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Items: 1 to 50 of 61

1.

Protease-activated receptor-2 signaling through β-arrestin-2 mediates Alternaria alkaline serine protease-induced airway inflammation.

Yee MC, Nichols HL, Polley D, Saifeddine M, Pal K, Lee K, Wilson EH, Daines MO, Hollenberg MD, Boitano S, DeFea KA.

Am J Physiol Lung Cell Mol Physiol. 2018 Dec 1;315(6):L1042-L1057. doi: 10.1152/ajplung.00196.2018. Epub 2018 Oct 18.

PMID:
30335499
2.

Microenvironment proteinases, proteinase-activated receptor regulation, cancer and inflammation.

Eftekhari R, de Lima SG, Liu Y, Mihara K, Saifeddine M, Noorbakhsh F, Scarisbrick IA, Hollenberg MD.

Biol Chem. 2018 Sep 25;399(9):1023-1039. doi: 10.1515/hsz-2018-0001.

PMID:
29924723
3.

Hyperglycaemic impairment of PAR2-mediated vasodilation: Prevention by inhibition of aortic endothelial sodium-glucose-co-Transporter-2 and minimizing oxidative stress.

El-Daly M, Pulakazhi Venu VK, Saifeddine M, Mihara K, Kang S, Fedak PWM, Alston LA, Hirota SA, Ding H, Triggle CR, Hollenberg MD.

Vascul Pharmacol. 2018 Oct;109:56-71. doi: 10.1016/j.vph.2018.06.006. Epub 2018 Jun 13.

PMID:
29908295
4.

Myopia-Inhibiting Concentrations of Muscarinic Receptor Antagonists Block Activation of Alpha2A-Adrenoceptors In Vitro.

Carr BJ, Mihara K, Ramachandran R, Saifeddine M, Nathanson NM, Stell WK, Hollenberg MD.

Invest Ophthalmol Vis Sci. 2018 Jun 1;59(7):2778-2791. doi: 10.1167/iovs.17-22562.

PMID:
29860464
5.

Heat shock protein-27 and sex-selective regulation of muscarinic and proteinase-activated receptor 2-mediated vasodilatation: differential sensitivity to endothelial NOS inhibition.

Pulakazhi Venu VK, Saifeddine M, Mihara K, El-Daly M, Belke D, Dean JLE, O'Brien ER, Hirota SA, Hollenberg MD.

Br J Pharmacol. 2018 Jun;175(11):2063-2076. doi: 10.1111/bph.14200. Epub 2018 Apr 25.

PMID:
29532457
6.

Cockroach allergen serine proteinases: Isolation, sequencing and signalling via proteinase-activated receptor-2.

Polley DJ, Mihara K, Ramachandran R, Vliagoftis H, Renaux B, Saifeddine M, Daines MO, Boitano S, Hollenberg MD.

Clin Exp Allergy. 2017 Jul;47(7):946-960. doi: 10.1111/cea.12921. Epub 2017 Apr 27.

7.

Targeting a Proteinase-Activated Receptor 4 (PAR4) Carboxyl Terminal Motif to Regulate Platelet Function.

Ramachandran R, Mihara K, Thibeault P, Vanderboor CM, Petri B, Saifeddine M, Bouvier M, Hollenberg MD.

Mol Pharmacol. 2017 Apr;91(4):287-295. doi: 10.1124/mol.116.106526. Epub 2017 Jan 26.

PMID:
28126849
8.

Thrombin-Mediated Direct Activation of Proteinase-Activated Receptor-2: Another Target for Thrombin Signaling.

Mihara K, Ramachandran R, Saifeddine M, Hansen KK, Renaux B, Polley D, Gibson S, Vanderboor C, Hollenberg MD.

Mol Pharmacol. 2016 May;89(5):606-14. doi: 10.1124/mol.115.102723. Epub 2016 Mar 8.

PMID:
26957205
9.

GPCR-mediated EGF receptor transactivation regulates TRPV4 action in the vasculature.

Saifeddine M, El-Daly M, Mihara K, Bunnett NW, McIntyre P, Altier C, Hollenberg MD, Ramachandran R.

Br J Pharmacol. 2015 May;172(10):2493-506. doi: 10.1111/bph.13072. Epub 2015 Mar 18.

