Format
Sort by
Items per page

Send to

Choose Destination

Search results

Items: 1 to 50 of 282

1.

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.

Nagata K, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC.

Nat Commun. 2018 May 4;9(1):1800. doi: 10.1038/s41467-018-04238-0.

2.

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease.

Hashimoto S, Saido TC.

Open Biol. 2018 Apr;8(4). pii: 180024. doi: 10.1098/rsob.180024. Review.

3.

Targeting Alzheimer's disease with gene and cell therapies.

Loera-Valencia R, Piras A, Ismail MAM, Manchanda S, Eyjolfsdottir H, Saido TC, Johansson J, Eriksdotter M, Winblad B, Nilsson P.

J Intern Med. 2018 Jul;284(1):2-36. doi: 10.1111/joim.12759. Review.

PMID:
29582495
4.

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.

Neuroscience. 2018 May 1;377:87-97. doi: 10.1016/j.neuroscience.2018.02.031. Epub 2018 Mar 3.

PMID:
29510211
5.

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG.

Neurobiol Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001. Epub 2018 Feb 7.

PMID:
29427755
6.

Correction for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival".

Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.

Mol Cell Biol. 2018 Jan 29;38(4). pii: e00614-17. doi: 10.1128/MCB.00614-17. Print 2018 Feb 15. No abstract available.

7.

DNA methylation level of the neprilysin promoter in Alzheimer's disease brains.

Nagata K, Mano T, Murayama S, Saido TC, Iwata A.

Neurosci Lett. 2018 Mar 23;670:8-13. doi: 10.1016/j.neulet.2018.01.003. Epub 2018 Jan 12.

PMID:
29339171
8.

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.

EMBO Mol Med. 2018 Mar;10(3). pii: e8184. doi: 10.15252/emmm.201708184.

9.

Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.

Hashimoto S, Ishii A, Kamano N, Watamura N, Saito T, Ohshima T, Yokosuka M, Saido TC.

J Biol Chem. 2018 Mar 2;293(9):3118-3125. doi: 10.1074/jbc.M117.811315. Epub 2018 Jan 3.

PMID:
29298895
10.

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.

Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K.

Neuropharmacology. 2018 Mar 15;131:291-303. doi: 10.1016/j.neuropharm.2017.12.037. Epub 2017 Dec 22.

PMID:
29274751
11.

Expression of Concern for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival".

Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.

Mol Cell Biol. 2017 Nov 13;37(23). pii: e00530-17. doi: 10.1128/MCB.00530-17. Print 2017 Dec 1. No abstract available.

12.

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders.

Nagata K, Takahashi M, Kiryu-Seo S, Kiyama H, Saido TC.

Acta Neuropathol Commun. 2017 Nov 13;5(1):83. doi: 10.1186/s40478-017-0486-9.

13.

Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L.

Neurobiol Dis. 2018 Feb;110:29-36. doi: 10.1016/j.nbd.2017.10.014. Epub 2017 Oct 31.

PMID:
29100987
14.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9645-E9654. doi: 10.1073/pnas.1707151114. Epub 2017 Oct 17.

15.

Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease.

Whyte LS, Hemsley KM, Lau AA, Hassiotis S, Saito T, Saido TC, Hopwood JJ, Sargeant TJ.

Behav Brain Res. 2018 Jan 15;336:177-181. doi: 10.1016/j.bbr.2017.09.006. Epub 2017 Sep 5.

PMID:
28887197
16.

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G.

PLoS One. 2017 Aug 23;12(8):e0182844. doi: 10.1371/journal.pone.0182844. eCollection 2017.

17.

APP mouse models for Alzheimer's disease preclinical studies.

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC.

EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1. Review.

18.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

PMID:
28753424
19.

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model.

Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM.

Front Syst Neurosci. 2017 Jun 30;11:48. doi: 10.3389/fnsys.2017.00048. eCollection 2017.

20.

PLD3 gene and processing of APP.

Fazzari P, Horre K, Arranz AM, Frigerio CS, Saito T, Saido TC, De Strooper B.

Nature. 2017 Jan 25;541(7638):E1-E2. doi: 10.1038/nature21030. No abstract available.

PMID:
28128235
21.

Calpain research for drug discovery: challenges and potential.

