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Items: 6


M344 promotes nonamyloidogenic amyloid precursor protein processing while normalizing Alzheimer's disease genes and improving memory.

Volmar CH, Salah-Uddin H, Janczura KJ, Halley P, Lambert G, Wodrich A, Manoah S, Patel NH, Sartor GC, Mehta N, Miles NTH, Desse S, Dorcius D, Cameron MD, Brothers SP, Wahlestedt C.

Proc Natl Acad Sci U S A. 2017 Oct 24;114(43):E9135-E9144. doi: 10.1073/pnas.1707544114. Epub 2017 Oct 9.


Amygdala-dependent fear is regulated by Oprl1 in mice and humans with PTSD.

Andero R, Brothers SP, Jovanovic T, Chen YT, Salah-Uddin H, Cameron M, Bannister TD, Almli L, Stevens JS, Bradley B, Binder EB, Wahlestedt C, Ressler KJ.

Sci Transl Med. 2013 Jun 5;5(188):188ra73. doi: 10.1126/scitranslmed.3005656.


Regulation of neuronal plasticity and fear by a dynamic change in PAR1-G protein coupling in the amygdala.

Bourgognon JM, Schiavon E, Salah-Uddin H, Skrzypiec AE, Attwood BK, Shah RS, Patel SG, Mucha M, John Challiss RA, Forsythe ID, Pawlak R.

Mol Psychiatry. 2013 Oct;18(10):1136-45. doi: 10.1038/mp.2012.133. Epub 2012 Oct 2.


Altered M(1) muscarinic acetylcholine receptor (CHRM1)-Galpha(q/11) coupling in a schizophrenia endophenotype.

Salah-Uddin H, Scarr E, Pavey G, Harris K, Hagan JJ, Dean B, Challiss RA, Watson JM.

Neuropsychopharmacology. 2009 Aug;34(9):2156-66. doi: 10.1038/npp.2009.41. Epub 2009 Apr 29.


Pharmacological assessment of m1 muscarinic acetylcholine receptor-gq/11 protein coupling in membranes prepared from postmortem human brain tissue.

Salah-Uddin H, Thomas DR, Davies CH, Hagan JJ, Wood MD, Watson JM, Challiss RA.

J Pharmacol Exp Ther. 2008 Jun;325(3):869-74. doi: 10.1124/jpet.108.137968. Epub 2008 Mar 5.


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