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Items: 1 to 50 of 193

1.

Dual Bioorthogonal Labeling of the Amyloid-β Protein Precursor Facilitates Simultaneous Visualization of the Protein and Its Cleavage Products.

van Husen LS, Schedin-Weiss S, Trung MN, Kazmi M, Winblad B, Sakmar TP, Elsässer SJ, Tjernberg LO.

J Alzheimers Dis. 2019 Oct 8. doi: 10.3233/JAD-190898. [Epub ahead of print]

PMID:
31609694
2.

Multiplexed analysis of the secretin-like GPCR-RAMP interactome.

Lorenzen E, Dodig-Crnković T, Kotliar IB, Pin E, Ceraudo E, Vaughan RD, Uhlèn M, Huber T, Schwenk JM, Sakmar TP.

Sci Adv. 2019 Sep 18;5(9):eaaw2778. doi: 10.1126/sciadv.aaw2778. eCollection 2019 Sep.

3.

Genetic code expansion and photocross-linking identify different β-arrestin binding modes to the angiotensin II type 1 receptor.

Gagnon L, Cao Y, Cho A, Sedki D, Huber T, Sakmar TP, Laporte SA.

J Biol Chem. 2019 Sep 17. pii: jbc.RA119.010324. doi: 10.1074/jbc.RA119.010324. [Epub ahead of print]

4.

High-Affinity Binding of Chemokine Analogs that Display Ligand Bias at the HIV-1 Coreceptor CCR5.

Rico CA, Berchiche YA, Horioka M, Peeler JC, Lorenzen E, Tian H, Kazmi MA, Fürstenberg A, Gaertner H, Hartley O, Sakmar TP, Huber T.

Biophys J. 2019 Sep 3;117(5):903-919. doi: 10.1016/j.bpj.2019.07.043. Epub 2019 Aug 2.

PMID:
31421836
5.

14-3-3 signal adaptor and scaffold proteins mediate GPCR trafficking.

Yuan L, Barbash S, Kongsamut S, Eishingdrelo A, Sakmar TP, Eishingdrelo H.

Sci Rep. 2019 Aug 1;9(1):11156. doi: 10.1038/s41598-019-47478-w.

6.

Tracking Pore Hydration in Channelrhodopsin by Site-Directed Infrared-Active Azido Probes.

Krause BS, Kaufmann JCD, Kuhne J, Vierock J, Huber T, Sakmar TP, Gerwert K, Bartl FJ, Hegemann P.

Biochemistry. 2019 Mar 5;58(9):1275-1286. doi: 10.1021/acs.biochem.8b01211. Epub 2019 Feb 19.

PMID:
30702875
7.

Receptor Structures for a Caldron of Cannabinoids.

Lorenzen E, Sakmar TP.

Cell. 2019 Jan 24;176(3):409-411. doi: 10.1016/j.cell.2019.01.012.

PMID:
30682366
8.

Conformation-specific antibodies against multiple amyloid protofibril species from a single amyloid immunogen.

Bonito-Oliva A, Schedin-Weiss S, Younesi SS, Tiiman A, Adura C, Paknejad N, Brendel M, Romin Y, Parchem RJ, Graff C, Vukojević V, Tjernberg LO, Terenius L, Winblad B, Sakmar TP, Graham WV.

J Cell Mol Med. 2019 Mar;23(3):2103-2114. doi: 10.1111/jcmm.14119. Epub 2019 Jan 20.

9.

Detection of Concordance between Transcriptional Levels of GPCRs and Receptor-Activity-Modifying Proteins.

Barbash S, Persson T, Lorenzen E, Kazmi MA, Huber T, Sakmar TP.

iScience. 2019 Jan 25;11:366-374. doi: 10.1016/j.isci.2018.12.024. Epub 2018 Dec 31.

10.

Third-Party Capture of Elusive GPCR Dimers.

Huber T, Sakmar TP.

Biophys J. 2019 Jan 8;116(1):1-3. doi: 10.1016/j.bpj.2018.11.018. Epub 2018 Nov 22. No abstract available.

PMID:
30558887
11.

Ancient Family of Retinal Proteins Brought to Light "Sight-Unseen".

Sakmar TP, Huber T.

Biochemistry. 2018 Dec 11;57(49):6735-6737. doi: 10.1021/acs.biochem.8b01188. Epub 2018 Nov 30. No abstract available.

PMID:
30499659
12.

G protein subtype-specific signaling bias in a series of CCR5 chemokine analogs.

Lorenzen E, Ceraudo E, Berchiche YA, Rico CA, Fürstenberg A, Sakmar TP, Huber T.

