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Items: 1 to 50 of 66

1.

Phytochemical, antioxidant, anti-proliferative and antimicrobial properties of Catharanthus roseus root extract, saponin-enriched and aqueous fractions.

Pham HNT, Sakoff JA, Vuong QV, Bowyer MC, Scarlett CJ.

Mol Biol Rep. 2019 Jun;46(3):3265-3273. doi: 10.1007/s11033-019-04786-8. Epub 2019 Apr 3.

PMID:
30945069
2.

Synthesis and Cytotoxicity of Octahydroepoxyisoindole-7-carboxylic Acids and Norcantharidin-Amide Hybrids as Norcantharidin Analogues.

Hizartzidis L, Gilbert J, Gordon CP, Sakoff JA, McCluskey A.

ChemMedChem. 2019 Jun 18;14(12):1152-1161. doi: 10.1002/cmdc.201900180. Epub 2019 May 14.

PMID:
30938091
3.

o-Vanillin Derived Schiff Bases and Their Organotin(IV) Compounds: Synthesis, Structural Characterisation, In-Silico Studies and Cytotoxicity.

Yusof ENM, Latif MAM, Tahir MIM, Sakoff JA, Simone MI, Page AJ, Veerakumarasivam A, Tiekink ERT, Ravoof TBSA.

Int J Mol Sci. 2019 Feb 15;20(4). pii: E854. doi: 10.3390/ijms20040854.

4.

Comparative cytotoxic activity between kaempferol and gallic acid against various cancer cell lines.

Pham HNT, Sakoff JA, Vuong QV, Bowyer MC, Scarlett CJ.

Data Brief. 2018 Oct 27;21:1033-1036. doi: 10.1016/j.dib.2018.10.121. eCollection 2018 Dec.

5.

In vitro antibacterial and anticancer properties of Helicteres hirsuta Lour. leaf and stem extracts and their fractions.

Pham HNT, Sakoff JA, Bond DR, Vuong QV, Bowyer MC, Scarlett CJ.

Mol Biol Rep. 2018 Dec;45(6):2125-2133. doi: 10.1007/s11033-018-4370-x. Epub 2018 Sep 12.

PMID:
30209740
6.

Small-Molecule Inhibitors of the NusB-NusE Protein-Protein Interaction with Antibiotic Activity.

Cossar PJ, Abdel-Hamid MK, Ma C, Sakoff JA, Trinh TN, Gordon CP, Lewis PJ, McCluskey A.

ACS Omega. 2017 Jul 31;2(7):3839-3857. doi: 10.1021/acsomega.7b00273. Epub 2017 Jul 25.

7.

Dichlorophenylacrylonitriles as AhR Ligands That Display Selective Breast Cancer Cytotoxicity in vitro.

Baker JR, Gilbert J, Paula S, Zhu X, Sakoff JA, McCluskey A.

ChemMedChem. 2018 Jul 18;13(14):1447-1458. doi: 10.1002/cmdc.201800256. Epub 2018 Jul 2.

PMID:
29771007
8.

A focused library synthesis and cytotoxicity of quinones derived from the natural product bolinaquinone.

Ghods A, Gilbert J, Baker JR, Russell CC, Sakoff JA, McCluskey A.

R Soc Open Sci. 2018 Apr 4;5(4):171189. doi: 10.1098/rsos.171189. eCollection 2018 Apr.

9.

(Z)-2-(3,4-Dichlorophenyl)-3-(1H-Pyrrol-2-yl)Acrylonitrile Exhibits Selective Antitumor Activity in Breast Cancer Cell Lines via the Aryl Hydrocarbon Receptor Pathway.

Gilbert J, De Iuliis GN, Tarleton M, McCluskey A, Sakoff JA.

Mol Pharmacol. 2018 Feb;93(2):168-177. doi: 10.1124/mol.117.109827. Epub 2017 Dec 21.

PMID:
29269419
10.

Combining the platinum(ii) drug candidate kiteplatin with 1,10-phenanthroline analogues.

