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Items: 1 to 50 of 192

1.

Characterization of the Jomthonic Acids Biosynthesis Pathway and Isolation of Novel Analogues in Streptomyces caniferus GUA-06-05-006A.

García-Salcedo R, Álvarez-Álvarez R, Olano C, Cañedo L, Braña AF, Méndez C, de la Calle F, Salas JA.

Mar Drugs. 2018 Jul 31;16(8). pii: E259. doi: 10.3390/md16080259.

2.

Cooperative Involvement of Glycosyltransferases in the Transfer of Amino Sugars during the Biosynthesis of the Macrolactam Sipanmycin by Streptomyces sp. Strain CS149.

Malmierca MG, Pérez-Victoria I, Martín J, Reyes F, Méndez C, Olano C, Salas JA.

Appl Environ Microbiol. 2018 Aug 31;84(18). pii: e01462-18. doi: 10.1128/AEM.01462-18. Print 2018 Sep 15.

3.

Uncovering production of specialized metabolites by Streptomyces argillaceus: Activation of cryptic biosynthesis gene clusters using nutritional and genetic approaches.

Becerril A, Álvarez S, Braña AF, Rico S, Díaz M, Santamaría RI, Salas JA, Méndez C.

PLoS One. 2018 May 24;13(5):e0198145. doi: 10.1371/journal.pone.0198145. eCollection 2018.

4.

New Insights into the Biosynthesis Pathway of Polyketide Alkaloid Argimycins P in Streptomyces argillaceus.

Ye S, Braña AF, González-Sabín J, Morís F, Olano C, Salas JA, Méndez C.

Front Microbiol. 2018 Feb 16;9:252. doi: 10.3389/fmicb.2018.00252. eCollection 2018.

5.

Searching for Glycosylated Natural Products in Actinomycetes and Identification of Novel Macrolactams and Angucyclines.

Malmierca MG, González-Montes L, Pérez-Victoria I, Sialer C, Braña AF, García Salcedo R, Martín J, Reyes F, Méndez C, Olano C, Salas JA.

Front Microbiol. 2018 Jan 30;9:39. doi: 10.3389/fmicb.2018.00039. eCollection 2018.

6.

Novel Bioactive Paulomycin Derivatives Produced by Streptomyces albus J1074.

Hoz JF, Méndez C, Salas JA, Olano C.

Molecules. 2017 Oct 18;22(10). pii: E1758. doi: 10.3390/molecules22101758.

7.

Exploring the biocombinatorial potential of benzoxazoles: generation of novel caboxamycin derivatives.

Losada AA, Méndez C, Salas JA, Olano C.

Microb Cell Fact. 2017 May 25;16(1):93. doi: 10.1186/s12934-017-0709-6.

8.

Engineered jadomycin analogues with altered sugar moieties revealing JadS as a substrate flexible O-glycosyltransferase.

Li L, Pan G, Zhu X, Fan K, Gao W, Ai G, Ren J, Shi M, Olano C, Salas JA, Yang K.

Appl Microbiol Biotechnol. 2017 Jul;101(13):5291-5300. doi: 10.1007/s00253-017-8256-y. Epub 2017 Apr 20.

PMID:
28429060
9.

Caboxamycin biosynthesis pathway and identification of novel benzoxazoles produced by cross-talk in Streptomyces sp. NTK 937.

Losada AA, Cano-Prieto C, García-Salcedo R, Braña AF, Méndez C, Salas JA, Olano C.

Microb Biotechnol. 2017 Jul;10(4):873-885. doi: 10.1111/1751-7915.12716. Epub 2017 Apr 18.

10.

Identification by Genome Mining of a Type I Polyketide Gene Cluster from Streptomyces argillaceus Involved in the Biosynthesis of Pyridine and Piperidine Alkaloids Argimycins P.

Ye S, Molloy B, Braña AF, Zabala D, Olano C, Cortés J, Morís F, Salas JA, Méndez C.

Front Microbiol. 2017 Feb 10;8:194. doi: 10.3389/fmicb.2017.00194. eCollection 2017.

11.

Elucidation of the glycosylation steps during biosynthesis of antitumor macrolides PM100117 and PM100118 and engineering for novel derivatives.

Salcedo RG, Olano C, Fernández R, Braña AF, Méndez C, de la Calle F, Salas JA.

Microb Cell Fact. 2016 Nov 9;15(1):187.

