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Rhinovirus-Induced SIRT-1 via TLR2 Regulates Subsequent Type I and Type III IFN Responses in Airway Epithelial Cells.

Xander N, Reddy Vari H, Eskandar R, Li W, Bolla S, Marchetti N, Sajjan US.

J Immunol. 2019 Sep 23. pii: ji1900165. doi: 10.4049/jimmunol.1900165. [Epub ahead of print]


Rhinovirus-induces progression of lung disease in a mouse model of COPD via IL-33/ST2 signaling axis.

Gimenes JA Jr, Srivastava V, ReddyVari H, Kotnala S, Mishra R, Farazuddin M, Li W, Sajjan US.

Clin Sci (Lond). 2019 Apr 29;133(8):983-996. doi: 10.1042/CS20181088. Print 2019 Apr 30.


Rhinovirus and COPD airway epithelium.

Owuor N, Nalamala N, Gimenes JA Jr, Sajjan US.

Pulm Crit Care Med. 2017 Oct;2(3). doi: 10.15761/PCCM.1000139. Epub 2017 Sep 7.


Bioenergetic Responses to Mycobacterium tuberculosis: A Step Closer to Developing a New Therapy to Treat Tuberculosis in Smokers?

Sajjan US.

Am J Respir Cell Mol Biol. 2018 Nov;59(5):527-528. doi: 10.1165/rcmb.2018-0225ED. No abstract available.


Quercetin prevents rhinovirus-induced progression of lung disease in mice with COPD phenotype.

Farazuddin M, Mishra R, Jing Y, Srivastava V, Comstock AT, Sajjan US.

PLoS One. 2018 Jul 5;13(7):e0199612. doi: 10.1371/journal.pone.0199612. eCollection 2018.


TLR2 Activation Limits Rhinovirus-Stimulated CXCL-10 by Attenuating IRAK-1-Dependent IL-33 Receptor Signaling in Human Bronchial Epithelial Cells.

Ganesan S, Pham D, Jing Y, Farazuddin M, Hudy MH, Unger B, Comstock AT, Proud D, Lauring AS, Sajjan US.

J Immunol. 2016 Sep 15;197(6):2409-20. doi: 10.4049/jimmunol.1502702. Epub 2016 Aug 8.


Rhinovirus Delays Cell Repolarization in a Model of Injured/Regenerating Human Airway Epithelium.

Faris AN, Ganesan S, Chattoraj A, Chattoraj SS, Comstock AT, Unger BL, Hershenson MB, Sajjan US.

Am J Respir Cell Mol Biol. 2016 Oct;55(4):487-499.


Enhancement of Inducible Nitric Oxide Synthase Activity by Low Molecular Weight Peptides Derived from Protamine: A Potential Therapy for Chronic Rhinosinusitis.

Balijepalli AS, Comstock AT, Wang X, Jensen GC, Hershenson MB, Zacharek MA, Sajjan US, Meyerhoff ME.

Mol Pharm. 2015 Jul 6;12(7):2396-405. doi: 10.1021/acs.molpharmaceut.5b00110. Epub 2015 Jun 2.


Neonatal rhinovirus induces mucous metaplasia and airways hyperresponsiveness through IL-25 and type 2 innate lymphoid cells.

Hong JY, Bentley JK, Chung Y, Lei J, Steenrod JM, Chen Q, Sajjan US, Hershenson MB.

J Allergy Clin Immunol. 2014 Aug;134(2):429-39. doi: 10.1016/j.jaci.2014.04.020. Epub 2014 Jun 6.


Macrophage activation state determines the response to rhinovirus infection in a mouse model of allergic asthma.

Hong JY, Chung Y, Steenrod J, Chen Q, Lei J, Comstock AT, Goldsmith AM, Bentley JK, Sajjan US, Hershenson MB.

Respir Res. 2014 Jun 7;15:63. doi: 10.1186/1465-9921-15-63.


Rhinovirus-induced macrophage cytokine expression does not require endocytosis or replication.

Saba TG, Chung Y, Hong JY, Sajjan US, Bentley JK, Hershenson MB.

Am J Respir Cell Mol Biol. 2014 May;50(5):974-84. doi: 10.1165/rcmb.2013-0354OC.


Barrier function of airway tract epithelium.

