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Functional dissociations between subregions of the medial prefrontal cortex on the rodent touchscreen continuous performance test (rCPT) of attention.

Fisher BM, Saksida LM, Robbins TW, Bussey TJ.

Behav Neurosci. 2020 Feb;134(1):1-14. doi: 10.1037/bne0000338. Epub 2019 Dec 12.


MouseBytes, an open-access high-throughput pipeline and database for rodent touchscreen-based cognitive assessment.

Beraldo FH, Palmer D, Memar S, Wasserman DI, Lee WV, Liang S, Creighton SD, Kolisnyk B, Cowan MF, Mels J, Masood TS, Fodor C, Al-Onaizi MA, Bartha R, Gee T, Saksida LM, Bussey TJ, Strother SS, Prado VF, Winters BD, Prado MA.

Elife. 2019 Dec 11;8. pii: e49630. doi: 10.7554/eLife.49630.


A Touchscreen Motivation Assessment Evaluated in Huntington's Disease Patients and R6/1 Model Mice.

Heath CJ, O'Callaghan C, Mason SL, Phillips BU, Saksida LM, Robbins TW, Barker RA, Bussey TJ, Sahakian BJ.

Front Neurol. 2019 Aug 9;10:858. doi: 10.3389/fneur.2019.00858. eCollection 2019.


Perineuronal Nets: Plasticity, Protection, and Therapeutic Potential.

Reichelt AC, Hare DJ, Bussey TJ, Saksida LM.

Trends Neurosci. 2019 Jul;42(7):458-470. doi: 10.1016/j.tins.2019.04.003. Epub 2019 Jun 4. Review.


Selective decrease of cholinergic signaling from pedunculopontine and laterodorsal tegmental nuclei has little impact on cognition but markedly increases susceptibility to stress.

Janickova H, Kljakic O, Rosborough K, Raulic S, Matovic S, Gros R, Saksida LM, Bussey TJ, Inoue W, Prado VF, Prado MAM.

FASEB J. 2019 Jun;33(6):7018-7036. doi: 10.1096/fj.201802108R. Epub 2019 Mar 11.


Blockade of muscarinic acetylcholine receptors facilitates motivated behaviour and rescues a model of antipsychotic-induced amotivation.

Hailwood JM, Heath CJ, Phillips BU, Robbins TW, Saksida LM, Bussey TJ.

Neuropsychopharmacology. 2019 May;44(6):1068-1075. doi: 10.1038/s41386-018-0281-8. Epub 2018 Nov 27.


Continuous performance test impairment in a 22q11.2 microdeletion mouse model: improvement by amphetamine.

Nilsson SRO, Heath CJ, Takillah S, Didienne S, Fejgin K, Nielsen V, Nielsen J, Saksida LM, Mariani J, Faure P, Didriksen M, Robbins TW, Bussey TJ, Mar AC.

Transl Psychiatry. 2018 Nov 14;8(1):247. doi: 10.1038/s41398-018-0295-3.


Impaired object-location learning and recognition memory but enhanced sustained attention in M2 muscarinic receptor-deficient mice.

Romberg C, Bartko S, Wess J, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2018 Dec;235(12):3495-3508. doi: 10.1007/s00213-018-5065-7. Epub 2018 Oct 16.


Translational tests involving non-reward: methodological considerations.

Phillips BU, Lopez-Cruz L, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2019 Jan;236(1):449-461. doi: 10.1007/s00213-018-5062-x. Epub 2018 Oct 10. Review.


Oxygen responses within the nucleus accumbens are associated with individual differences in effort exertion in rats.

Hailwood JM, Gilmour G, Robbins TW, Saksida LM, Bussey TJ, Marston HM, Gastambide F.

Eur J Neurosci. 2018 Nov;48(9):2971-2987. doi: 10.1111/ejn.14150. Epub 2018 Sep 28.


Assessment of Cognitive Impairment in a Mouse Model of High-Fat Diet-Induced Metabolic Stress with Touchscreen-Based Automated Battery System.

Lee S, Kim JY, Kim E, Seo K, Kang YJ, Kim JY, Kim CH, Song HT, Saksida LM, Lee JE.

