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Genome-wide association study in frontal fibrosing alopecia identifies four susceptibility loci including HLA-B*07:02.

Tziotzios C, Petridis C, Dand N, Ainali C, Saklatvala JR, Pullabhatla V, Onoufriadis A, Pramanik R, Baudry D, Lee SH, Wood K, Liu L, Seegobin S, Michelotti GA, Lwin SM, Christou EAA, Curtis CJ, de Rinaldis E, Saxena A, Holmes S, Harries M, Palamaras I, Cunningham F, Parkins G, Kaur M, Farrant P, McDonagh A, Messenger A, Jones J, Jolliffe V, Ali I, Ardern-Jones M, Mitchell C, Burrows N, Atkar R, Banfield C, Alexandroff A, Champagne C, Cooper HL, Vañó-Galván S, Molina-Ruiz AM, Perez NO, Patel GK, Macbeth A, Page M, Bryden A, Mowbray M, Wahie S, Armstrong K, Cooke N, Goodfield M, Man I, de Berker D, Dunnill G, Takwale A, Rao A, Siah TW, Sinclair R, Wade MS, Dlova NC, Setterfield J, Lewis F, Bhargava K, Kirkpatrick N, Estivill X, Stefanato CM, Flohr C, Spector T, Watt FM, Smith CH, Barker JN, Fenton DA, Simpson MA, McGrath JA.

Nat Commun. 2019 Mar 8;10(1):1150. doi: 10.1038/s41467-019-09117-w.


Genome-wide meta-analysis implicates mediators of hair follicle development and morphogenesis in risk for severe acne.

Petridis C, Navarini AA, Dand N, Saklatvala J, Baudry D, Duckworth M, Allen MH, Curtis CJ, Lee SH, Burden AD, Layton A, Bataille V, Pink AE; Acne Genetic Study Group, Carlavan I, Voegel JJ, Spector TD, Trembath RC, McGrath JA, Smith CH, Barker JN, Simpson MA.

Nat Commun. 2018 Dec 12;9(1):5075. doi: 10.1038/s41467-018-07459-5.


Connective tissue growth factor contributes to joint homeostasis and osteoarthritis severity by controlling the matrix sequestration and activation of latent TGFβ.

Tang X, Muhammad H, McLean C, Miotla-Zarebska J, Fleming J, Didangelos A, Önnerfjord P, Leask A, Saklatvala J, Vincent TL.

Ann Rheum Dis. 2018 Sep;77(9):1372-1380. doi: 10.1136/annrheumdis-2018-212964. Epub 2018 Jun 20.


Text-mined phenotype annotation and vector-based similarity to improve identification of similar phenotypes and causative genes in monogenic disease patients.

Saklatvala JR, Dand N, Simpson MA.

Hum Mutat. 2018 May;39(5):643-652. doi: 10.1002/humu.23413. Epub 2018 Mar 15.


Acute Molecular Changes in Synovial Fluid Following Human Knee Injury: Association With Early Clinical Outcomes.

Watt FE, Paterson E, Freidin A, Kenny M, Judge A, Saklatvala J, Williams A, Vincent TL.

Arthritis Rheumatol. 2016 Sep;68(9):2129-40. doi: 10.1002/art.39677.


Brief Report: JNK-2 Controls Aggrecan Degradation in Murine Articular Cartilage and the Development of Experimental Osteoarthritis.

Ismail HM, Miotla-Zarebska J, Troeberg L, Tang X, Stott B, Yamamoto K, Nagase H, Fosang AJ, Vincent TL, Saklatvala J.

Arthritis Rheumatol. 2016 May;68(5):1165-71. doi: 10.1002/art.39547.


Dual-Specificity Phosphatase 1 and Tristetraprolin Cooperate To Regulate Macrophage Responses to Lipopolysaccharide.

