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Items: 1 to 50 of 113

1.

MC159 of Molluscum Contagiosum Virus Suppresses Autophagy by Recruiting Cellular SH3BP4 via an SH3 Domain-Mediated Interaction.

Schmotz C, Uğurlu H, Vilen S, Shrestha S, Fagerlund R, Saksela K.

J Virol. 2019 May 1;93(10). pii: e01613-18. doi: 10.1128/JVI.01613-18. Print 2019 May 15.

PMID:
30842330
2.

Tyrosine phosphorylation directs TACE into extracellular vesicles via unconventional secretion.

Zhao Z, Kesti T, Uğurlu H, Baur AS, Fagerlund R, Saksela K.

Traffic. 2019 Mar;20(3):202-212. doi: 10.1111/tra.12630. Epub 2019 Jan 21.

PMID:
30569492
3.

HIV Activates the Tyrosine Kinase Hck to Secrete ADAM Protease-Containing Extracellular Vesicles.

Lee JH, Ostalecki C, Zhao Z, Kesti T, Bruns H, Simon B, Harrer T, Saksela K, Baur AS.

EBioMedicine. 2018 Feb;28:151-161. doi: 10.1016/j.ebiom.2018.01.004. Epub 2018 Jan 4. No abstract available.

4.

ANKRD54 preferentially selects Bruton's Tyrosine Kinase (BTK) from a Human Src-Homology 3 (SH3) domain library.

Gustafsson MO, Mohammad DK, Ylösmäki E, Choi H, Shrestha S, Wang Q, Nore BF, Saksela K, Smith CI.

PLoS One. 2017 Apr 3;12(4):e0174909. doi: 10.1371/journal.pone.0174909. eCollection 2017.

5.

Large-Scale Screening of Preferred Interactions of Human Src Homology-3 (SH3) Domains Using Native Target Proteins as Affinity Ligands.

Kazlauskas A, Schmotz C, Kesti T, Hepojoki J, Kleino I, Kaneko T, Li SS, Saksela K.

Mol Cell Proteomics. 2016 Oct;15(10):3270-3281. Epub 2016 Jul 20.

6.

Identification of specific residues in avian influenza A virus NS1 that enhance viral replication and pathogenicity in mammalian systems.

Kanrai P, Mostafa A, Madhugiri R, Lechner M, Wilk E, Schughart K, Ylösmäki L, Saksela K, Ziebuhr J, Pleschka S.

J Gen Virol. 2016 Sep;97(9):2135-48. doi: 10.1099/jgv.0.000542. Epub 2016 Jul 12.

PMID:
27405649
7.

Structural Basis of the High Affinity Interaction between the Alphavirus Nonstructural Protein-3 (nsP3) and the SH3 Domain of Amphiphysin-2.

Tossavainen H, Aitio O, Hellman M, Saksela K, Permi P.

J Biol Chem. 2016 Jul 29;291(31):16307-17. doi: 10.1074/jbc.M116.732412. Epub 2016 Jun 6.

8.

HIV-Nef and ADAM17-Containing Plasma Extracellular Vesicles Induce and Correlate with Immune Pathogenesis in Chronic HIV Infection.

Lee JH, Schierer S, Blume K, Dindorf J, Wittki S, Xiang W, Ostalecki C, Koliha N, Wild S, Schuler G, Fackler OT, Saksela K, Harrer T, Baur AS.

EBioMedicine. 2016 Apr;6:103-113. doi: 10.1016/j.ebiom.2016.03.004. Epub 2016 Mar 3.

9.

Nuclear Translocation of Crk Adaptor Proteins by the Influenza A Virus NS1 Protein.

Ylösmäki L, Fagerlund R, Kuisma I, Julkunen I, Saksela K.

Viruses. 2016 Apr 15;8(4):101. doi: 10.3390/v8040101.

10.

Association with PAK2 Enables Functional Interactions of Lentiviral Nef Proteins with the Exocyst Complex.

Imle A, Abraham L, Tsopoulidis N, Hoflack B, Saksela K, Fackler OT.

MBio. 2015 Sep 8;6(5):e01309-15. doi: 10.1128/mBio.01309-15.

11.

MicroRNA-Attenuated Clone of Virulent Semliki Forest Virus Overcomes Antiviral Type I Interferon in Resistant Mouse CT-2A Glioma.

Martikainen M, Niittykoski M, von und zu Fraunberg M, Immonen A, Koponen S, van Geenen M, Vähä-Koskela M, Ylösmäki E, Jääskeläinen JE, Saksela K, Hinkkanen A.

J Virol. 2015 Oct;89(20):10637-47. doi: 10.1128/JVI.01868-15. Epub 2015 Aug 12.

12.