Pages BJ, Sakoff J, Gilbert J, Zhang Y, Kelly SM, Hoeschele JD, Aldrich-Wright JR.

Dalton Trans. 2018 Feb 13;47(7):2156-2163. doi: 10.1039/c7dt04108j.

PMID:
29192713
11.

Physicochemical Properties, Antioxidant and Cytotoxic Activities of Crude Extracts and Fractions from Phyllanthus amarus.

Nguyen VT, Sakoff JA, Scarlett CJ.

Medicines (Basel). 2017 Jun 18;4(2). pii: E42. doi: 10.3390/medicines4020042.

12.

In vitro anticancer properties of selected Eucalyptus species.

Bhuyan DJ, Sakoff J, Bond DR, Predebon M, Vuong QV, Chalmers AC, van Altena IA, Bowyer MC, Scarlett CJ.

In Vitro Cell Dev Biol Anim. 2017 Aug;53(7):604-615. doi: 10.1007/s11626-017-0149-y. Epub 2017 Apr 27.

PMID:
28452004
13.

Physicochemical Properties, Antioxidant and Anti-proliferative Capacities of Dried Leaf and Its Extract from Xao tam phan (Paramignya trimera).

Nguyen VT, Sakoff JA, Scarlett CJ.

Chem Biodivers. 2017 Jun;14(6). doi: 10.1002/cbdv.201600498. Epub 2017 May 3.

PMID:
28122160
14.

Physicochemical, Antioxidant, and Cytotoxic Properties of Xao Tam Phan (Paramignya trimera) Root Extract and Its Fractions.

Nguyen VT, Sakoff JA, Scarlett CJ.

Chem Biodivers. 2017 Apr;14(4). doi: 10.1002/cbdv.201600396. Epub 2017 Mar 20.

PMID:
28029227
15.

Pyrimidine-Based Inhibitors of Dynamin I GTPase Activity: Competitive Inhibition at the Pleckstrin Homology Domain.

Odell LR, Abdel-Hamid MK, Hill TA, Chau N, Young KA, Deane FM, Sakoff JA, Andersson S, Daniel JA, Robinson PJ, McCluskey A.

J Med Chem. 2017 Jan 12;60(1):349-361. doi: 10.1021/acs.jmedchem.6b01422. Epub 2016 Dec 20.

PMID:
27997171
16.

Cytotoxicity of a Series of Norcantharidin-Inspired Tetrahydroepoxyisoindole Carboxamides.

Spare LK, Falsetta P, Gilbert J, Harman DG, Baker MA, Li F, McCluskey A, Clegg JK, Sakoff JA, Aldrich-Wright JR, Gordon CP.

ChemMedChem. 2017 Jan 20;12(2):130-145. doi: 10.1002/cmdc.201600573. Epub 2017 Jan 3.

PMID:
27921386
17.

A facile hybrid 'flow and batch' access to substituted 3,4-dihydro-2H-benzo[b][1,4]oxazinones.

Lin AJ, Russell CC, Baker JR, Frailey SL, Sakoff JA, McCluskey A.

Org Biomol Chem. 2016 Sep 21;14(37):8732-8742.

PMID:
27714138
18.

Investigating the cytotoxicity of platinum(II) complexes incorporating bidentate pyridyl-1,2,3-triazole "click" ligands.

Pages BJ, Sakoff J, Gilbert J, Zhang Y, Li F, Preston D, Crowley JD, Aldrich-Wright JR.

J Inorg Biochem. 2016 Dec;165:92-99. doi: 10.1016/j.jinorgbio.2016.06.017. Epub 2016 Jun 15.

PMID:
27389828
19.

Quinolone-1-(2H)-ones as hedgehog signalling pathway inhibitors.

Trinh TN, McLaughlin EA, Abdel-Hamid MK, Gordon CP, Bernstein IR, Pye V, Cossar P, Sakoff JA, McCluskey A.

Org Biomol Chem. 2016 Jul 14;14(26):6304-15. doi: 10.1039/c6ob00606j. Epub 2016 Jun 7.

