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Repurposing Drugs for Acute Myeloid Leukemia: A Worthy Cause or a Futile Pursuit?

Wojcicki AV, Kadapakkam M, Frymoyer A, Lacayo N, Chae HD, Sakamoto KM.

Cancers (Basel). 2020 Feb 13;12(2). pii: E441. doi: 10.3390/cancers12020441. Review.



Huang M, Zeki J, Sumarsono N, Coles GL, Taylor JS, Danzer E, Bruzoni M, Hazard FK, Lacayo NJ, Sakamoto KM, Dunn JCY, Spunt SL, Chiu B.

Cancer Res. 2020 Jan 3. pii: canres.2560.2019. doi: 10.1158/0008-5472.CAN-19-2560. [Epub ahead of print]


MMP9 inhibition increases erythropoiesis in RPS14-deficient del(5q) MDS models through suppression of TGF-β pathways.

Youn M, Huang H, Chen C, Kam S, Wilkes MC, Chae HD, Sridhar KJ, Greenberg PL, Glader B, Narla A, Lin S, Sakamoto KM.

Blood Adv. 2019 Sep 24;3(18):2751-2763. doi: 10.1182/bloodadvances.2019000537.


SAR optimization studies on modified salicylamides as a potential treatment for acute myeloid leukemia through inhibition of the CREB pathway.

Chae HD, Cox N, Capolicchio S, Lee JW, Horikoshi N, Kam S, Ng AA, Edwards J, Butler TL, Chan J, Lee Y, Potter G, Capece MC, Liu CW, Wakatsuki S, Smith M, Sakamoto KM.

Bioorg Med Chem Lett. 2019 Aug 15;29(16):2307-2315. doi: 10.1016/j.bmcl.2019.06.023. Epub 2019 Jun 19.


CBP Modulates Sensitivity to Dasatinib in Pre-BCR+ Acute Lymphoblastic Leukemia.

Duque-Afonso J, Lin CH, Han K, Morgens DW, Jeng EE, Weng Z, Jeong J, Wong SHK, Zhu L, Wei MC, Chae HD, Schrappe M, Cario G, Duyster J, Xiao X, Sakamoto KM, Bassik MC, Cleary ML.

Cancer Res. 2018 Nov 15;78(22):6497-6508. doi: 10.1158/0008-5472.CAN-18-1703. Epub 2018 Sep 27.


Innate immune system activation in zebrafish and cellular models of Diamond Blackfan Anemia.

Danilova N, Wilkes M, Bibikova E, Youn MY, Sakamoto KM, Lin S.

Sci Rep. 2018 Mar 26;8(1):5165. doi: 10.1038/s41598-018-23561-6.


Niclosamide suppresses acute myeloid leukemia cell proliferation through inhibition of CREB-dependent signaling pathways.

Chae HD, Cox N, Dahl GV, Lacayo NJ, Davis KL, Capolicchio S, Smith M, Sakamoto KM.

Oncotarget. 2017 Dec 31;9(4):4301-4317. doi: 10.18632/oncotarget.23794. eCollection 2018 Jan 12.


Perspective on Diamond-Blackfan anemia: lessons from a rare congenital bone marrow failure syndrome.

Sakamoto KM, Narla A.

Leukemia. 2018 Feb;32(2):249-251. doi: 10.1038/leu.2017.314. Epub 2017 Sep 8. Review. No abstract available.


A PET/MR Imaging Approach for the Integrated Assessment of Chemotherapy-induced Brain, Heart, and Bone Injuries in Pediatric Cancer Survivors: A Pilot Study.

Theruvath AJ, Ilivitzki A, Muehe A, Theruvath J, Gulaka P, Kim C, Luna-Fineman S, Sakamoto KM, Yeom KW, Yang P, Moseley M, Chan F, Daldrup-Link HE.

Radiology. 2017 Dec;285(3):971-979. doi: 10.1148/radiol.2017170073. Epub 2017 Aug 4.


Beyond mRNA: The role of non-coding RNAs in normal and aberrant hematopoiesis.

Wilkes MC, Repellin CE, Sakamoto KM.

Mol Genet Metab. 2017 Nov;122(3):28-38. doi: 10.1016/j.ymgme.2017.07.008. Epub 2017 Jul 25. Review.


Lost in translation: RP and GATA1 mutations in DBA.

Sakamoto KM.

Blood. 2017 Jun 8;129(23):3048-3049. doi: 10.1182/blood-2017-04-778969. No abstract available.


Loss of Forkhead box M1 promotes erythropoiesis through increased proliferation of erythroid progenitors.