Reorganization of the host cell Crk(L)-PI3 kinase signaling complex by the influenza A virus NS1 protein.

Ylösmäki L, Schmotz C, Ylösmäki E, Saksela K.

Virology. 2015 Oct;484:146-52. doi: 10.1016/j.virol.2015.06.009. Epub 2015 Jun 19.

13.

The C terminus of NS1 protein of influenza A/WSN/1933(H1N1) virus modulates antiviral responses in infected human macrophages and mice.

Anastasina M, Schepens B, Söderholm S, Nyman TA, Matikainen S, Saksela K, Saelens X, Kainov DE.

J Gen Virol. 2015 Aug;96(8):2086-91. doi: 10.1099/vir.0.000171. Epub 2015 May 1.

PMID:
25934792
14.

Optimization of absorption placement using geometrical acoustic models and least squares.

Saksela K, Botts J, Savioja L.

J Acoust Soc Am. 2015 Apr;137(4):EL274-80. doi: 10.1121/1.4915063.

PMID:
25920877
15.

Hepatitis C virus NS5A protein blocks epidermal growth factor receptor degradation via a proline motif- dependent interaction.

Igloi Z, Kazlauskas A, Saksela K, Macdonald A, Mankouri J, Harris M.

J Gen Virol. 2015 Aug;96(8):2133-44. doi: 10.1099/vir.0.000145. Epub 2015 Apr 13.

16.

Preferred SH3 domain partners of ADAM metalloproteases include shared and ADAM-specific SH3 interactions.

Kleino I, Järviluoma A, Hepojoki J, Huovila AP, Saksela K.

PLoS One. 2015 Mar 31;10(3):e0121301. doi: 10.1371/journal.pone.0121301. eCollection 2015.

17.

Structural basis for the inhibition of HIV-1 Nef by a high-affinity binding single-domain antibody.

Lülf S, Matz J, Rouyez MC, Järviluoma A, Saksela K, Benichou S, Geyer M.

Retrovirology. 2014 Mar 13;11:24. doi: 10.1186/1742-4690-11-24.

18.

Primate lentiviral Nef proteins deregulate T-cell development by multiple mechanisms.

Van Nuffel A, Ariën KK, Stove V, Schindler M, O'Neill E, Schmökel J, Van de Walle I, Naessens E, Vanderstraeten H, Van Landeghem K, Taghon T, Pulkkinen K, Saksela K, Garcia JV, Fackler OT, Kirchhoff F, Verhasselt B.

Retrovirology. 2013 Nov 15;10:137. doi: 10.1186/1742-4690-10-137.

19.

Hepatitis C virus NS5A inhibits mixed lineage kinase 3 to block apoptosis.

Amako Y, Igloi Z, Mankouri J, Kazlauskas A, Saksela K, Dallas M, Peers C, Harris M.

J Biol Chem. 2013 Aug 23;288(34):24753-63. doi: 10.1074/jbc.M113.491985. Epub 2013 Jul 15.

20.

The mechanism of tissue-restricted antigen gene expression by AIRE.

Zumer K, Saksela K, Peterlin BM.

J Immunol. 2013 Mar 15;190(6):2479-82. doi: 10.4049/jimmunol.1203210. Review.

21.

MicroRNA-mediated suppression of oncolytic adenovirus replication in human liver.

Ylösmäki E, Lavilla-Alonso S, Jäämaa S, Vähä-Koskela M, af Hällström T, Hemminki A, Arola J, Mäkisalo H, Saksela K.

PLoS One. 2013;8(1):e54506. doi: 10.1371/journal.pone.0054506. Epub 2013 Jan 22.

22.

HIV Nef, paxillin, and Pak1/2 regulate activation and secretion of TACE/ADAM10 proteases.

Lee JH, Wittki S, Bräu T, Dreyer FS, Krätzel K, Dindorf J, Johnston IC, Gross S, Kremmer E, Zeidler R, Schlötzer-Schrehardt U, Lichtenheld M, Saksela K, Harrer T, Schuler G, Federico M, Baur AS.

Mol Cell. 2013 Feb 21;49(4):668-79. doi: 10.1016/j.molcel.2012.12.004. Epub 2013 Jan 11.

23.

Attenuation of Semliki Forest virus neurovirulence by microRNA-mediated detargeting.

Ylösmäki E, Martikainen M, Hinkkanen A, Saksela K.

J Virol. 2013 Jan;87(1):335-44. doi: 10.1128/JVI.01940-12. Epub 2012 Oct 17.

24.

Enterohaemorrhagic Escherichia coli exploits a tryptophan switch to hijack host f-actin assembly.

Aitio O, Hellman M, Skehan B, Kesti T, Leong JM, Saksela K, Permi P.

