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Items: 1 to 50 of 659

1.

Introduction of fluorine atoms to vitamin D3 side-chain and synthesis of 24,24-difluoro-25-hydroxyvitamin D3.

Kawagoe F, Mototani S, Yasuda K, Nagasawa K, Uesugi M, Sakaki T, Kittaka A.

J Steroid Biochem Mol Biol. 2019 Dec;195:105477. doi: 10.1016/j.jsbmb.2019.105477. Epub 2019 Sep 18.

PMID:
31541729
2.

Preparation of a Major Metabolite of Iguratimod and Simultaneous Assay of Iguratimod and Its Metabolite by HPLC in Rat Plasma.

Han JP, Zhu ZH, Wu YZ, Qian W, Li ZY, Nishikawa M, Sakaki T, Yang CQ.

Iran J Pharm Res. 2019 Spring;18(2):631-641. doi: 10.22037/ijpr.2019.1100641.

3.

Synthesis and CYP24A1-Dependent Metabolism of 23-Fluorinated Vitamin D3 Analogues.

Kawagoe F, Yasuda K, Mototani S, Sugiyama T, Uesugi M, Sakaki T, Kittaka A.

ACS Omega. 2019 Jun 28;4(6):11332-11337. doi: 10.1021/acsomega.9b01500. eCollection 2019 Jun 30.

4.

Sulfate conjugates are the major metabolites in rats administrated with sesamin.

Yasuda K, Okamoto K, Ueno S, Itoh K, Nishikawa M, Ikushiro S, Sakaki T.

Drug Metab Pharmacokinet. 2019 Apr;34(2):134-140. doi: 10.1016/j.dmpk.2018.12.004. Epub 2018 Dec 31.

PMID:
30770184
5.

Dimethyl fumarate and vitamin D derivatives cooperatively enhance VDR and Nrf2 signaling in differentiating AML cells in vitro and inhibit leukemia progression in a xenograft mouse model.

Nachliely M, Trachtenberg A, Khalfin B, Nalbandyan K, Cohen-Lahav M, Yasuda K, Sakaki T, Kutner A, Danilenko M.

J Steroid Biochem Mol Biol. 2019 Apr;188:8-16. doi: 10.1016/j.jsbmb.2018.11.017. Epub 2018 Nov 30.

PMID:
30508646
6.

Concise synthesis of 23-hydroxylated vitamin D3 metabolites.

Kawagoe F, Sugiyama T, Yasuda K, Uesugi M, Sakaki T, Kittaka A.

J Steroid Biochem Mol Biol. 2019 Feb;186:161-168. doi: 10.1016/j.jsbmb.2018.10.010. Epub 2018 Oct 24.

PMID:
30367940
7.

Eldecalcitol is more effective in promoting osteogenesis than alfacalcidol in Cyp27b1-knockout mice.

Hirota Y, Nakagawa K, Isomoto K, Sakaki T, Kubodera N, Kamao M, Osakabe N, Suhara Y, Okano T.

PLoS One. 2018 Oct 3;13(10):e0199856. doi: 10.1371/journal.pone.0199856. eCollection 2018.

8.

Novel biosensor using split-luciferase for detecting vitamin D receptor ligands based on the interaction between vitamin D receptor and coactivator.

Mano H, Takano M, Ikushiro S, Kittaka A, Sakaki T.

Biochem Biophys Res Commun. 2018 Oct 28;505(2):460-465. doi: 10.1016/j.bbrc.2018.09.122. Epub 2018 Sep 26.

PMID:
30268505
9.

Generation of 1,25-dihydroxyvitamin D3 in Cyp27b1 knockout mice by treatment with 25-hydroxyvitamin D3 rescued their rachitic phenotypes.

Nishikawa M, Yasuda K, Takamatsu M, Abe K, Nakagawa K, Tsugawa N, Hirota Y, Tanaka K, Yamashita S, Ikushiro S, Suda T, Okano T, Sakaki T.

J Steroid Biochem Mol Biol. 2019 Jan;185:71-79. doi: 10.1016/j.jsbmb.2018.07.012. Epub 2018 Jul 18.

PMID:
30031146
10.

Novel split luciferase-based biosensors for evaluation of vitamin D receptor ligands and their application to estimate CYP27B1 activity in living cells.