Ono Y, Saido TC, Sorimachi H.

Nat Rev Drug Discov. 2016 Dec;15(12):854-876. doi: 10.1038/nrd.2016.212. Epub 2016 Nov 11. Review.

PMID:
27833121
22.

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido TC.

J Neurosci. 2016 Sep 21;36(38):9933-6. doi: 10.1523/JNEUROSCI.1907-16.2016.

23.

Cognitive deficits in single App knock-in mouse models.

Masuda A, Kobayashi Y, Kogo N, Saito T, Saido TC, Itohara S.

Neurobiol Learn Mem. 2016 Nov;135:73-82. doi: 10.1016/j.nlm.2016.07.001. Epub 2016 Jul 1.

24.

Familial Alzheimer's Disease Mutations in Presenilin Generate Amyloidogenic Aβ Peptide Seeds.

Veugelen S, Saito T, Saido TC, Chávez-Gutiérrez L, De Strooper B.

Neuron. 2016 Apr 20;90(2):410-6. doi: 10.1016/j.neuron.2016.03.010.

25.

Leukocyte Calpain Deficiency Reduces Angiotensin II-Induced Inflammation and Atherosclerosis But Not Abdominal Aortic Aneurysms in Mice.

Howatt DA, Balakrishnan A, Moorleghen JJ, Muniappan L, Rateri DL, Uchida HA, Takano J, Saido TC, Chishti AH, Baud L, Subramanian V.

Arterioscler Thromb Vasc Biol. 2016 May;36(5):835-45. doi: 10.1161/ATVBAHA.116.307285. Epub 2016 Mar 10.

26.

ECEL1 mutation implicates impaired axonal arborization of motor nerves in the pathogenesis of distal arthrogryposis.

Nagata K, Kiryu-Seo S, Tamada H, Okuyama-Uchimura F, Kiyama H, Saido TC.

Acta Neuropathol. 2016 Jul;132(1):111-26. doi: 10.1007/s00401-016-1554-0. Epub 2016 Mar 7.

PMID:
26951213
27.

Loss of GPR3 reduces the amyloid plaque burden and improves memory in Alzheimer's disease mouse models.

Huang Y, Skwarek-Maruszewska A, Horré K, Vandewyer E, Wolfs L, Snellinx A, Saito T, Radaelli E, Corthout N, Colombelli J, Lo AC, Van Aerschot L, Callaerts-Vegh Z, Trabzuni D, Bossers K, Verhaagen J, Ryten M, Munck S, D'Hooge R, Swaab DF, Hardy J, Saido TC, De Strooper B, Thathiah A.

Sci Transl Med. 2015 Oct 14;7(309):309ra164. doi: 10.1126/scitranslmed.aab3492.

PMID:
26468326
28.

Bisecting GlcNAc modification stabilizes BACE1 protein under oxidative stress conditions.

Kizuka Y, Nakano M, Kitazume S, Saito T, Saido TC, Taniguchi N.

Biochem J. 2016 Jan 1;473(1):21-30. doi: 10.1042/BJ20150607. Epub 2015 Oct 14.

PMID:
26467158
29.

Activation of Calpain-2 by Mediators in Pulmonary Vascular Remodeling of Pulmonary Arterial Hypertension.

Kovacs L, Han W, Rafikov R, Bagi Z, Offermanns S, Saido TC, Black SM, Su Y.

Am J Respir Cell Mol Biol. 2016 Mar;54(3):384-93. doi: 10.1165/rcmb.2015-0151OC.

30.

Loss of neprilysin alters protein expression in the brain of Alzheimer's disease model mice.

Nilsson P, Loganathan K, Sekiguchi M, Winblad B, Iwata N, Saido TC, Tjernberg LO.

Proteomics. 2015 Oct;15(19):3349-55. doi: 10.1002/pmic.201400211. Epub 2015 Aug 13.

PMID:
26194619
31.

Involvement of calpains in adult neurogenesis: implications for stroke.

Machado VM, Morte MI, Carreira BP, Azevedo MM, Takano J, Iwata N, Saido TC, Asmussen H, Horwitz AR, Carvalho CM, Araújo IM.