Structure. 2012 Oct 10;20(10):1692-703. doi: 10.1016/j.str.2012.07.015. Epub 2012 Aug 23.

25.

High-affinity target binding engineered via fusion of a single-domain antibody fragment with a ligand-tailored SH3 domain.

Järviluoma A, Strandin T, Lülf S, Bouchet J, Mäkelä AR, Geyer M, Benichou S, Saksela K.

PLoS One. 2012;7(7):e40331. doi: 10.1371/journal.pone.0040331. Epub 2012 Jul 5.

26.

Comprehensive analysis of interactions between the Src-associated protein in mitosis of 68 kDa and the human Src-homology 3 proteome.

Asbach B, Ludwig C, Saksela K, Wagner R.

PLoS One. 2012;7(6):e38540. doi: 10.1371/journal.pone.0038540. Epub 2012 Jun 20.

27.

SH3 domain ligand binding: What's the consensus and where's the specificity?

Saksela K, Permi P.

FEBS Lett. 2012 Aug 14;586(17):2609-14. doi: 10.1016/j.febslet.2012.04.042. Epub 2012 May 2. Review.

28.

Identification of a highly conserved valine-glycine-phenylalanine amino acid triplet required for HIV-1 Nef function.

Meuwissen PJ, Stolp B, Iannucci V, Vermeire J, Naessens E, Saksela K, Geyer M, Vanham G, Arien KK, Fackler OT, Verhasselt B.

Retrovirology. 2012 Apr 27;9:34. doi: 10.1186/1742-4690-9-34.

29.

Single-domain antibody-SH3 fusions for efficient neutralization of HIV-1 Nef functions.

Bouchet J, Hérate C, Guenzel CA, Vérollet C, Järviluoma A, Mazzolini J, Rafie S, Chames P, Baty D, Saksela K, Niedergang F, Maridonneau-Parini I, Benichou S.

J Virol. 2012 May;86(9):4856-67. doi: 10.1128/JVI.06329-11. Epub 2012 Feb 15.

30.

Unmodified histone H3K4 and DNA-dependent protein kinase recruit autoimmune regulator to target genes.

Žumer K, Low AK, Jiang H, Saksela K, Peterlin BM.

Mol Cell Biol. 2012 Apr;32(8):1354-62. doi: 10.1128/MCB.06359-11. Epub 2012 Feb 6.

31.

SH3 domain-mediated recruitment of host cell amphiphysins by alphavirus nsP3 promotes viral RNA replication.

Neuvonen M, Kazlauskas A, Martikainen M, Hinkkanen A, Ahola T, Saksela K.

PLoS Pathog. 2011 Nov;7(11):e1002383. doi: 10.1371/journal.ppat.1002383. Epub 2011 Nov 17.

32.
33.

Macrophage metalloelastase (MME) as adjuvant for intra-tumoral injection of oncolytic adenovirus and its influence on metastases development.

Lavilla-Alonso S, Bauer MM, Abo-Ramadan U, Ristimäki A, Halavaara J, Desmond RA, Wang D, Escutenaire S, Ahtiainen L, Saksela K, Tatlisumak T, Hemminki A, Pesonen S.

Cancer Gene Ther. 2012 Feb;19(2):126-34. doi: 10.1038/cgt.2011.76. Epub 2011 Nov 18.

PMID:
22095385
34.

Optimized mouse model for the imaging of tumor metastasis upon experimental therapy.

Lavilla-Alonso S, Abo-Ramadan U, Halavaara J, Escutenaire S, Tatlisumak T, Saksela K, Kanerva A, Hemminki A, Pesonen S.

PLoS One. 2011;6(11):e26810. doi: 10.1371/journal.pone.0026810. Epub 2011 Nov 3.

35.

Patient mutation in AIRE disrupts P-TEFb binding and target gene transcription.

Žumer K, Plemenitaš A, Saksela K, Peterlin BM.

Nucleic Acids Res. 2011 Oct;39(18):7908-19. doi: 10.1093/nar/gkr527. Epub 2011 Jun 30.

36.

Conformation of the dileucine-based sorting motif in HIV-1 Nef revealed by intermolecular domain assembly.

Horenkamp FA, Breuer S, Schulte A, Lülf S, Weyand M, Saksela K, Geyer M.

Traffic. 2011 Jul;12(7):867-77. doi: 10.1111/j.1600-0854.2011.01205.x. Epub 2011 May 5.

37.

Recognition of tandem PxxP motifs as a unique Src homology 3-binding mode triggers pathogen-driven actin assembly.

Aitio O, Hellman M, Kazlauskas A, Vingadassalom DF, Leong JM, Saksela K, Permi P.

Proc Natl Acad Sci U S A. 2010 Dec 14;107(50):21743-8. doi: 10.1073/pnas.1010243107. Epub 2010 Nov 22.