12.

New insights into paulomycin biosynthesis pathway in Streptomyces albus J1074 and generation of novel derivatives by combinatorial biosynthesis.

González A, Rodríguez M, Braña AF, Méndez C, Salas JA, Olano C.

Microb Cell Fact. 2016 Mar 21;15:56. doi: 10.1186/s12934-016-0452-4.

13.

Characterization and engineering of the biosynthesis gene cluster for antitumor macrolides PM100117 and PM100118 from a marine actinobacteria: generation of a novel improved derivative.

Salcedo RG, Olano C, Gómez C, Fernández R, Braña AF, Méndez C, de la Calle F, Salas JA.

Microb Cell Fact. 2016 Feb 22;15:44. doi: 10.1186/s12934-016-0443-5.

14.

Increasing antibiotic production yields by favoring the biosynthesis of precursor metabolites glucose-1-phosphate and/or malonyl-CoA in Streptomyces producer strains.

Zabala D, Braña AF, Salas JA, Méndez C.

J Antibiot (Tokyo). 2016 Mar;69(3):179-82. doi: 10.1038/ja.2015.104. Epub 2015 Oct 14. No abstract available.

PMID:
26464013
15.

Expanding the Chemical Diversity of the Antitumoral Compound Mithramycin by Combinatorial Biosynthesis and Biocatalysis: The Quest for Mithralogs with Improved Therapeutic Window.

Méndez C, González-Sabín J, Morís F, Salas JA.

Planta Med. 2015 Oct;81(15):1326-38. doi: 10.1055/s-0035-1557876. Epub 2015 Sep 21. Review.

PMID:
26393942
16.

Minimum Information about a Biosynthetic Gene cluster.

Medema MH, Kottmann R, Yilmaz P, Cummings M, Biggins JB, Blin K, de Bruijn I, Chooi YH, Claesen J, Coates RC, Cruz-Morales P, Duddela S, Düsterhus S, Edwards DJ, Fewer DP, Garg N, Geiger C, Gomez-Escribano JP, Greule A, Hadjithomas M, Haines AS, Helfrich EJ, Hillwig ML, Ishida K, Jones AC, Jones CS, Jungmann K, Kegler C, Kim HU, Kötter P, Krug D, Masschelein J, Melnik AV, Mantovani SM, Monroe EA, Moore M, Moss N, Nützmann HW, Pan G, Pati A, Petras D, Reen FJ, Rosconi F, Rui Z, Tian Z, Tobias NJ, Tsunematsu Y, Wiemann P, Wyckoff E, Yan X, Yim G, Yu F, Xie Y, Aigle B, Apel AK, Balibar CJ, Balskus EP, Barona-Gómez F, Bechthold A, Bode HB, Borriss R, Brady SF, Brakhage AA, Caffrey P, Cheng YQ, Clardy J, Cox RJ, De Mot R, Donadio S, Donia MS, van der Donk WA, Dorrestein PC, Doyle S, Driessen AJ, Ehling-Schulz M, Entian KD, Fischbach MA, Gerwick L, Gerwick WH, Gross H, Gust B, Hertweck C, Höfte M, Jensen SE, Ju J, Katz L, Kaysser L, Klassen JL, Keller NP, Kormanec J, Kuipers OP, Kuzuyama T, Kyrpides NC, Kwon HJ, Lautru S, Lavigne R, Lee CY, Linquan B, Liu X, Liu W, Luzhetskyy A, Mahmud T, Mast Y, Méndez C, Metsä-Ketelä M, Micklefield J, Mitchell DA, Moore BS, Moreira LM, Müller R, Neilan BA, Nett M, Nielsen J, O'Gara F, Oikawa H, Osbourn A, Osburne MS, Ostash B, Payne SM, Pernodet JL, Petricek M, Piel J, Ploux O, Raaijmakers JM, Salas JA, Schmitt EK, Scott B, Seipke RF, Shen B, Sherman DH, Sivonen K, Smanski MJ, Sosio M, Stegmann E, Süssmuth RD, Tahlan K, Thomas CM, Tang Y, Truman AW, Viaud M, Walton JD, Walsh CT, Weber T, van Wezel GP, Wilkinson B, Willey JM, Wohlleben W, Wright GD, Ziemert N, Zhang C, Zotchev SB, Breitling R, Takano E, Glöckner FO.