Front Cell Neurosci. 2015 Feb 4;9:22. doi: 10.3389/fncel.2015.00022. eCollection 2015.

32.

An aberrant sugar modification of BACE1 blocks its lysosomal targeting in Alzheimer's disease.

Kizuka Y, Kitazume S, Fujinawa R, Saito T, Iwata N, Saido TC, Nakano M, Yamaguchi Y, Hashimoto Y, Staufenbiel M, Hatsuta H, Murayama S, Manya H, Endo T, Taniguchi N.

EMBO Mol Med. 2015 Feb;7(2):175-89. doi: 10.15252/emmm.201404438.

33.

Neuropathology and biochemistry of Aβ and its aggregates in Alzheimer's disease.

Thal DR, Walter J, Saido TC, Fändrich M.

Acta Neuropathol. 2015 Feb;129(2):167-82. doi: 10.1007/s00401-014-1375-y. Epub 2014 Dec 23. Review.

PMID:
25534025
34.

Autophagy-related protein 7 deficiency in amyloid β (Aβ) precursor protein transgenic mice decreases Aβ in the multivesicular bodies and induces Aβ accumulation in the Golgi.

Nilsson P, Sekiguchi M, Akagi T, Izumi S, Komori T, Hui K, Sörgjerd K, Tanaka M, Saito T, Iwata N, Saido TC.

Am J Pathol. 2015 Feb;185(2):305-13. doi: 10.1016/j.ajpath.2014.10.011. Epub 2014 Nov 26.

PMID:
25433221
35.

Calpain-dependent cleavage of N-cadherin is involved in the progression of post-myocardial infarction remodeling.

Kudo-Sakamoto Y, Akazawa H, Ito K, Takano J, Yano M, Yabumoto C, Naito AT, Oka T, Lee JK, Sakata Y, Suzuki J, Saido TC, Komuro I.

J Biol Chem. 2014 Jul 11;289(28):19408-19. doi: 10.1074/jbc.M114.567206. Epub 2014 Jun 2.

36.

New mouse model of Alzheimer's.

Nilsson P, Saito T, Saido TC.

ACS Chem Neurosci. 2014 Jul 16;5(7):499-502. doi: 10.1021/cn500105p. Epub 2014 May 22.

37.

Single App knock-in mouse models of Alzheimer's disease.

Saito T, Matsuba Y, Mihira N, Takano J, Nilsson P, Itohara S, Iwata N, Saido TC.

Nat Neurosci. 2014 May;17(5):661-3. doi: 10.1038/nn.3697. Epub 2014 Apr 13.

PMID:
24728269
38.

Dual roles for autophagy: degradation and secretion of Alzheimer's disease Aβ peptide.

Nilsson P, Saido TC.

Bioessays. 2014 Jun;36(6):570-8. doi: 10.1002/bies.201400002. Epub 2014 Apr 8. Review.

39.

Overexpression of the calpain-specific inhibitor calpastatin reduces human alpha-Synuclein processing, aggregation and synaptic impairment in [A30P]αSyn transgenic mice.

Diepenbroek M, Casadei N, Esmer H, Saido TC, Takano J, Kahle PJ, Nixon RA, Rao MV, Melki R, Pieri L, Helling S, Marcus K, Krueger R, Masliah E, Riess O, Nuber S.

Hum Mol Genet. 2014 Aug 1;23(15):3975-89. doi: 10.1093/hmg/ddu112. Epub 2014 Mar 11.

40.

Soft-diet feeding after weaning affects behavior in mice: Potential increase in vulnerability to mental disorders.

Nose-Ishibashi K, Watahiki J, Yamada K, Maekawa M, Watanabe A, Yamamoto G, Enomoto A, Matsuba Y, Nampo T, Taguchi T, Ichikawa Y, Saido TC, Mishima K, Yamaguchi Y, Yoshikawa T, Maki K.

Neuroscience. 2014 Mar 28;263:257-68. doi: 10.1016/j.neuroscience.2013.12.065. Epub 2014 Jan 18.

PMID:
24444829
41.

Substrate ectodomain is critical for substrate preference and inhibition of γ-secretase.

Funamoto S, Sasaki T, Ishihara S, Nobuhara M, Nakano M, Watanabe-Takahashi M, Saito T, Kakuda N, Miyasaka T, Nishikawa K, Saido TC, Ihara Y.

