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Items: 1 to 50 of 310

1.

Biology of splicing in Alzheimer's disease research.

Nagata K, Saito T, Saido TC, Morihara T.

Prog Mol Biol Transl Sci. 2019;168:79-84. doi: 10.1016/bs.pmbts.2019.08.003. Epub 2019 Oct 17.

PMID:
31699329
2.

ABCA7 haplodeficiency disturbs microglial immune responses in the mouse brain.

Aikawa T, Ren Y, Yamazaki Y, Tachibana M, Johnson MR, Anderson CT, Martens YA, Holm ML, Asmann YW, Saito T, Saido TC, Fitzgerald ML, Bu G, Kanekiyo T.

Proc Natl Acad Sci U S A. 2019 Nov 19;116(47):23790-23796. doi: 10.1073/pnas.1908529116. Epub 2019 Nov 5.

PMID:
31690660
3.

An impaired intrinsic microglial clock system induces neuroinflammatory alterations in the early stage of amyloid precursor protein knock-in mouse brain.

Ni J, Wu Z, Meng J, Saito T, Saido TC, Qing H, Nakanishi H.

J Neuroinflammation. 2019 Aug 30;16(1):173. doi: 10.1186/s12974-019-1562-9.

4.

Inhibition of p38 MAPK in the brain through nasal administration of p38 inhibitor loaded in chitosan nanocapsules.

Casadomé-Perales Á, Matteis L, Alleva M, Infantes-Rodríguez C, Palomares-Pérez I, Saito T, Saido TC, Esteban JA, Nebreda AR, de la Fuente JM, Dotti CG.

Nanomedicine (Lond). 2019 Sep;14(18):2409-2422. doi: 10.2217/nnm-2018-0496. Epub 2019 Aug 28.

PMID:
31456488
5.

Insoluble Aβ overexpression in an App knock-in mouse model alters microstructure and gamma oscillations in the prefrontal cortex, affecting anxiety-related behaviours.

Pervolaraki E, Hall SP, Foresteire D, Saito T, Saido TC, Whittington MA, Lever C, Dachtler J.

Dis Model Mech. 2019 Sep 24;12(9). pii: dmm040550. doi: 10.1242/dmm.040550.

6.

Serine Phosphorylation of IRS1 Correlates with Aβ-Unrelated Memory Deficits and Elevation in Aβ Level Prior to the Onset of Memory Decline in AD.

Wang W, Tanokashira D, Fukui Y, Maruyama M, Kuroiwa C, Saito T, Saido TC, Taguchi A.

Nutrients. 2019 Aug 17;11(8). pii: E1942. doi: 10.3390/nu11081942.

7.

Longitudinal PET Monitoring of Amyloidosis and Microglial Activation in a Second Generation Amyloid-beta Mouse Model.

Sacher C, Blume T, Beyer L, Peters F, Eckenweber F, Sgobio C, Deussing M, Albert NL, Unterrainer M, Lindner S, Gildehaus FJ, von Ungern-Sternberg B, Brzak I, Neumann U, Saito T, Saido TC, Bartenstein P, Rominger A, Herms J, Brendel M.

J Nucl Med. 2019 Jul 13. pii: jnumed.119.227322. doi: 10.2967/jnumed.119.227322. [Epub ahead of print]

PMID:
31302633
8.

Temporal progression of Alzheimer's disease in brains and intestines of transgenic mice.

Manocha GD, Floden AM, Miller NM, Smith AJ, Nagamoto-Combs K, Saito T, Saido TC, Combs CK.

Neurobiol Aging. 2019 Sep;81:166-176. doi: 10.1016/j.neurobiolaging.2019.05.025. Epub 2019 Jun 13.

PMID:
31284126
9.

Humanization of the entire murine Mapt gene provides a murine model of pathological human tau propagation.

Saito T, Mihira N, Matsuba Y, Sasaguri H, Hashimoto S, Narasimhan S, Zhang B, Murayama S, Higuchi M, Lee VMY, Trojanowski JQ, Saido TC.

J Biol Chem. 2019 Aug 23;294(34):12754-12765. doi: 10.1074/jbc.RA119.009487. Epub 2019 Jul 4.

PMID:
31273083
10.

Author Correction: Tau binding protein CAPON induces tau aggregation and neurodegeneration.

Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T.

Nat Commun. 2019 Jul 1;10(1):2964. doi: 10.1038/s41467-019-10990-8.

11.

Amyloid β oligomers constrict human capillaries in Alzheimer's disease via signaling to pericytes.

