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Items: 1 to 50 of 52

1.

Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro.

Baker JR, Gilbert J, Paula S, Zhu X, Sakoff JA, McCluskey A.

ChemMedChem. 2018 May 17. doi: 10.1002/cmdc.201800256. [Epub ahead of print]

PMID:
29771007
2.

A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone.

Ghods A, Gilbert J, Baker JR, Russell CC, Sakoff JA, McCluskey A.

R Soc Open Sci. 2018 Apr 4;5(4):171189. doi: 10.1098/rsos.171189. eCollection 2018 Apr.

3.

(Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway.

Gilbert J, De Iuliis GN, Tarleton M, McCluskey A, Sakoff JA.

Mol Pharmacol. 2018 Feb;93(2):168-177. doi: 10.1124/mol.117.109827. Epub 2017 Dec 21.

PMID:
29269419
4.

Physicochemical Properties, Antioxidant and Cytotoxic Activities of Crude Extracts and Fractions from Phyllanthus amarus.

Nguyen VT, Sakoff JA, Scarlett CJ.

Medicines (Basel). 2017 Jun 18;4(2). pii: E42. doi: 10.3390/medicines4020042.

5.

Physicochemical Properties, Antioxidant and Anti-proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera).

Nguyen VT, Sakoff JA, Scarlett CJ.

Chem Biodivers. 2017 Jun;14(6). doi: 10.1002/cbdv.201600498. Epub 2017 May 3.

PMID:
28122160
6.

Physicochemical, Antioxidant, and Cytotoxic Properties of Xao Tam Phan (Paramignya trimera) Root Extract and Its Fractions.

Nguyen VT, Sakoff JA, Scarlett CJ.

Chem Biodivers. 2017 Apr;14(4). doi: 10.1002/cbdv.201600396. Epub 2017 Mar 20.

PMID:
28029227
7.

Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.

Odell LR, Abdel-Hamid MK, Hill TA, Chau N, Young KA, Deane FM, Sakoff JA, Andersson S, Daniel JA, Robinson PJ, McCluskey A.

J Med Chem. 2017 Jan 12;60(1):349-361. doi: 10.1021/acs.jmedchem.6b01422. Epub 2016 Dec 20.

PMID:
27997171
8.

Cytotoxicity of a Series of Norcantharidin-Inspired Tetrahydroepoxyisoindole Carboxamides.

Spare LK, Falsetta P, Gilbert J, Harman DG, Baker MA, Li F, McCluskey A, Clegg JK, Sakoff JA, Aldrich-Wright JR, Gordon CP.

ChemMedChem. 2017 Jan 20;12(2):130-145. doi: 10.1002/cmdc.201600573. Epub 2017 Jan 3.

PMID:
27921386
9.

A facile hybrid 'flow and batch' access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones.

Lin AJ, Russell CC, Baker JR, Frailey SL, Sakoff JA, McCluskey A.

Org Biomol Chem. 2016 Sep 21;14(37):8732-8742.

PMID:
27714138
10.

Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors.

Trinh TN, McLaughlin EA, Abdel-Hamid MK, Gordon CP, Bernstein IR, Pye V, Cossar P, Sakoff JA, McCluskey A.

Org Biomol Chem. 2016 Jul 14;14(26):6304-15. doi: 10.1039/c6ob00606j. Epub 2016 Jun 7.

PMID:
27272335
11.

Cytotoxic compounds from Laurencia pacifica.

Zaleta-Pinet DA, Holland IP, Muñoz-Ochoa M, Murillo-Alvarez JI, Sakoff JA, van Altena IA, McCluskey A.

Org Med Chem Lett. 2014 Dec;4(1):8. doi: 10.1186/s13588-014-0008-8. Epub 2014 Sep 20.

12.

The synthesis and biological activity of novel anthracenone-pyranones and anthracenone-furans.

