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Items: 41

1.

Functional evaluation of the pathological significance of MEFV variants using induced pluripotent stem cell-derived macrophages.

Shiba T, Tanaka T, Ida H, Watanabe M, Nakaseko H, Osawa M, Shibata H, Izawa K, Yasumi T, Kawasaki Y, Saito MK, Takita J, Heike T, Nishikomori R.

J Allergy Clin Immunol. 2019 Sep 13. pii: S0091-6749(19)31039-5. doi: 10.1016/j.jaci.2019.07.039. [Epub ahead of print] No abstract available.

PMID:
31542286
2.

iPSC-derived functional human neuromuscular junctions model the pathophysiology of neuromuscular diseases.

Lin CY, Yoshida M, Li LT, Ikenaka A, Oshima S, Nakagawa K, Sakurai H, Matsui E, Nakahata T, Saito MK.

JCI Insight. 2019 Sep 19;4(18). pii: 124299. doi: 10.1172/jci.insight.124299.

3.

Hemogenic Endothelium Differentiation from Human Pluripotent Stem Cells in A Feeder- and Xeno-free Defined Condition.

Ohta R, Sugimura R, Niwa A, Saito MK.

J Vis Exp. 2019 Jun 16;(148). doi: 10.3791/59823.

PMID:
31259914
4.

Induced pluripotent stem cells representing Nakajo-Nishimura syndrome.

Kanazawa N, Honda-Ozaki F, Saito MK.

Inflamm Regen. 2019 May 23;39:11. doi: 10.1186/s41232-019-0099-8. eCollection 2019. Review.

5.

Beneficial effect of methotrexate on a child case of Nakajo-Nishimura syndrome.

Kunimoto K, Honda-Ozaki F, Saito MK, Furukawa F, Kanazawa N.

J Dermatol. 2019 Oct;46(10):e365-e367. doi: 10.1111/1346-8138.14907. Epub 2019 May 6. No abstract available.

PMID:
31058345
6.

Induction of human pluripotent stem cell-derived natural killer cells for immunotherapy under chemically defined conditions.

Matsubara H, Niwa A, Nakahata T, Saito MK.

Biochem Biophys Res Commun. 2019 Jul 12;515(1):1-8. doi: 10.1016/j.bbrc.2019.03.085. Epub 2019 Apr 2.

PMID:
30948156
7.

Generation of a human induced pluripotent stem cell line, BRCi001-A, derived from a patient with mucopolysaccharidosis type I.

Suga M, Kondo T, Imamura K, Shibukawa R, Okanishi Y, Sagara Y, Tsukita K, Enami T, Furujo M, Saijo K, Nakamura Y, Osawa M, Saito MK, Yamanaka S, Inoue H.

Stem Cell Res. 2019 Apr;36:101406. doi: 10.1016/j.scr.2019.101406. Epub 2019 Feb 12.

8.

Verification and rectification of cell type-specific splicing of a Seckel syndrome-associated ATR mutation using iPS cell model.

Ichisima J, Suzuki NM, Samata B, Awaya T, Takahashi J, Hagiwara M, Nakahata T, Saito MK.

J Hum Genet. 2019 May;64(5):445-458. doi: 10.1038/s10038-019-0574-8. Epub 2019 Mar 8.

PMID:
30846821
9.

Application of induced pluripotent stem cells to primary immunodeficiency diseases.

Karagiannis P, Yamanaka S, Saito MK.

Exp Hematol. 2019 Mar;71:43-50. doi: 10.1016/j.exphem.2019.01.005. Epub 2019 Jan 19. Review.

PMID:
30664903
10.

Disease modeling of immunological disorders using induced pluripotent stem cells.

Saito MK.

Immunol Med. 2018 Jun;41(2):68-74. doi: 10.1080/13497413.2018.1481583. Epub 2018 Sep 7.

PMID:
30618339
11.

Modelling the cost-effectiveness of a rapid diagnostic test (IgMFA) for uncomplicated typhoid fever in Cambodia.