PMID:
27272335
20.

Multifaceted Studies of the DNA Interactions and In Vitro Cytotoxicity of Anticancer Polyaromatic Platinum(II) Complexes.

Pages BJ, Sakoff J, Gilbert J, Rodger A, Chmel NP, Jones NC, Kelly SM, Ang DL, Aldrich-Wright JR.

Chemistry. 2016 Jun 20;22(26):8943-54. doi: 10.1002/chem.201601221. Epub 2016 May 24.

PMID:
27219069
21.

Cytotoxic compounds from Laurencia pacifica.

Zaleta-Pinet DA, Holland IP, Muñoz-Ochoa M, Murillo-Alvarez JI, Sakoff JA, van Altena IA, McCluskey A.

Org Med Chem Lett. 2014 Dec;4(1):8. doi: 10.1186/s13588-014-0008-8. Epub 2014 Sep 20.

22.

Synthesis and Analysis of the Structure, Diffusion and Cytotoxicity of Heterocyclic Platinum(IV) Complexes.

Macias FJ, Deo KM, Pages BJ, Wormell P, Clegg JK, Zhang Y, Li F, Zheng G, Sakoff J, Gilbert J, Aldrich-Wright JR.

Chemistry. 2015 Nov 16;21(47):16990-7001. doi: 10.1002/chem.201502159. Epub 2015 Oct 6.

PMID:
26439874
23.

The synthesis and biological activity of novel anthracenone-pyranones and anthracenone-furans.

Rixson JE, Abraham JR, Egoshi Y, Skelton BW, Young K, Gilbert J, Sakoff JA, Gericke KM, McCluskey A, Stewart SG.

Bioorg Med Chem. 2015 Jul 1;23(13):3552-65. doi: 10.1016/j.bmc.2015.04.032. Epub 2015 Apr 22.

PMID:
25979375
24.

Synthesis and anticancer activity of focused compound libraries from the natural product lead, oroidin.

Dyson L, Wright AD, Young KA, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2014 Mar 1;22(5):1690-9. doi: 10.1016/j.bmc.2014.01.021. Epub 2014 Jan 24.

PMID:
24508308
25.

Building a better dynasore: the dyngo compounds potently inhibit dynamin and endocytosis.

McCluskey A, Daniel JA, Hadzic G, Chau N, Clayton EL, Mariana A, Whiting A, Gorgani NN, Lloyd J, Quan A, Moshkanbaryans L, Krishnan S, Perera S, Chircop M, von Kleist L, McGeachie AB, Howes MT, Parton RG, Campbell M, Sakoff JA, Wang X, Sun JY, Robertson MJ, Deane FM, Nguyen TH, Meunier FA, Cousin MA, Robinson PJ.

Traffic. 2013 Dec;14(12):1272-89. doi: 10.1111/tra.12119. Epub 2013 Oct 9.

26.

Pyrimidyn compounds: dual-action small molecule pyrimidine-based dynamin inhibitors.

McGeachie AB, Odell LR, Quan A, Daniel JA, Chau N, Hill TA, Gorgani NN, Keating DJ, Cousin MA, van Dam EM, Mariana A, Whiting A, Perera S, Novelle A, Young KA, Deane FM, Gilbert J, Sakoff JA, Chircop M, McCluskey A, Robinson PJ.

ACS Chem Biol. 2013 Jul 19;8(7):1507-18. doi: 10.1021/cb400137p. Epub 2013 May 30.

PMID:
23642287
27.

Synthesis and evaluation of novel ellipticines as potential anti-cancer agents.

Deane FM, O'Sullivan EC, Maguire AR, Gilbert J, Sakoff JA, McCluskey A, McCarthy FO.

Org Biomol Chem. 2013 Feb 28;11(8):1334-44. doi: 10.1039/c2ob27186a.

PMID:
23314103
28.

Focused library development of 2-phenylacrylamides as broad spectrum cytotoxic agents.

