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How the gut microbiome regulates host immune responses to viral vaccines.

Vlasova AN, Takanashi S, Miyazaki A, Rajashekara G, Saif LJ.

Curr Opin Virol. 2019 Jun 1;37:16-25. doi: 10.1016/j.coviro.2019.05.001. [Epub ahead of print] Review.


Engineering a live attenuated PEDV vaccine candidate via inactivation of the viral 2'-O methyltransferase and the endocytosis signal of the spike protein.

Hou Y, Ke H, Kim J, Yoo D, Su Y, Boley P, Chepngeno J, Vlasova AN, Saif LJ, Wang Q.

J Virol. 2019 May 22. pii: JVI.00406-19. doi: 10.1128/JVI.00406-19. [Epub ahead of print]


Stage of Gestation at Porcine Epidemic Diarrhea Virus Infection of Pregnant Swine Impacts Maternal Immunity and Lactogenic Immune Protection of Neonatal Suckling Piglets.

Langel SN, Paim FC, Alhamo MA, Buckley A, Van Geelen A, Lager KM, Vlasova AN, Saif LJ.

Front Immunol. 2019 Apr 24;10:727. doi: 10.3389/fimmu.2019.00727. eCollection 2019.


Infectivity of GII.4 human norovirus does not differ between T-B-NK+ severe combined immunodeficiency (SCID) and non-SCID gnotobiotic pigs, implicating the role of NK cells in mediation of human norovirus infection.

Annamalai T, Lu Z, Jung K, Langel SN, Tuggle CK, Dekkers JCM, Waide EH, Kandasamy S, Saif LJ.

Virus Res. 2019 Jul 2;267:21-25. doi: 10.1016/j.virusres.2019.05.002. Epub 2019 May 2.


Epidemiological study of Middle East respiratory syndrome coronavirus infection in dromedary camels in Saudi Arabia, April-May 2015.

Elfadil AA, Ahmed AG, Abdalla MO, Gumaa E, Osman OH, Younis AE, Al-Hafufi AN, Saif LJ, Zaki A, Al-Rumaihi A, Al-Harbi N, Kasem S, Al-Brahim RH, Al-Sahhaf A, Bayoumi FE, Qasim IA, Abu-Obeida A, Al-Dowairij A.

Rev Sci Tech. 2018 Dec;37(3):985-997. doi: 10.20506/rst.37.3.2901.


Decline of transmissible gastroenteritis virus and its complex evolutionary relationship with porcine respiratory coronavirus in the United States.

Chen F, Knutson TP, Rossow S, Saif LJ, Marthaler DG.

Sci Rep. 2019 Mar 8;9(1):3953. doi: 10.1038/s41598-019-40564-z.


Emerging and re-emerging coronaviruses in pigs.

Wang Q, Vlasova AN, Kenney SP, Saif LJ.

Curr Opin Virol. 2019 Feb;34:39-49. doi: 10.1016/j.coviro.2018.12.001. Epub 2019 Jan 14. Review.


Pathogenicity and immunogenicity of attenuated porcine epidemic diarrhea virus PC22A strain in conventional weaned pigs.

Lin CM, Ghimire S, Hou Y, Boley P, Langel SN, Vlasova AN, Saif LJ, Wang Q.

BMC Vet Res. 2019 Jan 11;15(1):26. doi: 10.1186/s12917-018-1756-x.


Protein deficiency reduces efficacy of oral attenuated human rotavirus vaccine in a human infant fecal microbiota transplanted gnotobiotic pig model.

Miyazaki A, Kandasamy S, Michael H, Langel SN, Paim FC, Chepngeno J, Alhamo MA, Fischer DD, Huang HC, Srivastava V, Kathayat D, Deblais L, Rajashekara G, Saif LJ, Vlasova AN.

Vaccine. 2018 Oct 8;36(42):6270-6281. doi: 10.1016/j.vaccine.2018.09.008. Epub 2018 Sep 12.


Vesicle-Cloaked Virus Clusters Are Optimal Units for Inter-organismal Viral Transmission.

Santiana M, Ghosh S, Ho BA, Rajasekaran V, Du WL, Mutsafi Y, De Jésus-Diaz DA, Sosnovtsev SV, Levenson EA, Parra GI, Takvorian PM, Cali A, Bleck C, Vlasova AN, Saif LJ, Patton JT, Lopalco P, Corcelli A, Green KY, Altan-Bonnet N.

Cell Host Microbe. 2018 Aug 8;24(2):208-220.e8. doi: 10.1016/j.chom.2018.07.006.


Impact of nutrition and rotavirus infection on the infant gut microbiota in a humanized pig model.