Sci Signal. 2018 Oct 16;11(552). pii: eaao6152. doi: 10.1126/scisignal.aao6152.

PMID:
30327411
13.

DNA-encircled lipid bilayers.

Iric K, Subramanian M, Oertel J, Agarwal NP, Matthies M, Periole X, Sakmar TP, Huber T, Fahmy K, Schmidt TL.

Nanoscale. 2018 Oct 21;10(39):18463-18467. doi: 10.1039/c8nr06505e. Epub 2018 Oct 1.

PMID:
30272763
14.

Photoaffinity Cross-Linking and Unnatural Amino Acid Mutagenesis Reveal Insights into Calcitonin Gene-Related Peptide Binding to the Calcitonin Receptor-like Receptor/Receptor Activity-Modifying Protein 1 (CLR/RAMP1) Complex.

Simms J, Uddin R, Sakmar TP, Gingell JJ, Garelja ML, Hay DL, Brimble MA, Harris PW, Reynolds CA, Poyner DR.

Biochemistry. 2018 Aug 14;57(32):4915-4922. doi: 10.1021/acs.biochem.8b00502. Epub 2018 Jul 25.

15.

Probing Antibody Binding Sites on G Protein-Coupled Receptors Using Genetically Encoded Photo-Activatable Cross-Linkers.

Huber T, Sakmar TP.

Methods Mol Biol. 2018;1785:65-75. doi: 10.1007/978-1-4939-7841-0_5.

PMID:
29714012
16.

Energetics Underlying Twist Polymorphisms in Amyloid Fibrils.

Periole X, Huber T, Bonito-Oliva A, Aberg KC, van der Wel PCA, Sakmar TP, Marrink SJ.

J Phys Chem B. 2018 Jan 25;122(3):1081-1091. doi: 10.1021/acs.jpcb.7b10233. Epub 2018 Jan 5.

17.

Brain gene expression signature on primate genomic sequence evolution.

Barbash S, Sakmar TP.

Sci Rep. 2017 Dec 11;7(1):17329. doi: 10.1038/s41598-017-17462-3.

18.

Epitranscriptomic profiling across cell types reveals associations between APOBEC1-mediated RNA editing, gene expression outcomes, and cellular function.

Rayon-Estrada V, Harjanto D, Hamilton CE, Berchiche YA, Gantman EC, Sakmar TP, Bulloch K, Gagnidze K, Harroch S, McEwen BS, Papavasiliou FN.

Proc Natl Acad Sci U S A. 2017 Dec 12;114(50):13296-13301. doi: 10.1073/pnas.1714227114. Epub 2017 Nov 22.

19.

Isopeptide and ester bond ubiquitination both regulate degradation of the human dopamine receptor 4.

Peeler JC, Schedin-Weiss S, Soula M, Kazmi MA, Sakmar TP.

J Biol Chem. 2017 Dec 29;292(52):21623-21630. doi: 10.1074/jbc.M116.758961. Epub 2017 Nov 3.

20.

GPCRs globally coevolved with receptor activity-modifying proteins, RAMPs.

Barbash S, Lorenzen E, Persson T, Huber T, Sakmar TP.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):12015-12020. doi: 10.1073/pnas.1713074114. Epub 2017 Oct 23.

21.

The Energetics of Chromophore Binding in the Visual Photoreceptor Rhodopsin.

Tian H, Sakmar TP, Huber T.

Biophys J. 2017 Jul 11;113(1):60-72. doi: 10.1016/j.bpj.2017.05.036.

22.

Complex Photochemistry within the Green-Absorbing Channelrhodopsin ReaChR.

Krause BS, Grimm C, Kaufmann JCD, Schneider F, Sakmar TP, Bartl FJ, Hegemann P.

Biophys J. 2017 Mar 28;112(6):1166-1175. doi: 10.1016/j.bpj.2017.02.001.

23.

Length-dependent gene misexpression is associated with Alzheimer's disease progression.

Barbash S, Sakmar TP.

Sci Rep. 2017 Mar 15;7(1):190. doi: 10.1038/s41598-017-00250-4.

24.

Genetically encoded photocross-linkers determine the biological binding site of exendin-4 peptide in the N-terminal domain of the intact human glucagon-like peptide-1 receptor (GLP-1R).

Koole C, Reynolds CA, Mobarec JC, Hick C, Sexton PM, Sakmar TP.

J Biol Chem. 2017 Apr 28;292(17):7131-7144. doi: 10.1074/jbc.M117.779496. Epub 2017 Mar 10.

25.

Nucleobindin 1 binds to multiple types of pre-fibrillar amyloid and inhibits fibrillization.