Rixson JE, Abraham JR, Egoshi Y, Skelton BW, Young K, Gilbert J, Sakoff JA, Gericke KM, McCluskey A, Stewart SG.

Bioorg Med Chem. 2015 Jul 1;23(13):3552-65. doi: 10.1016/j.bmc.2015.04.032. Epub 2015 Apr 22.

PMID:
25979375
13.

Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.

Dyson L, Wright AD, Young KA, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2014 Mar 1;22(5):1690-9. doi: 10.1016/j.bmc.2014.01.021. Epub 2014 Jan 24.

PMID:
24508308
14.

Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.

McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ.

Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9.

15.

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ.

ACS Chem Biol. 2013 Jul 19;8(7):1507-18. doi: 10.1021/cb400137p. Epub 2013 May 30.

PMID:
23642287
16.

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.

Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO.

Org Biomol Chem. 2013 Feb 28;11(8):1334-44. doi: 10.1039/c2ob27186a.

PMID:
23314103
17.

Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents.

Tarleton M, Dyson L, Gilbert J, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2013 Jan 1;21(1):333-47. doi: 10.1016/j.bmc.2012.10.003. Epub 2012 Oct 23.

PMID:
23176751
18.

Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents.

Tarleton M, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2012 Nov;57:65-73. doi: 10.1016/j.ejmech.2012.09.019. Epub 2012 Sep 18.

PMID:
23047225
19.

Predicting 5-fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length: a multivariate analysis.

Garg MB, Lincz LF, Adler K, Scorgie FE, Ackland SP, Sakoff JA.

Br J Cancer. 2012 Oct 23;107(9):1525-33. doi: 10.1038/bjc.2012.421. Epub 2012 Sep 18.

20.

Synthesis and anticancer activity of a series of norcantharidin analogues.

Tarleton M, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2012 Aug;54:573-81. doi: 10.1016/j.ejmech.2012.06.010. Epub 2012 Jun 15.

PMID:
22796041
21.

Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA.

Bioorg Med Chem. 2011 Sep 15;19(18):5734-41. doi: 10.1016/j.bmc.2011.01.031. Epub 2011 Feb 1.

PMID:
21855357
22.

A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients.

Garg MB, Sakoff JA, Ackland SP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 1;879(23):2201-5. doi: 10.1016/j.jchromb.2011.06.001. Epub 2011 Jun 13.

PMID:
21719363
23.

Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3277-81. doi: 10.1016/j.bmcl.2011.04.031. Epub 2011 Apr 13.

PMID:
21536433
24.

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M.

Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161. Epub 2010 Jun 22.

25.

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo.

de Bock CE, Garg MB, Scott N, Sakoff JA, Scorgie FE, Ackland SP, Lincz LF.

Pharmacogenomics J. 2011 Aug;11(4):307-14. doi: 10.1038/tpj.2010.43. Epub 2010 Jun 8.

PMID:
20531375
26.

Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.

Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2010 May;45(5):1717-23. doi: 10.1016/j.ejmech.2010.01.004. Epub 2010 Jan 14.

PMID:
20153915
27.

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m.

PMID:
19459681
28.

Steroids from an Australian sponge Psammoclema sp.

Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, Motti CA, Wright AD, van Altena IA.

J Nat Prod. 2009 Jan;72(1):102-6. doi: 10.1021/np800688f.

PMID:
19132863
29.

Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

ChemMedChem. 2008 Dec;3(12):1878-92. doi: 10.1002/cmdc.200800192.

PMID:
19025735
30.
31.

Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Stewart SG, Hill TA, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Dec 1;15(23):7301-10. Epub 2007 Aug 24.

PMID:
17870547
32.

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Hill TA, Stewart SG, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Sep 15;15(18):6126-34. Epub 2007 Jun 20.

PMID:
17606377
33.

Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3392-7. Epub 2007 Apr 2.

PMID:
17451951
34.

Telomere length predicts neutrophil recovery in the absence of G-CSF after autologous peripheral blood stem cell transplantation.