Saito MK, Parry CM, Yeung S.

PLoS Negl Trop Dis. 2018 Nov 19;12(11):e0006961. doi: 10.1371/journal.pntd.0006961. eCollection 2018 Nov.

12.

Rescue of recurrent deep intronic mutation underlying cell type-dependent quantitative NEMO deficiency.

Boisson B, Honda Y, Ajiro M, Bustamante J, Bendavid M, Gennery AR, Kawasaki Y, Ichishima J, Osawa M, Nihira H, Shiba T, Tanaka T, Chrabieh M, Bigio B, Hur H, Itan Y, Liang Y, Okada S, Izawa K, Nishikomori R, Ohara O, Heike T, Abel L, Puel A, Saito MK, Casanova JL, Hagiwara M, Yasumi T.

J Clin Invest. 2019 Feb 1;129(2):583-597. doi: 10.1172/JCI124011. Epub 2018 Dec 18.

13.

Efficient derivation of sympathetic neurons from human pluripotent stem cells with a defined condition.

Kirino K, Nakahata T, Taguchi T, Saito MK.

Sci Rep. 2018 Aug 27;8(1):12865. doi: 10.1038/s41598-018-31256-1.

14.

Lysosomal membrane permeabilization causes secretion of IL-1β in human vascular smooth muscle cells.

Ono H, Ohta R, Kawasaki Y, Niwa A, Takada H, Nakahata T, Ohga S, Saito MK.

Inflamm Res. 2018 Oct;67(10):879-889. doi: 10.1007/s00011-018-1178-z. Epub 2018 Aug 22.

15.

Pluripotent Stem Cell Model of Nakajo-Nishimura Syndrome Untangles Proinflammatory Pathways Mediated by Oxidative Stress.

Honda-Ozaki F, Terashima M, Niwa A, Saiki N, Kawasaki Y, Ito H, Hotta A, Nagahashi A, Igura K, Asaka I, Li HL, Yanagimachi M, Furukawa F, Kanazawa N, Nakahata T, Saito MK.

Stem Cell Reports. 2018 Jun 5;10(6):1835-1850. doi: 10.1016/j.stemcr.2018.04.004. Epub 2018 May 3.

16.

Human AK2 links intracellular bioenergetic redistribution to the fate of hematopoietic progenitors.

Oshima K, Saiki N, Tanaka M, Imamura H, Niwa A, Tanimura A, Nagahashi A, Hirayama A, Okita K, Hotta A, Kitayama S, Osawa M, Kaneko S, Watanabe A, Asaka I, Fujibuchi W, Imai K, Yabe H, Kamachi Y, Hara J, Kojima S, Tomita M, Soga T, Noma T, Nonoyama S, Nakahata T, Saito MK.

Biochem Biophys Res Commun. 2018 Mar 4;497(2):719-725. doi: 10.1016/j.bbrc.2018.02.139. Epub 2018 Feb 17.

17.

Human pluripotent stem cell-derived erythropoietin-producing cells ameliorate renal anemia in mice.

Hitomi H, Kasahara T, Katagiri N, Hoshina A, Mae SI, Kotaka M, Toyohara T, Rahman A, Nakano D, Niwa A, Saito MK, Nakahata T, Nishiyama A, Osafune K.

Sci Transl Med. 2017 Sep 27;9(409). pii: eaaj2300. doi: 10.1126/scitranslmed.aaj2300.

PMID:
28954928
18.

Microarray analyses of otospheres derived from the cochlea in the inner ear identify putative transcription factors that regulate the characteristics of otospheres.

Iki T, Tanaka M, Kitajiri SI, Kita T, Kawasaki Y, Mizukoshi A, Fujibuchi W, Nakagawa T, Nakahata T, Ito J, Omori K, Saito MK.

PLoS One. 2017 Jun 29;12(6):e0179901. doi: 10.1371/journal.pone.0179901. eCollection 2017.

