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Items: 1 to 50 of 272

1.

Lycii fructus extract ameliorates hydrogen peroxide-induced cytotoxicity through indirect antioxidant action.

Xu W, Saiki S, Myojin T, Liu Y, Zhu B, Murata Y, Ashida H, Tsunenaga M, Nakamura Y.

Biosci Biotechnol Biochem. 2018 Jun 18:1-9. doi: 10.1080/09168451.2018.1487274. [Epub ahead of print]

PMID:
29912670
2.

Soluble epoxide hydrolase plays a key role in the pathogenesis of Parkinson's disease.

Ren Q, Ma M, Yang J, Nonaka R, Yamaguchi A, Ishikawa KI, Kobayashi K, Murayama S, Hwang SH, Saiki S, Akamatsu W, Hattori N, Hammock BD, Hashimoto K.

Proc Natl Acad Sci U S A. 2018 Jun 19;115(25):E5815-E5823. doi: 10.1073/pnas.1802179115. Epub 2018 May 7.

PMID:
29735655
3.

Loss of autophagy in dopaminergic neurons causes Lewy pathology and motor dysfunction in aged mice.

Sato S, Uchihara T, Fukuda T, Noda S, Kondo H, Saiki S, Komatsu M, Uchiyama Y, Tanaka K, Hattori N.

Sci Rep. 2018 Feb 12;8(1):2813. doi: 10.1038/s41598-018-21325-w.

4.

Serum caffeine and metabolites are reliable biomarkers of early Parkinson disease.

Fujimaki M, Saiki S, Li Y, Kaga N, Taka H, Hatano T, Ishikawa KI, Oji Y, Mori A, Okuzumi A, Koinuma T, Ueno SI, Imamichi Y, Ueno T, Miura Y, Funayama M, Hattori N.

Neurology. 2018 Jan 30;90(5):e404-e411. doi: 10.1212/WNL.0000000000004888. Epub 2018 Jan 3.

5.

Connectome analysis with diffusion MRI in idiopathic Parkinson's disease: Evaluation using multi-shell, multi-tissue, constrained spherical deconvolution.

Kamagata K, Zalesky A, Hatano T, Di Biase MA, El Samad O, Saiki S, Shimoji K, Kumamaru KK, Kamiya K, Hori M, Hattori N, Aoki S, Pantelis C.

Neuroimage Clin. 2017 Nov 10;17:518-529. doi: 10.1016/j.nicl.2017.11.007. eCollection 2018.

6.

Decreased long-chain acylcarnitines from insufficient β-oxidation as potential early diagnostic markers for Parkinson's disease.

Saiki S, Hatano T, Fujimaki M, Ishikawa KI, Mori A, Oji Y, Okuzumi A, Fukuhara T, Koinuma T, Imamichi Y, Nagumo M, Furuya N, Nojiri S, Amo T, Yamashiro K, Hattori N.

Sci Rep. 2017 Aug 4;7(1):7328. doi: 10.1038/s41598-017-06767-y.

7.

Cardiovascular Responses Associated with the Moving Beans Task: Influence of Psychological Characteristics.

Iokawa K, Munakata M, Hattori T, Saiki S, Sone T, Kohzuki M.

J Stroke Cerebrovasc Dis. 2017 Sep;26(9):2013-2018. doi: 10.1016/j.jstrokecerebrovasdis.2017.06.008. Epub 2017 Jun 27.

PMID:
28666804
8.

CSAHi study-2: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes: Assessment of reference compounds and comparison with non-clinical studies and clinical information.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Tanaka K, Takahashi E, Miyamoto K, Morimura K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Shinozawa T, Saito F, Kunimatsu T.

Regul Toxicol Pharmacol. 2017 Aug;88:238-251. doi: 10.1016/j.yrtph.2017.06.006. Epub 2017 Jun 17.

PMID:
28634147
9.

Physiological mechanisms of drought-induced tree die-off in relation to carbon, hydraulic and respiratory stress in a drought-tolerant woody plant.

Saiki ST, Ishida A, Yoshimura K, Yazaki K.

Sci Rep. 2017 Jun 7;7(1):2995. doi: 10.1038/s41598-017-03162-5.

10.

3,4-Dihydroxyphenylacetic acid is a predominant biologically-active catabolite of quercetin glycosides.