10.

Proteinase-activated receptors 1 and 2 and the regulation of porcine coronary artery contractility: a role for distinct tyrosine kinase pathways.

El-Daly M, Saifeddine M, Mihara K, Ramachandran R, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2014 May;171(9):2413-25. doi: 10.1111/bph.12593.

11.

Implantation serine proteinase 2 is a monomeric enzyme with mixed serine proteolytic activity and can silence signalling via proteinase activated receptors.

Sharma N, Fahr J, Renaux B, Saifeddine M, Kumar R, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE.

Biochem Cell Biol. 2013 Dec;91(6):487-97. doi: 10.1139/bcb-2013-0006. Epub 2013 Aug 6.

PMID:
24219291
12.

Neutrophil elastase and proteinase-3 trigger G protein-biased signaling through proteinase-activated receptor-1 (PAR1).

Mihara K, Ramachandran R, Renaux B, Saifeddine M, Hollenberg MD.

J Biol Chem. 2013 Nov 15;288(46):32979-90. doi: 10.1074/jbc.M113.483123. Epub 2013 Sep 19.

13.

Proteinase-activated receptors (PARs): differential signalling by kallikrein-related peptidases KLK8 and KLK14.

Ramachandran R, Eissa A, Mihara K, Oikonomopoulou K, Saifeddine M, Renaux B, Diamandis E, Hollenberg MD.

Biol Chem. 2012 Apr;393(5):421-7. doi: 10.1515/hsz-2011-0251.

PMID:
22505524
14.

Kallikrein-related peptidase signaling in colon carcinoma cells: targeting proteinase-activated receptors.

Chung H, Hamza M, Oikonomopoulou K, Gratio V, Saifeddine M, Virca GD, Diamandis EP, Hollenberg MD, Darmoul D.

Biol Chem. 2012 Apr;393(5):413-20. doi: 10.1515/bc-2011-231.

PMID:
22505523
15.

Implantation serine proteinase 1 exhibits mixed substrate specificity that silences signaling via proteinase-activated receptors.

Sharma N, Kumar R, Renaux B, Saifeddine M, Nishikawa S, Mihara K, Ramachandran R, Hollenberg MD, Rancourt DE.

PLoS One. 2011;6(11):e27888. doi: 10.1371/journal.pone.0027888. Epub 2011 Nov 23.

16.

Carbon dioxide enhances substance P-induced epithelium-dependent bronchial smooth muscle relaxation in Sprague-Dawley rats.

El Mays TY, Saifeddine M, Choudhury P, Hollenberg MD, Green FH.

Can J Physiol Pharmacol. 2011 Jul;89(7):513-20. doi: 10.1139/Y11-052.

PMID:
21812529
17.

Perivascular adipose tissue-derived relaxing factors: release by peptide agonists via proteinase-activated receptor-2 (PAR2) and non-PAR2 mechanisms.

Li Y, Mihara K, Saifeddine M, Krawetz A, Lau DC, Li H, Ding H, Triggle CR, Hollenberg MD.

Br J Pharmacol. 2011 Dec;164(8):1990-2002. doi: 10.1111/j.1476-5381.2011.01501.x.

18.

Activation of proteinase-activated receptor 2 stimulates soluble vascular endothelial growth factor receptor 1 release via epidermal growth factor receptor transactivation in endothelial cells.

Al-Ani B, Hewett PW, Cudmore MJ, Fujisawa T, Saifeddine M, Williams H, Ramma W, Sissaoui S, Jayaraman PS, Ohba M, Ahmad S, Hollenberg MD, Ahmed A.

Hypertension. 2010 Mar;55(3):689-97. doi: 10.1161/HYPERTENSIONAHA.109.136333. Epub 2010 Feb 1.

PMID:
20124108
19.

Met receptor tyrosine kinase transactivation is involved in proteinase-activated receptor-2-mediated hepatocellular carcinoma cell invasion.

Kaufmann R, Oettel C, Horn A, Halbhuber KJ, Eitner A, Krieg R, Katenkamp K, Henklein P, Westermann M, Böhmer FD, Ramachandran R, Saifeddine M, Hollenberg MD, Settmacher U.

