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Items: 9

1.

GI-530159, a novel, selective, mechanosensitive two-pore-domain potassium (K2P ) channel opener, reduces rat dorsal root ganglion neuron excitability.

Loucif AJC, Saintot PP, Liu J, Antonio BM, Zellmer SG, Yoger K, Veale EL, Wilbrey A, Omoto K, Cao L, Gutteridge A, Castle NA, Stevens EB, Mathie A.

Br J Pharmacol. 2018 Jun;175(12):2272-2283. doi: 10.1111/bph.14098. Epub 2017 Dec 29.

2.

Corrigendum to "Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1" [Bioorg. Med. Chem. Lett. 26 (2016) 4919-4924].

Monteillier A, Loucif A, Omoto K, Stevens EB, Lainez S, Saintot PP, Cao L, Pryde DC.

Bioorg Med Chem Lett. 2017 May 1;27(9):2082. doi: 10.1016/j.bmcl.2017.02.063. Epub 2017 Mar 17. No abstract available.

PMID:
28320618
3.

Investigation of the structure activity relationship of flufenamic acid derivatives at the human TRESK channel K2P18.1.

Monteillier A, Loucif A, Omoto K, Stevens EB, Lainez S, Saintot PP, Cao L, Pryde DC.

Bioorg Med Chem Lett. 2016 Oct 15;26(20):4919-4924. doi: 10.1016/j.bmcl.2016.09.020. Epub 2016 Sep 8. Erratum in: Bioorg Med Chem Lett. 2017 May 1;27(9):2082.

PMID:
27641472
4.

Pharmacological reversal of a pain phenotype in iPSC-derived sensory neurons and patients with inherited erythromelalgia.

Cao L, McDonnell A, Nitzsche A, Alexandrou A, Saintot PP, Loucif AJ, Brown AR, Young G, Mis M, Randall A, Waxman SG, Stanley P, Kirby S, Tarabar S, Gutteridge A, Butt R, McKernan RM, Whiting P, Ali Z, Bilsland J, Stevens EB.

Sci Transl Med. 2016 Apr 20;8(335):335ra56. doi: 10.1126/scitranslmed.aad7653.

PMID:
27099175
5.

Coordinated Regulation of Synaptic Plasticity at Striatopallidal and Striatonigral Neurons Orchestrates Motor Control.

Trusel M, Cavaccini A, Gritti M, Greco B, Saintot PP, Nazzaro C, Cerovic M, Morella I, Brambilla R, Tonini R.

Cell Rep. 2015 Nov 17;13(7):1353-1365. doi: 10.1016/j.celrep.2015.10.009. Epub 2015 Nov 5.

6.

Inhibition of TRPM8 channels reduces pain in the cold pressor test in humans.

Winchester WJ, Gore K, Glatt S, Petit W, Gardiner JC, Conlon K, Postlethwaite M, Saintot PP, Roberts S, Gosset JR, Matsuura T, Andrews MD, Glossop PA, Palmer MJ, Clear N, Collins S, Beaumont K, Reynolds DS.

J Pharmacol Exp Ther. 2014 Nov;351(2):259-69. doi: 10.1124/jpet.114.216010. Epub 2014 Aug 14.

7.

Reduced gamma oscillations in a mouse model of intellectual disability: a role for impaired repetitive neurotransmission?

Powell AD, Saintot PP, Gill KK, Bharathan A, Buck SC, Morris G, Jiruska P, Jefferys JG.

PLoS One. 2014 May 6;9(5):e95871. doi: 10.1371/journal.pone.0095871. eCollection 2014.

8.

Rapid reversal of impaired inhibitory and excitatory transmission but not spine dysgenesis in a mouse model of mental retardation.

Powell AD, Gill KK, Saintot PP, Jiruska P, Chelly J, Billuart P, Jefferys JG.

J Physiol. 2012 Feb 15;590(4):763-76. doi: 10.1113/jphysiol.2011.219907. Epub 2011 Nov 28.

9.

Locking the dimeric GABA(B) G-protein-coupled receptor in its active state.

Kniazeff J, Saintot PP, Goudet C, Liu J, Charnet A, Guillon G, Pin JP.

J Neurosci. 2004 Jan 14;24(2):370-7.

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