Bonito-Oliva A, Barbash S, Sakmar TP, Graham WV.

Sci Rep. 2017 Feb 21;7:42880. doi: 10.1038/srep42880.

26.

Update on Alzheimer's Disease Therapy and Prevention Strategies.

Graham WV, Bonito-Oliva A, Sakmar TP.

Annu Rev Med. 2017 Jan 14;68:413-430. doi: 10.1146/annurev-med-042915-103753. Review.

PMID:
28099083
27.

Measurement of Slow Spontaneous Release of 11-cis-Retinal from Rhodopsin.

Tian H, Sakmar TP, Huber T.

Biophys J. 2017 Jan 10;112(1):153-161. doi: 10.1016/j.bpj.2016.12.005.

28.

Introduction: G-Protein Coupled Receptors.

Sakmar TP.

Chem Rev. 2017 Jan 11;117(1):1-3. doi: 10.1021/acs.chemrev.6b00686. No abstract available.

PMID:
28073249
29.

Pharmacology: Inside-out receptor inhibition.

Sakmar TP, Huber T.

Nature. 2016 Dec 15;540(7633):344-345. doi: 10.1038/nature20486. Epub 2016 Dec 7. No abstract available.

PMID:
27926728
30.

CXC Chemokine Receptor 3 Alternative Splice Variants Selectively Activate Different Signaling Pathways.

Berchiche YA, Sakmar TP.

Mol Pharmacol. 2016 Oct;90(4):483-95. doi: 10.1124/mol.116.105502. Epub 2016 Aug 10.

PMID:
27512119
31.

Genetically encoded photocrosslinkers locate the high-affinity binding site of antidepressant drugs in the human serotonin transporter.

Rannversson H, Andersen J, Sørensen L, Bang-Andersen B, Park M, Huber T, Sakmar TP, Strømgaard K.

Nat Commun. 2016 Apr 19;7:11261. doi: 10.1038/ncomms11261.

32.

Recurrent activating mutations of G-protein-coupled receptor CYSLTR2 in uveal melanoma.

Moore AR, Ceraudo E, Sher JJ, Guan Y, Shoushtari AN, Chang MT, Zhang JQ, Walczak EG, Kazmi MA, Taylor BS, Huber T, Chi P, Sakmar TP, Chen Y.

Nat Genet. 2016 Jun;48(6):675-80. doi: 10.1038/ng.3549. Epub 2016 Apr 18.

33.

A simple method for enhancing the bioorthogonality of cyclooctyne reagent.

Tian H, Sakmar TP, Huber T.

Chem Commun (Camb). 2016 Apr 7;52(31):5451-4. doi: 10.1039/c6cc01321j.

34.

Defeating Alzheimer's disease and other dementias: a priority for European science and society.

Winblad B, Amouyel P, Andrieu S, Ballard C, Brayne C, Brodaty H, Cedazo-Minguez A, Dubois B, Edvardsson D, Feldman H, Fratiglioni L, Frisoni GB, Gauthier S, Georges J, Graff C, Iqbal K, Jessen F, Johansson G, Jönsson L, Kivipelto M, Knapp M, Mangialasche F, Melis R, Nordberg A, Rikkert MO, Qiu C, Sakmar TP, Scheltens P, Schneider LS, Sperling R, Tjernberg LO, Waldemar G, Wimo A, Zetterberg H.

Lancet Neurol. 2016 Apr;15(5):455-532. doi: 10.1016/S1474-4422(16)00062-4. Review. No abstract available.

PMID:
26987701
35.

Preparation and Analysis of N-Terminal Chemokine Receptor Sulfopeptides Using Tyrosylprotein Sulfotransferase Enzymes.

Seibert C, Sanfiz A, Sakmar TP, Veldkamp CT.

Methods Enzymol. 2016;570:357-88. doi: 10.1016/bs.mie.2015.09.004. Epub 2015 Nov 14.

36.

Targeting of the pulmonary capillary vascular niche promotes lung alveolar repair and ameliorates fibrosis.

Cao Z, Lis R, Ginsberg M, Chavez D, Shido K, Rabbany SY, Fong GH, Sakmar TP, Rafii S, Ding BS.

Nat Med. 2016 Feb;22(2):154-62. doi: 10.1038/nm.4035. Epub 2016 Jan 18.

37.

Bioorthogonal Labeling of Ghrelin Receptor to Facilitate Studies of Ligand-Dependent Conformational Dynamics.

Park M, Sivertsen BB, Els-Heindl S, Huber T, Holst B, Beck-Sickinger AG, Schwartz TW, Sakmar TP.