Ganesan S, Comstock AT, Sajjan US.

Tissue Barriers. 2013 Oct 1;1(4):e24997. doi: 10.4161/tisb.24997. Epub 2013 May 30. Review.


Differential responses to rhinovirus- and influenza-associated pulmonary exacerbations in patients with cystic fibrosis.

Ramirez IA, Caverly LJ, Kalikin LM, Goldsmith AM, Lewis TC, Burke DT, LiPuma JJ, Sajjan US, Hershenson MB.

Ann Am Thorac Soc. 2014 May;11(4):554-61. doi: 10.1513/AnnalsATS.201310-346OC. Erratum in: Ann Am Thorac Soc. 2015 Jun;12(6):960. Caverly, Lindsay L [corrected to Caverly, Lindsay J].


Combined exposure to cigarette smoke and nontypeable Haemophilus influenzae drives development of a COPD phenotype in mice.

Ganesan S, Comstock AT, Kinker B, Mancuso P, Beck JM, Sajjan US.

Respir Res. 2014 Feb 4;15:11. doi: 10.1186/1465-9921-15-11.


Nod-like receptor X-1 is required for rhinovirus-induced barrier dysfunction in airway epithelial cells.

Unger BL, Ganesan S, Comstock AT, Faris AN, Hershenson MB, Sajjan US.

J Virol. 2014 Apr;88(7):3705-18. doi: 10.1128/JVI.03039-13. Epub 2014 Jan 15.


Repair and Remodeling of airway epithelium after injury in Chronic Obstructive Pulmonary Disease.

Ganesan S, Sajjan US.

Curr Respir Care Rep. 2013 Sep 1;2(3). doi: 10.1007/s13665-013-0052-2.


Rhinovirus colocalizes with CD68- and CD11b-positive macrophages following experimental infection in humans.

Bentley JK, Sajjan US, Dzaman MB, Jarjour NN, Lee WM, Gern JE, Hershenson MB.

J Allergy Clin Immunol. 2013 Sep;132(3):758-761.e3. doi: 10.1016/j.jaci.2013.04.020. Epub 2013 May 31. No abstract available.


Susceptibility to viral infections in chronic obstructive pulmonary disease: role of epithelial cells.

Sajjan US.

Curr Opin Pulm Med. 2013 Mar;19(2):125-32. doi: 10.1097/MCP.0b013e32835cef10. Review.


Aberrantly activated EGFR contributes to enhanced IL-8 expression in COPD airways epithelial cells via regulation of nuclear FoxO3A.

Ganesan S, Unger BL, Comstock AT, Angel KA, Mancuso P, Martinez FJ, Sajjan US.

Thorax. 2013 Feb;68(2):131-41. doi: 10.1136/thoraxjnl-2012-201719. Epub 2012 Oct 25.


Rhinovirus attenuates non-typeable Hemophilus influenzae-stimulated IL-8 responses via TLR2-dependent degradation of IRAK-1.

Unger BL, Faris AN, Ganesan S, Comstock AT, Hershenson MB, Sajjan US.

PLoS Pathog. 2012;8(10):e1002969. doi: 10.1371/journal.ppat.1002969. Epub 2012 Oct 4.


Quercetin inhibits rhinovirus replication in vitro and in vivo.

Ganesan S, Faris AN, Comstock AT, Wang Q, Nanua S, Hershenson MB, Sajjan US.

Antiviral Res. 2012 Jun;94(3):258-71. doi: 10.1016/j.antiviral.2012.03.005. Epub 2012 Mar 23.


Neonatal rhinovirus infection induces mucous metaplasia and airways hyperresponsiveness.

Schneider D, Hong JY, Popova AP, Bowman ER, Linn MJ, McLean AM, Zhao Y, Sonstein J, Bentley JK, Weinberg JB, Lukacs NW, Curtis JL, Sajjan US, Hershenson MB.

J Immunol. 2012 Mar 15;188(6):2894-904. doi: 10.4049/jimmunol.1101391. Epub 2012 Feb 13.


Elastase/LPS-exposed mice exhibit impaired innate immune responses to bacterial challenge: role of scavenger receptor A.

Ganesan S, Faris AN, Comstock AT, Sonstein J, Curtis JL, Sajjan US.