19.

Pluripotent stem cell models of Blau syndrome reveal an IFN-γ-dependent inflammatory response in macrophages.

Takada S, Kambe N, Kawasaki Y, Niwa A, Honda-Ozaki F, Kobayashi K, Osawa M, Nagahashi A, Semi K, Hotta A, Asaka I, Yamada Y, Nishikomori R, Heike T, Matsue H, Nakahata T, Saito MK.

J Allergy Clin Immunol. 2018 Jan;141(1):339-349.e11. doi: 10.1016/j.jaci.2017.04.013. Epub 2017 Jun 3.

PMID:
28587749
20.

Hypoxic adaptation of leukemic cells infiltrating the CNS affords a therapeutic strategy targeting VEGFA.

Kato I, Nishinaka Y, Nakamura M, Akarca AU, Niwa A, Ozawa H, Yoshida K, Mori M, Wang D, Morita M, Ueno H, Shiozawa Y, Shiraishi Y, Miyano S, Gupta R, Umeda K, Watanabe K, Koh K, Adachi S, Heike T, Saito MK, Sanada M, Ogawa S, Marafioti T, Watanabe A, Nakahata T, Enver T.

Blood. 2017 Jun 8;129(23):3126-3129. doi: 10.1182/blood-2016-06-721712. Epub 2017 Apr 19. No abstract available.

21.

Laminin-guided highly efficient endothelial commitment from human pluripotent stem cells.

Ohta R, Niwa A, Taniguchi Y, Suzuki NM, Toga J, Yagi E, Saiki N, Nishinaka-Arai Y, Okada C, Watanabe A, Nakahata T, Sekiguchi K, Saito MK.

Sci Rep. 2016 Nov 2;6:35680. doi: 10.1038/srep35680.

22.

Identification of a High-Frequency Somatic NLRC4 Mutation as a Cause of Autoinflammation by Pluripotent Cell-Based Phenotype Dissection.

Kawasaki Y, Oda H, Ito J, Niwa A, Tanaka T, Hijikata A, Seki R, Nagahashi A, Osawa M, Asaka I, Watanabe A, Nishimata S, Shirai T, Kawashima H, Ohara O, Nakahata T, Nishikomori R, Heike T, Saito MK.

Arthritis Rheumatol. 2017 Feb;69(2):447-459. doi: 10.1002/art.39960.

23.

A portable platform for stepwise hematopoiesis from human pluripotent stem cells within PET-reinforced collagen sponges.

Sugimine Y, Niwa A, Matsubara H, Kobayashi K, Tabata Y, Heike T, Nakahata T, Saito MK.

Int J Hematol. 2016 Dec;104(6):647-660. Epub 2016 Sep 6.

PMID:
27599982
24.

Mislocalization of syntaxin-1 and impaired neurite growth observed in a human iPSC model for STXBP1-related epileptic encephalopathy.

Yamashita S, Chiyonobu T, Yoshida M, Maeda H, Zuiki M, Kidowaki S, Isoda K, Morimoto M, Kato M, Saitsu H, Matsumoto N, Nakahata T, Saito MK, Hosoi H.

Epilepsia. 2016 Apr;57(4):e81-6. doi: 10.1111/epi.13338. Epub 2016 Feb 25.

25.

Establishment of isogenic iPSCs from an individual with SCN1A mutation mosaicism as a model for investigating neurocognitive impairment in Dravet syndrome.

Maeda H, Chiyonobu T, Yoshida M, Yamashita S, Zuiki M, Kidowaki S, Isoda K, Yamakawa K, Morimoto M, Nakahata T, Saito MK, Hosoi H.

J Hum Genet. 2016 Jun;61(6):565-9. doi: 10.1038/jhg.2016.5. Epub 2016 Feb 4.

PMID:
26841829
26.

GSK3β inhibition activates the CDX/HOX pathway and promotes hemogenic endothelial progenitor differentiation from human pluripotent stem cells.