Exp Neurobiol. 2018 Aug;27(4):277-286. doi: 10.5607/en.2018.27.4.277. Epub 2018 Aug 30.


NMDA receptors and BDNF are necessary for discrimination of overlapping spatial and non-spatial memories in perirhinal cortex and hippocampus.

Miranda M, Kent BA, Morici JF, Gallo F, Saksida LM, Bussey TJ, Weisstaub N, Bekinschtein P.

Neurobiol Learn Mem. 2018 Nov;155:337-343. doi: 10.1016/j.nlm.2018.08.019. Epub 2018 Aug 30.


Basal Forebrain and Brainstem Cholinergic Neurons Differentially Impact Amygdala Circuits and Learning-Related Behavior.

Aitta-Aho T, Hay YA, Phillips BU, Saksida LM, Bussey TJ, Paulsen O, Apergis-Schoute J.

Curr Biol. 2018 Aug 20;28(16):2557-2569.e4. doi: 10.1016/j.cub.2018.06.064. Epub 2018 Aug 9.


Validation and optimisation of a touchscreen progressive ratio test of motivation in male rats.

Hailwood JM, Heath CJ, Robbins TW, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2018 Sep;235(9):2739-2753. doi: 10.1007/s00213-018-4969-6. Epub 2018 Jul 14.


Publisher Correction: TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.

White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S, Massenzio F, Lin Z, Andrews S, Segonds-Pichon A, Metterville J, Saksida LM, Mead R, Ribchester RR, Barhomi Y, Serre T, Coleman MP, Fallon JR, Bussey TJ, Brown RH Jr, Sreedharan J.

Nat Neurosci. 2018 Aug;21(8):1138. doi: 10.1038/s41593-018-0160-y.


Small vessels, dementia and chronic diseases - molecular mechanisms and pathophysiology.

Horsburgh K, Wardlaw JM, van Agtmael T, Allan SM, Ashford MLJ, Bath PM, Brown R, Berwick J, Cader MZ, Carare RO, Davis JB, Duncombe J, Farr TD, Fowler JH, Goense J, Granata A, Hall CN, Hainsworth AH, Harvey A, Hawkes CA, Joutel A, Kalaria RN, Kehoe PG, Lawrence CB, Lockhart A, Love S, Macleod MR, Macrae IM, Markus HS, McCabe C, McColl BW, Meakin PJ, Miller A, Nedergaard M, O'Sullivan M, Quinn TJ, Rajani R, Saksida LM, Smith C, Smith KJ, Touyz RM, Trueman RC, Wang T, Williams A, Williams SCR, Work LM.

Clin Sci (Lond). 2018 Apr 30;132(8):851-868. doi: 10.1042/CS20171620. Print 2018 Apr 30.


Selective effects of 5-HT2C receptor modulation on performance of a novel valence-probe visual discrimination task and probabilistic reversal learning in mice.

Phillips BU, Dewan S, Nilsson SRO, Robbins TW, Heath CJ, Saksida LM, Bussey TJ, Alsiö J.

Psychopharmacology (Berl). 2018 Jul;235(7):2101-2111. doi: 10.1007/s00213-018-4907-7. Epub 2018 Apr 22.


Longitudinal evaluation of Tau-P301L transgenic mice reveals no cognitive impairments at 17 months of age.

Kent BA, Heath CJ, Kim CH, Ahrens R, Fraser PE, St George-Hyslop P, Bussey TJ, Saksida LM.

Brain Behav. 2017 Dec 18;8(1):e00896. doi: 10.1002/brb3.896. eCollection 2018 Jan.


TDP-43 gains function due to perturbed autoregulation in a Tardbp knock-in mouse model of ALS-FTD.

White MA, Kim E, Duffy A, Adalbert R, Phillips BU, Peters OM, Stephenson J, Yang S, Massenzio F, Lin Z, Andrews S, Segonds-Pichon A, Metterville J, Saksida LM, Mead R, Ribchester RR, Barhomi Y, Serre T, Coleman MP, Fallon JR, Bussey TJ, Brown RH Jr, Sreedharan J.