Smallie T, Ross EA, Ammit AJ, Cunliffe HE, Tang T, Rosner DR, Ridley ML, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):277-88. doi: 10.4049/jimmunol.1402830. Epub 2015 May 27.


Dominant Suppression of Inflammation via Targeted Mutation of the mRNA Destabilizing Protein Tristetraprolin.

Ross EA, Smallie T, Ding Q, O'Neil JD, Cunliffe HE, Tang T, Rosner DR, Klevernic I, Morrice NA, Monaco C, Cunningham AF, Buckley CD, Saklatvala J, Dean JL, Clark AR.

J Immunol. 2015 Jul 1;195(1):265-76. doi: 10.4049/jimmunol.1402826. Epub 2015 May 22.


Interleukin-1 Acts via the JNK-2 Signaling Pathway to Induce Aggrecan Degradation by Human Chondrocytes.

Ismail HM, Yamamoto K, Vincent TL, Nagase H, Troeberg L, Saklatvala J.

Arthritis Rheumatol. 2015 Jul;67(7):1826-36. doi: 10.1002/art.39099.


Transcriptional analysis of micro-dissected articular cartilage in post-traumatic murine osteoarthritis.

Gardiner MD, Vincent TL, Driscoll C, Burleigh A, Bou-Gharios G, Saklatvala J, Nagase H, Chanalaris A.

Osteoarthritis Cartilage. 2015 Apr;23(4):616-28. doi: 10.1016/j.joca.2014.12.014. Epub 2014 Dec 26.


Generation of a mouse line harboring a Bi-transgene expressing luciferase and tamoxifen-activatable creER(T2) recombinase in cartilage.

Lo Cascio L, Liu K, Nakamura H, Chu G, Lim NH, Chanalaris A, Saklatvala J, Nagase H, Bou-Gharios G.

Genesis. 2014 Feb;52(2):110-9. doi: 10.1002/dvg.22734. Epub 2013 Dec 27.


Heat shock protein B1-deficient mice display impaired wound healing.

Crowe J, Aubareda A, McNamee K, Przybycien PM, Lu X, Williams RO, Bou-Gharios G, Saklatvala J, Dean JL.

PLoS One. 2013 Oct 15;8(10):e77383. doi: 10.1371/journal.pone.0077383. eCollection 2013.


Fibroblast growth factor 2 drives changes in gene expression following injury to murine cartilage in vitro and in vivo.

Chong KW, Chanalaris A, Burleigh A, Jin H, Watt FE, Saklatvala J, Vincent TL.

Arthritis Rheum. 2013 Sep;65(9):2346-55. doi: 10.1002/art.38039. Erratum in: Arthritis Rheumatol. 2019 Mar;71(3):360.


Cyclin-dependent kinase 6 phosphorylates NF-κB P65 at serine 536 and contributes to the regulation of inflammatory gene expression.

Buss H, Handschick K, Jurrmann N, Pekkonen P, Beuerlein K, Müller H, Wait R, Saklatvala J, Ojala PM, Schmitz ML, Naumann M, Kracht M.

PLoS One. 2012;7(12):e51847. doi: 10.1371/journal.pone.0051847. Epub 2012 Dec 26.


Src and fibroblast growth factor 2 independently regulate signaling and gene expression induced by experimental injury to intact articular cartilage.

Watt FE, Ismail HM, Didangelos A, Peirce M, Vincent TL, Wait R, Saklatvala J.

Arthritis Rheum. 2013 Feb;65(2):397-407. doi: 10.1002/art.37765.


Joint immobilization prevents murine osteoarthritis and reveals the highly mechanosensitive nature of protease expression in vivo.

Burleigh A, Chanalaris A, Gardiner MD, Driscoll C, Boruc O, Saklatvala J, Vincent TL.

Arthritis Rheum. 2012 Jul;64(7):2278-88. doi: 10.1002/art.34420.


Anti-inflammatory effects of selective glucocorticoid receptor modulators are partially dependent on up-regulation of dual specificity phosphatase 1.