Kitajima K, Nakajima M, Kanokoda M, Kyba M, Dandapat A, Tolar J, Saito MK, Toyoda M, Umezawa A, Hara T.

Exp Hematol. 2016 Jan;44(1):68-74.e1-10. doi: 10.1016/j.exphem.2015.09.007. Epub 2015 Oct 23.

27.

Studies of hematopoietic and immunological disorders using disease - associated iPS cells.

Saito MK.

Nihon Rinsho. 2015 Jun;73 Suppl 5:423-8. Japanese. No abstract available.

PMID:
30458091
28.

Modeling the early phenotype at the neuromuscular junction of spinal muscular atrophy using patient-derived iPSCs.

Yoshida M, Kitaoka S, Egawa N, Yamane M, Ikeda R, Tsukita K, Amano N, Watanabe A, Morimoto M, Takahashi J, Hosoi H, Nakahata T, Inoue H, Saito MK.

Stem Cell Reports. 2015 Apr 14;4(4):561-8. doi: 10.1016/j.stemcr.2015.02.010. Epub 2015 Mar 19.

29.

Pluripotent cell models of fanconi anemia identify the early pathological defect in human hemoangiogenic progenitors.

Suzuki NM, Niwa A, Yabe M, Hira A, Okada C, Amano N, Watanabe A, Watanabe K, Heike T, Takata M, Nakahata T, Saito MK.

Stem Cells Transl Med. 2015 Apr;4(4):333-8. doi: 10.5966/sctm.2013-0172. Epub 2015 Mar 11.

30.

Enhanced chondrogenesis of induced pluripotent stem cells from patients with neonatal-onset multisystem inflammatory disease occurs via the caspase 1-independent cAMP/protein kinase A/CREB pathway.

Yokoyama K, Ikeya M, Umeda K, Oda H, Nodomi S, Nasu A, Matsumoto Y, Izawa K, Horigome K, Kusaka T, Tanaka T, Saito MK, Yasumi T, Nishikomori R, Ohara O, Nakayama N, Nakahata T, Heike T, Toguchida J.

Arthritis Rheumatol. 2015 Jan;67(1):302-14. doi: 10.1002/art.38912.

31.

Somatic NLRP3 mosaicism in Muckle-Wells syndrome. A genetic mechanism shared by different phenotypes of cryopyrin-associated periodic syndromes.

Nakagawa K, Gonzalez-Roca E, Souto A, Kawai T, Umebayashi H, Campistol JM, Cañellas J, Takei S, Kobayashi N, Callejas-Rubio JL, Ortego-Centeno N, Ruiz-Ortiz E, Rius F, Anton J, Iglesias E, Jimenez-Treviño S, Vargas C, Fernandez-Martin J, Calvo I, Hernández-Rodríguez J, Mendez M, Dordal MT, Basagaña M, Bujan S, Yashiro M, Kubota T, Koike R, Akuta N, Shimoyama K, Iwata N, Saito MK, Ohara O, Kambe N, Yasumi T, Izawa K, Kawai T, Heike T, Yagüe J, Nishikomori R, Aróstegui JI.

Ann Rheum Dis. 2015 Mar;74(3):603-10. doi: 10.1136/annrheumdis-2013-204361. Epub 2013 Dec 10.

32.

Genetic correction of HAX1 in induced pluripotent stem cells from a patient with severe congenital neutropenia improves defective granulopoiesis.

Morishima T, Watanabe K, Niwa A, Hirai H, Saida S, Tanaka T, Kato I, Umeda K, Hiramatsu H, Saito MK, Matsubara K, Adachi S, Kobayashi M, Nakahata T, Heike T.

Haematologica. 2014 Jan;99(1):19-27. doi: 10.3324/haematol.2013.083873. Epub 2013 Aug 23.

33.

Robust and highly-efficient differentiation of functional monocytic cells from human pluripotent stem cells under serum- and feeder cell-free conditions.

