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Items: 1 to 50 of 119

1.

Chromosomal instability causes sensitivity to protein folding stress and ATP depletion.

Khan M, Shaukat Z, Saint R, Gregory SL.

Biol Open. 2018 Oct 16;7(10). pii: bio038000. doi: 10.1242/bio.038000.

2.

3D-printed components for quantum devices.

Saint R, Evans W, Zhou Y, Barrett T, Fromhold TM, Saleh E, Maskery I, Tuck C, Wildman R, Oručević F, Krüger P.

Sci Rep. 2018 May 30;8(1):8368. doi: 10.1038/s41598-018-26455-9.

3.

Frazzled can act through distinct molecular pathways in epithelial cells to regulate motility, apical constriction, and localisation of E-Cadherin.

Golenkina S, Chaturvedi V, Saint R, Murray MJ.

PLoS One. 2018 Mar 8;13(3):e0194003. doi: 10.1371/journal.pone.0194003. eCollection 2018.

4.

Phosphoenolpyruvate Carboxykinase Maintains Glycolysis-driven Growth in Drosophila Tumors.

Hussain R, Shaukat Z, Khan M, Saint R, Gregory SL.

Sci Rep. 2017 Sep 14;7(1):11531. doi: 10.1038/s41598-017-11613-2.

5.

Mitogen-activated protein kinases (MAPKs) are modulated during in vitro and in vivo infection with the intracellular bacterium Burkholderia pseudomallei.

D'Elia RV, Saint RJ, Newstead SL, Clark GC, Atkins HS.

Eur J Clin Microbiol Infect Dis. 2017 Nov;36(11):2147-2154. doi: 10.1007/s10096-017-3038-0. Epub 2017 Aug 30.

6.

An integrated computational-experimental approach reveals Yersinia pestis genes essential across a narrow or a broad range of environmental conditions.

Senior NJ, Sasidharan K, Saint RJ, Scott AE, Sarkar-Tyson M, Ireland PM, Bullifent HL, Rong Yang Z, Moore K, Oyston PCF, Atkins TP, Atkins HS, Soyer OS, Titball RW.

BMC Microbiol. 2017 Jul 21;17(1):163. doi: 10.1186/s12866-017-1073-8.

7.

A Noise Trimming and Positional Significance of Transposon Insertion System to Identify Essential Genes in Yersinia pestis.

Yang ZR, Bullifent HL, Moore K, Paszkiewicz K, Saint RJ, Southern SJ, Champion OL, Senior NJ, Sarkar-Tyson M, Oyston PC, Atkins TP, Titball RW.

Sci Rep. 2017 Feb 6;7:41923. doi: 10.1038/srep41923.

8.
9.

Autophagy regulates the survival of cells with chromosomal instability.

Liu D, Shaukat Z, Xu T, Denton D, Saint R, Gregory S.

Oncotarget. 2016 Sep 27;7(39):63913-63923. doi: 10.18632/oncotarget.11736.

10.

Chromosomal instability triggers cell death via local signalling through the innate immune receptor Toll.

Liu D, Shaukat Z, Saint RB, Gregory SL.

Oncotarget. 2015 Nov 17;6(36):38552-65. doi: 10.18632/oncotarget.6035.

11.

Systematic mutagenesis of genes encoding predicted autotransported proteins of Burkholderia pseudomallei identifies factors mediating virulence in mice, net intracellular replication and a novel protein conferring serum resistance.

Lazar Adler NR, Stevens MP, Dean RE, Saint RJ, Pankhania D, Prior JL, Atkins TP, Kessler B, Nithichanon A, Lertmemongkolchai G, Galyov EE.

PLoS One. 2015 Apr 1;10(4):e0121271. doi: 10.1371/journal.pone.0121271. eCollection 2015.

12.

Netrins and Frazzled/DCC promote the migration and mesenchymal to epithelial transition of Drosophila midgut cells.

Pert M, Gan M, Saint R, Murray MJ.

Biol Open. 2015 Jan 23;4(2):233-43. doi: 10.1242/bio.201410827.

13.

The organizer in evolution-gastrulation and organizer gene expression highlight the importance of Brachyury during development of the coral, Acropora millepora.

Hayward DC, Grasso LC, Saint R, Miller DJ, Ball EE.

Dev Biol. 2015 Mar 15;399(2):337-47. doi: 10.1016/j.ydbio.2015.01.006. Epub 2015 Jan 16.