Tarleton M, Dyson L, Gilbert J, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2013 Jan 1;21(1):333-47. doi: 10.1016/j.bmc.2012.10.003. Epub 2012 Oct 23.

PMID:
23176751
29.

Cytotoxic 2-phenyacrylnitriles, the importance of the cyanide moiety and discovery of potent broad spectrum cytotoxic agents.

Tarleton M, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2012 Nov;57:65-73. doi: 10.1016/j.ejmech.2012.09.019. Epub 2012 Sep 18.

PMID:
23047225
30.

Predicting 5-fluorouracil toxicity in colorectal cancer patients from peripheral blood cell telomere length: a multivariate analysis.

Garg MB, Lincz LF, Adler K, Scorgie FE, Ackland SP, Sakoff JA.

Br J Cancer. 2012 Oct 23;107(9):1525-33. doi: 10.1038/bjc.2012.421. Epub 2012 Sep 18.

31.

Synthesis and anticancer activity of a series of norcantharidin analogues.

Tarleton M, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2012 Aug;54:573-81. doi: 10.1016/j.ejmech.2012.06.010. Epub 2012 Jun 15.

PMID:
22796041
32.

Norcantharimide analogues possessing terminal phosphate esters and their anti-cancer activity.

Robertson MJ, Gordon CP, Gilbert J, McCluskey A, Sakoff JA.

Bioorg Med Chem. 2011 Sep 15;19(18):5734-41. doi: 10.1016/j.bmc.2011.01.031. Epub 2011 Feb 1.

PMID:
21855357
33.

Role of the clathrin terminal domain in regulating coated pit dynamics revealed by small molecule inhibition.

von Kleist L, Stahlschmidt W, Bulut H, Gromova K, Puchkov D, Robertson MJ, MacGregor KA, Tomilin N, Pechstein A, Chau N, Chircop M, Sakoff J, von Kries JP, Saenger W, Kräusslich HG, Shupliakov O, Robinson PJ, McCluskey A, Haucke V.

Cell. 2011 Aug 5;146(3):471-84. doi: 10.1016/j.cell.2011.06.025. Erratum in: Cell. 2011 Sep 2;146(5):841. Tomlin, Nikolay [corrected to Tomilin, Nikolay].

34.

Inhibition of dynamin by dynole 34-2 induces cell death following cytokinesis failure in cancer cells.

Chircop M, Perera S, Mariana A, Lau H, Ma MP, Gilbert J, Jones NC, Gordon CP, Young KA, Morokoff A, Sakoff J, O'Brien TJ, McCluskey A, Robinson PJ.

Mol Cancer Ther. 2011 Sep;10(9):1553-62. doi: 10.1158/1535-7163.MCT-11-0067. Epub 2011 Jul 12.

35.

A simple HPLC method for plasma level monitoring of mitotane and its two main metabolites in adrenocortical cancer patients.

Garg MB, Sakoff JA, Ackland SP.

J Chromatogr B Analyt Technol Biomed Life Sci. 2011 Aug 1;879(23):2201-5. doi: 10.1016/j.jchromb.2011.06.001. Epub 2011 Jun 13.

PMID:
21719363
36.

Norcantharidin analogues with nematocidal activity in Haemonchus contortus.

Campbell BE, Tarleton M, Gordon CP, Sakoff JA, Gilbert J, McCluskey A, Gasser RB.

Bioorg Med Chem Lett. 2011 Jun 1;21(11):3277-81. doi: 10.1016/j.bmcl.2011.04.031. Epub 2011 Apr 13.

PMID:
21536433
37.

The dynamin inhibitors MiTMAB and OcTMAB induce cytokinesis failure and inhibit cell proliferation in human cancer cells.

Joshi S, Perera S, Gilbert J, Smith CM, Mariana A, Gordon CP, Sakoff JA, McCluskey A, Robinson PJ, Braithwaite AW, Chircop M.

Mol Cancer Ther. 2010 Jul;9(7):1995-2006. doi: 10.1158/1535-7163.MCT-10-0161. Epub 2010 Jun 22.

38.