Am J Pathol. 2012 Jan;180(1):61-72. doi: 10.1016/j.ajpath.2011.09.029. Epub 2011 Nov 8.


Pseudomonas aeruginosa suppresses interferon response to rhinovirus infection in cystic fibrosis but not in normal bronchial epithelial cells.

Chattoraj SS, Ganesan S, Faris A, Comstock A, Lee WM, Sajjan US.

Infect Immun. 2011 Oct;79(10):4131-45. doi: 10.1128/IAI.05120-11. Epub 2011 Aug 8.


Cable pili and the associated 22 kDa adhesin contribute to Burkholderia cenocepacia persistence in vivo.

Goldberg JB, Ganesan S, Comstock AT, Zhao Y, Sajjan US.

PLoS One. 2011;6(7):e22435. doi: 10.1371/journal.pone.0022435. Epub 2011 Jul 21.


MDA5 and TLR3 initiate pro-inflammatory signaling pathways leading to rhinovirus-induced airways inflammation and hyperresponsiveness.

Wang Q, Miller DJ, Bowman ER, Nagarkar DR, Schneider D, Zhao Y, Linn MJ, Goldsmith AM, Bentley JK, Sajjan US, Hershenson MB.

PLoS Pathog. 2011 May;7(5):e1002070. doi: 10.1371/journal.ppat.1002070. Epub 2011 May 26.


Rhinovirus-induced barrier dysfunction in polarized airway epithelial cells is mediated by NADPH oxidase 1.

Comstock AT, Ganesan S, Chattoraj A, Faris AN, Margolis BL, Hershenson MB, Sajjan US.

J Virol. 2011 Jul;85(13):6795-808. doi: 10.1128/JVI.02074-10. Epub 2011 Apr 20.


Rhinovirus infection liberates planktonic bacteria from biofilm and increases chemokine responses in cystic fibrosis airway epithelial cells.

Chattoraj SS, Ganesan S, Jones AM, Helm JM, Comstock AT, Bright-Thomas R, LiPuma JJ, Hershenson MB, Sajjan US.

Thorax. 2011 Apr;66(4):333-9. doi: 10.1136/thx.2010.151431. Epub 2011 Feb 2.


Host evasion by Burkholderia cenocepacia.

Ganesan S, Sajjan US.

Front Cell Infect Microbiol. 2012 Jan 11;1:25. doi: 10.3389/fcimb.2011.00025. eCollection 2011. Review.


Quercetin prevents progression of disease in elastase/LPS-exposed mice by negatively regulating MMP expression.

Ganesan S, Faris AN, Comstock AT, Chattoraj SS, Chattoraj A, Burgess JR, Curtis JL, Martinez FJ, Zick S, Hershenson MB, Sajjan US.

Respir Res. 2010 Sep 28;11:131. doi: 10.1186/1465-9921-11-131.


Rhinovirus infection of allergen-sensitized and -challenged mice induces eotaxin release from functionally polarized macrophages.

Nagarkar DR, Bowman ER, Schneider D, Wang Q, Shim J, Zhao Y, Linn MJ, McHenry CL, Gosangi B, Bentley JK, Tsai WC, Sajjan US, Lukacs NW, Hershenson MB.

J Immunol. 2010 Aug 15;185(4):2525-35. doi: 10.4049/jimmunol.1000286. Epub 2010 Jul 19.


Pseudomonas aeruginosa alginate promotes Burkholderia cenocepacia persistence in cystic fibrosis transmembrane conductance regulator knockout mice.

Chattoraj SS, Murthy R, Ganesan S, Goldberg JB, Zhao Y, Hershenson MB, Sajjan US.

Infect Immun. 2010 Mar;78(3):984-93. doi: 10.1128/IAI.01192-09. Epub 2010 Jan 4.


Efficacy of bacteriophage therapy in a model of Burkholderia cenocepacia pulmonary infection.

Carmody LA, Gill JJ, Summer EJ, Sajjan US, Gonzalez CF, Young RF, LiPuma JJ.

J Infect Dis. 2010 Jan 15;201(2):264-71. doi: 10.1086/649227.


Human rhinovirus 1B exposure induces phosphatidylinositol 3-kinase-dependent airway inflammation in mice.