Youn M, Wang N, LaVasseur C, Bibikova E, Kam S, Glader B, Sakamoto KM, Narla A.

Haematologica. 2017 May;102(5):826-834. doi: 10.3324/haematol.2016.156257. Epub 2017 Feb 2.


Varicella-Zoster Virus Activates CREB, and Inhibition of the pCREB-p300/CBP Interaction Inhibits Viral Replication In Vitro and Skin Pathogenesis In Vivo.

François S, Sen N, Mitton B, Xiao X, Sakamoto KM, Arvin A.

J Virol. 2016 Sep 12;90(19):8686-97. doi: 10.1128/JVI.00920-16. Print 2016 Oct 1.


CBP/p300 acetyltransferase activity in hematologic malignancies.

Dutta R, Tiu B, Sakamoto KM.

Mol Genet Metab. 2016 Sep;119(1-2):37-43. doi: 10.1016/j.ymgme.2016.06.013. Epub 2016 Jun 30. Review.


Navigating your career path in pediatric hematology/oncology: On and off the beaten track.

Zweidler-McKay PA, Hogan MJ, Jubran R, Black V, Casillas J, Harper J, Malempati S, Margolin J, Felgenhauer J, Sakamoto KM, Franklin J, Shah M, Seibel N, Buchanan G, Vaiselbuh SR, Hastings C, Hilden J, Stork LC.

Pediatr Blood Cancer. 2016 Oct;63(10):1723-30. doi: 10.1002/pbc.26094. Epub 2016 Jun 13. No abstract available.


A Zebrafish Model of 5q-Syndrome Using CRISPR/Cas9 Targeting RPS14 Reveals a p53-Independent and p53-Dependent Mechanism of Erythroid Failure.

Ear J, Hsueh J, Nguyen M, Zhang Q, Sung V, Chopra R, Sakamoto KM, Lin S.

J Genet Genomics. 2016 May 20;43(5):307-18. doi: 10.1016/j.jgg.2016.03.007. Epub 2016 Apr 2.


Small molecule inhibition of cAMP response element binding protein in human acute myeloid leukemia cells.

Mitton B, Chae HD, Hsu K, Dutta R, Aldana-Masangkay G, Ferrari R, Davis K, Tiu BC, Kaul A, Lacayo N, Dahl G, Xie F, Li BX, Breese MR, Landaw EM, Nolan G, Pellegrini M, Romanov S, Xiao X, Sakamoto KM.

Leukemia. 2016 Dec;30(12):2302-2311. doi: 10.1038/leu.2016.139. Epub 2016 May 23.


The role of Fas-associated phosphatase 1 in leukemia stem cell persistence during tyrosine kinase inhibitor treatment of chronic myeloid leukemia.

Huang W, Luan CH, Hjort EE, Bei L, Mishra R, Sakamoto KM, Platanias LC, Eklund EA.

Leukemia. 2016 Jul;30(7):1502-9. doi: 10.1038/leu.2016.66. Epub 2016 Mar 17.


Small molecule screen for inhibitors of expression from canonical CREB response element-containing promoters.

Mitton B, Hsu K, Dutta R, Tiu BC, Cox N, McLure KG, Chae HD, Smith M, Eklund EA, Solow-Cordero DE, Sakamoto KM.

Oncotarget. 2016 Feb 23;7(8):8653-62. doi: 10.18632/oncotarget.7085.


Progressing Toward a Cohesive Pediatric 18F-FDG PET/MR Protocol: Is Administration of Gadolinium Chelates Necessary?

Klenk C, Gawande R, Tran VT, Leung JT, Chi K, Owen D, Luna-Fineman S, Sakamoto KM, McMillan A, Quon A, Daldrup-Link HE.

J Nucl Med. 2016 Jan;57(1):70-7. doi: 10.2967/jnumed.115.161646. Epub 2015 Oct 15.


Biology of the bone marrow microenvironment and myelodysplastic syndromes.

Rankin EB, Narla A, Park JK, Lin S, Sakamoto KM.

Mol Genet Metab. 2015 Sep-Oct;116(1-2):24-8. doi: 10.1016/j.ymgme.2015.07.004. Epub 2015 Jul 20. Review.


Flow-induced protein kinase A-CREB pathway acts via BMP signaling to promote HSC emergence.

Kim PG, Nakano H, Das PP, Chen MJ, Rowe RG, Chou SS, Ross SJ, Sakamoto KM, Zon LI, Schlaeger TM, Orkin SH, Nakano A, Daley GQ.

J Exp Med. 2015 May 4;212(5):633-48. doi: 10.1084/jem.20141514. Epub 2015 Apr 13.