Joanny E, Ding Q, Gong L, Kong P, Saklatvala J, Clark AR.

Br J Pharmacol. 2012 Feb;165(4b):1124-36. doi: 10.1111/j.1476-5381.2011.01574.x.


MAPKAP kinase 2 blocks tristetraprolin-directed mRNA decay by inhibiting CAF1 deadenylase recruitment.

Marchese FP, Aubareda A, Tudor C, Saklatvala J, Clark AR, Dean JL.

J Biol Chem. 2010 Sep 3;285(36):27590-600. doi: 10.1074/jbc.M110.136473. Epub 2010 Jul 1.


Glucocorticoid regulation of mouse and human dual specificity phosphatase 1 (DUSP1) genes: unusual cis-acting elements and unexpected evolutionary divergence.

Tchen CR, Martins JR, Paktiawal N, Perelli R, Saklatvala J, Clark AR.

J Biol Chem. 2010 Jan 22;285(4):2642-52. doi: 10.1074/jbc.M109.037309. Epub 2009 Nov 23.


The p38 MAPK pathway mediates both antiinflammatory and proinflammatory processes: comment on the article by Damjanov and the editorial by Genovese.

Clark AR, Dean JL, Saklatvala J.

Arthritis Rheum. 2009 Nov;60(11):3513-4. doi: 10.1002/art.24919. No abstract available.


Fibroblast growth factor 2 is an intrinsic chondroprotective agent that suppresses ADAMTS-5 and delays cartilage degradation in murine osteoarthritis.

Chia SL, Sawaji Y, Burleigh A, McLean C, Inglis J, Saklatvala J, Vincent T.

Arthritis Rheum. 2009 Jul;60(7):2019-27. doi: 10.1002/art.24654.


The p38 MAPK pathway inhibits tristetraprolin-directed decay of interleukin-10 and pro-inflammatory mediator mRNAs in murine macrophages.

Tudor C, Marchese FP, Hitti E, Aubareda A, Rawlinson L, Gaestel M, Blackshear PJ, Clark AR, Saklatvala J, Dean JL.

FEBS Lett. 2009 Jun 18;583(12):1933-8. doi: 10.1016/j.febslet.2009.04.039. Epub 2009 May 3.


Post-transcriptional gene regulation by MAP kinases via AU-rich elements.

Clark A, Dean J, Tudor C, Saklatvala J.

Front Biosci (Landmark Ed). 2009 Jan 1;14:847-71. Review.


Fibroblast growth factor 2 inhibits induction of aggrecanase activity in human articular cartilage.

Sawaji Y, Hynes J, Vincent T, Saklatvala J.

Arthritis Rheum. 2008 Nov;58(11):3498-509. doi: 10.1002/art.24025.


Is the response of cartilage to injury relevant to osteoarthritis?

Vincent TL, Saklatvala J.

Arthritis Rheum. 2008 May;58(5):1207-10. doi: 10.1002/art.23443. Review. No abstract available.


Mapping lymphocyte plasma membrane proteins: a proteomic approach.

Peirce MJ, Saklatvala J, Cope AP, Wait R.

Methods Mol Med. 2007;136:361-7.


Two-dimensional electrophoresis of proteins secreted from articular cartilage.

Hermansson M, Saklatvala J, Wait R.

Methods Mol Med. 2007;136:349-59.


FGF-2 is bound to perlecan in the pericellular matrix of articular cartilage, where it acts as a chondrocyte mechanotransducer.

Vincent TL, McLean CJ, Full LE, Peston D, Saklatvala J.

Osteoarthritis Cartilage. 2007 Jul;15(7):752-63. Epub 2007 Mar 23.


Cervical spine magnetic resonance imaging in primary care consulters with shoulder pain: a case control study.

Paul A, Lewis M, Saklatvala J, McCall I, Shadforth M, Croft P, Hay E.