38.

Role of the Kaposi's sarcoma-associated herpesvirus K15 SH3 binding site in inflammatory signaling and B-cell activation.

Pietrek M, Brinkmann MM, Glowacka I, Enlund A, Hävemeier A, Dittrich-Breiholz O, Kracht M, Lewitzky M, Saksela K, Feller SM, Schulz TF.

J Virol. 2010 Aug;84(16):8231-40. doi: 10.1128/JVI.01696-09. Epub 2010 Jun 9.

39.

Modulation of cell spreading and cell-substrate adhesion dynamics by dystroglycan.

Thompson O, Moore CJ, Hussain SA, Kleino I, Peckham M, Hohenester E, Ayscough KR, Saksela K, Winder SJ.

J Cell Sci. 2010 Jan 1;123(Pt 1):118-27. doi: 10.1242/jcs.047902.

40.

Molecular priming of Lyn by GPVI enables an immune receptor to adopt a hemostatic role.

Schmaier AA, Zou Z, Kazlauskas A, Emert-Sedlak L, Fong KP, Neeves KB, Maloney SF, Diamond SL, Kunapuli SP, Ware J, Brass LF, Smithgall TE, Saksela K, Kahn ML.

Proc Natl Acad Sci U S A. 2009 Dec 15;106(50):21167-72. doi: 10.1073/pnas.0906436106. Epub 2009 Nov 25.

41.

Alternative splicing of ADAM15 regulates its interactions with cellular SH3 proteins.

Kleino I, Ortiz RM, Yritys M, Huovila AP, Saksela K.

J Cell Biochem. 2009 Nov 1;108(4):877-85. doi: 10.1002/jcb.22317.

PMID:
19718658
42.

Insulin receptor tyrosine kinase substrate links the E. coli O157:H7 actin assembly effectors Tir and EspF(U) during pedestal formation.

Vingadassalom D, Kazlauskas A, Skehan B, Cheng HC, Magoun L, Robbins D, Rosen MK, Saksela K, Leong JM.

Proc Natl Acad Sci U S A. 2009 Apr 21;106(16):6754-9. doi: 10.1073/pnas.0809131106. Epub 2009 Apr 6.

43.

Dystroglycan, Tks5 and Src mediated assembly of podosomes in myoblasts.

Thompson O, Kleino I, Crimaldi L, Gimona M, Saksela K, Winder SJ.

PLoS One. 2008;3(11):e3638. doi: 10.1371/journal.pone.0003638. Epub 2008 Nov 4.

44.

Generation of a conditionally replicating adenovirus based on targeted destruction of E1A mRNA by a cell type-specific MicroRNA.

Ylösmäki E, Hakkarainen T, Hemminki A, Visakorpi T, Andino R, Saksela K.

J Virol. 2008 Nov;82(22):11009-15. doi: 10.1128/JVI.01608-08. Epub 2008 Sep 17.

45.

Harnessing endogenous miRNAs to control virus tissue tropism as a strategy for developing attenuated virus vaccines.

Barnes D, Kunitomi M, Vignuzzi M, Saksela K, Andino R.

Cell Host Microbe. 2008 Sep 11;4(3):239-48. doi: 10.1016/j.chom.2008.08.003.

46.

A crucial role in cell spreading for the interaction of Abl PxxP motifs with Crk and Nck adaptors.

Antoku S, Saksela K, Rivera GM, Mayer BJ.

J Cell Sci. 2008 Sep 15;121(Pt 18):3071-82. doi: 10.1242/jcs.031575.

47.

Structural basis of PxxDY motif recognition in SH3 binding.

Aitio O, Hellman M, Kesti T, Kleino I, Samuilova O, Pääkkönen K, Tossavainen H, Saksela K, Permi P.

J Mol Biol. 2008 Sep 26;382(1):167-78. doi: 10.1016/j.jmb.2008.07.008. Epub 2008 Jul 11.

PMID:
18644376
48.

Avian and 1918 Spanish influenza a virus NS1 proteins bind to Crk/CrkL Src homology 3 domains to activate host cell signaling.

Heikkinen LS, Kazlauskas A, Melén K, Wagner R, Ziegler T, Julkunen I, Saksela K.

J Biol Chem. 2008 Feb 29;283(9):5719-27. doi: 10.1074/jbc.M707195200. Epub 2007 Dec 28.

50.

Association of Nef with p21-activated kinase 2 is dispensable for efficient human immunodeficiency virus type 1 replication and cytopathicity in ex vivo-infected human lymphoid tissue.

Schindler M, Rajan D, Specht A, Ritter C, Pulkkinen K, Saksela K, Kirchhoff F.

J Virol. 2007 Dec;81(23):13005-14. Epub 2007 Sep 19.

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