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Items: 1 to 50 of 423

1.

18PCholine transporter-like protein 1 (CTL1/SLC44A1) is a therapeutic target molecule for prostate cancer therapy.

Inazu M, Saiki I, Uchino H, Yamanaka T.

Ann Oncol. 2019 Feb 1;30(Supplement_1). pii: mdz029.011. doi: 10.1093/annonc/mdz029.011. No abstract available.

PMID:
30810170
2.

Analgesic effects of systemic fentanyl on cancer pain are mediated by not only central but also peripheral opioid receptors in mice.

Shinohara A, Andoh T, Saiki I, Kuraishi Y.

Eur J Pharmacol. 2018 Aug 15;833:275-282. doi: 10.1016/j.ejphar.2018.06.008. Epub 2018 Jun 7.

PMID:
29886241
3.

COP9 signalosome subunit 5 regulates cancer metastasis by deubiquitinating SNAIL.

Watanabe K, Yokoyama S, Kaneto N, Hori T, Iwakami Y, Kato S, Hayakawa Y, Sakurai H, Fukuoka J, Saiki I.

Oncotarget. 2018 Apr 17;9(29):20670-20680. doi: 10.18632/oncotarget.25060. eCollection 2018 Apr 17.

4.

Retrospective screening of microarray data to identify candidate IFN-inducible genes in a HTLV-1 transformed model.

Refaat A, Owis M, Abdelhamed S, Saiki I, Sakurai H.

Oncol Lett. 2018 Apr;15(4):4753-4758. doi: 10.3892/ol.2018.8014. Epub 2018 Feb 9.

5.

NK Cells Control Tumor-Promoting Function of Neutrophils in Mice.

Ogura K, Sato-Matsushita M, Yamamoto S, Hori T, Sasahara M, Iwakura Y, Saiki I, Tahara H, Hayakawa Y.

Cancer Immunol Res. 2018 Jan 23. doi: 10.1158/2326-6066.CIR-17-0204. [Epub ahead of print]

PMID:
29362222
6.

Coptidis Rhizoma induces intrinsic apoptosis through BAX and BAK activation in human melanoma.

Xu X, Yokoyama S, Hayakawa Y, Saiki I.

Oncol Rep. 2017 Jul;38(1):538-544. doi: 10.3892/or.2017.5672. Epub 2017 May 26.

PMID:
28560413
7.

Ethanolic extract of Thevetia peruviana flowers enhances TNF-α and TRAIL-induced apoptosis of human cervical cancer cells via intrinsic and extrinsic pathways.

Managit C, Sakurai H, Saiki I.

Oncol Lett. 2017 Apr;13(4):2791-2798. doi: 10.3892/ol.2017.5748. Epub 2017 Feb 17.

8.

Highly oxygenated antiausterity agents from the leaves of Uvaria dac.

Awale S, Tawila AM, Dibwe DF, Ueda JY, Sun S, Athikomkulchai S, Balachandran C, Saiki I, Matsumoto K, Esumi H.

Bioorg Med Chem Lett. 2017 May 1;27(9):1967-1971. doi: 10.1016/j.bmcl.2017.03.021. Epub 2017 Mar 11.

PMID:
28342587
9.

Chemosensitizing Effect of Saikosaponin B on B16F10 Melanoma Cells.

Ma H, Yokoyama S, Saiki I, Hayakawa Y.

Nutr Cancer. 2017 Apr;69(3):505-511. doi: 10.1080/01635581.2017.1285407. Epub 2017 Feb 17.

PMID:
28287317
10.

Nonthmicin, a Polyether Polyketide Bearing a Halogen-Modified Tetronate with Neuroprotective and Antiinvasive Activity from Actinomadura sp.

Igarashi Y, Matsuoka N, In Y, Kataura T, Tashiro E, Saiki I, Sudoh Y, Duangmal K, Thamchaipenet A.

Org Lett. 2017 Mar 17;19(6):1406-1409. doi: 10.1021/acs.orglett.7b00318. Epub 2017 Mar 3.