Tang Y, Nakashima S, Saiki S, Myoi Y, Abe N, Kuwazuru S, Zhu B, Ashida H, Murata Y, Nakamura Y.

Food Res Int. 2016 Nov;89(Pt 1):716-723. doi: 10.1016/j.foodres.2016.09.034. Epub 2016 Sep 30.

PMID:
28460970
11.

Immunocytochemical Monitoring of PINK1/Parkin-Mediated Mitophagy in Cultured Cells.

Fujimaki M, Saiki S, Sasazawa Y, Ishikawa KI, Imamichi Y, Sumiyoshi K, Hattori N.

Methods Mol Biol. 2017 Mar 31. doi: 10.1007/7651_2017_20. [Epub ahead of print]

PMID:
28361483
12.

A novel tag-free probe for targeting molecules interacting with a flavonoid catabolite.

Nakashima S, Liu Z, Yamaguchi Y, Saiki S, Munemasa S, Nakamura T, Murata Y, Nakamura Y.

Biochem Biophys Rep. 2016 Jun 30;7:240-245. doi: 10.1016/j.bbrep.2016.06.020. eCollection 2016 Sep.

13.

The dynamics of carbon stored in xylem sapwood to drought-induced hydraulic stress in mature trees.

Yoshimura K, Saiki ST, Yazaki K, Ogasa MY, Shirai M, Nakano T, Yoshimura J, Ishida A.

Sci Rep. 2016 Apr 15;6:24513. doi: 10.1038/srep24513.

14.

CSAHi study: Validation of multi-electrode array systems (MEA60/2100) for prediction of drug-induced proarrhythmia using human iPS cell-derived cardiomyocytes -assessment of inter-facility and cells lot-to-lot-variability.

Nozaki Y, Honda Y, Watanabe H, Saiki S, Koyabu K, Itoh T, Nagasawa C, Nakamori C, Nakayama C, Iwasaki H, Suzuki S, Washio I, Takahashi E, Miyamoto K, Yamanishi A, Endo H, Shinozaki J, Nogawa H, Kunimatsu T.

Regul Toxicol Pharmacol. 2016 Jun;77:75-86. doi: 10.1016/j.yrtph.2016.02.007. Epub 2016 Feb 13.

PMID:
26884090
15.

Ethambutol neutralizes lysosomes and causes lysosomal zinc accumulation.

Yamada D, Saiki S, Furuya N, Ishikawa K, Imamichi Y, Kambe T, Fujimura T, Ueno T, Koike M, Sumiyoshi K, Hattori N.

Biochem Biophys Res Commun. 2016 Feb 26;471(1):109-16. doi: 10.1016/j.bbrc.2016.01.171. Epub 2016 Feb 4.

16.

Improving Walking, Muscle Strength, and Balance in the Elderly with an Exergame Using Kinect: A Randomized Controlled Trial.

Sato K, Kuroki K, Saiki S, Nagatomi R.

Games Health J. 2015 Jun;4(3):161-7. doi: 10.1089/g4h.2014.0057. Epub 2015 Jan 28.

PMID:
26182059
17.

VPS29-VPS35 intermediate of retromer is stable and may be involved in the retromer complex assembly process.

Fuse A, Furuya N, Kakuta S, Inose A, Sato M, Koike M, Saiki S, Hattori N.

FEBS Lett. 2015 Jun 4;589(13):1430-6. doi: 10.1016/j.febslet.2015.04.040. Epub 2015 May 1.

18.

Identification of novel biomarkers for Parkinson's disease by metabolomic technologies.

Hatano T, Saiki S, Okuzumi A, Mohney RP, Hattori N.

J Neurol Neurosurg Psychiatry. 2016 Mar;87(3):295-301. doi: 10.1136/jnnp-2014-309676. Epub 2015 Mar 20.

PMID:
25795009
19.

High frequency of beta-propeller protein-associated neurodegeneration (BPAN) among patients with intellectual disability and young-onset parkinsonism.

Nishioka K, Oyama G, Yoshino H, Li Y, Matsushima T, Takeuchi C, Mochizuki Y, Mori-Yoshimura M, Murata M, Yamasita C, Nakamura N, Konishi Y, Ohi K, Ichikawa K, Terada T, Obi T, Funayama M, Saiki S, Hattori N.

Neurobiol Aging. 2015 May;36(5):2004.e9-2004.e15. doi: 10.1016/j.neurobiolaging.2015.01.020. Epub 2015 Jan 30.