Mano H, Ikushiro S, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Oct;183:221-227. doi: 10.1016/j.jsbmb.2018.06.017. Epub 2018 Jul 9.

PMID:
30004013
11.

Microbial production of novel sulphated alkaloids for drug discovery.

Matsumura E, Nakagawa A, Tomabechi Y, Ikushiro S, Sakaki T, Katayama T, Yamamoto K, Kumagai H, Sato F, Minami H.

Sci Rep. 2018 May 22;8(1):7980. doi: 10.1038/s41598-018-26306-7.

12.

[Metabolism of Sesamin and Drug-Sesamin Interaction].

Sakaki T, Yasuda K, Nishikawa M, Ikushiro S.

Yakugaku Zasshi. 2018;138(3):357-363. doi: 10.1248/yakushi.17-00191-4. Japanese.

13.

Metabolism of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3 by CYP24A1 and biological activity of its 24R-hydroxylated metabolite.

Yasuda K, Tohyama E, Takano M, Kittaka A, Ohta M, Ikushiro S, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Apr;178:333-339. doi: 10.1016/j.jsbmb.2018.02.001. Epub 2018 Feb 6.

PMID:
29425808
14.

Whole-cell-dependent biosynthesis of sulfo-conjugate using human sulfotransferase expressing budding yeast.

Nishikawa M, Masuyama Y, Nunome M, Yasuda K, Sakaki T, Ikushiro S.

Appl Microbiol Biotechnol. 2018 Jan;102(2):723-732. doi: 10.1007/s00253-017-8621-x. Epub 2017 Nov 13.

PMID:
29134333
15.

Development of a highly sensitive in vitro system to detect and discriminate between vitamin D receptor agonists and antagonists based on split-luciferase technique.

Mano H, Ikushiro S, Saito N, Kittaka A, Sakaki T.

J Steroid Biochem Mol Biol. 2018 Apr;178:55-59. doi: 10.1016/j.jsbmb.2017.10.024. Epub 2017 Nov 1.

PMID:
29101064
16.

Molecular insights into the role of a distal F240A mutation that alters CYP1A1 activity towards persistent organic pollutants.

Navrátilová V, Paloncýová M, Berka K, Mise S, Haga Y, Matsumura C, Sakaki T, Inui H, Otyepka M.

Biochim Biophys Acta Gen Subj. 2017 Nov;1861(11 Pt A):2852-2860. doi: 10.1016/j.bbagen.2017.08.002. Epub 2017 Aug 3.

PMID:
28780123
17.

S-Equol Activates cAMP Signaling at the Plasma Membrane of INS-1 Pancreatic β-Cells and Protects against Streptozotocin-Induced Hyperglycemia by Increasing β-Cell Function in Male Mice.

Horiuchi H, Usami A, Shirai R, Harada N, Ikushiro S, Sakaki T, Nakano Y, Inui H, Yamaji R.

J Nutr. 2017 Sep;147(9):1631-1639. doi: 10.3945/jn.117.250860. Epub 2017 Aug 2.

PMID:
28768836
18.

Overlapping stent-assisted coil embolization for a ruptured intracranial vertebral artery dissection.

Asai K, Nakamura H, Nishida T, Morris S, Sakaki T.

J Surg Case Rep. 2017 Jun 14;2017(6):rjx105. doi: 10.1093/jscr/rjx105. eCollection 2017 Jun.

19.

Protein engineering of CYP105s for their industrial uses.

Yasuda K, Sugimoto H, Hayashi K, Takita T, Yasukawa K, Ohta M, Kamakura M, Ikushiro S, Shiro Y, Sakaki T.

Biochim Biophys Acta Proteins Proteom. 2018 Jan;1866(1):23-31. doi: 10.1016/j.bbapap.2017.05.014. Epub 2017 Jun 2. Review.

PMID:
28583351
20.

In vivo absorption and metabolism of leptosperin and methyl syringate, abundantly present in manuka honey.

Ishisaka A, Ikushiro S, Takeuchi M, Araki Y, Juri M, Yoshiki Y, Kawai Y, Niwa T, Kitamoto N, Sakaki T, Ishikawa H, Kato Y.

Mol Nutr Food Res. 2017 Sep;61(9). doi: 10.1002/mnfr.201700122. Epub 2017 Jun 12.

PMID:
28444960
21.