Nortley R, Korte N, Izquierdo P, Hirunpattarasilp C, Mishra A, Jaunmuktane Z, Kyrargyri V, Pfeiffer T, Khennouf L, Madry C, Gong H, Richard-Loendt A, Huang W, Saito T, Saido TC, Brandner S, Sethi H, Attwell D.

Science. 2019 Jul 19;365(6450). pii: eaav9518. doi: 10.1126/science.aav9518. Epub 2019 Jun 20.

PMID:
31221773
12.

An App knock-in mouse inducing the formation of a toxic conformer of Aβ as a model for evaluating only oligomer-induced cognitive decline in Alzheimer's disease.

Izuo N, Murakami K, Fujihara Y, Maeda M, Saito T, Saido TC, Irie K, Shimizu T.

Biochem Biophys Res Commun. 2019 Jul 30;515(3):462-467. doi: 10.1016/j.bbrc.2019.05.131. Epub 2019 Jun 1.

PMID:
31164199
13.

Tau binding protein CAPON induces tau aggregation and neurodegeneration.

Hashimoto S, Matsuba Y, Kamano N, Mihira N, Sahara N, Takano J, Muramatsu SI, Saido TC, Saito T.

Nat Commun. 2019 Jun 3;10(1):2394. doi: 10.1038/s41467-019-10278-x. Erratum in: Nat Commun. 2019 Jul 1;10(1):2964.

14.

AppNL-G-F/NL-G-F mice overall do not show impaired motivation, but cored amyloid plaques in the striatum are inversely correlated with motivation.

Hamaguchi T, Tsutsui-Kimura I, Mimura M, Saito T, Saido TC, Tanaka KF.

Neurochem Int. 2019 Oct;129:104470. doi: 10.1016/j.neuint.2019.104470. Epub 2019 May 16.

PMID:
31102607
15.

Aminophospholipids are signal-transducing TREM2 ligands on apoptotic cells.

Shirotani K, Hori Y, Yoshizaki R, Higuchi E, Colonna M, Saito T, Hashimoto S, Saito T, Saido TC, Iwata N.

Sci Rep. 2019 May 17;9(1):7508. doi: 10.1038/s41598-019-43535-6.

16.

GABARAPs dysfunction by autophagy deficiency in adolescent brain impairs GABAA receptor trafficking and social behavior.

Hui KK, Takashima N, Watanabe A, Chater TE, Matsukawa H, Nekooki-Machida Y, Nilsson P, Endo R, Goda Y, Saido TC, Yoshikawa T, Tanaka M.

Sci Adv. 2019 Apr 10;5(4):eaau8237. doi: 10.1126/sciadv.aau8237. eCollection 2019 Apr.

17.

Amyloid-β plaque formation and reactive gliosis are required for induction of cognitive deficits in App knock-in mouse models of Alzheimer's disease.

Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM.

BMC Neurosci. 2019 Mar 20;20(1):13. doi: 10.1186/s12868-019-0496-6.

18.

Reducing ADAMTS-3 Inhibits Amyloid β Deposition in App Knock-in Mouse.

Yamakage Y, Tsuiji H, Kohno T, Ogino H, Saito T, Saido TC, Hattori M.

Biol Pharm Bull. 2019;42(3):354-356. doi: 10.1248/bpb.b18-00899.

19.

Aberrant Excitatory-Inhibitory Synaptic Mechanisms in Entorhinal Cortex Microcircuits During the Pathogenesis of Alzheimer's Disease.

Petrache AL, Rajulawalla A, Shi A, Wetzel A, Saito T, Saido TC, Harvey K, Ali AB.

Cereb Cortex. 2019 Apr 1;29(4):1834-1850. doi: 10.1093/cercor/bhz016.

20.

Correction: T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

Wang S, Yabuki Y, Matsuo K, Xu J, Izumi H, Sakimura K, Saito T, Saido TC, Fukunaga K.

PLoS One. 2019 Jan 25;14(1):e0211590. doi: 10.1371/journal.pone.0211590. eCollection 2019.

21.

T-type calcium channel enhancer SAK3 promotes dopamine and serotonin releases in the hippocampus in naive and amyloid precursor protein knock-in mice.

Wang S, Yabuki Y, Matsuo K, Xu J, Izumi H, Sakimura K, Saito T, Saido TC, Fukunaga K.

PLoS One. 2018 Dec 20;13(12):e0206986. doi: 10.1371/journal.pone.0206986. eCollection 2018. Erratum in: PLoS One. 2019 Jan 25;14(1):e0211590.

