 Feb 17.


Improvements in osteoporosis testing and care are found following the wide scale implementation of the Ontario Fracture Clinic Screening Program: An interrupted time series analysis.

Beaton DE, Mamdani M, Zheng H, Jaglal S, Cadarette SM, Bogoch ER, Sale JEM, Sujic R, Jain R; Ontario Osteoporosis Strategy Fracture Clinic Screening Program Evaluation Team.

Medicine (Baltimore). 2017 Dec;96(48):e9012. doi: 10.1097/MD.0000000000009012.


Local epigenetic reprogramming induced by G-quadruplex ligands.

Guilbaud G, Murat P, Recolin B, Campbell BC, Maiter A, Sale JE, Balasubramanian S.

Nat Chem. 2017 Nov;9(11):1110-1117. doi: 10.1038/nchem.2828. Epub 2017 Jul 31.


Equal treatment: no evidence of gender inequity in osteoporosis management in a coordinator-based fragility fracture screening program.

Ansari H, Beaton DE, Sujic R, Rotondi NK, Cullen JD, Slater M, Sale JEM, Jain R, Bogoch ER; Ontario Osteoporosis Strategy Fracture Screening and Prevention Program Evaluation Team.

Osteoporos Int. 2017 Dec;28(12):3401-3406. doi: 10.1007/s00198-017-4206-x. Epub 2017 Sep 10.


Pain and fracture-related limitations persist 6 months after a fragility fracture.

Sale JEM, Frankel L, Thielke S, Funnell L.

Rheumatol Int. 2017 Aug;37(8):1317-1322. doi: 10.1007/s00296-017-3761-y. Epub 2017 Jun 20.


Fracture Prevention in the Orthopaedic Environment: Outcomes of a Coordinator-Based Fracture Liaison Service.

Bogoch ER, Elliot-Gibson V, Beaton D, Sale J, Josse RG.

J Bone Joint Surg Am. 2017 May 17;99(10):820-831. doi: 10.2106/JBJS.16.01042.


The theory of planned behaviour explains intentions to use antiresorptive medication after a fragility fracture.

Sale JEM, Cameron C, Thielke S, Meadows L, Senior K.

Rheumatol Int. 2017 Jun;37(6):875-882. doi: 10.1007/s00296-017-3712-7. Epub 2017 Apr 18.


The dominant role of proofreading exonuclease activity of replicative polymerase ε in cellular tolerance to cytarabine (Ara-C).

Tsuda M, Terada K, Ooka M, Kobayashi K, Sasanuma H, Fujisawa R, Tsurimoto T, Yamamoto J, Iwai S, Kadoda K, Akagawa R, Huang SN, Pommier Y, Sale JE, Takeda S, Hirota K.

Oncotarget. 2017 May 16;8(20):33457-33474. doi: 10.18632/oncotarget.16508.


Homologous Recombination and Translesion DNA Synthesis Play Critical Roles on Tolerating DNA Damage Caused by Trace Levels of Hexavalent Chromium.

Tian X, Patel K, Ridpath JR, Chen Y, Zhou YH, Neo D, Clement J, Takata M, Takeda S, Sale J, Wright FA, Swenberg JA, Nakamura J.

PLoS One. 2016 Dec 1;11(12):e0167503. doi: 10.1371/journal.pone.0167503. eCollection 2016.


Reduction of emergency department visits using an urgent clinic for children with established epilepsy.

Patel AD, Terry D, Moore JP, Sale J, Wood EG, Grinspan ZM, Cohen DM.

Neurol Clin Pract. 2016 Dec;6(6):480-486. doi: 10.1212/CPJ.0000000000000286.


The Effects of Replication Stress on S Phase Histone Management and Epigenetic Memory.

Šviković S, Sale JE.

J Mol Biol. 2017 Jun 30;429(13):2011-2029. doi: 10.1016/j.jmb.2016.11.011. Epub 2016 Nov 19. Review.


Addition of a fracture risk assessment to a coordinator's role improved treatment rates within 6 months of screening in a fragility fracture screening program.