PMID:
25744623
20.

[The association of Parkinson's disease pathogenesis with inflammation].

Saiki S.

Rinsho Shinkeigaku. 2014;54(12):1125-7. doi: 10.5692/clinicalneurol.54.1125. Review. Japanese.

PMID:
25672726
21.

CHCHD2 mutations in autosomal dominant late-onset Parkinson's disease: a genome-wide linkage and sequencing study.

Funayama M, Ohe K, Amo T, Furuya N, Yamaguchi J, Saiki S, Li Y, Ogaki K, Ando M, Yoshino H, Tomiyama H, Nishioka K, Hasegawa K, Saiki H, Satake W, Mogushi K, Sasaki R, Kokubo Y, Kuzuhara S, Toda T, Mizuno Y, Uchiyama Y, Ohno K, Hattori N.

Lancet Neurol. 2015 Mar;14(3):274-82. doi: 10.1016/S1474-4422(14)70266-2. Epub 2015 Feb 4.

PMID:
25662902
22.

Detailed analysis of mitochondrial respiratory chain defects caused by loss of PINK1.

Amo T, Saiki S, Sawayama T, Sato S, Hattori N.

Neurosci Lett. 2014 Sep 19;580:37-40. doi: 10.1016/j.neulet.2014.07.045. Epub 2014 Aug 1.

PMID:
25092611
23.

Identification of licopyranocoumarin and glycyrurol from herbal medicines as neuroprotective compounds for Parkinson's disease.

Fujimaki T, Saiki S, Tashiro E, Yamada D, Kitagawa M, Hattori N, Imoto M.

PLoS One. 2014 Jun 24;9(6):e100395. doi: 10.1371/journal.pone.0100395. eCollection 2014.

24.

Regulation by mitophagy.

Hattori N, Saiki S, Imai Y.

Int J Biochem Cell Biol. 2014 Aug;53:147-50. doi: 10.1016/j.biocel.2014.05.012. Epub 2014 May 16. Review.

PMID:
24842103
25.

P150glued-associated disorders are caused by activation of intrinsic apoptotic pathway.

Ishikawa K, Saiki S, Furuya N, Yamada D, Imamichi Y, Li Y, Kawajiri S, Sasaki H, Koike M, Tsuboi Y, Hattori N.

PLoS One. 2014 Apr 10;9(4):e94645. doi: 10.1371/journal.pone.0094645. eCollection 2014.

26.

Ascorbic acid synergistically potentiates phloxine b-induced photocytotoxicity in human acute promyelocytic leukemia cells.

Qi H, Wu Q, Abe N, Saiki S, Zhu B, Murata Y, Nakamura Y.

J Biochem Mol Toxicol. 2014 Apr;28(4):167-73. doi: 10.1002/jbt.21549. Epub 2014 Jan 31.

PMID:
24488945
27.

A novel avenue to gold nanostructured microtubes using functionalized fiber as the ligand, the reductant, and the template.

Ma H, Chi H, Wu J, Wang M, Li J, Hoshina H, Saiki S, Seko N.

ACS Appl Mater Interfaces. 2013 Sep 11;5(17):8761-5. doi: 10.1021/am402574b. Epub 2013 Aug 23.

PMID:
23931764
28.

[Recrudescent prostate cancer with a low serum PSA level and a high serum CEA level treated with docetaxel : a case report].

Fujita M, Goto T, Uchida K, Saiki S, Arima R.

Hinyokika Kiyo. 2013 Mar;59(3):183-8. Japanese.

29.

Single-molecule imaging of gold-binding peptide adsorbed on Au(111).

Kanata S, Nishino T, Makiura R, Saiki S, Hayashi N.

Anal Sci. 2013;29(4):405-9.

30.

Voltage-dependent N-type Ca2+ channels in endothelial cells contribute to oxidative stress-related endothelial dysfunction induced by angiotensin II in mice.

Nishida M, Ishikawa T, Saiki S, Sunggip C, Aritomi S, Harada E, Kuwahara K, Hirano K, Mori Y, Kim-Mitsuyama S.

Biochem Biophys Res Commun. 2013 May 3;434(2):210-6. doi: 10.1016/j.bbrc.2013.03.040. Epub 2013 Mar 26.

31.