Kumar A, Vlasova AN, Deblais L, Huang HC, Wijeratne A, Kandasamy S, Fischer DD, Langel SN, Paim FC, Alhamo MA, Shao L, Saif LJ, Rajashekara G.

BMC Gastroenterol. 2018 Jun 22;18(1):93. doi: 10.1186/s12876-018-0810-2.


Broad receptor engagement of an emerging global coronavirus may potentiate its diverse cross-species transmissibility.

Li W, Hulswit RJG, Kenney SP, Widjaja I, Jung K, Alhamo MA, van Dieren B, van Kuppeveld FJM, Saif LJ, Bosch BJ.

Proc Natl Acad Sci U S A. 2018 May 29;115(22):E5135-E5143. doi: 10.1073/pnas.1802879115. Epub 2018 May 14.


Tissue Distribution and Visualization of Internalized Human Norovirus in Leafy Greens.

Esseili MA, Meulia T, Saif LJ, Wang Q.

Appl Environ Microbiol. 2018 May 31;84(12). pii: e00292-18. doi: 10.1128/AEM.00292-18. Print 2018 Jun 15.


Development of a one-step RT-PCR assay for detection of pancoronaviruses (α-, β-, γ-, and δ-coronaviruses) using newly designed degenerate primers for porcine and avian `fecal samples.

Hu H, Jung K, Wang Q, Saif LJ, Vlasova AN.

J Virol Methods. 2018 Jun;256:116-122. doi: 10.1016/j.jviromet.2018.02.021. Epub 2018 Feb 27.


Attempts to grow human noroviruses, a sapovirus, and a bovine norovirus in vitro.

Oka T, Stoltzfus GT, Zhu C, Jung K, Wang Q, Saif LJ.

PLoS One. 2018 Feb 13;13(2):e0178157. doi: 10.1371/journal.pone.0178157. eCollection 2018.


Effect of antibiotic, probiotic, and human rotavirus infection on colonisation dynamics of defined commensal microbiota in a gnotobiotic pig model.

Huang HC, Vlasova AN, Kumar A, Kandasamy S, Fischer DD, Deblais L, Paim FC, Langel SN, Alhamo MA, Rauf A, Shao L, Saif LJ, Rajashekara G.

Benef Microbes. 2018 Jan 29;9(1):71-86. doi: 10.3920/BM2016.0225. Epub 2017 Oct 12.


Protein Malnutrition Alters Tryptophan and Angiotensin-Converting Enzyme 2 Homeostasis and Adaptive Immune Responses in Human Rotavirus-Infected Gnotobiotic Pigs with Human Infant Fecal Microbiota Transplant.

Fischer DD, Kandasamy S, Paim FC, Langel SN, Alhamo MA, Shao L, Chepngeno J, Miyazaki A, Huang HC, Kumar A, Rajashekara G, Saif LJ, Vlasova AN.

Clin Vaccine Immunol. 2017 Aug 4;24(8). pii: e00172-17. doi: 10.1128/CVI.00172-17. Print 2017 Aug.


Deletion of a 197-Amino-Acid Region in the N-Terminal Domain of Spike Protein Attenuates Porcine Epidemic Diarrhea Virus in Piglets.

Hou Y, Lin CM, Yokoyama M, Yount BL, Marthaler D, Douglas AL, Ghimire S, Qin Y, Baric RS, Saif LJ, Wang Q.

J Virol. 2017 Jun 26;91(14). pii: e00227-17. doi: 10.1128/JVI.00227-17. Print 2017 Jul 15.


Unraveling the Differences between Gram-Positive and Gram-Negative Probiotics in Modulating Protective Immunity to Enteric Infections.

Kandasamy S, Vlasova AN, Fischer DD, Chattha KS, Shao L, Kumar A, Langel SN, Rauf A, Huang HC, Rajashekara G, Saif LJ.

Front Immunol. 2017 Mar 27;8:334. doi: 10.3389/fimmu.2017.00334. eCollection 2017. Review.


Calves are susceptible to infection with the newly emerged porcine deltacoronavirus, but not with the swine enteric alphacoronavirus, porcine epidemic diarrhea virus.

Jung K, Hu H, Saif LJ.

Arch Virol. 2017 Aug;162(8):2357-2362. doi: 10.1007/s00705-017-3351-z. Epub 2017 Apr 3.


Porcine Rotaviruses: Epidemiology, Immune Responses and Control Strategies.

Vlasova AN, Amimo JO, Saif LJ.

Viruses. 2017 Mar 18;9(3). pii: E48. doi: 10.3390/v9030048. Review.


Attenuation of an original US porcine epidemic diarrhea virus strain PC22A via serial cell culture passage.