Nat Chem Biol. 2015 Sep;11(9):625-31. doi: 10.1038/nchembio.1890. No abstract available.

17.

Crosstalk of Nataxazole Pathway with Chorismate-Derived Ionophore Biosynthesis Pathways in Streptomyces sp. Tü 6176.

Cano-Prieto C, Losada AA, Braña AF, Méndez C, Salas JA, Olano C.

Chembiochem. 2015 Sep 7;16(13):1925-1932. doi: 10.1002/cbic.201500261. Epub 2015 Jul 14.

PMID:
26083234
18.

Genome Mining of Streptomyces sp. Tü 6176: Characterization of the Nataxazole Biosynthesis Pathway.

Cano-Prieto C, García-Salcedo R, Sánchez-Hidalgo M, Braña AF, Fiedler HP, Méndez C, Salas JA, Olano C.

Chembiochem. 2015 Jul 6;16(10):1461-73. doi: 10.1002/cbic.201500153. Epub 2015 May 26.

PMID:
25892546
19.

Transcriptional regulation of mithramycin biosynthesis in Streptomyces argillaceus: dual role as activator and repressor of the PadR-like regulator MtrY.

Flórez AB, Álvarez S, Zabala D, Braña AF, Salas JA, Méndez C.

Microbiology. 2015 Feb;161(Pt 2):272-84.

PMID:
25416691
20.

Draft Genome Sequence of Marine Actinomycete Streptomyces sp. Strain NTK 937, Producer of the Benzoxazole Antibiotic Caboxamycin.

Olano C, Cano-Prieto C, Losada AA, Bull AT, Goodfellow M, Fiedler HP, Méndez C, Salas JA.

Genome Announc. 2014 Jul 3;2(4). pii: e00534-14. doi: 10.1128/genomeA.00534-14.

21.

Activation and identification of five clusters for secondary metabolites in Streptomyces albus J1074.

Olano C, García I, González A, Rodriguez M, Rozas D, Rubio J, Sánchez-Hidalgo M, Braña AF, Méndez C, Salas JA.

Microb Biotechnol. 2014 May;7(3):242-56. doi: 10.1111/1751-7915.12116. Epub 2014 Mar 4.

22.

Collismycin A biosynthesis in Streptomyces sp. CS40 is regulated by iron levels through two pathway-specific regulators.

Vior NM, Olano C, García I, Méndez C, Salas JA.

Microbiology. 2014 Mar;160(Pt 3):467-78. doi: 10.1099/mic.0.075218-0. Epub 2013 Dec 18.

PMID:
24353310
23.

Engineering precursor metabolite pools for increasing production of antitumor mithramycins in Streptomyces argillaceus.

Zabala D, Braña AF, Flórez AB, Salas JA, Méndez C.

Metab Eng. 2013 Nov;20:187-97. doi: 10.1016/j.ymben.2013.10.002. Epub 2013 Oct 19.

PMID:
24148183
24.

Generation by mutasynthesis of potential neuroprotectant derivatives of the bipyridyl collismycin A.

Sialer C, García I, González-Sabín J, Braña AF, Méndez C, Morís F, Salas JA.

Bioorg Med Chem Lett. 2013 Oct 15;23(20):5707-9. doi: 10.1016/j.bmcl.2013.08.017. Epub 2013 Aug 12.

PMID:
23993774
25.

Engineering the biosynthesis of the polyketide-nonribosomal peptide collismycin A for generation of analogs with neuroprotective activity.

Garcia I, Vior NM, González-Sabín J, Braña AF, Rohr J, Moris F, Méndez C, Salas JA.

Chem Biol. 2013 Aug 22;20(8):1022-32. doi: 10.1016/j.chembiol.2013.06.014. Epub 2013 Aug 1.

26.

High level of antibiotic production in a double polyphosphate kinase and phosphate-binding protein mutant of Streptomyces lividans.

Díaz M, Sevillano L, Rico S, Lombo F, Braña AF, Salas JA, Mendez C, Santamaría RI.

FEMS Microbiol Lett. 2013 May;342(2):123-9. doi: 10.1111/1574-6968.12098. Epub 2013 Feb 28.

27.

Novel mithramycins abrogate the involvement of protein factors in the transcription of cell cycle control genes.

Vizcaíno C, Mansilla S, Núñez LE, Méndez C, Salas JA, Morís F, Portugal J.