ATP13A2 deficiency induces a decrease in cathepsin D activity, fingerprint-like inclusion body formation, and selective degeneration of dopaminergic neurons.

Matsui H, Sato F, Sato S, Koike M, Taruno Y, Saiki S, Funayama M, Ito H, Taniguchi Y, Uemura N, Toyoda A, Sakaki Y, Takeda S, Uchiyama Y, Hattori N, Takahashi R.

FEBS Lett. 2013 May 2;587(9):1316-25. doi: 10.1016/j.febslet.2013.02.046. Epub 2013 Mar 13.

32.
33.

Challenges, solutions, and best practices in telemental health service delivery across the pacific rim-a summary.

Doarn CR, Shore J, Ferguson S, Jordan PJ, Saiki S, Poropatich RK.

Telemed J E Health. 2012 Oct;18(8):654-60. doi: 10.1089/tmj.2012.0123.

PMID:
23061646
34.

Blood-brain barrier disruption is more severe in neuromyelitis optica than in multiple sclerosis and correlates with clinical disability.

Tomizawa Y, Yokoyama K, Saiki S, Takahashi T, Matsuoka J, Hattori N.

J Int Med Res. 2012;40(4):1483-91.

PMID:
22971500
35.

Mutations in the gene PRRT2 cause paroxysmal kinesigenic dyskinesia with infantile convulsions.

Lee HY, Huang Y, Bruneau N, Roll P, Roberson ED, Hermann M, Quinn E, Maas J, Edwards R, Ashizawa T, Baykan B, Bhatia K, Bressman S, Bruno MK, Brunt ER, Caraballo R, Echenne B, Fejerman N, Frucht S, Gurnett CA, Hirsch E, Houlden H, Jankovic J, Lee WL, Lynch DR, Mohammed S, Müller U, Nespeca MP, Renner D, Rochette J, Rudolf G, Saiki S, Soong BW, Swoboda KJ, Tucker S, Wood N, Hanna M, Bowcock AM, Szepetowski P, Fu YH, Ptáček LJ.

Cell Rep. 2012 Jan 26;1(1):2-12. doi: 10.1016/j.celrep.2011.11.001. Epub 2011 Dec 15.

36.

Mutation in the CHAC gene in a family of autosomal dominant chorea-acanthocytosis.

Walker RH, Velayos-Baeza A, Bader B, Danek A, Saiki S.

Neurology. 2012 Jul 10;79(2):198-9; author reply 199. doi: 10.1212/01.wnl.0000416389.94466.01. No abstract available.

PMID:
22778235
37.

[The pathomechanisms of young-onset Parkinson's disease (PD), approach to the causes of PD form the mechanisms of insulin secretion system].

Hattori N, Eguchi H, Imaizumi M, Saiki S, Sato S, Nagamatsu S.

Rinsho Shinkeigaku. 2011 Nov;51(11):986-7. Japanese. No abstract available.

PMID:
22277450
38.

Molecular pathogenesis of Parkinson's disease: update.

Saiki S, Sato S, Hattori N.

J Neurol Neurosurg Psychiatry. 2012 Apr;83(4):430-6. doi: 10.1136/jnnp-2011-301205. Epub 2011 Dec 3. Review.

PMID:
22138181
39.

Spin-trapping reactions of a novel gauchetype radical trapper G-CYPMPO.

Oka T, Yamashita S, Midorikawa M, Saiki S, Muroya Y, Kamibayashi M, Yamashita M, Anzai K, Katsumura Y.

Anal Chem. 2011 Dec 15;83(24):9600-4. doi: 10.1021/ac2023926. Epub 2011 Nov 14.

PMID:
22007796
40.

Cilostazol suppresses angiotensin II-induced vasoconstriction via protein kinase A-mediated phosphorylation of the transient receptor potential canonical 6 channel.

Nishioka K, Nishida M, Ariyoshi M, Jian Z, Saiki S, Hirano M, Nakaya M, Sato Y, Kita S, Iwamoto T, Hirano K, Inoue R, Kurose H.

Arterioscler Thromb Vasc Biol. 2011 Oct;31(10):2278-86. doi: 10.1161/ATVBAHA.110.221010. Epub 2011 Jul 28.

41.

Genetic mutations and functions of PINK1.

Kawajiri S, Saiki S, Sato S, Hattori N.

Trends Pharmacol Sci. 2011 Oct;32(10):573-80. doi: 10.1016/j.tips.2011.06.001. Epub 2011 Jul 23. Review.