Beaton DE, Vidmar M, Pitzul KB, Sujic R, Rotondi NK, Bogoch ER, Sale JEM, Jain R, Weldon J.

Osteoporos Int. 2017 Mar;28(3):863-869. doi: 10.1007/s00198-016-3794-1. Epub 2016 Oct 21.


The disease of corruption: views on how to fight corruption to advance 21st century global health goals.

Mackey TK, Kohler JC, Savedoff WD, Vogl F, Lewis M, Sale J, Michaud J, Vian T.

BMC Med. 2016 Sep 29;14(1):149.


The impact of fragility fractures on work and characteristics associated with time to return to work.

Rotondi NK, Beaton DE, Ilieff M, Adhihetty C, Linton D, Bogoch E, Sale J, Hogg-Johnson S, Jaglal S, Jain R, Weldon J.

Osteoporos Int. 2017 Jan;28(1):349-358. doi: 10.1007/s00198-016-3730-4. Epub 2016 Aug 5.


Starting over: Primpol reprimes after chain termination.

Sale JE.

Cell Cycle. 2016 Aug 17;15(16):2099-2100. Epub 2016 Jul 6. No abstract available.


Comparison of CAROC and FRAX in Fragility Fracture Patients: Agreement, Clinical Utility, and Implications for Clinical Practice.

Rotondi NK, Beaton DE, Elliot-Gibson V, Sujic R, Josse RG, Sale JE, Leslie WD, Bogoch ER.

J Rheumatol. 2016 Aug;43(8):1593-9. doi: 10.3899/jrheum.151409. Epub 2016 Jun 15.


Men's health-seeking behaviours regarding bone health after a fragility fracture: a secondary analysis of qualitative data.

Sale JE, Ashe MC, Beaton D, Bogoch E, Frankel L.

Osteoporos Int. 2016 Oct;27(10):3113-9. doi: 10.1007/s00198-016-3641-4. Epub 2016 May 27.


Histone H3.3 promotes IgV gene diversification by enhancing formation of AID-accessible single-stranded DNA.

Romanello M, Schiavone D, Frey A, Sale JE.

EMBO J. 2016 Jul 1;35(13):1452-64. doi: 10.15252/embj.201693958. Epub 2016 May 23.


In vivo evidence for translesion synthesis by the replicative DNA polymerase δ.

Hirota K, Tsuda M, Mohiuddin, Tsurimoto T, Cohen IS, Livneh Z, Kobayashi K, Narita T, Nishihara K, Murai J, Iwai S, Guilbaud G, Sale JE, Takeda S.

Nucleic Acids Res. 2016 Sep 6;44(15):7242-50. doi: 10.1093/nar/gkw439. Epub 2016 May 16.



Sale JE, Cox TM.

Expert Rev Mol Med. 2016 May 10;18:e10. doi: 10.1017/erm.2016.10. No abstract available.


The KRAB Zinc Finger Protein Roma/Zfp157 Is a Critical Regulator of Cell-Cycle Progression and Genomic Stability.

Ho TLF, Guilbaud G, Blow JJ, Sale JE, Watson CJ.

Cell Rep. 2016 Apr 26;15(4):724-734. doi: 10.1016/j.celrep.2016.03.078. Epub 2016 Apr 14.


The topography of mutational processes in breast cancer genomes.

Morganella S, Alexandrov LB, Glodzik D, Zou X, Davies H, Staaf J, Sieuwerts AM, Brinkman AB, Martin S, Ramakrishna M, Butler A, Kim HY, Borg Å, Sotiriou C, Futreal PA, Campbell PJ, Span PN, Van Laere S, Lakhani SR, Eyfjord JE, Thompson AM, Stunnenberg HG, van de Vijver MJ, Martens JW, Børresen-Dale AL, Richardson AL, Kong G, Thomas G, Sale J, Rada C, Stratton MR, Birney E, Nik-Zainal S.

Nat Commun. 2016 May 2;7:11383. doi: 10.1038/ncomms11383.


The role of HERC2 and RNF8 ubiquitin E3 ligases in the promotion of translesion DNA synthesis in the chicken DT40 cell line.