Nat Neurosci. 2018 Apr;21(4):552-563. doi: 10.1038/s41593-018-0113-5. Epub 2018 Mar 19. Erratum in: Nat Neurosci. 2018 Aug;21(8):1138.


Effects of anterior cingulate cortex lesions on a continuous performance task for mice.

Hvoslef-Eide M, Nilsson SR, Hailwood JM, Robbins TW, Saksida LM, Mar AC, Bussey TJ.

Brain Neurosci Adv. 2018 Jan;2. doi: 10.1177/2398212818772962. Epub 2018 May 29.


Enhanced cognition and dysregulated hippocampal synaptic physiology in mice with a heterozygous deletion of PSD-95.

Horner AE, McLaughlin CL, Afinowi NO, Bussey TJ, Saksida LM, Komiyama NH, Grant SGN, Kopanitsa MV.

Eur J Neurosci. 2018 Jan;47(2):164-176. doi: 10.1111/ejn.13792. Epub 2018 Jan 10.


Molecular Mechanisms in Perirhinal Cortex Selectively Necessary for Discrimination of Overlapping Memories, but Independent of Memory Persistence.

Miranda M, Kent BA, Morici JF, Gallo F, Weisstaub NV, Saksida LM, Bussey TJ, Bekinschtein P.

eNeuro. 2017 Oct 18;4(5). pii: ENEURO.0293-17.2017. doi: 10.1523/ENEURO.0293-17.2017. eCollection 2017 Sep-Oct.


Antibody recognizing 4-sulfated chondroitin sulfate proteoglycans restores memory in tauopathy-induced neurodegeneration.

Yang S, Hilton S, Alves JN, Saksida LM, Bussey T, Matthews RT, Kitagawa H, Spillantini MG, Kwok JCF, Fawcett JW.

Neurobiol Aging. 2017 Nov;59:197-209. doi: 10.1016/j.neurobiolaging.2017.08.002. Epub 2017 Aug 9.


MAM-E17 rat model impairments on a novel continuous performance task: effects of potential cognitive enhancing drugs.

Mar AC, Nilsson SRO, Gamallo-Lana B, Lei M, Dourado T, Alsiö J, Saksida LM, Bussey TJ, Robbins TW.

Psychopharmacology (Berl). 2017 Oct;234(19):2837-2857. doi: 10.1007/s00213-017-4679-5. Epub 2017 Jul 26.


Optimizing reproducibility of operant testing through reinforcer standardization: identification of key nutritional constituents determining reward strength in touchscreens.

Kim EW, Phillips BU, Heath CJ, Cho SY, Kim H, Sreedharan J, Song HT, Lee JE, Bussey TJ, Kim CH, Kim E, Saksida LM.

Mol Brain. 2017 Jul 17;10(1):31. doi: 10.1186/s13041-017-0312-0.


Accumbal Cholinergic Interneurons Differentially Influence Motivation Related to Satiety Signaling.

Aitta-Aho T, Phillips BU, Pappa E, Hay YA, Harnischfeger F, Heath CJ, Saksida LM, Bussey TJ, Apergis-Schoute J.

eNeuro. 2017 May 9;4(2). pii: ENEURO.0328-16.2017. doi: 10.1523/ENEURO.0328-16.2017. eCollection 2017 Mar-Apr.


Optimisation of cognitive performance in rodent operant (touchscreen) testing: Evaluation and effects of reinforcer strength.

Phillips BU, Heath CJ, Ossowska Z, Bussey TJ, Saksida LM.

Learn Behav. 2017 Sep;45(3):252-262. doi: 10.3758/s13420-017-0260-7.


Haploinsufficiency of EHMT1 improves pattern separation and increases hippocampal cell proliferation.

Benevento M, Oomen CA, Horner AE, Amiri H, Jacobs T, Pauwels C, Frega M, Kleefstra T, Kopanitsa MV, Grant SG, Bussey TJ, Saksida LM, Van der Zee CE, van Bokhoven H, Glennon JC, Kasri NN.

Sci Rep. 2017 Jan 10;7:40284. doi: 10.1038/srep40284.


Assessing the Cognitive Translational Potential of a Mouse Model of the 22q11.2 Microdeletion Syndrome.