Newcomb DC, Sajjan US, Nagarkar DR, Wang Q, Nanua S, Zhou Y, McHenry CL, Hennrick KT, Tsai WC, Bentley JK, Lukacs NW, Johnston SL, Hershenson MB.

Am J Respir Crit Care Med. 2008 May 15;177(10):1111-21. doi: 10.1164/rccm.200708-1243OC. Epub 2008 Feb 14.


Burkholderia cenocepacia ET12 strain activates TNFR1 signalling in cystic fibrosis airway epithelial cells.

Sajjan US, Hershenson MB, Forstner JF, LiPuma JJ.

Cell Microbiol. 2008 Jan;10(1):188-201. Epub 2007 Aug 14.


Cooperative effects of rhinovirus and TNF-{alpha} on airway epithelial cell chemokine expression.

Newcomb DC, Sajjan US, Nagarkar DR, Goldsmith AM, Bentley JK, Hershenson MB.

Am J Physiol Lung Cell Mol Physiol. 2007 Oct;293(4):L1021-8. Epub 2007 Jul 13.


Lung cells from neonates show a mesenchymal stem cell phenotype.

Hennrick KT, Keeton AG, Nanua S, Kijek TG, Goldsmith AM, Sajjan US, Bentley JK, Lama VN, Moore BB, Schumacher RE, Thannickal VJ, Hershenson MB.

Am J Respir Crit Care Med. 2007 Jun 1;175(11):1158-64. Epub 2007 Mar 1.


Rhinovirus activates interleukin-8 expression via a Src/p110beta phosphatidylinositol 3-kinase/Akt pathway in human airway epithelial cells.

Bentley JK, Newcomb DC, Goldsmith AM, Jia Y, Sajjan US, Hershenson MB.

J Virol. 2007 Feb;81(3):1186-94. Epub 2006 Nov 22.


Intracellular trafficking and replication of Burkholderia cenocepacia in human cystic fibrosis airway epithelial cells.

Sajjan US, Yang JH, Hershenson MB, LiPuma JJ.

Cell Microbiol. 2006 Sep;8(9):1456-66.


H. influenzae potentiates airway epithelial cell responses to rhinovirus by increasing ICAM-1 and TLR3 expression.

Sajjan US, Jia Y, Newcomb DC, Bentley JK, Lukacs NW, LiPuma JJ, Hershenson MB.

FASEB J. 2006 Oct;20(12):2121-3. Epub 2006 Aug 16.


Quercetin blocks airway epithelial cell chemokine expression.

Nanua S, Zick SM, Andrade JE, Sajjan US, Burgess JR, Lukacs NW, Hershenson MB.

Am J Respir Cell Mol Biol. 2006 Nov;35(5):602-10. Epub 2006 Jun 22.


Disruption of tight junctions during traversal of the respiratory epithelium by Burkholderia cenocepacia.

Kim JY, Sajjan US, Krasan GP, LiPuma JJ.

Infect Immun. 2005 Nov;73(11):7107-12.


Identification and molecular analysis of cable pilus biosynthesis genes in Burkholderia cepacia.

Sajjan US, Xie H, Lefebre MD, Valvano MA, Forstner JF.

Microbiology. 2003 Apr;149(Pt 4):961-71.


P-113D, an antimicrobial peptide active against Pseudomonas aeruginosa, retains activity in the presence of sputum from cystic fibrosis patients.

Sajjan US, Tran LT, Sole N, Rovaldi C, Akiyama A, Friden PM, Forstner JF, Rothstein DM.

Antimicrob Agents Chemother. 2001 Dec;45(12):3437-44.


Cable-piliated Burkholderia cepacia binds to cytokeratin 13 of epithelial cells.

Sajjan US, Sylvester FA, Forstner JF.

Infect Immun. 2000 Apr;68(4):1787-95.


Burkholderia (basonym Pseudomonas) cepacia binding to lipid receptors.

Sylvester FA, Sajjan US, Forstner JF.

Infect Immun. 1996 Apr;64(4):1420-5.


Human intestinal mucin-like protein (MLP) is homologous with rat MLP in the C-terminal region, and is encoded by a gene on chromosome 11 p 15.5.

Xu G, Huan L, Khatri I, Sajjan US, McCool D, Wang D, Jones C, Forstner G, Forstner J.

Biochem Biophys Res Commun. 1992 Mar 16;183(2):821-8.


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