PMID:
28256141
11.

P38 pathway as a key downstream signal of connective tissue growth factor to regulate metastatic potential in non-small-cell lung cancer.

Kato S, Yokoyama S, Hayakawa Y, Li L, Iwakami Y, Sakurai H, Saiki I.

Cancer Sci. 2016 Oct;107(10):1416-1421. doi: 10.1111/cas.13009. Epub 2016 Sep 1.

12.

AKT-STAT3 Pathway as a Downstream Target of EGFR Signaling to Regulate PD-L1 Expression on NSCLC cells.

Abdelhamed S, Ogura K, Yokoyama S, Saiki I, Hayakawa Y.

J Cancer. 2016 Jul 18;7(12):1579-1586. eCollection 2016.

13.

IL-17A-producing CD30(+) Vδ1 T cells drive inflammation-induced cancer progression.

Kimura Y, Nagai N, Tsunekawa N, Sato-Matsushita M, Yoshimoto T, Cua DJ, Iwakura Y, Yagita H, Okada F, Tahara H, Saiki I, Irimura T, Hayakawa Y.

Cancer Sci. 2016 Sep;107(9):1206-14. doi: 10.1111/cas.13005. Epub 2016 Sep 1.

14.

Efficient Use of a Crude Drug/Herb Library Reveals Ephedra Herb As a Specific Antagonist for TH2-Specific Chemokine Receptors CCR3, CCR4, and CCR8.

Matsuo K, Koizumi K, Fujita M, Morikawa T, Jo M, Shibahara N, Saiki I, Yoshie O, Nakayama T.

Front Cell Dev Biol. 2016 Jun 7;4:54. doi: 10.3389/fcell.2016.00054. eCollection 2016.

15.

Targeting the ataxia telangiectasia mutated pathway for effective therapy against hirsutine-resistant breast cancer cells.

Lou C, Yokoyama S, Abdelhamed S, Saiki I, Hayakawa Y.

Oncol Lett. 2016 Jul;12(1):295-300. Epub 2016 May 11.

16.
17.

Immune adjuvant effect of Juzentaihoto, a Japanese traditional herbal medicine, on tumor vaccine therapy in a mouse model.

Takeno N, Inujima A, Shinohara K, Yamada M, Shibahara N, Sakurai H, Saiki I, Koizumi K.

Int J Oncol. 2015 Dec;47(6):2115-22. doi: 10.3892/ijo.2015.3208. Epub 2015 Oct 15.

PMID:
26496932
18.

Crucial roles of RSK in cell motility by catalysing serine phosphorylation of EphA2.

Zhou Y, Yamada N, Tanaka T, Hori T, Yokoyama S, Hayakawa Y, Yano S, Fukuoka J, Koizumi K, Saiki I, Sakurai H.

Nat Commun. 2015 Jul 9;6:7679. doi: 10.1038/ncomms8679.

19.

Multi-pathway cellular analysis on crude natural drugs/herbs from Japanese Kampo formulations.

Eshima S, Yokoyama S, Abe T, Hayakawa Y, Saiki I.

PLoS One. 2015 Jun 2;10(6):e0128872. doi: 10.1371/journal.pone.0128872. eCollection 2015.

20.

Role of chemokine CX3CL1 in progression of multiple myeloma via CX3CR1 in bone microenvironments.

Wada A, Ito A, Iitsuka H, Tsuneyama K, Miyazono T, Murakami J, Shibahara N, Sakurai H, Saiki I, Nakayama T, Yoshie O, Koizumi K, Sugiyama T.

Oncol Rep. 2015 Jun;33(6):2935-9. doi: 10.3892/or.2015.3941. Epub 2015 Apr 28.

PMID:
25962684
21.

Mammary tissue microenvironment determines T cell-dependent breast cancer-associated inflammation.

Takahashi K, Nagai N, Ogura K, Tsuneyama K, Saiki I, Irimura T, Hayakawa Y.