14.

Chromosomal instability causes sensitivity to metabolic stress.

Shaukat Z, Liu D, Choo A, Hussain R, O'Keefe L, Richards R, Saint R, Gregory SL.

Oncogene. 2015 Jul 30;34(31):4044-55. doi: 10.1038/onc.2014.344. Epub 2014 Oct 27.

PMID:
25347746
15.

In vivo imaging and tracking of individual nanodiamonds in drosophila melanogaster embryos.

Simpson DA, Thompson AJ, Kowarsky M, Zeeshan NF, Barson MS, Hall LT, Yan Y, Kaufmann S, Johnson BC, Ohshima T, Caruso F, Scholten RE, Saint RB, Murray MJ, Hollenberg LC.

Biomed Opt Express. 2014 Mar 20;5(4):1250-61. doi: 10.1364/BOE.5.001250. eCollection 2014 Apr 1.

16.

Construction of an inducible system for the analysis of essential genes in Yersinia pestis.

Ford DC, Ireland PM, Bullifent HL, Saint RJ, McAlister EV, Sarkar-Tyson M, Oyston PC.

J Microbiol Methods. 2014 May;100:1-7. doi: 10.1016/j.mimet.2014.01.017. Epub 2014 Feb 11.

PMID:
24524852
17.

Correction: Identification of a Predicted Trimeric Autotransporter Adhesin Required for Biofilm Formation of Burkholderia pseudomallei.

Lazar Adler NR, Dean RE, Saint RJ, Stevens MP, Prior JL, Atkins TP, Galyov EE.

PLoS One. 2014 Jan 9;9(1). doi: 10.1371/annotation/f016476b-5b84-4c9a-899f-fe8b8bc927b5. eCollection 2014.

18.

JNK signaling is needed to tolerate chromosomal instability.

Wong HW, Shaukat Z, Wang J, Saint R, Gregory SL.

Cell Cycle. 2014;13(4):622-31. doi: 10.4161/cc.27484. Epub 2013 Dec 12.

19.

Netrin-dependent downregulation of Frazzled/DCC is required for the dissociation of the peripodial epithelium in Drosophila.

Manhire-Heath R, Golenkina S, Saint R, Murray MJ.

Nat Commun. 2013;4:2790. doi: 10.1038/ncomms3790.

PMID:
24225841
20.

Identification of a predicted trimeric autotransporter adhesin required for biofilm formation of Burkholderia pseudomallei.

Lazar Adler NR, Dean RE, Saint RJ, Stevens MP, Prior JL, Atkins TP, Galyov EE.

PLoS One. 2013 Nov 5;8(11):e79461. doi: 10.1371/journal.pone.0079461. eCollection 2013. Erratum in: PLoS One. 2014 Jan 9;9(1):.

21.

C. elegans RNA-dependent RNA polymerases rrf-1 and ego-1 silence Drosophila transgenes by differing mechanisms.

Duan G, Saint RB, Helliwell CA, Behm CA, Wang MB, Waterhouse PM, Gordon KH.

Cell Mol Life Sci. 2013 Apr;70(8):1469-81. doi: 10.1007/s00018-012-1218-8. Epub 2012 Dec 8.

PMID:
23224429
22.

A screen for selective killing of cells with chromosomal instability induced by a spindle checkpoint defect.

Shaukat Z, Wong HW, Nicolson S, Saint RB, Gregory SL.

PLoS One. 2012;7(10):e47447. doi: 10.1371/journal.pone.0047447. Epub 2012 Oct 15.

23.

Regulation of Drosophila mesoderm migration by phosphoinositides and the PH domain of the Rho GTP exchange factor Pebble.

Murray MJ, Ng MM, Fraval H, Tan J, Liu W, Smallhorn M, Brill JA, Field SJ, Saint R.

Dev Biol. 2012 Dec 1;372(1):17-27. doi: 10.1016/j.ydbio.2012.09.008. Epub 2012 Sep 19.

24.

Snail-dependent repression of the RhoGEF pebble is required for gastrulation consistency in Drosophila melanogaster.

Murray MJ, Southall TD, Liu W, Fraval H, Lorensuhewa N, Brand AH, Saint R.

Dev Genes Evol. 2012 Nov;222(6):361-8. doi: 10.1007/s00427-012-0414-8. Epub 2012 Sep 4.

25.