Production of an active form of vitamin D2 by genetically engineered CYP105A1.

Yasuda K, Yogo Y, Sugimoto H, Mano H, Takita T, Ohta M, Kamakura M, Ikushiro S, Yasukawa K, Shiro Y, Sakaki T.

Biochem Biophys Res Commun. 2017 Apr 29;486(2):336-341. doi: 10.1016/j.bbrc.2017.03.040. Epub 2017 Mar 14.

PMID:
28302483
22.

Nongenomic effects of 1α,25-dihydroxyvitamin D3 on cartilage formation deduced from comparisons between Cyp27b1 and Vdr knockout mice.

Hirota Y, Nakagawa K, Mimatsu S, Sawada N, Sakaki T, Kubodera N, Kamao M, Tsugawa N, Suhara Y, Okano T.

Biochem Biophys Res Commun. 2017 Jan 29;483(1):359-365. doi: 10.1016/j.bbrc.2016.12.139. Epub 2016 Dec 24.

23.

Synthesis of the CYP24A1 major metabolite of 2α-[2-(tetrazol-2-yl)ethyl]-1α,25-dihydroxyvitamin D3.

Takano M, Yasuda K, Tohyama E, Higuchi E, Sakaki T, Kittaka A.

J Steroid Biochem Mol Biol. 2017 Oct;173:75-78. doi: 10.1016/j.jsbmb.2016.11.022. Epub 2016 Dec 5.

PMID:
27923594
24.

Novel screening system for high-affinity ligand of heredity vitamin D-resistant rickets-associated vitamin D receptor mutant R274L using bioluminescent sensor.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Sawada D, Honzawa S, Takano M, Kittaka A, Sakaki T.

J Steroid Biochem Mol Biol. 2017 Mar;167:61-66. doi: 10.1016/j.jsbmb.2016.11.008. Epub 2016 Nov 15.

PMID:
27864003
25.

Biosynthesis of Drug Glucuronide Metabolites in the Budding Yeast Saccharomyces cerevisiae.

Ikushiro S, Nishikawa M, Masuyama Y, Shouji T, Fujii M, Hamada M, Nakajima N, Finel M, Yasuda K, Kamakura M, Sakaki T.

Mol Pharm. 2016 Jul 5;13(7):2274-82. doi: 10.1021/acs.molpharmaceut.5b00954. Epub 2016 Jun 8.

PMID:
27241161
26.

From the Cover: Structural Determinants of the Position of 2,3',4,4',5-Pentachlorobiphenyl (CB118) Hydroxylation by Mammalian Cytochrome P450 Monooxygenases.

Mise S, Haga Y, Itoh T, Kato A, Fukuda I, Goto E, Yamamoto K, Yabu M, Matsumura C, Nakano T, Sakaki T, Inui H.

Toxicol Sci. 2016 Aug;152(2):340-8. doi: 10.1093/toxsci/kfw086. Epub 2016 May 13.

PMID:
27208082
27.

Sequential hydroxylation of vitamin D2 by a genetically engineered CYP105A1.

Hayashi K, Yasuda K, Yogo Y, Takita T, Yasukawa K, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Biochem Biophys Res Commun. 2016 May 13;473(4):853-858. doi: 10.1016/j.bbrc.2016.03.139. Epub 2016 Mar 30.

PMID:
27037023
28.

Biological Evaluation of Double Point Modified Analogues of 1,25-Dihydroxyvitamin D₂ as Potential Anti-Leukemic Agents.

Corcoran A, Nadkarni S, Yasuda K, Sakaki T, Brown G, Kutner A, Marcinkowska E.

Int J Mol Sci. 2016 Feb 1;17(2). pii: E91. doi: 10.3390/ijms17020091.

29.

Metabolism and Action of 25-Hydroxy-19-nor-Vitamin D₃ in Human Prostate Cells.

Munetsuna E, Kittaka A, Chen TC, Sakaki T.

Vitam Horm. 2016;100:357-77. doi: 10.1016/bs.vh.2015.10.009. Epub 2015 Dec 8. Review.

PMID:
26827959
30.

[Reconsideration of molecular mechanism of vitamin D action based on its metabolism].

Sakaki T.

Seikagaku. 2015 Aug;87(4):438-44. Review. Japanese. No abstract available.

PMID:
26571614
31.