Nilsson SR, Fejgin K, Gastambide F, Vogt MA, Kent BA, Nielsen V, Nielsen J, Gass P, Robbins TW, Saksida LM, Stensbøl TB, Tricklebank MD, Didriksen M, Bussey TJ.

Cereb Cortex. 2016 Oct;26(10):3991-4003. doi: 10.1093/cercor/bhw229. Epub 2016 Aug 9.


Erratum to: The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function.

Kim CH, Hvoslef-Eide M, Nilsson SR, Johnson MR, Herbert BR, Robbins TW, Saksida LM, Bussey TJ, Mar AC.

Psychopharmacology (Berl). 2016 Sep;233(18):3471. No abstract available.


Cognitive Translation Using the Rodent Touchscreen Testing Approach.

Hvoslef-Eide M, Nilsson SR, Saksida LM, Bussey TJ.

Curr Top Behav Neurosci. 2016;28:423-47. doi: 10.1007/7854_2015_5007. Review.


A mouse model of the 15q13.3 microdeletion syndrome shows prefrontal neurophysiological dysfunctions and attentional impairment.

Nilsson SRO, Celada P, Fejgin K, Thelin J, Nielsen J, Santana N, Heath CJ, Larsen PH, Nielsen V, Kent BA, Saksida LM, Stensbøl TB, Robbins TW, Bastlund JF, Bussey TJ, Artigas F, Didriksen M.

Psychopharmacology (Berl). 2016 Jun;233(11):2151-2163. doi: 10.1007/s00213-016-4265-2. Epub 2016 Mar 17.


The representational-hierarchical view of pattern separation: Not just hippocampus, not just space, not just memory?

Kent BA, Hvoslef-Eide M, Saksida LM, Bussey TJ.

Neurobiol Learn Mem. 2016 Mar;129:99-106. doi: 10.1016/j.nlm.2016.01.006. Epub 2016 Feb 1.


Measuring Motivation and Reward-Related Decision Making in the Rodent Operant Touchscreen System.

Heath CJ, Phillips BU, Bussey TJ, Saksida LM.

Curr Protoc Neurosci. 2016 Jan 4;74:8.34.1-8.34.20. doi: 10.1002/0471142301.ns0834s74.


Performance of transgenic TgTau-P301L mice in a 5-choice serial reaction time task (5-CSRTT) as a model of Alzheimer's disease.

Bharmal AV, Kent BA, Bussey TJ, Saksida LM.

Psychiatr Danub. 2015 Sep;27 Suppl 1:S515-25.


Bridging the translational divide: identical cognitive touchscreen testing in mice and humans carrying mutations in a disease-relevant homologous gene.

Nithianantharajah J, McKechanie AG, Stewart TJ, Johnstone M, Blackwood DH, St Clair D, Grant SG, Bussey TJ, Saksida LM.

Sci Rep. 2015 Oct 1;5:14613. doi: 10.1038/srep14613.


The continuous performance test (rCPT) for mice: a novel operant touchscreen test of attentional function.

Kim CH, Hvoslef-Eide M, Nilsson SR, Johnson MR, Herbert BR, Robbins TW, Saksida LM, Bussey TJ, Mar AC.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3947-66. doi: 10.1007/s00213-015-4081-0. Epub 2015 Sep 29. Erratum in: Psychopharmacology (Berl). 2016 Sep;233(18):3471.


Adult hippocampal neurogenesis and its role in cognition.

Oomen CA, Bekinschtein P, Kent BA, Saksida LM, Bussey TJ.

Wiley Interdiscip Rev Cogn Sci. 2014 Sep;5(5):573-587. doi: 10.1002/wcs.1304. Epub 2014 Aug 12.


Facilitation of spatial working memory performance following intra-prefrontal cortical administration of the adrenergic alpha1 agonist phenylephrine.

Hvoslef-Eide M, Oomen CA, Fisher BM, Heath CJ, Robbins TW, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2015 Nov;232(21-22):4005-16. doi: 10.1007/s00213-015-4038-3. Epub 2015 Aug 12.