Cancer Sci. 2015 Jul;106(7):867-74. doi: 10.1111/cas.12685. Epub 2015 May 29.

22.

Effect of keishibukuryogan on genetic and dietary obesity models.

Gao F, Yokoyama S, Fujimoto M, Tsuneyama K, Saiki I, Shimada Y, Hayakawa Y.

Evid Based Complement Alternat Med. 2015;2015:801291. doi: 10.1155/2015/801291. Epub 2015 Feb 22.

23.

Anti-inflammatory effect of cinnamaldehyde in Helicobacter pylori induced gastric inflammation.

Muhammad JS, Zaidi SF, Shaharyar S, Refaat A, Usmanghani K, Saiki I, Sugiyama T.

Biol Pharm Bull. 2015;38(1):109-15. doi: 10.1248/bpb.b14-00609.

24.

[Pathophysiology and mechanisms of postoperative cognitive dysfunction].

Uchino H, Nagashima F, Nishiyama R, Ishida Y, Saiki I, Yara M, Hara N.

Masui. 2014 Nov;63(11):1202-10. Japanese.

PMID:
25731051
25.

Helicobacter pylori Induces Serine Phosphorylation of EGFR via Novel TAK1-p38 Activation Pathway in an HB-EGF-Independent Manner.

Zaidi SF, Refaat A, Zhou Y, Sualeh Muhammad J, Shin MS, Saiki I, Sakurai H, Sugiyama T.

Helicobacter. 2015 Oct;20(5):381-9. doi: 10.1111/hel.12215. Epub 2015 Feb 23.

PMID:
25704183
26.

Role of tyrosine kinase-independent phosphorylation of EGFR with activating mutation in cisplatin-treated lung cancer cells.

Refaat A, Aminullah, Zhou Y, Kawanishi M, Tomaru R, Abdelhamed S, Shin MS, Koizumi K, Yokoyama S, Saiki I, Sakurai H.

Biochem Biophys Res Commun. 2015 Mar 20;458(4):856-61. doi: 10.1016/j.bbrc.2015.02.044. Epub 2015 Feb 18.

PMID:
25701783
27.

[Perioperative management of off-pump CABG for a 93-year-old man].

Yara M, Tomino M, Miyata K, Ishida Y, Saiki I, Seta N, Hara N, Uchino H.

Masui. 2014 Oct;63(10):1146-8. Japanese.

PMID:
25693348
28.

Selective anticancer activity of hirsutine against HER2‑positive breast cancer cells by inducing DNA damage.

Lou C, Yokoyama S, Saiki I, Hayakawa Y.

Oncol Rep. 2015 Apr;33(4):2072-6. doi: 10.3892/or.2015.3796. Epub 2015 Feb 12.

PMID:
25672479
29.

Critical contribution of MCL-1 in EMT-associated chemo-resistance in A549 non-small cell lung cancer.

Toge M, Yokoyama S, Kato S, Sakurai H, Senda K, Doki Y, Hayakawa Y, Yoshimura N, Saiki I.

Int J Oncol. 2015 Apr;46(4):1844-8. doi: 10.3892/ijo.2015.2861. Epub 2015 Jan 30.

PMID:
25647738
30.

TXA9, a cardiac glycoside from Streptocaulon juventas, exerts a potent anti-tumor activity against human non-small cell lung cancer cells in vitro and in vivo.

Xue R, Han N, Xia M, Ye C, Hao Z, Wang L, Wang Y, Yang J, Saiki I, Yin J.

Steroids. 2015 Feb;94:51-9. doi: 10.1016/j.steroids.2014.12.015. Epub 2014 Dec 30.

PMID:
25555472
31.

Inhibitory effect of Moutan Cortex aqueous fraction on mast cell-mediated allergic inflammation.

Kee JY, Inujima A, Andoh T, Tanaka K, Li F, Kuraishi Y, Sakurai H, Shibahara N, Saiki I, Koizumi K.