Mohiuddin, Kobayashi S, Keka IS, Guilbaud G, Sale J, Narita T, Abdel-Aziz HI, Wang X, Ogawa S, Sasanuma H, Chiu R, Oestergaard VH, Lisby M, Takeda S.

DNA Repair (Amst). 2016 Apr;40:67-76. doi: 10.1016/j.dnarep.2016.02.002. Epub 2016 Mar 2.


Understanding Referral Patterns for Bone Mineral Density Testing among Family Physicians: A Qualitative Descriptive Study.

Munce SE, Allin S, Carlin L, Sale J, Hawker G, Kim S, Butt DA, Polidoulis I, Tu K, Jaglal SB.

J Osteoporos. 2016;2016:2937426. doi: 10.1155/2016/2937426. Epub 2016 Jan 19.


Targeting BRCA1 and BRCA2 Deficiencies with G-Quadruplex-Interacting Compounds.

Zimmer J, Tacconi EMC, Folio C, Badie S, Porru M, Klare K, Tumiati M, Markkanen E, Halder S, Ryan A, Jackson SP, Ramadan K, Kuznetsov SG, Biroccio A, Sale JE, Tarsounas M.

Mol Cell. 2016 Feb 4;61(3):449-460. doi: 10.1016/j.molcel.2015.12.004. Epub 2015 Dec 31.


Nucleotide Pool Depletion Induces G-Quadruplex-Dependent Perturbation of Gene Expression.

Papadopoulou C, Guilbaud G, Schiavone D, Sale JE.

Cell Rep. 2015 Dec 22;13(11):2491-2503. doi: 10.1016/j.celrep.2015.11.039. Epub 2015 Dec 10.


PrimPol Is Required for Replicative Tolerance of G Quadruplexes in Vertebrate Cells.

Schiavone D, Jozwiakowski SK, Romanello M, Guilbaud G, Guilliam TA, Bailey LJ, Sale JE, Doherty AJ.

Mol Cell. 2016 Jan 7;61(1):161-9. doi: 10.1016/j.molcel.2015.10.038. Epub 2015 Nov 25.


Clock-like mutational processes in human somatic cells.

Alexandrov LB, Jones PH, Wedge DC, Sale JE, Campbell PJ, Nik-Zainal S, Stratton MR.

Nat Genet. 2015 Dec;47(12):1402-7. doi: 10.1038/ng.3441. Epub 2015 Nov 9.


Bone Mineral Density Reporting Underestimates Fracture Risk in Ontario.

Sale JE, Bogoch E, Meadows L, Gignac M, Frankel L, Inrig T, Beaton D, Jain R.

Health (Irvine Calif). 2015 May;7(5):566-571.


What Do We Know about Individuals Who Are Assessed as Being at Moderate Risk for Future Fracture in Canada?

Sale JE, Jain R, Akilan K, Senior K, Beaton D, Bogoch E, Boire G, Beaulieu MC, Lightfoot D, Funnell L.

Health (Irvine Calif). 2015 May;7(5):514-520.


Directed evolution of human scFvs in DT40 cells.

Lim AW, Williams GT, Rada C, Sale JE.

Protein Eng Des Sel. 2016 Feb;29(2):39-48. doi: 10.1093/protein/gzv058. Epub 2015 Oct 30.


Primary care physicians' perceptions about and confidence in deciding which patients to refer for total joint arthroplasty of the hip and knee.

Waugh EJ, Badley EM, Borkhoff CM, Croxford R, Davis AM, Dunn S, Gignac MA, Jaglal SB, Sale J, Hawker GA.

Osteoarthritis Cartilage. 2016 Mar;24(3):451-7. doi: 10.1016/j.joca.2015.09.017. Epub 2015 Oct 23.


Qualitative Study Exploring the Meaning of Knee Symptoms to Adults Ages 35-65 Years.

MacKay C, Sale J, Badley EM, Jaglal SB, Davis AM.

Arthritis Care Res (Hoboken). 2016 Mar;68(3):341-7. doi: 10.1002/acr.22664.

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