Yanagimachi MD, Niwa A, Tanaka T, Honda-Ozaki F, Nishimoto S, Murata Y, Yasumi T, Ito J, Tomida S, Oshima K, Asaka I, Goto H, Heike T, Nakahata T, Saito MK.

PLoS One. 2013;8(4):e59243. doi: 10.1371/journal.pone.0059243. Epub 2013 Apr 3.

34.

Induced pluripotent stem cells from CINCA syndrome patients as a model for dissecting somatic mosaicism and drug discovery.

Tanaka T, Takahashi K, Yamane M, Tomida S, Nakamura S, Oshima K, Niwa A, Nishikomori R, Kambe N, Hara H, Mitsuyama M, Morone N, Heuser JE, Yamamoto T, Watanabe A, Sato-Otsubo A, Ogawa S, Asaka I, Heike T, Yamanaka S, Nakahata T, Saito MK.

Blood. 2012 Aug 9;120(6):1299-308. doi: 10.1182/blood-2012-03-417881. Epub 2012 Jun 21.

PMID:
22723549
35.

Detection of base substitution-type somatic mosaicism of the NLRP3 gene with >99.9% statistical confidence by massively parallel sequencing.

Izawa K, Hijikata A, Tanaka N, Kawai T, Saito MK, Goldbach-Mansky R, Aksentijevich I, Yasumi T, Nakahata T, Heike T, Nishikomori R, Ohara O.

DNA Res. 2012 Apr;19(2):143-52. doi: 10.1093/dnares/dsr047. Epub 2012 Jan 24.

36.

Identification of hepatic niche harboring human acute lymphoblastic leukemic cells via the SDF-1/CXCR4 axis.

Kato I, Niwa A, Heike T, Fujino H, Saito MK, Umeda K, Hiramatsu H, Ito M, Morita M, Nishinaka Y, Adachi S, Ishikawa F, Nakahata T.

PLoS One. 2011;6(11):e27042. doi: 10.1371/journal.pone.0027042. Epub 2011 Nov 1.

37.

[CAPS: cryopyrin-associated periodic syndrome].

Saito MK.

Nihon Rinsho Meneki Gakkai Kaishi. 2011;34(5):369-77. Review. Japanese.

38.

A novel serum-free monolayer culture for orderly hematopoietic differentiation of human pluripotent cells via mesodermal progenitors.

Niwa A, Heike T, Umeda K, Oshima K, Kato I, Sakai H, Suemori H, Nakahata T, Saito MK.

PLoS One. 2011;6(7):e22261. doi: 10.1371/journal.pone.0022261. Epub 2011 Jul 27.

39.

High incidence of NLRP3 somatic mosaicism in patients with chronic infantile neurologic, cutaneous, articular syndrome: results of an International Multicenter Collaborative Study.

Tanaka N, Izawa K, Saito MK, Sakuma M, Oshima K, Ohara O, Nishikomori R, Morimoto T, Kambe N, Goldbach-Mansky R, Aksentijevich I, de Saint Basile G, Neven B, van Gijn M, Frenkel J, Aróstegui JI, Yagüe J, Merino R, Ibañez M, Pontillo A, Takada H, Imagawa T, Kawai T, Yasumi T, Nakahata T, Heike T.

Arthritis Rheum. 2011 Nov;63(11):3625-32. doi: 10.1002/art.30512.

40.

[Inflammasomes and related diseases].

Saito MK.

Nihon Rinsho Meneki Gakkai Kaishi. 2011;34(1):20-8. Review. Japanese.

41.

Enhanced NF-κB activation with an inflammasome activator correlates with activity of autoinflammatory disease associated with NLRP3 mutations outside of exon 3: comment on the article by Jéru et al.

Kambe N, Satoh T, Tanizaki H, Fujisawa A, Saito MK, Nishikomori R.

Arthritis Rheum. 2010 Oct;62(10):3123-4; author reply 3124-5. doi: 10.1002/art.27619. No abstract available.

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