Lincz LF, Scorgie FE, Sakoff JA, Fagan KA, Ackland SP, Enno A.

Bone Marrow Transplant. 2004 Sep;34(5):439-45.

PMID:
15258557
35.

Protein phosphatase inhibition: structure based design. Towards new therapeutic agents.

Sakoff JA, McCluskey A.

Curr Pharm Des. 2004;10(10):1139-59. Review.

PMID:
15078146
36.

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73.

PMID:
15050639
37.

Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.

Sakoff JA, Howitt IJ, Ackland SP, McCluskey A.

Cancer Chemother Pharmacol. 2004 Mar;53(3):225-32. Epub 2003 Nov 25.

PMID:
14648018
38.

Cantharidin analogues: synthesis and evaluation of growth inhibition in a panel of selected tumour cell lines.

McCluskey A, Ackland SP, Bowyer MC, Baldwin ML, Garner J, Walkom CC, Sakoff JA.

Bioorg Chem. 2003 Feb;31(1):68-79.

PMID:
12697169
39.

Telomere length in haemopoietic stem cells can be determined from that of mononuclear blood cells or whole blood.

Sakoff JA, De Waal E, Garg MB, Denham J, Scorgie FE, Enno A, Lincz LF, Ackland SP.

Leuk Lymphoma. 2002 Oct;43(10):2017-20.

PMID:
12481901
40.

The inhibition of protein phosphatases 1 and 2A: a new target for rational anti-cancer drug design?

McCluskey A, Ackland SP, Gardiner E, Walkom CC, Sakoff JA.

Anticancer Drug Des. 2001 Dec;16(6):291-303.

PMID:
12375882
41.

Small molecule inhibitors of serine/threonine protein phosphatases.

McCluskey A, Sakoff JA.

Mini Rev Med Chem. 2001 May;1(1):43-55. Review.

PMID:
12369990
42.

Simple liquid chromatographic method for the determination of uracil and dihydrouracil plasma levels: a potential pretreatment predictor of 5-fluorouracil toxicity.

Garg MB, Sevester JC, Sakoff JA, Ackland SP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2002 Jul 15;774(2):223-30.

PMID:
12076692
43.

Anticancer activity and protein phosphatase 1 and 2A inhibition of a new generation of cantharidin analogues.

Sakoff JA, Ackland SP, Baldwin ML, Keane MA, McCluskey A.

Invest New Drugs. 2002 Feb;20(1):1-11.

PMID:
12003183
44.

Serine-threonine protein phosphatase inhibitors: development of potential therapeutic strategies.

McCluskey A, Sim AT, Sakoff JA.

J Med Chem. 2002 Mar 14;45(6):1151-75. Review. No abstract available.

PMID:
11881984
45.

The first two cantharidin analogues displaying PP1 selectivity.

McCluskey A, Keane MA, Walkom CC, Bowyer MC, Sim AT, Young DJ, Sakoff JA.

Bioorg Med Chem Lett. 2002 Feb 11;12(3):391-3.

PMID:
11814804
46.

Cantharimides: a new class of modified cantharidin analogues inhibiting protein phosphatases 1 and 2A.

McCluskey A, Walkom C, Bowyer MC, Ackland SP, Gardiner E, Sakoff JA.

Bioorg Med Chem Lett. 2001 Nov 19;11(22):2941-6.

PMID:
11677131
47.
48.

Anhydride modified cantharidin analogues: synthesis, inhibition of protein phosphatases 1 and 2A and anticancer activity.

McCluskey A, Bowyer MC, Collins E, Sim ATR, Sakoff JA, Baldwin ML.

Bioorg Med Chem Lett. 2000 Aug 7;10(15):1687-90.

PMID:
10937725
49.
50.

The role of calcium in the artificially induced decidual cell reaction in pseudopregnant mice.

Sakoff JA, Murdoch RN.

Biochem Mol Med. 1996 Apr;57(2):81-90.

PMID:
8733885

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