Biochem Pharmacol. 2012 Nov 1;84(9):1133-42. doi: 10.1016/j.bcp.2012.08.003. Epub 2012 Aug 14.

PMID:
22981341
28.

Three pathway-specific regulators control streptolydigin biosynthesis in Streptomyces lydicus.

Gómez C, Olano C, Méndez C, Salas JA.

Microbiology. 2012 Oct;158(Pt 10):2504-14. Epub 2012 Jul 19.

PMID:
22820841
29.

Participation of putative glycoside hydrolases SlgC1 and SlgC2 in the biosynthesis of streptolydigin in Streptomyces lydicus.

Gómez C, Horna DH, Olano C, Méndez C, Salas JA.

Microb Biotechnol. 2012 Sep;5(5):663-7. doi: 10.1111/j.1751-7915.2012.00352.x. Epub 2012 Jun 22.

30.

Lipase-catalyzed preparation of chromomycin A₃ analogues and biological evaluation for anticancer activity.

González-Sabín J, Núñez LE, Menéndez N, Braña AF, Méndez C, Salas JA, Gotor V, Morís F.

Bioorg Med Chem Lett. 2012 Jul 1;22(13):4310-3. doi: 10.1016/j.bmcl.2012.05.015. Epub 2012 May 11.

PMID:
22647722
31.

A novel mithramycin analogue with high antitumor activity and less toxicity generated by combinatorial biosynthesis.

Núñez LE, Nybo SE, González-Sabín J, Pérez M, Menéndez N, Braña AF, Shaaban KA, He M, Morís F, Salas JA, Rohr J, Méndez C.

J Med Chem. 2012 Jun 28;55(12):5813-25. doi: 10.1021/jm300234t. Epub 2012 Jun 7.

32.

Novel compounds produced by Streptomyces lydicus NRRL 2433 engineered mutants altered in the biosynthesis of streptolydigin.

Gómez C, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Antibiot (Tokyo). 2012 Jul;65(7):341-8. doi: 10.1038/ja.2012.37. Epub 2012 May 9.

PMID:
22569159
33.

Elucidating the biosynthetic pathway for the polyketide-nonribosomal peptide collismycin A: mechanism for formation of the 2,2'-bipyridyl ring.

Garcia I, Vior NM, Braña AF, González-Sabin J, Rohr J, Moris F, Méndez C, Salas JA.

Chem Biol. 2012 Mar 23;19(3):399-413. doi: 10.1016/j.chembiol.2012.01.014.

34.

Ketoolivosyl-tetracenomycin C: a new ketosugar bearing tetracenomycin reveals new insight into the substrate flexibility of glycosyltransferase ElmGT.

Nybo SE, Shabaan KA, Kharel MK, Sutardjo H, Salas JA, Méndez C, Rohr J.

Bioorg Med Chem Lett. 2012 Mar 15;22(6):2247-50. doi: 10.1016/j.bmcl.2012.01.094. Epub 2012 Feb 3.

35.

Amino acid precursor supply in the biosynthesis of the RNA polymerase inhibitor streptolydigin by Streptomyces lydicus.

Gómez C, Horna DH, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2011 Aug;193(16):4214-23. doi: 10.1128/JB.05062-11. Epub 2011 Jun 10.

36.

Biosynthesis of the RNA polymerase inhibitor streptolydigin in Streptomyces lydicus: tailoring modification of 3-methyl-aspartate.

Horna DH, Gómez C, Olano C, Palomino-Schätzlein M, Pineda-Lucena A, Carbajo RJ, Braña AF, Méndez C, Salas JA.

J Bacteriol. 2011 May;193(10):2647-51. doi: 10.1128/JB.00108-11. Epub 2011 Mar 11.

37.

The chromomycin CmmA acetyltransferase: a membrane-bound enzyme as a tool for increasing structural diversity of the antitumour mithramycin.

García B, González-Sabín J, Menéndez N, Braña AF, Núñez LE, Morís F, Salas JA, Méndez C.

Microb Biotechnol. 2011 Mar;4(2):226-38. doi: 10.1111/j.1751-7915.2010.00229.x. Epub 2010 Nov 18.

38.

Molecular insights on the biosynthesis of antitumour compounds by actinomycetes.

Olano C, Méndez C, Salas JA.

Microb Biotechnol. 2011 Mar;4(2):144-64. doi: 10.1111/j.1751-7915.2010.00231.x. Epub 2010 Nov 18. Review.