PMID:
21784538
42.

DJ-1 associates with synaptic membranes.

Usami Y, Hatano T, Imai S, Kubo S, Sato S, Saiki S, Fujioka Y, Ohba Y, Sato F, Funayama M, Eguchi H, Shiba K, Ariga H, Shen J, Hattori N.

Neurobiol Dis. 2011 Sep;43(3):651-62. doi: 10.1016/j.nbd.2011.05.014. Epub 2011 May 30.

PMID:
21645620
43.

Novel pathogenic mutations and copy number variations in the VPS13A gene in patients with chorea-acanthocytosis.

Tomiyasu A, Nakamura M, Ichiba M, Ueno S, Saiki S, Morimoto M, Kobal J, Kageyama Y, Inui T, Wakabayashi K, Yamada T, Kanemori Y, Jung HH, Tanaka H, Orimo S, Afawi Z, Blatt I, Aasly J, Ujike H, Babovic-Vuksanovic D, Josephs KA, Tohge R, Rodrigues GR, Dupré N, Yamada H, Yokochi F, Kotschet K, Takei T, Rudzińska M, Szczudlik A, Penco S, Fujiwara M, Tojo K, Sano A.

Am J Med Genet B Neuropsychiatr Genet. 2011 Jul;156B(5):620-31. doi: 10.1002/ajmg.b.31206. Epub 2011 May 19.

PMID:
21598378
44.

Heterologous down-regulation of angiotensin type 1 receptors by purinergic P2Y2 receptor stimulation through S-nitrosylation of NF-kappaB.

Nishida M, Ogushi M, Suda R, Toyotaka M, Saiki S, Kitajima N, Nakaya M, Kim KM, Ide T, Sato Y, Inoue K, Kurose H.

Proc Natl Acad Sci U S A. 2011 Apr 19;108(16):6662-7. doi: 10.1073/pnas.1017640108. Epub 2011 Apr 4.

45.

Lysosomal positioning coordinates cellular nutrient responses.

Korolchuk VI, Saiki S, Lichtenberg M, Siddiqi FH, Roberts EA, Imarisio S, Jahreiss L, Sarkar S, Futter M, Menzies FM, O'Kane CJ, Deretic V, Rubinsztein DC.

Nat Cell Biol. 2011 Apr;13(4):453-60. doi: 10.1038/ncb2204. Epub 2011 Mar 13.

46.

Caffeine induces apoptosis by enhancement of autophagy via PI3K/Akt/mTOR/p70S6K inhibition.

Saiki S, Sasazawa Y, Imamichi Y, Kawajiri S, Fujimaki T, Tanida I, Kobayashi H, Sato F, Sato S, Ishikawa K, Imoto M, Hattori N.

Autophagy. 2011 Feb;7(2):176-87. Epub 2011 Feb 1.

47.

Regulation of Angiotensin II receptor signaling by cysteine modification of NF-κB.

Nishida M, Kitajima N, Saiki S, Nakaya M, Kurose H.

Nitric Oxide. 2011 Aug 1;25(2):112-7. doi: 10.1016/j.niox.2010.10.003. Epub 2010 Nov 13. Review.

PMID:
21078404
48.

[Regulation of cardiovascular functions by the phosphorylation of TRPC channels].

Nishida M, Saiki S, Kitajima N, Nakaya M, Sato Y, Kurose H.

Yakugaku Zasshi. 2010 Nov;130(11):1427-33. Review. Japanese.

49.

Mitochondrial membrane potential decrease caused by loss of PINK1 is not due to proton leak, but to respiratory chain defects.

Amo T, Sato S, Saiki S, Wolf AM, Toyomizu M, Gautier CA, Shen J, Ohta S, Hattori N.

Neurobiol Dis. 2011 Jan;41(1):111-8. doi: 10.1016/j.nbd.2010.08.027. Epub 2010 Sep 15.

PMID:
20817094
50.

Zonisamide reduces cell death in SH-SY5Y cells via an anti-apoptotic effect and by upregulating MnSOD.

Kawajiri S, Machida Y, Saiki S, Sato S, Hattori N.

Neurosci Lett. 2010 Sep 6;481(2):88-91. doi: 10.1016/j.neulet.2010.06.058. Epub 2010 Jun 25.

PMID:
20600601

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