Chem Biol. 2015 Nov 19;22(11):1431-1436. doi: 10.1016/j.chembiol.2015.09.014. Epub 2015 Nov 5.

38.

Quantitative Multi-color Detection Strategies for Bioorthogonally Labeled GPCRs.

Park M, Tian H, Naganathan S, Sakmar TP, Huber T.

Methods Mol Biol. 2015;1335:67-93. doi: 10.1007/978-1-4939-2914-6_6.

PMID:
26260595
39.

Micelle-Enhanced Bioorthogonal Labeling of Genetically Encoded Azido Groups on the Lipid-Embedded Surface of a GPCR.

Tian H, Sakmar TP, Huber T.

Chembiochem. 2015 Jun 15;16(9):1314-22. doi: 10.1002/cbic.201500030. Epub 2015 May 11.

40.

Multiplex detection of functional G protein-coupled receptors harboring site-specifically modified unnatural amino acids.

Naganathan S, Ray-Saha S, Park M, Tian H, Sakmar TP, Huber T.

Biochemistry. 2015 Jan 27;54(3):776-86. doi: 10.1021/bi501267x. Epub 2015 Jan 8.

41.

Development of a CCK1R-membrane nanoparticle as a fish-out tool for bioactive peptides.

Staljanssens D, Rico CA, Park M, Van Camp J, Yu N, Huber T, Sakmar TP, Smagghe G.

Peptides. 2015 Jun;68:219-27. doi: 10.1016/j.peptides.2014.10.015. Epub 2014 Nov 5.

PMID:
25451329
42.

Chemical biology methods for investigating G protein-coupled receptor signaling.

Huber T, Sakmar TP.

Chem Biol. 2014 Sep 18;21(9):1224-37. doi: 10.1016/j.chembiol.2014.08.009. Review.

43.

Bioorthogonal fluorescent labeling of functional G-protein-coupled receptors.

Tian H, Naganathan S, Kazmi MA, Schwartz TW, Sakmar TP, Huber T.

Chembiochem. 2014 Aug 18;15(12):1820-9. doi: 10.1002/cbic.201402193. Epub 2014 Jul 18.

44.

Mapping substance P binding sites on the neurokinin-1 receptor using genetic incorporation of a photoreactive amino acid.

Valentin-Hansen L, Park M, Huber T, Grunbeck A, Naganathan S, Schwartz TW, Sakmar TP.

J Biol Chem. 2014 Jun 27;289(26):18045-54. doi: 10.1074/jbc.M113.527085. Epub 2014 May 15.

45.

Antibody epitopes on g protein-coupled receptors mapped with genetically encoded photoactivatable cross-linkers.

Ray-Saha S, Huber T, Sakmar TP.

Biochemistry. 2014 Mar 4;53(8):1302-10. doi: 10.1021/bi401289p. Epub 2014 Feb 18.

46.

Spectral tuning of ultraviolet cone pigments: an interhelical lock mechanism.

Sekharan S, Mooney VL, Rivalta I, Kazmi MA, Neitz M, Neitz J, Sakmar TP, Yan EC, Batista VS.

J Am Chem Soc. 2013 Dec 26;135(51):19064-7. doi: 10.1021/ja409896y. Epub 2013 Dec 12.

47.

Probing G protein-coupled receptor-ligand interactions with targeted photoactivatable cross-linkers.

Grunbeck A, Sakmar TP.

Biochemistry. 2013 Dec 3;52(48):8625-32. doi: 10.1021/bi401300y. Epub 2013 Nov 19. Review.

PMID:
24199838
48.

Site-specific labeling of genetically encoded azido groups for multicolor, single-molecule fluorescence imaging of GPCRs.

Tian H, Sakmar TP, Huber T.

Methods Cell Biol. 2013;117:267-303. doi: 10.1016/B978-0-12-408143-7.00015-3.

PMID:
24143983
49.

Genetically-encoded molecular probes to study G protein-coupled receptors.

Naganathan S, Grunbeck A, Tian H, Huber T, Sakmar TP.

J Vis Exp. 2013 Sep 13;(79). doi: 10.3791/50588.

50.

Use of G-protein-coupled and -uncoupled CCR5 receptors by CCR5 inhibitor-resistant and -sensitive human immunodeficiency virus type 1 variants.

Berro R, Yasmeen A, Abrol R, Trzaskowski B, Abi-Habib S, Grunbeck A, Lascano D, Goddard WA 3rd, Klasse PJ, Sakmar TP, Moore JP.

J Virol. 2013 Jun;87(12):6569-81. doi: 10.1128/JVI.00099-13. Epub 2013 Mar 6.

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