Electrochemical detection of the binding of Bacillus anthracis protective antigen (PA) to the membrane receptor on macrophages through release of nitric oxide.

Trouillon R, Williamson ED, Saint RJ, O'Hare D.

Biosens Bioelectron. 2012 Oct-Dec;38(1):138-44. doi: 10.1016/j.bios.2012.05.012. Epub 2012 May 24.

PMID:
22672762
26.

Imaging pluripotent cell migration in Drosophila.

Murray MJ, Saint R.

Methods Mol Biol. 2011;750:169-84. doi: 10.1007/978-1-61779-145-1_12.

PMID:
21618091
27.

The biology of coral metamorphosis: molecular responses of larvae to inducers of settlement and metamorphosis.

Grasso LC, Negri AP, Fôret S, Saint R, Hayward DC, Miller DJ, Ball EE.

Dev Biol. 2011 May 15;353(2):411-9. doi: 10.1016/j.ydbio.2011.02.010. Epub 2011 Feb 19.

28.

Expression of distinct RNAs from 3' untranslated regions.

Mercer TR, Wilhelm D, Dinger ME, Soldà G, Korbie DJ, Glazov EA, Truong V, Schwenke M, Simons C, Matthaei KI, Saint R, Koopman P, Mattick JS.

Nucleic Acids Res. 2011 Mar;39(6):2393-403. doi: 10.1093/nar/gkq1158. Epub 2010 Nov 12.

29.

Polo kinase interacts with RacGAP50C and is required to localize the cytokinesis initiation complex.

Ebrahimi S, Fraval H, Murray M, Saint R, Gregory SL.

J Biol Chem. 2010 Sep 10;285(37):28667-73. doi: 10.1074/jbc.M110.103887. Epub 2010 Jul 13.

30.

Cytokinesis proteins Tum and Pav have a nuclear role in Wnt regulation.

Jones WM, Chao AT, Zavortink M, Saint R, Bejsovec A.

J Cell Sci. 2010 Jul 1;123(Pt 13):2179-89. doi: 10.1242/jcs.067868. Epub 2010 Jun 1.

31.

The ROQUIN family of proteins localizes to stress granules via the ROQ domain and binds target mRNAs.

Athanasopoulos V, Barker A, Yu D, Tan AH, Srivastava M, Contreras N, Wang J, Lam KP, Brown SH, Goodnow CC, Dixon NE, Leedman PJ, Saint R, Vinuesa CG.

FEBS J. 2010 May;277(9):2109-27. doi: 10.1111/j.1742-4658.2010.07628.x.

32.

Signalling through the RhoGEF Pebble in Drosophila.

Gregory SL, Lorensuhewa N, Saint R.

IUBMB Life. 2010 Apr;62(4):290-5. doi: 10.1002/iub.310. Review.

33.

Expression of Caenorhabditis elegans RNA-directed RNA polymerase in transgenic Drosophila melanogaster does not affect morphological development.

Duan G, Saint RB, Helliwell CA, Behm CA, Waterhouse PM, Gordon KH.

Transgenic Res. 2010 Dec;19(6):1121-8. doi: 10.1007/s11248-010-9372-y. Epub 2010 Feb 6.

PMID:
20140643
34.

Chaperone-assisted selective autophagy is essential for muscle maintenance.

Arndt V, Dick N, Tawo R, Dreiseidler M, Wenzel D, Hesse M, Fürst DO, Saftig P, Saint R, Fleischmann BK, Hoch M, Höhfeld J.

Curr Biol. 2010 Jan 26;20(2):143-8. doi: 10.1016/j.cub.2009.11.022. Epub 2010 Jan 7.

35.

Transglutaminase inhibition ameliorates experimental diabetic nephropathy.

Huang L, Haylor JL, Hau Z, Jones RA, Vickers ME, Wagner B, Griffin M, Saint RE, Coutts IG, El Nahas AM, Johnson TS.

Kidney Int. 2009 Aug;76(4):383-94. doi: 10.1038/ki.2009.230. Epub 2009 Jun 24.

36.

Microarray analysis identifies candidate genes for key roles in coral development.

Grasso LC, Maindonald J, Rudd S, Hayward DC, Saint R, Miller DJ, Ball EE.

BMC Genomics. 2008 Nov 14;9:540. doi: 10.1186/1471-2164-9-540.

37.

Synthesis of potent water-soluble tissue transglutaminase inhibitors.

