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Usefulness of the Transcatheter Aortic Valve Replacement Risk Score to Determine Mid-Term Outcomes.

Saji M, Tobaru T, Higuchi R, Mahara K, Takamisawa I, Iguchi N, Doi S, Okazaki S, Tamura H, Takanashi S, Takayama M, Isobe M.

Circ J. 2019 Jul 25;83(8):1755-1761. doi: 10.1253/circj.CJ-18-1394. Epub 2019 Jun 12.


MAPK- and AKT-activated thyroid cancers are sensitive to group I PAK inhibition.

Knippler CM, Saji M, Rajan N, Porter K, La Perle K, Ringel MD.

Endocr Relat Cancer. 2019 May 1. pii: ERC-19-0188.R1. doi: 10.1530/ERC-19-0188. [Epub ahead of print]


Daytime sleepiness in epilepsy patients with special attention to traffic accidents.

Matsuoka E, Saji M, Kanemoto K.

Seizure. 2019 Jul;69:279-282. doi: 10.1016/j.seizure.2019.04.006. Epub 2019 May 18.


Inhibiting BRAF Oncogene-Mediated Radioresistance Effectively Radiosensitizes BRAFV600E-Mutant Thyroid Cancer Cells by Constraining DNA Double-Strand Break Repair.

Robb R, Yang L, Shen C, Wolfe AR, Webb A, Zhang X, Vedaie M, Saji M, Jhiang S, Ringel MD, Williams TM.

Clin Cancer Res. 2019 Aug 1;25(15):4749-4760. doi: 10.1158/1078-0432.CCR-18-3625. Epub 2019 May 16.


Complete endovascular repair of iliac artery perforation during transcatheter aortic valve implantation: a bailout with Viabahn endoprosthesis.

Kojima Y, Higuchi R, Saji M, Takamisawa I, Tobaru T, Takayama M.

Cardiovasc Interv Ther. 2019 Apr 30. doi: 10.1007/s12928-019-00586-w. [Epub ahead of print] No abstract available.


Cognitive assessment using the revised Hasegawa's dementia scale to determine the mid-term outcomes following transcatheter aortic valve replacement.

Saji M, Tobaru T, Higuchi R, Hagiya K, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M, Isobe M.

J Cardiol. 2019 Sep;74(3):206-211. doi: 10.1016/j.jjcc.2019.03.017. Epub 2019 Apr 20.


Long-term outcomes in Japanese nonagenarians undergoing transcatheter aortic valve implantation: A multi-center analysis.

Yokoyama H, Tobaru T, Muto Y, Hagiya K, Higuchi R, Saji M, Takamisawa I, Shimizu J, Takanashi S, Takayama M, Tomita H, Tamura H, Doi S, Okazaki S, Isobe M.

Clin Cardiol. 2019 Jun;42(6):605-611. doi: 10.1002/clc.23183. Epub 2019 Apr 23.


Physical performance as a predictor of midterm outcome after mitral valve surgery.

Ashikaga K, Saji M, Takanashi S, Nagayama M, Akashi YJ, Isobe M.

Heart Vessels. 2019 Oct;34(10):1665-1673. doi: 10.1007/s00380-019-01397-y. Epub 2019 Apr 10.


Outcomes of Transcatheter Aortic Valve Implantation in Patients with Cirrhosis.

Higuchi R, Tobaru T, Hagiya K, Saji M, Mahara K, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M, Isobe M.

Int Heart J. 2019 Mar 20;60(2):352-358. doi: 10.1536/ihj.18-339. Epub 2019 Feb 8.


Higher non-cardiac mortality and lesser impact of early revascularization in patients with type 2 compared to type 1 acute myocardial infarction: results from the Tokyo CCU Network registry.

Higuchi S, Suzuki M, Horiuchi Y, Tanaka H, Saji M, Yoshino H, Nagao K, Yamamoto T, Takayama M.