A novel 2- and 3-choice touchscreen-based continuous trial-unique nonmatching-to-location task (cTUNL) sensitive to functional differences between dentate gyrus and CA3 subregions of the hippocampus.

Oomen CA, Hvoslef-Eide M, Kofink D, Preusser F, Mar AC, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3921-3933. doi: 10.1007/s00213-015-4019-6. Epub 2015 Jul 30.


Erratum to: The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice.

Kim CH, Heath CJ, Kent BA, Horner AE, Bussey TJ, Saksida LM.

Psychopharmacology (Berl). 2015 Dec;232(24):4537. doi: 10.1007/s00213-015-4025-8. No abstract available.


The NEWMEDS rodent touchscreen test battery for cognition relevant to schizophrenia.

Hvoslef-Eide M, Mar AC, Nilsson SR, Alsiö J, Heath CJ, Saksida LM, Robbins TW, Bussey TJ.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3853-72. doi: 10.1007/s00213-015-4007-x. Epub 2015 Jul 24. Review.


Comparing the effects of subchronic phencyclidine and medial prefrontal cortex dysfunction on cognitive tests relevant to schizophrenia.

McAllister KA, Mar AC, Theobald DE, Saksida LM, Bussey TJ.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3883-97. doi: 10.1007/s00213-015-4018-7. Epub 2015 Jul 21.


Trial-unique, delayed nonmatching-to-location (TUNL) touchscreen testing for mice: sensitivity to dorsal hippocampal dysfunction.

Kim CH, Romberg C, Hvoslef-Eide M, Oomen CA, Mar AC, Heath CJ, Berthiaume AA, Bussey TJ, Saksida LM.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3935-45. doi: 10.1007/s00213-015-4017-8. Epub 2015 Jul 15.


Motivational assessment of mice using the touchscreen operant testing system: effects of dopaminergic drugs.

Heath CJ, Bussey TJ, Saksida LM.

Psychopharmacology (Berl). 2015 Nov;232(21-22):4043-57. doi: 10.1007/s00213-015-4009-8. Epub 2015 Jul 10.


The role of the dorsal hippocampus in two versions of the touchscreen automated paired associates learning (PAL) task for mice.

Kim CH, Heath CJ, Kent BA, Bussey TJ, Saksida LM.

Psychopharmacology (Berl). 2015 Nov;232(21-22):3899-910. doi: 10.1007/s00213-015-3949-3. Epub 2015 May 13. Erratum in: Psychopharmacology (Berl). 2015 Dec;232(24):4537.


Perineuronal net digestion with chondroitinase restores memory in mice with tau pathology.

Yang S, Cacquevel M, Saksida LM, Bussey TJ, Schneider BL, Aebischer P, Melani R, Pizzorusso T, Fawcett JW, Spillantini MG.

Exp Neurol. 2015 Mar;265:48-58. doi: 10.1016/j.expneurol.2014.11.013. Epub 2014 Dec 4.


The orexigenic hormone acyl-ghrelin increases adult hippocampal neurogenesis and enhances pattern separation.

Kent BA, Beynon AL, Hornsby AK, Bekinschtein P, Bussey TJ, Davies JS, Saksida LM.

Psychoneuroendocrinology. 2015 Jan;51:431-9. doi: 10.1016/j.psyneuen.2014.10.015. Epub 2014 Oct 23.


Calpain inhibition mediates autophagy-dependent protection against polyglutamine toxicity.

Menzies FM, Garcia-Arencibia M, Imarisio S, O'Sullivan NC, Ricketts T, Kent BA, Rao MV, Lam W, Green-Thompson ZW, Nixon RA, Saksida LM, Bussey TJ, O'Kane CJ, Rubinsztein DC.

Cell Death Differ. 2015 Mar;22(3):433-44. doi: 10.1038/cdd.2014.151. Epub 2014 Sep 26.


Brain-derived neurotrophic factor interacts with adult-born immature cells in the dentate gyrus during consolidation of overlapping memories.

Bekinschtein P, Kent BA, Oomen CA, Clemenson GD, Gage FH, Saksida LM, Bussey TJ.

Hippocampus. 2014 Aug;24(8):905-11. doi: 10.1002/hipo.22304. Epub 2014 May 23.

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