Nat Commun. 2013;4:2529. doi: 10.1038/ncomms3529.

42.

Aβ secretion and plaque formation depend on autophagy.

Nilsson P, Loganathan K, Sekiguchi M, Matsuba Y, Hui K, Tsubuki S, Tanaka M, Iwata N, Saito T, Saido TC.

Cell Rep. 2013 Oct 17;5(1):61-9. doi: 10.1016/j.celrep.2013.08.042. Epub 2013 Oct 3.

43.

Imaging of tau pathology in a tauopathy mouse model and in Alzheimer patients compared to normal controls.

Maruyama M, Shimada H, Suhara T, Shinotoh H, Ji B, Maeda J, Zhang MR, Trojanowski JQ, Lee VM, Ono M, Masamoto K, Takano H, Sahara N, Iwata N, Okamura N, Furumoto S, Kudo Y, Chang Q, Saido TC, Takashima A, Lewis J, Jang MK, Aoki I, Ito H, Higuchi M.

Neuron. 2013 Sep 18;79(6):1094-108. doi: 10.1016/j.neuron.2013.07.037.

44.

Calpastatin prevents NF-κB-mediated hyperactivation of macrophages and attenuates colitis.

Huang Z, Rose AH, Hoffmann FW, Hashimoto AS, Bertino P, Denk T, Takano J, Iwata N, Saido TC, Hoffmann PR.

J Immunol. 2013 Oct 1;191(7):3778-88. doi: 10.4049/jimmunol.1300972. Epub 2013 Aug 28.

45.

Metabolism of amyloid β peptide and pathogenesis of Alzheimer's disease.

Saido TC.

Proc Jpn Acad Ser B Phys Biol Sci. 2013;89(7):321-39. Review.

46.

Pyroglutamate-3 amyloid-β deposition in the brains of humans, non-human primates, canines, and Alzheimer disease-like transgenic mouse models.

Frost JL, Le KX, Cynis H, Ekpo E, Kleinschmidt M, Palmour RM, Ervin FR, Snigdha S, Cotman CW, Saido TC, Vassar RJ, St George-Hyslop P, Ikezu T, Schilling S, Demuth HU, Lemere CA.

Am J Pathol. 2013 Aug;183(2):369-81. doi: 10.1016/j.ajpath.2013.05.005. Epub 2013 Jun 7.

47.

Human prefoldin inhibits amyloid-β (Aβ) fibrillation and contributes to formation of nontoxic Aβ aggregates.

Sörgjerd KM, Zako T, Sakono M, Stirling PC, Leroux MR, Saito T, Nilsson P, Sekimoto M, Saido TC, Maeda M.

Biochemistry. 2013 May 21;52(20):3532-42. doi: 10.1021/bi301705c. Epub 2013 May 8. Erratum in: Biochemistry. 2014 Jun 3;53(21):3520.

PMID:
23614719
48.

Global brain delivery of neprilysin gene by intravascular administration of AAV vector in mice.

Iwata N, Sekiguchi M, Hattori Y, Takahashi A, Asai M, Ji B, Higuchi M, Staufenbiel M, Muramatsu S, Saido TC.

Sci Rep. 2013;3:1472. doi: 10.1038/srep01472.

49.

A role for calpain-dependent cleavage of TDP-43 in amyotrophic lateral sclerosis pathology.

Yamashita T, Hideyama T, Hachiga K, Teramoto S, Takano J, Iwata N, Saido TC, Kwak S.

Nat Commun. 2012;3:1307. doi: 10.1038/ncomms2303.

PMID:
23250437
50.

Calpain-mediated ataxin-3 cleavage in the molecular pathogenesis of spinocerebellar ataxia type 3 (SCA3).

Hübener J, Weber JJ, Richter C, Honold L, Weiss A, Murad F, Breuer P, Wüllner U, Bellstedt P, Paquet-Durand F, Takano J, Saido TC, Riess O, Nguyen HP.

Hum Mol Genet. 2013 Feb 1;22(3):508-18. doi: 10.1093/hmg/dds449. Epub 2012 Oct 24.

PMID:
23100324

Supplemental Content

Loading ...
Support Center