Influence of sesamin on CYP2C-mediated diclofenac metabolism: in vitro and in vivo analysis.

Yasuda K, Ueno S, Ueda E, Nishikawa M, Takeda K, Kamakura M, Ikushiro S, Sakaki T.

Pharmacol Res Perspect. 2015 Oct;3(5):e00174. doi: 10.1002/prp2.174. Epub 2015 Aug 25.

32.

Identification and in silico prediction of metabolites of the model compound, tebufenozide by human CYP3A4 and CYP2C19.

Shirotani N, Togawa M, Ikushiro S, Sakaki T, Harada T, Miyagawa H, Matsui M, Nagahori H, Mikata K, Nishioka K, Hirai N, Akamatsu M.

Bioorg Med Chem. 2015 Oct 15;23(20):6594-601. doi: 10.1016/j.bmc.2015.09.019. Epub 2015 Sep 11.

PMID:
26404412
33.

Development of Novel Bioluminescent Sensor to Detect and Discriminate between Vitamin D Receptor Agonists and Antagonists in Living Cells.

Mano H, Nishikawa M, Yasuda K, Ikushiro S, Saito N, Takano M, Kittaka A, Sakaki T.

Bioconjug Chem. 2015 Oct 21;26(10):2038-45. doi: 10.1021/acs.bioconjchem.5b00433. Epub 2015 Sep 18.

PMID:
26355700
34.

Synthesis and evaluation of geometric analogs of 1α,25-dihydroxyvitamin D2 as potential therapeutics.

Bolla NR, Corcoran A, Yasuda K, Chodyński M, Krajewski K, Cmoch P, Marcinkowska E, Brown G, Sakaki T, Kutner A.

J Steroid Biochem Mol Biol. 2016 Nov;164:50-55. doi: 10.1016/j.jsbmb.2015.08.025. Epub 2015 Aug 28.

PMID:
26321387
35.

Synthesis, metabolism, and biological activity of 2-[3-(tetrazolyl)propyl]-1α,25-dihydroxy-19-norvitamin D3.

Takano M, Yasuda K, Higuchi E, Tohyama E, Takeuchi A, Sakaki T, Kittaka A.

J Steroid Biochem Mol Biol. 2016 Nov;164:40-44. doi: 10.1016/j.jsbmb.2015.07.016. Epub 2015 Jul 29.

PMID:
26232635
36.

Human hepatic metabolism of the anti-osteoporosis drug eldecalcitol involves sterol C4-methyl oxidase.

Yasuda K, Iwanaga Y, Ogawa K, Mano H, Ueno S, Kimoto S, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Pharmacol Res Perspect. 2015 Mar;3(2):e00120. doi: 10.1002/prp2.120. Epub 2015 Feb 10.

37.

Alteromonas gracilis sp. nov., a marine polysaccharide-producing bacterium.

Matsuyama H, Minami H, Sakaki T, Kasahara H, Baba S, Ishimaru S, Hirota K, Yumoto I.

Int J Syst Evol Microbiol. 2015 May;65(Pt 5):1498-503. doi: 10.1099/ijs.0.000127. Epub 2015 Feb 20.

PMID:
25701844
38.

Psychrobacter oceani sp. nov., isolated from marine sediment.

Matsuyama H, Minami H, Sakaki T, Kasahara H, Watanabe A, Onoda T, Hirota K, Yumoto I.

Int J Syst Evol Microbiol. 2015 May;65(Pt 5):1450-5. doi: 10.1099/ijs.0.000118. Epub 2015 Feb 12.

PMID:
25678681
39.

Effect of NAPL Source Morphology on Mass Transfer in the Vadose Zone.

Petri BG, Fučík R, Illangasekare TH, Smits KM, Christ JA, Sakaki T, Sauck CC.

Ground Water. 2015 Sep-Oct;53(5):685-98. doi: 10.1111/gwat.12284. Epub 2014 Dec 23.

PMID:
25535651
40.

Synthesis and metabolic studies of 1α,2α,25-, 1α,4α,25- and 1α,4β,25-trihydroxyvitamin D3.

Takano M, Sawada D, Yasuda K, Nishikawa M, Takeuchi A, Takagi K, Horie K, Reddy GS, Chen TC, Sakaki T, Kittaka A.

J Steroid Biochem Mol Biol. 2015 Apr;148:34-7. doi: 10.1016/j.jsbmb.2014.09.021. Epub 2014 Sep 26. Review.