J Nat Med. 2015 Apr;69(2):209-17. doi: 10.1007/s11418-014-0880-6. Epub 2014 Dec 17.

PMID:
25516374
32.

CXCL16 suppresses liver metastasis of colorectal cancer by promoting TNF-α-induced apoptosis by tumor-associated macrophages.

Kee JY, Ito A, Hojo S, Hashimoto I, Igarashi Y, Tsuneyama K, Tsukada K, Irimura T, Shibahara N, Takasaki I, Inujima A, Nakayama T, Yoshie O, Sakurai H, Saiki I, Koizumi K.

BMC Cancer. 2014 Dec 15;14:949. doi: 10.1186/1471-2407-14-949.

33.

Identification of Hirsutine as an anti-metastatic phytochemical by targeting NF-κB activation.

Lou C, Takahashi K, Irimura T, Saiki I, Hayakawa Y.

Int J Oncol. 2014 Nov;45(5):2085-91. doi: 10.3892/ijo.2014.2624. Epub 2014 Aug 27.

PMID:
25175557
34.

Survivin suppression through STAT3/β-catenin is essential for resveratrol-induced melanoma apoptosis.

Habibie, Yokoyama S, Abdelhamed S, Awale S, Sakurai H, Hayakawa Y, Saiki I.

Int J Oncol. 2014 Aug;45(2):895-901.

PMID:
24946930
35.

RAC1 inhibition as a therapeutic target for gefitinib-resistant non-small-cell lung cancer.

Kaneto N, Yokoyama S, Hayakawa Y, Kato S, Sakurai H, Saiki I.

Cancer Sci. 2014 Jul;105(7):788-94. doi: 10.1111/cas.12425. Epub 2014 May 15.

36.

Piperine enhances the efficacy of TRAIL-based therapy for triple-negative breast cancer cells.

Abdelhamed S, Yokoyama S, Refaat A, Ogura K, Yagita H, Awale S, Saiki I.

Anticancer Res. 2014 Apr;34(4):1893-9.

PMID:
24692724
37.

Campechic acids A and B: anti-invasive polyether polyketides from a soil-derived Streptomyces.

Yu L, Trujillo ME, Miyanaga S, Saiki I, Igarashi Y.

J Nat Prod. 2014 Apr 25;77(4):976-82. doi: 10.1021/np401071x. Epub 2014 Mar 4.

PMID:
24592993
38.

Functional analysis of [methyl-(3)H]choline uptake in glioblastoma cells: Influence of anti-cancer and central nervous system drugs.

Taguchi C, Inazu M, Saiki I, Yara M, Hara N, Yamanaka T, Uchino H.

Biochem Pharmacol. 2014 Apr 1;88(3):303-12. doi: 10.1016/j.bcp.2014.01.033. Epub 2014 Feb 12.

PMID:
24530235
39.

Dipasperoside A, a novel pyridine alkaloid-coupled iridoid glucoside from the roots of Dipsacus asper.

Li F, Tanaka K, Watanabe S, Tezuka Y, Saiki I.

Chem Pharm Bull (Tokyo). 2013;61(12):1318-22.

PMID:
24436964
40.

Bioimaging of fluorescence-labeled mitochondria in subcutaneously grafted murine melanoma cells by the "in vivo cryotechnique".

Lei T, Huang Z, Ohno N, Wu B, Sakoh T, Saitoh Y, Saiki I, Ohno S.

J Histochem Cytochem. 2014 Apr;62(4):251-64. doi: 10.1369/0022155413520313. Epub 2014 Jan 6.

41.

(+)-Grandifloracin, an antiausterity agent, induces autophagic PANC-1 pancreatic cancer cell death.

Ueda JY, Athikomkulchai S, Miyatake R, Saiki I, Esumi H, Awale S.

Drug Des Devel Ther. 2013 Dec 18;8:39-47. doi: 10.2147/DDDT.S52168. eCollection 2014.

42.