Heart Vessels. 2019 Jul;34(7):1140-1147. doi: 10.1007/s00380-019-01350-z. Epub 2019 Jan 25.


The Clinical Potential of Impella 5.0 Support in the Treatment of Recurrent Fulminant Viral Myocarditis with Profound Cardiogenic Shock.

Ogawa S, Suzuki M, Ochi H, Saji M, Mahara K, Takamisawa I, Nishigawa K, Furuichi Y, Takanashi S, Isobe M.

Intern Med. 2019 May 15;58(10):1459-1462. doi: 10.2169/internalmedicine.1866-18. Epub 2019 Jan 10.


Transcatheter aortic valve replacement in patients with degenerative calcified rheumatic aortic stenosis: A 10-patient case series.

Saji M, Highchi R, Iguchi N, Shimuzu J, Tobaru T, Takanashi S, Takayama M, Isobe M.

Int J Cardiol. 2019 Apr 1;280:38-42. doi: 10.1016/j.ijcard.2018.11.090. Epub 2018 Nov 16.


Renoprotective Transcatheter Aortic Valve Implantation Without Contrast Media.

Higuchi R, Tobaru T, Hagiya K, Saji M, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M.

Int Heart J. 2018 Nov 28;59(6):1469-1472. doi: 10.1536/ihj.17-588. Epub 2018 Sep 25.


Transcriptional targeting of oncogene addiction in medullary thyroid cancer.

Valenciaga A, Saji M, Yu L, Zhang X, Bumrah C, Yilmaz AS, Knippler CM, Miles W, Giordano TJ, Cote GJ, Ringel MD.

JCI Insight. 2018 Aug 23;3(16). pii: 122225. doi: 10.1172/jci.insight.122225. eCollection 2018 Aug 23.


Outcomes of patients requiring extracorporeal membrane oxygenation in transcatheter aortic valve implantation: a clinical case series.

Higuchi R, Tobaru T, Hagiya K, Saji M, Takamisawa I, Shimizu J, Iguchi N, Takanashi S, Takayama M, Isobe M.

Heart Vessels. 2018 Nov;33(11):1343-1349. doi: 10.1007/s00380-018-1183-8. Epub 2018 May 2.


Clinical impact of thrombus aspiration on in-hospital mortality in each culprit lesion in the setting of ST-segment elevation myocardial infarction.

Higuchi S, Suzuki M, Horiuchi Y, Tanaka H, Saji M, Yoshino H, Nagao K, Yamamoto T, Takayama M.

Heart Vessels. 2018 Oct;33(10):1168-1174. doi: 10.1007/s00380-018-1171-z. Epub 2018 Apr 27.


6-Minute walk test predicts prolonged hospitalization in patients undergoing transcatheter mitral valve repair by MitraClip.

Saji M, Katz MR, Ailawadi G, Welch TS, Fowler DE, Kennedy JLW, Bergin JD, Kuntjoro I, Dent JM, Ragosta M, Lim DS.

Catheter Cardiovasc Interv. 2018 Sep 1;92(3):566-573. doi: 10.1002/ccd.27600. Epub 2018 Apr 15.


Repeat transcatheter aortic valve replacement using a 23 mm Evolut R in a small patient with a failed 20 mm SAPIEN XT.

Saji M, Tobaru T, Higuchi R, Takanashi S, Takayama M, Isobe M.

Cardiovasc Interv Ther. 2019 Jan;34(1):80-82. doi: 10.1007/s12928-018-0519-8. Epub 2018 Mar 26. No abstract available.


Impact of Frailty Markers for Unplanned Hospital Readmission Following Transcatheter Aortic Valve Implantation.

Saji M, Higuchi R, Tobaru T, Iguchi N, Takanashi S, Takayama M, Isobe M.

Circ J. 2018 Jul 25;82(8):2191-2198. doi: 10.1253/circj.CJ-17-0816. Epub 2017 Dec 29.