Replication factor C3 is a CREB target gene that regulates cell cycle progression through the modulation of chromatin loading of PCNA.

Chae HD, Mitton B, Lacayo NJ, Sakamoto KM.

Leukemia. 2015 Jun;29(6):1379-89. doi: 10.1038/leu.2014.350. Epub 2014 Dec 26.


Targeting novel signaling pathways for resistant acute myeloid leukemia.

Sakamoto KM, Grant S, Saleiro D, Crispino JD, Hijiya N, Giles F, Platanias L, Eklund EA.

Mol Genet Metab. 2015 Mar;114(3):397-402. doi: 10.1016/j.ymgme.2014.11.017. Epub 2014 Dec 5. Review.


TNF-mediated inflammation represses GATA1 and activates p38 MAP kinase in RPS19-deficient hematopoietic progenitors.

Bibikova E, Youn MY, Danilova N, Ono-Uruga Y, Konto-Ghiorghi Y, Ochoa R, Narla A, Glader B, Lin S, Sakamoto KM.

Blood. 2014 Dec 11;124(25):3791-8. doi: 10.1182/blood-2014-06-584656. Epub 2014 Sep 30.


The role of the DNA damage response in zebrafish and cellular models of Diamond Blackfan anemia.

Danilova N, Bibikova E, Covey TM, Nathanson D, Dimitrova E, Konto Y, Lindgren A, Glader B, Radu CG, Sakamoto KM, Lin S.

Dis Model Mech. 2014 Jul;7(7):895-905. doi: 10.1242/dmm.015495. Epub 2014 May 8.


Efficacy and safety of eculizumab in children and adolescents with paroxysmal nocturnal hemoglobinuria.

Reiss UM, Schwartz J, Sakamoto KM, Puthenveetil G, Ogawa M, Bedrosian CL, Ware RE.

Pediatr Blood Cancer. 2014 Sep;61(9):1544-50. doi: 10.1002/pbc.25068. Epub 2014 Apr 29.


Letting microRNAs overcome resistance to chemotherapy in acute myeloid leukemia.

Sakamoto KM.

Leuk Lymphoma. 2014 Jul;55(7):1449-50. doi: 10.3109/10428194.2013.862244. Epub 2014 Jan 28. No abstract available.


Increased abscess formation and defective chemokine regulation in CREB transgenic mice.

Wen AY, Landaw EM, Ochoa R, Cho M, Chao A, Lawson G, Sakamoto KM.

PLoS One. 2013;8(2):e55866. doi: 10.1371/journal.pone.0055866. Epub 2013 Feb 6.


Identification of somatic and germline mutations using whole exome sequencing of congenital acute lymphoblastic leukemia.

Chang VY, Basso G, Sakamoto KM, Nelson SF.

BMC Cancer. 2013 Feb 4;13:55. doi: 10.1186/1471-2407-13-55.


MicroRNA-34b promoter hypermethylation induces CREB overexpression and contributes to myeloid transformation.

Pigazzi M, Manara E, Bresolin S, Tregnago C, Beghin A, Baron E, Giarin E, Cho EC, Masetti R, Rao DS, Sakamoto KM, Basso G.

Haematologica. 2013 Apr;98(4):602-10. doi: 10.3324/haematol.2012.070664. Epub 2012 Oct 25.


The neutropenic diet... still ageless?

Aftandilian CC, Milotich C, Sakamoto KM.

Oncology (Williston Park). 2012 Jun;26(6):586, 588-9. No abstract available.


Sox4 cooperates with CREB in myeloid transformation.

Sandoval S, Kraus C, Cho EC, Cho M, Bies J, Manara E, Accordi B, Landaw EM, Wolff L, Pigazzi M, Sakamoto KM.

Blood. 2012 Jul 5;120(1):155-65. doi: 10.1182/blood-2011-05-357418. Epub 2012 May 24.


CREB and leukemogenesis.

Cho EC, Mitton B, Sakamoto KM.

Crit Rev Oncog. 2011;16(1-2):37-46. Review.


Transplantation for congenital bone marrow failure syndromes.

Morimoto K, Moore TB, Schiller G, Sakamoto KM.

Bone Marrow Res. 2011;2011:849387. doi: 10.1155/2011/849387. Epub 2010 Nov 29.


The function of cyclic-adenosine monophosphate responsive element-binding protein in hematologic malignancies.

Mitton B, Cho EC, Aldana-Masangkay GI, Sakamoto KM.

Leuk Lymphoma. 2011 Nov;52(11):2057-63. doi: 10.3109/10428194.2011.584994. Review.


Editorial: granulopoiesis versus monopoiesis: a consequence of transcription factors dancing with the right partners.