The long-term effects of a kampo medicine, juzentaihoto, on maintenance of antibody titer in elderly people after influenza vaccination.

Saiki I, Koizumi K, Goto H, Inujima A, Namiki T, Raimura M, Kogure T, Tatsumi T, Inoue H, Sakai S, Oka H, Fujimoto M, Hikiami H, Sakurai H, Shibahara N, Shimada Y, Origasa H.

Evid Based Complement Alternat Med. 2013;2013:568074. doi: 10.1155/2013/568074. Epub 2013 Nov 18.

43.

Mesenchymal-transitioned cancer cells instigate the invasion of epithelial cancer cells through secretion of WNT3 and WNT5B.

Kato S, Hayakawa Y, Sakurai H, Saiki I, Yokoyama S.

Cancer Sci. 2014 Mar;105(3):281-9. doi: 10.1111/cas.12336. Epub 2014 Jan 29.

44.

Imaging of thrombosis and microcirculation in mouse lungs of initial melanoma metastasis with in vivo cryotechnique.

Saitoh Y, Terada N, Ohno N, Hamano A, Okumura N, Jin T, Saiki I, Ohno S.

Microvasc Res. 2014 Jan;91:73-83. doi: 10.1016/j.mvr.2013.11.004. Epub 2013 Dec 5.

PMID:
24316421
45.

p38-Mediated phosphorylation of Eps15 endocytic adaptor protein.

Zhou Y, Tanaka T, Sugiyama N, Yokoyama S, Kawasaki Y, Sakuma T, Ishihama Y, Saiki I, Sakurai H.

FEBS Lett. 2014 Jan 3;588(1):131-7. doi: 10.1016/j.febslet.2013.11.020. Epub 2013 Nov 21.

46.

Herbal Medicine Goshajinkigan Prevents Paclitaxel-Induced Mechanical Allodynia without Impairing Antitumor Activity of Paclitaxel.

Bahar MA, Andoh T, Ogura K, Hayakawa Y, Saiki I, Kuraishi Y.

Evid Based Complement Alternat Med. 2013;2013:849754. doi: 10.1155/2013/849754. Epub 2013 Oct 2.

47.

Procyanidin C1 from Cinnamomi Cortex inhibits TGF-β-induced epithelial-to-mesenchymal transition in the A549 lung cancer cell line.

Kin R, Kato S, Kaneto N, Sakurai H, Hayakawa Y, Li F, Tanaka K, Saiki I, Yokoyama S.

Int J Oncol. 2013 Dec;43(6):1901-6. doi: 10.3892/ijo.2013.2139. Epub 2013 Oct 16.

PMID:
24141365
48.

Berberine enhances tumor necrosis factor-related apoptosis-inducing ligand-mediated apoptosis in breast cancer.

Refaat A, Abdelhamed S, Yagita H, Inoue H, Yokoyama S, Hayakawa Y, Saiki I.

Oncol Lett. 2013 Sep;6(3):840-844. Epub 2013 Jul 1.

49.

TAK1 promotes cell survival by TNFAIP3 and IL-8 dependent and NF-κB independent pathway in HeLa cells exposed to heat stress.

Li P, Furusawa Y, Wei ZL, Sakurai H, Tabuchi Y, Zhao QL, Saiki I, Kondo T.

Int J Hyperthermia. 2013 Nov;29(7):688-95. doi: 10.3109/02656736.2013.828104. Epub 2013 Sep 12.

PMID:
24028082
50.

A flavonoid chrysin suppresses hypoxic survival and metastatic growth of mouse breast cancer cells.

Lirdprapamongkol K, Sakurai H, Abdelhamed S, Yokoyama S, Maruyama T, Athikomkulchai S, Viriyaroj A, Awale S, Yagita H, Ruchirawat S, Svasti J, Saiki I.

Oncol Rep. 2013 Nov;30(5):2357-64. doi: 10.3892/or.2013.2667. Epub 2013 Aug 20.

PMID:
23969634

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