Carcinogenesis. 2009 Sep;30(9):1487-96. doi: 10.1093/carcin/bgp153. Epub 2009 Jun 22.

PMID:
19546160
20.

Design, synthesis and biological evaluation of non-peptide PAR1 thrombin receptor antagonists based on small bifunctional templates: arginine and phenylalanine side chain groups are keys for receptor activity.

Androutsou ME, Saifeddine M, Hollenberg MD, Matsoukas J, Agelis G.

Amino Acids. 2010 Apr;38(4):985-90. doi: 10.1007/s00726-009-0306-z. Epub 2009 May 31.

PMID:
19484400
21.

Kallikreins and proteinase-mediated signaling: proteinase-activated receptors (PARs) and the pathophysiology of inflammatory diseases and cancer.

Hollenberg MD, Oikonomopoulou K, Hansen KK, Saifeddine M, Ramachandran R, Diamandis EP.

Biol Chem. 2008 Jun;389(6):643-51. doi: 10.1515/BC.2008.077. Review.

PMID:
18627296
22.

Derivatized 2-furoyl-LIGRLO-amide, a versatile and selective probe for proteinase-activated receptor 2: binding and visualization.

Hollenberg MD, Renaux B, Hyun E, Houle S, Vergnolle N, Saifeddine M, Ramachandran R.

J Pharmacol Exp Ther. 2008 Aug;326(2):453-62. doi: 10.1124/jpet.108.136432. Epub 2008 May 13.

PMID:
18477767
23.

Proteinase-activated receptor-2 activating peptides: distinct canine coronary artery receptor systems.

Saifeddine M, Seymour ML, Xiao YP, Compton SJ, Houle S, Ramachandran R, MacNaughton WK, Simonet S, Vayssettes-Courchay C, Verbeuren TJ, Hollenberg MD.

Am J Physiol Heart Circ Physiol. 2007 Dec;293(6):H3279-89. Epub 2007 Aug 31.

24.

Proteinase-activated receptors, targets for kallikrein signaling.

Oikonomopoulou K, Hansen KK, Saifeddine M, Tea I, Blaber M, Blaber SI, Scarisbrick I, Andrade-Gordon P, Cottrell GS, Bunnett NW, Diamandis EP, Hollenberg MD.

J Biol Chem. 2006 Oct 27;281(43):32095-112. Epub 2006 Aug 2.

25.

Kallikrein-mediated cell signalling: targeting proteinase-activated receptors (PARs).

Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Blaber M, Blaber SI, Scarisbrick I, Diamandis EP, Hollenberg MD.

Biol Chem. 2006 Jun;387(6):817-24.

PMID:
16800746
26.

Proteinase-mediated cell signalling: targeting proteinase-activated receptors (PARs) by kallikreins and more.

Oikonomopoulou K, Hansen KK, Saifeddine M, Vergnolle N, Tea I, Diamandis EP, Hollenberg MD.

Biol Chem. 2006 Jun;387(6):677-85. Review.

PMID:
16800728
27.

Surfactant as an airway smooth muscle relaxant.

Koetzler R, Saifeddine M, Yu Z, Schürch FS, Hollenberg MD, Green FH.

Am J Respir Cell Mol Biol. 2006 May;34(5):609-15. Epub 2006 Jan 13.

PMID:
16415252
28.

Proteinase-activated receptor-4: evaluation of tethered ligand-derived peptides as probes for receptor function and as inflammatory agonists in vivo.

Hollenberg MD, Saifeddine M, Sandhu S, Houle S, Vergnolle N.

Br J Pharmacol. 2004 Oct;143(4):443-54. Epub 2004 Sep 27.

29.
30.

2-furoyl-LIGRLO-amide: a potent and selective proteinase-activated receptor 2 agonist.

McGuire JJ, Saifeddine M, Triggle CR, Sun K, Hollenberg MD.

J Pharmacol Exp Ther. 2004 Jun;309(3):1124-31. Epub 2004 Feb 19.

PMID:
14976230
31.

Restricted ability of human mast cell tryptase to activate proteinase-activated receptor-2 in rat aorta.

Compton SJ, McGuire JJ, Saifeddine M, Hollenberg MD.