Lin CM, Hou Y, Marthaler DG, Gao X, Liu X, Zheng L, Saif LJ, Wang Q.

Vet Microbiol. 2017 Mar;201:62-71. doi: 10.1016/j.vetmic.2017.01.015. Epub 2017 Jan 15.


Protein Malnutrition Modifies Innate Immunity and Gene Expression by Intestinal Epithelial Cells and Human Rotavirus Infection in Neonatal Gnotobiotic Pigs.

Vlasova AN, Paim FC, Kandasamy S, Alhamo MA, Fischer DD, Langel SN, Deblais L, Kumar A, Chepngeno J, Shao L, Huang HC, Candelero-Rueda RA, Rajashekara G, Saif LJ.

mSphere. 2017 Mar 1;2(2). pii: e00046-17. doi: 10.1128/mSphere.00046-17. eCollection 2017 Mar-Apr.


Effects of Escherichia coli Nissle 1917 and Ciprofloxacin on small intestinal epithelial cell mRNA expression in the neonatal piglet model of human rotavirus infection.

Paim FC, Langel SN, Fischer DD, Kandasamy S, Shao L, Alhamo MA, Huang HC, Kumar A, Rajashekara G, Saif LJ, Vlasova AN.

Gut Pathog. 2016 Dec 13;8:66. doi: 10.1186/s13099-016-0148-7. eCollection 2016.


Skin Vaccination against Rotavirus Using Microneedles: Proof of Concept in Gnotobiotic Piglets.

Wang Y, Vlasova A, Velasquez DE, Saif LJ, Kandasamy S, Kochba E, Levin Y, Jiang B.

PLoS One. 2016 Nov 8;11(11):e0166038. doi: 10.1371/journal.pone.0166038. eCollection 2016.


Antiviral effect of theaflavins against caliciviruses.

Ohba M, Oka T, Ando T, Arahata S, Ikegaya A, Takagi H, Ogo N, Zhu C, Owada K, Kawamori F, Wang Q, Saif LJ, Asai A.

J Antibiot (Tokyo). 2017 Apr;70(4):443-447. doi: 10.1038/ja.2016.128. Epub 2016 Oct 19.


Experimental infection of gnotobiotic pigs with the cell-culture-adapted porcine deltacoronavirus strain OH-FD22.

Hu H, Jung K, Vlasova AN, Saif LJ.

Arch Virol. 2016 Dec;161(12):3421-3434. Epub 2016 Sep 12.


Escherichia coli Nissle 1917 protects gnotobiotic pigs against human rotavirus by modulating pDC and NK-cell responses.

Vlasova AN, Shao L, Kandasamy S, Fischer DD, Rauf A, Langel SN, Chattha KS, Kumar A, Huang HC, Rajashekara G, Saif LJ.

Eur J Immunol. 2016 Oct;46(10):2426-2437. doi: 10.1002/eji.201646498. Epub 2016 Aug 11.


First detection and molecular characterization of sapoviruses and noroviruses with zoonotic potential in swine in Ethiopia.

Sisay Z, Djikeng A, Berhe N, Belay G, Abegaz WE, Wang QH, Saif LJ.

Arch Virol. 2016 Oct;161(10):2739-47. doi: 10.1007/s00705-016-2974-9. Epub 2016 Jul 16.


Evolution, antigenicity and pathogenicity of global porcine epidemic diarrhea virus strains.

Lin CM, Saif LJ, Marthaler D, Wang Q.

Virus Res. 2016 Dec 2;226:20-39. doi: 10.1016/j.virusres.2016.05.023. Epub 2016 Jun 8. Review.


Genetic Characterization and Classification of Human and Animal Sapoviruses.

Oka T, Lu Z, Phan T, Delwart EL, Saif LJ, Wang Q.

PLoS One. 2016 May 26;11(5):e0156373. doi: 10.1371/journal.pone.0156373. eCollection 2016.


Lactogenic immunity and vaccines for porcine epidemic diarrhea virus (PEDV): Historical and current concepts.

Langel SN, Paim FC, Lager KM, Vlasova AN, Saif LJ.

Virus Res. 2016 Dec 2;226:93-107. doi: 10.1016/j.virusres.2016.05.016. Epub 2016 May 19. Review.


Prevalence and molecular characterization of human noroviruses and sapoviruses in Ethiopia.

Sisay Z, Djikeng A, Berhe N, Belay G, Gebreyes W, Abegaz WE, Njahira MN, Wang QH, Saif LJ.

Arch Virol. 2016 Aug;161(8):2169-82. doi: 10.1007/s00705-016-2887-7. Epub 2016 May 19.