Pulmonary Hemorrhaging Caused by Acute Severe Mitral Regurgitation during Transcatheter Aortic Valve Implantation.

Higuchi R, Tobaru T, Saji M, Mahara K, Takamisawa I, Shimizu J, Takanashi S, Takayama M.

Intern Med. 2018 Apr 15;57(8):1115-1117. doi: 10.2169/internalmedicine.9712-17. Epub 2017 Dec 21.


Reduced Retinoblastoma Protein Expression Is Associated with Decreased Patient Survival in Medullary Thyroid Cancer.

Valenciaga A, Grubbs EG, Porter K, Wakely PE Jr, Williams MD, Cote GJ, Vasko VV, Saji M, Ringel MD.

Thyroid. 2017 Dec;27(12):1523-1533. doi: 10.1089/thy.2017.0113.


Prolonged Intensive Care Unit Stay Following Transcatheter Aortic Valve Replacement.

Higuchi R, Takayama M, Hagiya K, Saji M, Mahara K, Takamisawa I, Shimizu J, Tobaru T, Iguchi N, Takanashi S.

J Intensive Care Med. 2017 Jan 1:885066617732290. doi: 10.1177/0885066617732290. [Epub ahead of print]


Chronic inguinal pain after laparoscopic intraperitoneal onlay mesh (IPOM) repair for inguinal hernia treated successfully with laparoscopic selective neurectomy: A case report.

Hanada K, Narita M, Goto K, Okada H, Okura K, Jikihara S, Nakanishi H, Saji M, Matsusue R, Hata H, Yamaguchi T, Otani T, Ikai I.

Int J Surg Case Rep. 2017;38:172-175. doi: 10.1016/j.ijscr.2017.07.044. Epub 2017 Jul 25.


Biological Evaluation of a Fluorescent-Imaging Agent for Medullary Thyroid Cancer in an Orthotopic Model.

Rossfeld KK, Justiniano SE, Ding H, Gong L, Kothandaraman S, Sawant D, Saji M, Wright CL, Kirschner LS, Ringel MD, Tweedle MF, Phay JE.

J Clin Endocrinol Metab. 2017 Sep 1;102(9):3268-3277. doi: 10.1210/jc.2017-00573.


Transcatheter aortic valve implantation in patients on corticosteroid therapy.

Higuchi R, Tobaru T, Hagiya K, Saji M, Mahara K, Takamisawa I, Shimizu J, Takanashi S, Takayama M.

Heart Vessels. 2017 Oct;32(10):1236-1243. doi: 10.1007/s00380-017-0996-1. Epub 2017 May 23.


Predictive Value of Age-Adjusted Charlson Co-Morbidity Index for 1-, 3-, and 5-Year Mortality in Patients Requiring Transcatheter Mitral Valve Repair.

Saji M, Katz MR, Ailawadi G, Fowler DE, Ragosta M, Lim DS.

Am J Cardiol. 2017 Jul 15;120(2):309-314. doi: 10.1016/j.amjcard.2017.04.022. Epub 2017 Apr 27.


Intracardiac echocardiography during transcatheter tricuspid valve-in-valve implantation.

Saji M, Ailawadi G, Izarnotegui V, Fowler DE, Lim DS.

Cardiovasc Interv Ther. 2018 Jul;33(3):285-287. doi: 10.1007/s12928-017-0469-6. Epub 2017 May 5. No abstract available.


RCAN1-4 is a thyroid cancer growth and metastasis suppressor.

Wang C, Saji M, Justiniano SE, Yusof AM, Zhang X, Yu L, Fernández S, Wakely P Jr, La Perle K, Nakanishi H, Pohlman N, Ringel MD.

JCI Insight. 2017 Mar 9;2(5):e90651. doi: 10.1172/jci.insight.90651.