PMID:
25263656
41.

Partial cloning of CYP2C23a genes and hepatic protein expression in eight representative avian species.

Watanabe KP, Kawai YK, Nakayama SM, Ikenaka Y, Mizukawa H, Takaesu N, Ito M, Ikushiro SI, Sakaki T, Ishizuka M.

J Vet Pharmacol Ther. 2015 Apr;38(2):190-5. doi: 10.1111/jvp.12159. Epub 2014 Sep 17.

PMID:
25229839
42.

Mammalian cytochrome P450-dependent metabolism of polychlorinated dibenzo-p-dioxins and coplanar polychlorinated biphenyls.

Inui H, Itoh T, Yamamoto K, Ikushiro S, Sakaki T.

Int J Mol Sci. 2014 Aug 13;15(8):14044-57. doi: 10.3390/ijms150814044. Review.

43.

Maintenance of Chloroplast Structure and Function by Overexpression of the Rice MONOGALACTOSYLDIACYLGLYCEROL SYNTHASE Gene Leads to Enhanced Salt Tolerance in Tobacco.

Wang S, Uddin MI, Tanaka K, Yin L, Shi Z, Qi Y, Mano J, Matsui K, Shimomura N, Sakaki T, Deng X, Zhang S.

Plant Physiol. 2014 Jul;165(3):1144-1155. Epub 2014 May 19.

44.

Potent antiproliferative effects of 25-hydroxy-16-ene-23-yne-vitamin D₃ that resists the catalytic activity of both CYP27B1 and CYP24A1.

Rhieu SY, Annalora AJ, LaPorta E, Welsh J, Itoh T, Yamamoto K, Sakaki T, Chen TC, Uskokovic MR, Reddy GS.

J Cell Biochem. 2014 Aug;115(8):1392-402. doi: 10.1002/jcb.24789.

PMID:
24535953
45.

Synthesis and biological activity of 1α,2α,25-trihydroxyvitamin D3: active metabolite of 2α-(3-hydroxypropoxy)-1α,25-dihydroxyvitamin D3 by human CYP3A4.

Takano M, Ohya S, Yasuda K, Nishikawa M, Takeuchi A, Sawada D, Sakaki T, Kittaka A.

Chem Pharm Bull (Tokyo). 2014;62(2):182-4.

46.

Anti-proliferative activity of 25-hydroxyvitamin D3 in human prostate cells.

Munetsuna E, Kawanami R, Nishikawa M, Ikeda S, Nakabayashi S, Yasuda K, Ohta M, Kamakura M, Ikushiro S, Sakaki T.

Mol Cell Endocrinol. 2014 Feb 15;382(2):960-70. doi: 10.1016/j.mce.2013.11.014. Epub 2013 Nov 27.

PMID:
24291609
47.

7-Dehydrocholesterol metabolites produced by sterol 27-hydroxylase (CYP27A1) modulate liver X receptor activity.

Endo-Umeda K, Yasuda K, Sugita K, Honda A, Ohta M, Ishikawa M, Hashimoto Y, Sakaki T, Makishima M.

J Steroid Biochem Mol Biol. 2014 Mar;140:7-16. doi: 10.1016/j.jsbmb.2013.11.010. Epub 2013 Nov 21.

PMID:
24269243
48.

Avian cytochrome P450 (CYP) 1-3 family genes: isoforms, evolutionary relationships, and mRNA expression in chicken liver.

Watanabe KP, Kawai YK, Ikenaka Y, Kawata M, Ikushiro S, Sakaki T, Ishizuka M.

PLoS One. 2013 Sep 30;8(9):e75689. doi: 10.1371/journal.pone.0075689. eCollection 2013.

49.

CYP24A1 as a potential target for cancer therapy.

Sakaki T, Yasuda K, Kittaka A, Yamamoto K, Chen TC.

Anticancer Agents Med Chem. 2014 Jan;14(1):97-108. Review.

PMID:
23869781
50.

Sophisticated design of PVC membrane ion-selective electrodes based on the mixed potential theory.

Imoto M, Sakaki T, Osakai T.

Anal Chem. 2013 May 7;85(9):4753-60. doi: 10.1021/ac400427p. Epub 2013 Apr 17.

PMID:
23594104

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