Griffin M, Mongeot A, Collighan R, Saint RE, Jones RA, Coutts IG, Rathbone DL.

Bioorg Med Chem Lett. 2008 Oct 15;18(20):5559-62. doi: 10.1016/j.bmcl.2008.09.006. Epub 2008 Sep 6.

PMID:
18812257
38.

A Drosophila overexpression screen for modifiers of Rho signalling in cytokinesis.

Gregory SL, Shandala T, O'Keefe L, Jones L, Murray MJ, Saint R.

Fly (Austin). 2007 Jan-Feb;1(1):13-22. Epub 2007 Jan 4.

PMID:
18690061
39.

Cell division requires a direct link between microtubule-bound RacGAP and Anillin in the contractile ring.

Gregory SL, Ebrahimi S, Milverton J, Jones WM, Bejsovec A, Saint R.

Curr Biol. 2008 Jan 8;18(1):25-9. Epub 2007 Dec 27.

40.

Transglutaminase inhibition reduces fibrosis and preserves function in experimental chronic kidney disease.

Johnson TS, Fisher M, Haylor JL, Hau Z, Skill NJ, Jones R, Saint R, Coutts I, Vickers ME, El Nahas AM, Griffin M.

J Am Soc Nephrol. 2007 Dec;18(12):3078-88. Epub 2007 Nov 14. No abstract available.

41.

Photoactivatable GFP resolves Drosophila mesoderm migration behaviour.

Murray MJ, Saint R.

Development. 2007 Nov;134(22):3975-83. Epub 2007 Oct 17.

42.

Know thy fly.

O'Keefe LV, Smibert P, Colella A, Chataway TK, Saint R, Richards RI.

Trends Genet. 2007 May;23(5):238-42. Epub 2007 Mar 28.

PMID:
17395332
43.

RNAi-induced phenotypes suggest a novel role for a chemosensory protein CSP5 in the development of embryonic integument in the honeybee (Apis mellifera).

Maleszka J, Forêt S, Saint R, Maleszka R.

Dev Genes Evol. 2007 Mar;217(3):189-96. Epub 2007 Jan 10.

PMID:
17216269
44.

Tum/RacGAP50C provides a critical link between anaphase microtubules and the assembly of the contractile ring in Drosophila melanogaster.

Zavortink M, Contreras N, Addy T, Bejsovec A, Saint R.

J Cell Sci. 2005 Nov 15;118(Pt 22):5381-92.

45.

Maintenance of ancestral complexity and non-metazoan genes in two basal cnidarians.

Technau U, Rudd S, Maxwell P, Gordon PM, Saina M, Grasso LC, Hayward DC, Sensen CW, Saint R, Holstein TW, Ball EE, Miller DJ.

Trends Genet. 2005 Dec;21(12):633-9. Epub 2005 Oct 13.

PMID:
16226338
46.

Drosophila starvin encodes a tissue-specific BAG-domain protein required for larval food uptake.

Coulson M, Robert S, Saint R.

Genetics. 2005 Dec;171(4):1799-812. Epub 2005 Sep 2.

47.

FRA16D common chromosomal fragile site oxido-reductase (FOR/WWOX) protects against the effects of ionizing radiation in Drosophila.

O'Keefe LV, Liu Y, Perkins A, Dayan S, Saint R, Richards RI.

Oncogene. 2005 Sep 29;24(43):6590-6. Erratum in: Oncogene. 2006 Dec 7;25(58):7662.

PMID:
16007179
48.

Citron kinase is an essential effector of the Pbl-activated Rho signalling pathway in Drosophila melanogaster.

Shandala T, Gregory SL, Dalton HE, Smallhorn M, Saint R.

Development. 2004 Oct;131(20):5053-63.

49.

A genetic screen for dominant modifiers of a cyclin E hypomorphic mutation identifies novel regulators of S-phase entry in Drosophila.

Brumby A, Secombe J, Horsfield J, Coombe M, Amin N, Coates D, Saint R, Richardson H.

Genetics. 2004 Sep;168(1):227-51.

50.

Inhibition of transglutaminase activity reduces extracellular matrix accumulation induced by high glucose levels in proximal tubular epithelial cells.

Skill NJ, Johnson TS, Coutts IG, Saint RE, Fisher M, Huang L, El Nahas AM, Collighan RJ, Griffin M.

J Biol Chem. 2004 Nov 12;279(46):47754-62. Epub 2004 Aug 23.

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