Germline compound heterozygous poly-glutamine deletion in USF3 may be involved in predisposition to heritable and sporadic epithelial thyroid carcinoma.

Ni Y, Seballos S, Fletcher B, Romigh T, Yehia L, Mester J, Senter L, Niazi F, Saji M, Ringel MD, LaFramboise T, Eng C.

Hum Mol Genet. 2017 Jan 15;26(2):243-257. doi: 10.1093/hmg/ddw382.


Current characteristics and management of ST elevation and non-ST elevation myocardial infarction in the Tokyo metropolitan area: from the Tokyo CCU network registered cohort.

Miyachi H, Takagi A, Miyauchi K, Yamasaki M, Tanaka H, Yoshikawa M, Saji M, Suzuki M, Yamamoto T, Shimizu W, Nagao K, Takayama M.

Heart Vessels. 2016 Nov;31(11):1740-1751. Epub 2016 Jan 12.


Transcatheter Aortic Valve Replacement in Lower Surgical Risk Patients: Review of Major Trials and Future Perspectives.

Saji M, Lim DS.

Curr Cardiol Rep. 2016 Oct;18(10):103. doi: 10.1007/s11886-016-0772-3. Review.


Genetic variants in thyroid cancer distant metastases.

Justiniano SE, McElroy JP, Yu L, Yilmaz AS, Coombes KR, Senter L, Nagy R, Wakely P Jr, Volinia S, Vinco M, Giordano TJ, Croce CM, Saji M, Ringel MD.

Endocr Relat Cancer. 2016 Oct;23(10):L33-6. doi: 10.1530/ERC-16-0351. Epub 2016 Aug 19. No abstract available.


Bioassays for TSH Receptor Autoantibodies, from FRTL-5 Cells to TSH Receptor-LH/CG Receptor Chimeras: The Contribution of Leonard D. Kohn.

Giuliani C, Saji M, Bucci I, Napolitano G.

Front Endocrinol (Lausanne). 2016 Jul 25;7:103. doi: 10.3389/fendo.2016.00103. eCollection 2016. Review.


Progressive Mitral Stenosis After MitraClip Implantation in a Patient With Systemic Inflammatory Disease.

Saji M, Ailawadi G, Fowler DE, LaPar DJ, Dent JM, Ragosta M, Lim DS.

Ann Thorac Surg. 2016 Aug;102(2):e89-91. doi: 10.1016/j.athoracsur.2015.12.050.


Primary Cell Culture Systems for Human Thyroid Studies.

Wang Y, Li W, Phay JE, Shen R, Pellegata NS, Saji M, Ringel MD, de la Chapelle A, He H.

Thyroid. 2016 Aug;26(8):1131-40. doi: 10.1089/thy.2015.0518. Epub 2016 Jul 6.


Usefulness of Psoas Muscle Area to Predict Mortality in Patients Undergoing Transcatheter Aortic Valve Replacement.

Saji M, Lim DS, Ragosta M, LaPar DJ, Downs E, Ghanta RK, Kern JA, Dent JM, Ailawadi G.

Am J Cardiol. 2016 Jul 15;118(2):251-7. doi: 10.1016/j.amjcard.2016.04.043. Epub 2016 May 5.


Pre-Procedural 6-Min Walk Test as a Mortality Predictor in Patients Undergoing Transcatheter Mitral Valve Repair.

Saji M, Ailawadi G, Welch TS, Downs E, LaPar DJ, Ghanta R, Kennedy JL, Abuannadi M, Buda AJ, Bergin JD, Kern JA, Dent JM, Ragosta M, Lim DS.

J Am Coll Cardiol. 2016 May 3;67(17):2083-4. doi: 10.1016/j.jacc.2016.02.032. No abstract available.


Transcatheter Aortic Valve Replacement in a Young Adult Patient with a Failed Homograft.

Saji M, Hoyt WJ Jr, Ailawadi G, Mulloy DP, Ghanta RK, Ragosta M, Scott Lim D.