Association of thymidylate synthase enhancer region polymorphisms with thymidylate synthase activity in vivo.

de Bock CE, Garg MB, Scott N, Sakoff JA, Scorgie FE, Ackland SP, Lincz LF.

Pharmacogenomics J. 2011 Aug;11(4):307-14. doi: 10.1038/tpj.2010.43. Epub 2010 Jun 8.

PMID:
20531375
39.

Synthesis and biological activity of Delta-5,6-norcantharimides: importance of the 5,6-bridge.

Thaqi A, Scott JL, Gilbert J, Sakoff JA, McCluskey A.

Eur J Med Chem. 2010 May;45(5):1717-23. doi: 10.1016/j.ejmech.2010.01.004. Epub 2010 Jan 14.

PMID:
20153915
40.

Inhibition of dynamin mediated endocytosis by the dynoles--synthesis and functional activity of a family of indoles.

Hill TA, Gordon CP, McGeachie AB, Venn-Brown B, Odell LR, Chau N, Quan A, Mariana A, Sakoff JA, Chircop M, Robinson PJ, McCluskey A.

J Med Chem. 2009 Jun 25;52(12):3762-73. doi: 10.1021/jm900036m.

PMID:
19459681
41.

Steroids from an Australian sponge Psammoclema sp.

Holland IP, McCluskey A, Sakoff JA, Gilbert J, Chau N, Robinson PJ, Motti CA, Wright AD, van Altena IA.

J Nat Prod. 2009 Jan;72(1):102-6. doi: 10.1021/np800688f.

PMID:
19132863
42.

Norcantharidin analogues: synthesis, anticancer activity and protein phosphatase 1 and 2A inhibition.

Hill TA, Stewart SG, Gordon CP, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

ChemMedChem. 2008 Dec;3(12):1878-92. doi: 10.1002/cmdc.200800192.

PMID:
19025735
43.
44.

Synthesis and biological evaluation of norcantharidin analogues: towards PP1 selectivity.

Stewart SG, Hill TA, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Dec 1;15(23):7301-10. Epub 2007 Aug 24.

PMID:
17870547
45.

Norcantharimides, synthesis and anticancer activity: Synthesis of new norcantharidin analogues and their anticancer evaluation.

Hill TA, Stewart SG, Ackland SP, Gilbert J, Sauer B, Sakoff JA, McCluskey A.

Bioorg Med Chem. 2007 Sep 15;15(18):6126-34. Epub 2007 Jun 20.

PMID:
17606377
46.

Heterocyclic substituted cantharidin and norcantharidin analogues--synthesis, protein phosphatase (1 and 2A) inhibition, and anti-cancer activity.

Hill TA, Stewart SG, Sauer B, Gilbert J, Ackland SP, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2007 Jun 15;17(12):3392-7. Epub 2007 Apr 2.

PMID:
17451951
47.

Telomere length predicts neutrophil recovery in the absence of G-CSF after autologous peripheral blood stem cell transplantation.

Lincz LF, Scorgie FE, Sakoff JA, Fagan KA, Ackland SP, Enno A.

Bone Marrow Transplant. 2004 Sep;34(5):439-45.

PMID:
15258557
48.

Protein phosphatase inhibition: structure based design. Towards new therapeutic agents.

Sakoff JA, McCluskey A.

Curr Pharm Des. 2004;10(10):1139-59. Review.

PMID:
15078146
49.

Modified norcantharidins; synthesis, protein phosphatases 1 and 2A inhibition, and anticancer activity.

Hart ME, Chamberlin AR, Walkom C, Sakoff JA, McCluskey A.

Bioorg Med Chem Lett. 2004 Apr 19;14(8):1969-73.

PMID:
15050639
50.

Serine/threonine protein phosphatase inhibition enhances the effect of thymidylate synthase inhibition.

Sakoff JA, Howitt IJ, Ackland SP, McCluskey A.

Cancer Chemother Pharmacol. 2004 Mar;53(3):225-32. Epub 2003 Nov 25.

PMID:
14648018

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