Can J Physiol Pharmacol. 2002 Oct;80(10):987-92.

PMID:
12450065
32.

Modified proteinase-activated receptor-1 and -2 derived peptides inhibit proteinase-activated receptor-2 activation by trypsin.

Al-Ani B, Saifeddine M, Wijesuriya SJ, Hollenberg MD.

J Pharmacol Exp Ther. 2002 Feb;300(2):702-8.

PMID:
11805236
33.

Proteinase-activated receptor 4 (PAR4): activation and inhibition of rat platelet aggregation by PAR4-derived peptides.

Hollenberg MD, Saifeddine M.

Can J Physiol Pharmacol. 2001 May;79(5):439-42.

PMID:
11405248
34.
35.
36.

Proteinase activated receptor 2: Role of extracellular loop 2 for ligand-mediated activation.

Al-Ani B, Saifeddine M, Kawabata A, Hollenberg MD.

Br J Pharmacol. 1999 Nov;128(5):1105-13.

37.

cSrc is a major cytosolic tyrosine kinase in vascular tissue.

Oda Y, Renaux B, Bjorge J, Saifeddine M, Fujita DJ, Hollenberg MD.

Can J Physiol Pharmacol. 1999 Aug;77(8):606-17.

PMID:
10543724
38.
39.

Design and synthesis of thrombin receptor-derived nonpeptide mimetics utilizing a piperazine scaffold.

Alexopoulos K, Fatseas P, Melissari E, Vlahakos D, Smith J, Mavromoustakos T, Saifeddine M, Moore G, Hollenberg M, Matsoukas J.

Bioorg Med Chem. 1999 Jun;7(6):1033-41.

PMID:
10428371
40.

Proteinase-activated receptor 2 (PAR(2)): development of a ligand-binding assay correlating with activation of PAR(2) by PAR(1)- and PAR(2)-derived peptide ligands.

Al-Ani B, Saifeddine M, Kawabata A, Renaux B, Mokashi S, Hollenberg MD.

J Pharmacol Exp Ther. 1999 Aug;290(2):753-60.

PMID:
10411588
42.
43.

Proteinase-activated receptor 2 (PAR2)-activating peptides: identification of a receptor distinct from PAR2 that regulates intestinal transport.

Vergnolle N, Macnaughton WK, Al-Ani B, Saifeddine M, Wallace JL, Hollenberg MD.

Proc Natl Acad Sci U S A. 1998 Jun 23;95(13):7766-71.

44.

Dual endothelium-dependent vascular activities of proteinase-activated receptor-2-activating peptides: evidence for receptor heterogeneity.

Roy SS, Saifeddine M, Loutzenhiser R, Triggle CR, Hollenberg MD.

Br J Pharmacol. 1998 Apr;123(7):1434-40.

45.
46.

Endothelium-dependent contractile effect of trypsin-activated receptor (PAR2) stimulation in rat vascular tissue.

Roy S, Saifeddine M, Triggle CR, Loutzenhiser R, Hollenberg MD.

Proc West Pharmacol Soc. 1997;40:53-5. No abstract available.

PMID:
9436212
47.

Protease-activated receptors: development of agonists selective for receptors triggered by either thrombin (PAR1) or trypsin (PAR2).

Kawabata A, Saifeddine M, al-Ani B, Hollenberg MD.

Proc West Pharmacol Soc. 1997;40:49-51. No abstract available.

PMID:
9436211
48.

Synthesis and contractile activities of cyclic thrombin receptor-derived peptide analogues with a Phe-Leu-Leu-Arg motif: importance of the Phe/Arg relative conformation and the primary amino group for activity.

Matsoukas JM, Panagiotopoulos D, Keramida M, Mavromoustakos T, Yamdagni R, Wu Q, Moore GJ, Saifeddine M, Hollenberg MD.

J Med Chem. 1996 Aug 30;39(18):3585-91.

PMID:
8784457
49.

Rat proteinase-activated receptor-2 (PAR-2): cDNA sequence and activity of receptor-derived peptides in gastric and vascular tissue.

Saifeddine M, al-Ani B, Cheng CH, Wang L, Hollenberg MD.

Br J Pharmacol. 1996 Jun;118(3):521-30.

50.

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