Sakamoto KM.

J Leukoc Biol. 2011 Oct;90(4):637-8. doi: 10.1189/jlb.0411187. No abstract available.


Tubacin suppresses proliferation and induces apoptosis of acute lymphoblastic leukemia cells.

Aldana-Masangkay GI, Rodriguez-Gonzalez A, Lin T, Ikeda AK, Hsieh YT, Kim YM, Lomenick B, Okemoto K, Landaw EM, Wang D, Mazitschek R, Bradner JE, Sakamoto KM.

Leuk Lymphoma. 2011 Aug;52(8):1544-55. doi: 10.3109/10428194.2011.570821. Epub 2011 Jun 23.


The multitargeted receptor tyrosine kinase inhibitor linifanib (ABT-869) induces apoptosis through an Akt and glycogen synthase kinase 3β-dependent pathway.

Hernandez-Davies JE, Zape JP, Landaw EM, Tan X, Presnell A, Griffith D, Heinrich MC, Glaser KB, Sakamoto KM.

Mol Cancer Ther. 2011 Jun;10(6):949-59. doi: 10.1158/1535-7163.MCT-10-0904. Epub 2011 Apr 6.


Increasing diversity in pediatric hematology/oncology.

Frugé E, Lakoski JM, Luban N, Lipton JM, Poplack DG, Hagey A, Felgenhauer J, Hilden J, Margolin J, Vaiselbuh SR, Sakamoto KM.

Pediatr Blood Cancer. 2011 Jul 15;57(1):147-52. doi: 10.1002/pbc.22977. Epub 2011 Jan 31.


Self-renewal of acute lymphocytic leukemia cells is limited by the Hedgehog pathway inhibitors cyclopamine and IPI-926.

Lin TL, Wang QH, Brown P, Peacock C, Merchant AA, Brennan S, Jones E, McGovern K, Watkins DN, Sakamoto KM, Matsui W.

PLoS One. 2010 Dec 28;5(12):e15262. doi: 10.1371/journal.pone.0015262.


Ribosomal protein L11 mutation in zebrafish leads to haematopoietic and metabolic defects.

Danilova N, Sakamoto KM, Lin S.

Br J Haematol. 2011 Jan;152(2):217-28. doi: 10.1111/j.1365-2141.2010.08396.x. Epub 2010 Nov 29.


The role of the transcription factor CREB in immune function.

Wen AY, Sakamoto KM, Miller LS.

J Immunol. 2010 Dec 1;185(11):6413-9. doi: 10.4049/jimmunol.1001829. Review.


The role of HDAC6 in cancer.

Aldana-Masangkay GI, Sakamoto KM.

J Biomed Biotechnol. 2011;2011:875824. doi: 10.1155/2011/875824. Epub 2010 Nov 7. Review.


Macroautophagy modulates cellular response to proteasome inhibitors in cancer therapy.

Wu WK, Sakamoto KM, Milani M, Aldana-Masankgay G, Fan D, Wu K, Lee CW, Cho CH, Yu J, Sung JJ.

Drug Resist Updat. 2010 Jun;13(3):87-92. doi: 10.1016/j.drup.2010.04.003. Epub 2010 May 11. Review.


Targeting CREB for cancer therapy: friend or foe.

Xiao X, Li BX, Mitton B, Ikeda A, Sakamoto KM.

Curr Cancer Drug Targets. 2010 Jun;10(4):384-91.


ABT-869 inhibits the proliferation of Ewing Sarcoma cells and suppresses platelet-derived growth factor receptor beta and c-KIT signaling pathways.

Ikeda AK, Judelson DR, Federman N, Glaser KB, Landaw EM, Denny CT, Sakamoto KM.

Mol Cancer Ther. 2010 Mar;9(3):653-60. doi: 10.1158/1535-7163.MCT-09-0812. Epub 2010 Mar 2.


Protacs for treatment of cancer.

Sakamoto KM.

Pediatr Res. 2010 May;67(5):505-8. doi: 10.1203/PDR.0b013e3181d35017. Review.


CREB: A Key Regulator of Normal and Neoplastic Hematopoiesis.

Sandoval S, Pigazzi M, Sakamoto KM.

Adv Hematol. 2009;2009:634292. doi: 10.1155/2009/634292. Epub 2009 Aug 27.


Congenital disorders of ribosome biogenesis and bone marrow failure.

Sakamoto KM, Shimamura A, Davies SM.

Biol Blood Marrow Transplant. 2010 Jan;16(1 Suppl):S12-7. doi: 10.1016/j.bbmt.2009.09.012. Epub 2009 Sep 19. Review.

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