Discovery and Synthesis of Heterocyclic Carboxamide Derivatives as Potent Anti-norovirus Agents.

Ohba M, Oka T, Ando T, Arahata S, Ikegaya A, Takagi H, Ogo N, Owada K, Kawamori F, Wang Q, Saif LJ, Asai A.

Chem Pharm Bull (Tokyo). 2016;64(5):465-75. doi: 10.1248/cpb.c16-00001.


Porcine deltacoronavirus infection: Etiology, cell culture for virus isolation and propagation, molecular epidemiology and pathogenesis.

Jung K, Hu H, Saif LJ.

Virus Res. 2016 Dec 2;226:50-59. doi: 10.1016/j.virusres.2016.04.009. Epub 2016 Apr 13. Review.


Recognition of Histo-Blood Group Antigen-Like Carbohydrates in Lettuce by Human GII.4 Norovirus.

Gao X, Esseili MA, Lu Z, Saif LJ, Wang Q.

Appl Environ Microbiol. 2016 May 2;82(10):2966-74. doi: 10.1128/AEM.04096-15. Print 2016 May 15.


Tissue-specific mRNA expression profiles of porcine Toll-like receptors at different ages in germ-free and conventional pigs.

Shao L, Fischer DD, Kandasamy S, Saif LJ, Vlasova AN.

Vet Immunol Immunopathol. 2016 Mar;171:7-16. doi: 10.1016/j.vetimm.2016.01.008. Epub 2016 Feb 1.


Comparison of probiotic lactobacilli and bifidobacteria effects, immune responses and rotavirus vaccines and infection in different host species.

Vlasova AN, Kandasamy S, Chattha KS, Rajashekara G, Saif LJ.

Vet Immunol Immunopathol. 2016 Apr;172:72-84. doi: 10.1016/j.vetimm.2016.01.003. Epub 2016 Jan 14. Review.


Differential Effects of Escherichia coli Nissle and Lactobacillus rhamnosus Strain GG on Human Rotavirus Binding, Infection, and B Cell Immunity.

Kandasamy S, Vlasova AN, Fischer D, Kumar A, Chattha KS, Rauf A, Shao L, Langel SN, Rajashekara G, Saif LJ.

J Immunol. 2016 Feb 15;196(4):1780-9. doi: 10.4049/jimmunol.1501705. Epub 2016 Jan 22.


Porcine deltacoronavirus induces apoptosis in swine testicular and LLC porcine kidney cell lines in vitro but not in infected intestinal enterocytes in vivo.

Jung K, Hu H, Saif LJ.

Vet Microbiol. 2016;182:57-63. doi: 10.1016/j.vetmic.2015.10.022. Epub 2015 Oct 30.


Experimental infection of a US spike-insertion deletion porcine epidemic diarrhea virus in conventional nursing piglets and cross-protection to the original US PEDV infection.

Lin CM, Annamalai T, Liu X, Gao X, Lu Z, El-Tholoth M, Hu H, Saif LJ, Wang Q.

Vet Res. 2015 Nov 20;46:134. doi: 10.1186/s13567-015-0278-9.


Mechanism of Cell Culture Adaptation of an Enteric Calicivirus, the Porcine Sapovirus Cowden Strain.

Lu Z, Yokoyama M, Chen N, Oka T, Jung K, Chang KO, Annamalai T, Wang Q, Saif LJ.

J Virol. 2015 Nov 18;90(3):1345-58. doi: 10.1128/JVI.02197-15. Print 2016 Feb 1.


Porcine lung mesenchymal stromal cells possess differentiation and immunoregulatory properties.

Khatri M, O'Brien TD, Chattha KS, Saif LJ.

Stem Cell Res Ther. 2015 Nov 11;6:222. doi: 10.1186/s13287-015-0220-0.


Molecular and antigenic characterization of bovine Coronavirus circulating in Argentinean cattle during 1994-2010.

Bok M, Miño S, Rodriguez D, Badaracco A, Nuñes I, Souza SP, Bilbao G, Louge Uriarte E, Galarza R, Vega C, Odeon A, Saif LJ, Parreño V.

Vet Microbiol. 2015 Dec 31;181(3-4):221-9. doi: 10.1016/j.vetmic.2015.10.017. Epub 2015 Oct 17.


Abiotic Stress and Phyllosphere Bacteria Influence the Survival of Human Norovirus and Its Surrogates on Preharvest Leafy Greens.

Esseili MA, Gao X, Tegtmeier S, Saif LJ, Wang Q.

Appl Environ Microbiol. 2015 Oct 23;82(1):352-63. doi: 10.1128/AEM.02763-15. Print 2016 Jan 1.

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