Ann Rheum Dis. 2007 Oct;66(10):1363-8. Epub 2007 Feb 8.


Heat shock protein 27 functions in inflammatory gene expression and transforming growth factor-beta-activated kinase-1 (TAK1)-mediated signaling.

Alford KA, Glennie S, Turrell BR, Rawlinson L, Saklatvala J, Dean JL.

J Biol Chem. 2007 Mar 2;282(9):6232-41. Epub 2007 Jan 3.


Antiinflammatory effects of dexamethasone are partly dependent on induction of dual specificity phosphatase 1.

Abraham SM, Lawrence T, Kleiman A, Warden P, Medghalchi M, Tuckermann J, Saklatvala J, Clark AR.

J Exp Med. 2006 Aug 7;203(8):1883-9. Epub 2006 Jul 31.


Basic fibroblast growth factor: an extracellular mechanotransducer in articular cartilage?

Vincent T, Saklatvala J.

Biochem Soc Trans. 2006 Jun;34(Pt 3):456-7. Review.


Development of a novel 2D proteomics approach for the identification of proteins secreted by primary chondrocytes after stimulation by IL-1 and oncostatin M.

Catterall JB, Rowan AD, Sarsfield S, Saklatvala J, Wait R, Cawston TE.

Rheumatology (Oxford). 2006 Sep;45(9):1101-9. Epub 2006 Mar 27.


Prevalence of radiographic osteoarthritis--it all depends on your point of view.

Duncan RC, Hay EM, Saklatvala J, Croft PR.

Rheumatology (Oxford). 2006 Jun;45(6):757-60. Epub 2006 Jan 17.


Two-stage affinity purification for inducibly phosphorylated membrane proteins.

Peirce MJ, Begum S, Saklatvala J, Cope AP, Wait R.

Proteomics. 2005 Jun;5(9):2417-21.


Report on the Molecular Approaches to Osteoarthritis Symposium, Imperial College London, UK, 18-20 April 2004.

Saklatvala J, Nagase H.

Arthritis Res Ther. 2004;6(5):203-7. Epub 2004 Jul 29. No abstract available.


Induction of interleukin-1 in articular cartilage by explantation and cutting.

Gruber J, Vincent TL, Hermansson M, Bolton M, Wait R, Saklatvala J.

Arthritis Rheum. 2004 Aug;50(8):2539-46.


Proteomic analysis of articular cartilage shows increased type II collagen synthesis in osteoarthritis and expression of inhibin betaA (activin A), a regulatory molecule for chondrocytes.

Hermansson M, Sawaji Y, Bolton M, Alexander S, Wallace A, Begum S, Wait R, Saklatvala J.

J Biol Chem. 2004 Oct 15;279(42):43514-21. Epub 2004 Aug 2.


The p38 MAP kinase pathway as a therapeutic target in inflammatory disease.

Saklatvala J.

Curr Opin Pharmacol. 2004 Aug;4(4):372-7. Review.


The involvement of AU-rich element-binding proteins in p38 mitogen-activated protein kinase pathway-mediated mRNA stabilisation.

Dean JL, Sully G, Clark AR, Saklatvala J.

Cell Signal. 2004 Oct;16(10):1113-21. Review.


The stability of tristetraprolin mRNA is regulated by mitogen-activated protein kinase p38 and by tristetraprolin itself.

Tchen CR, Brook M, Saklatvala J, Clark AR.

J Biol Chem. 2004 Jul 30;279(31):32393-400. Epub 2004 Jun 7.


Basic fibroblast growth factor mediates transduction of mechanical signals when articular cartilage is loaded.

Vincent TL, Hermansson MA, Hansen UN, Amis AA, Saklatvala J.

Arthritis Rheum. 2004 Feb;50(2):526-33.


Control of the expression of inflammatory response genes.

Saklatvala J, Dean J, Clark A.

Biochem Soc Symp. 2003;(70):95-106. Review.


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