39.

Mutational analysis of the thienamycin biosynthetic gene cluster from Streptomyces cattleya.

Rodríguez M, Núñez LE, Braña AF, Méndez C, Salas JA, Blanco G.

Antimicrob Agents Chemother. 2011 Apr;55(4):1638-49. doi: 10.1128/AAC.01366-10. Epub 2011 Jan 24.

40.

Characterization of the terminal activation step catalyzed by oxygenase CmmOIV of the chromomycin biosynthetic pathway from Streptomyces griseus.

Bosserman MA, Flórez AB, Shaaban KA, Braña AF, Salas JA, Méndez C, Rohr J.

Biochemistry. 2011 Mar 1;50(8):1421-8. doi: 10.1021/bi1016205. Epub 2011 Feb 2.

41.

Engineered biosynthesis of gilvocarcin analogues with altered deoxyhexopyranose moieties.

Shepherd MD, Liu T, Méndez C, Salas JA, Rohr J.

Appl Environ Microbiol. 2011 Jan;77(2):435-41. doi: 10.1128/AEM.01774-10. Epub 2010 Nov 12.

42.

Retraction.

Beloqui A, Guazzaroni ME, Pazos F, Vieites JM, Godoy M, Golyshina OV, Chernikova TN, Waliczek A, Silva-Rocha R, Al-Ramahi Y, La Cono V, Mendez C, Salas JA, Solano R, Yakimov MM, Timmis KN, Golyshin PN, Ferrer M.

Science. 2010 Nov 12;330(6006):912. doi: 10.1126/science.330.6006.912-a. No abstract available.

PMID:
21071648
43.

DNA binding characteristics of mithramycin and chromomycin analogues obtained by combinatorial biosynthesis.

Barceló F, Ortiz-Lombardía M, Martorell M, Oliver M, Méndez C, Salas JA, Portugal J.

Biochemistry. 2010 Dec 14;49(49):10543-52. doi: 10.1021/bi101398s. Epub 2010 Nov 16.

PMID:
21067184
44.
45.

Formation and attachment of the deoxysugar moiety and assembly of the gene cluster for caprazamycin biosynthesis.

Kaysser L, Wemakor E, Siebenberg S, Salas JA, Sohng JK, Kammerer B, Gust B.

Appl Environ Microbiol. 2010 Jun;76(12):4008-18. doi: 10.1128/AEM.02740-09. Epub 2010 Apr 23.

46.

Post-PKS tailoring steps in natural product-producing actinomycetes from the perspective of combinatorial biosynthesis.

Olano C, Méndez C, Salas JA.

Nat Prod Rep. 2010 Apr;27(4):571-616. Review.

PMID:
20352666
47.

Involvement of the beta subunit of RNA polymerase in resistance to streptolydigin and streptovaricin in the producer organisms Streptomyces lydicus and Streptomyces spectabilis.

Sánchez-Hidalgo M, Núñez LE, Méndez C, Salas JA.

Antimicrob Agents Chemother. 2010 May;54(5):1684-92. doi: 10.1128/AAC.01406-09. Epub 2010 Feb 22.

48.

A new scaffold of an old protein fold ensures binding to the bisintercalator thiocoraline.

Biswas T, Zolova OE, Lombó F, de la Calle F, Salas JA, Tsodikov OV, Garneau-Tsodikova S.

J Mol Biol. 2010 Mar 26;397(2):495-507. doi: 10.1016/j.jmb.2010.01.053. Epub 2010 Feb 1.

PMID:
20122935
49.

Transcriptional organization of ThnI-regulated thienamycin biosynthetic genes in Streptomyces cattleya.

Rodríguez M, Méndez C, Salas JA, Blanco G.

J Antibiot (Tokyo). 2010 Mar;63(3):135-8. doi: 10.1038/ja.2009.133. Epub 2010 Jan 22. No abstract available.

PMID:
20094070
50.

Differential inhibition of restriction enzyme cleavage by chromophore-modified analogues of the antitumour antibiotics mithramycin and chromomycin reveals structure-activity relationships.

Mansilla S, Garcia-Ferrer I, Méndez C, Salas JA, Portugal J.

Biochem Pharmacol. 2010 May 15;79(10):1418-27. doi: 10.1016/j.bcp.2010.01.005. Epub 2010 Jan 20.

PMID:
20093108

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