Pediatr Cardiol. 2016 Jun;37(5):986-8. doi: 10.1007/s00246-016-1399-2. Epub 2016 Apr 15. No abstract available.


Integrin-linked kinase affects signaling pathways and migration in thyroid cancer cells and is a potential therapeutic target.

Shirley LA, McCarty S, Yang MC, Saji M, Zhang X, Phay J, Ringel MD, Chen CS.

Surgery. 2016 Jan;159(1):163-70. doi: 10.1016/j.surg.2015.10.016. Epub 2015 Nov 6.


Anterior Mitral Leaflet Perforation During Transcatheter Aortic Valve Replacement in a Patient With Mitral Annular Calcification.

Saji M, Ailawadi G, Ragosta M, Fowler DE, Dent JM, Lim DS.

JACC Cardiovasc Interv. 2015 Nov;8(13):e215-6. doi: 10.1016/j.jcin.2015.06.027. Epub 2015 Oct 14. No abstract available.


Current state of transcatheter mitral valve repair with the MitraClip.

Downs EA, Lim DS, Saji M, Ailawadi G.

Ann Cardiothorac Surg. 2015 Jul;4(4):335-40. doi: 10.3978/j.issn.2225-319X.2015.02.02.


Adjunctive intracardiac echocardiography imaging from the left ventricle to guide percutaneous mitral valve repair with the MitraClip in patients with failed prior surgical rings.

Saji M, Rossi AM, Ailawadi G, Dent J, Ragosta M, Lim DS.

Catheter Cardiovasc Interv. 2016 Feb 1;87(2):E75-82. doi: 10.1002/ccd.25981. Epub 2015 Jun 23.


Use of intracardiac echocardiography to guide percutaneous transluminal mitral commissurotomy: A 20-patient case series.

Saji M, Ragosta M, Dent J, Lim DS.

Catheter Cardiovasc Interv. 2016 Feb 1;87(2):E69-74. doi: 10.1002/ccd.25943. Epub 2015 May 6.


Analysis of exosome release as a cellular response to MAPK pathway inhibition.

Agarwal K, Saji M, Lazaroff SM, Palmer AF, Ringel MD, Paulaitis ME.

Langmuir. 2015 May 19;31(19):5440-8. doi: 10.1021/acs.langmuir.5b00095. Epub 2015 May 5.


Breast Cancer-Specific miR Signature Unique to Extracellular Vesicles Includes "microRNA-like" tRNA Fragments.

Guzman N, Agarwal K, Asthagiri D, Yu L, Saji M, Ringel MD, Paulaitis ME.

Mol Cancer Res. 2015 May;13(5):891-901. doi: 10.1158/1541-7786.MCR-14-0533. Epub 2015 Feb 26.


A novel dual AMPK activator/mTOR inhibitor inhibits thyroid cancer cell growth.

Plews RL, Mohd Yusof A, Wang C, Saji M, Zhang X, Chen CS, Ringel MD, Phay JE.

J Clin Endocrinol Metab. 2015 May;100(5):E748-56. doi: 10.1210/jc.2014-1777. Epub 2015 Feb 24.


The NR2B antagonist, ifenprodil, corrects the l-DOPA-induced deficit of bilateral movement and reduces c-Fos expression in the subthalamic nucleus of hemiparkinsonian rats.

Igarashi M, Habata T, Akita H, Noda K, Ogata M, Saji M.

Neurosci Res. 2015 Jul;96:45-53. doi: 10.1016/j.neures.2015.02.003. Epub 2015 Feb 16.


BRAF activates and physically interacts with PAK to regulate cell motility.

McCarty SK, Saji M, Zhang X, Knippler CM, Kirschner LS, Fernandez S, Ringel MD.

Endocr Relat Cancer. 2014;21(6):865-77. doi: 10.1530/ERC-14-0424. Epub 2014 Sep 16.

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