22.

Neuroinflammation in mouse models of Alzheimer's disease.

Saito T, Saido TC.

Clin Exp Neuroimmunol. 2018 Nov;9(4):211-218. doi: 10.1111/cen3.12475. Epub 2018 Sep 23. Review.

23.

New Insights of a Neuronal Peptidase DINE/ECEL1: Nerve Development, Nerve Regeneration and Neurogenic Pathogenesis.

Kiryu-Seo S, Nagata K, Saido TC, Kiyama H.

Neurochem Res. 2019 Jun;44(6):1279-1288. doi: 10.1007/s11064-018-2665-x. Epub 2018 Oct 24. Review.

PMID:
30357652
24.

Increased Insoluble Amyloid-β Induces Negligible Cognitive Deficits in Old AppNL/NL Knock-In Mice.

Salas IH, Callaerts-Vegh Z, D'Hooge R, Saido TC, Dotti CG, De Strooper B.

J Alzheimers Dis. 2018;66(2):801-809. doi: 10.3233/JAD-180410.

25.

Novel Quantitative Analyses of Spontaneous Synaptic Events in Cortical Pyramidal Cells Reveal Subtle Parvalbumin-Expressing Interneuron Dysfunction in a Knock-In Mouse Model of Alzheimer's Disease.

Chen L, Saito T, Saido TC, Mody I.

eNeuro. 2018 Aug 13;5(4). pii: ENEURO.0059-18.2018. doi: 10.1523/ENEURO.0059-18.2018. eCollection 2018 Jul-Aug.

26.

Looking beyond the standard version of the Morris water task in the assessment of mouse models of cognitive deficits.

Mehla J, Deibel SH, Faraji J, Saito T, Saido TC, Mohajerani MH, McDonald RJ.

Hippocampus. 2019 Jan;29(1):3-14. doi: 10.1002/hipo.22999. Epub 2018 Nov 11.

PMID:
30069957
27.

Cognitive and emotional alterations in App knock-in mouse models of Aβ amyloidosis.

Sakakibara Y, Sekiya M, Saito T, Saido TC, Iijima KM.

BMC Neurosci. 2018 Jul 28;19(1):46. doi: 10.1186/s12868-018-0446-8.

28.

Introduction of pathogenic mutations into the mouse Psen1 gene by Base Editor and Target-AID.

Sasaguri H, Nagata K, Sekiguchi M, Fujioka R, Matsuba Y, Hashimoto S, Sato K, Kurup D, Yokota T, Saido TC.

Nat Commun. 2018 Jul 24;9(1):2892. doi: 10.1038/s41467-018-05262-w.

29.

Generation of App knock-in mice reveals deletion mutations protective against Alzheimer's disease-like pathology.

Nagata K, Takahashi M, Matsuba Y, Okuyama-Uchimura F, Sato K, Hashimoto S, Saito T, Saido TC.

Nat Commun. 2018 May 4;9(1):1800. doi: 10.1038/s41467-018-04238-0.

30.

Critical review: involvement of endoplasmic reticulum stress in the aetiology of Alzheimer's disease.

Hashimoto S, Saido TC.

Open Biol. 2018 Apr;8(4). pii: 180024. doi: 10.1098/rsob.180024. Review.

31.

Targeting Alzheimer's disease with gene and cell therapies.

Loera-Valencia R, Piras A, Ismail MAM, Manchanda S, Eyjolfsdottir H, Saido TC, Johansson J, Eriksdotter M, Winblad B, Nilsson P.

J Intern Med. 2018 Jul;284(1):2-36. doi: 10.1111/joim.12759. Review.

PMID:
29582495
32.

The Disease-modifying Drug Candidate, SAK3 Improves Cognitive Impairment and Inhibits Amyloid beta Deposition in App Knock-in Mice.

Izumi H, Shinoda Y, Saito T, Saido TC, Sato K, Yabuki Y, Matsumoto Y, Kanemitsu Y, Tomioka Y, Abolhassani N, Nakabeppu Y, Fukunaga K.

Neuroscience. 2018 May 1;377:87-97. doi: 10.1016/j.neuroscience.2018.02.031. Epub 2018 Mar 3.

PMID:
29510211
33.

High fat diet treatment impairs hippocampal long-term potentiation without alterations of the core neuropathological features of Alzheimer disease.

Salas IH, Weerasekera A, Ahmed T, Callaerts-Vegh Z, Himmelreich U, D'Hooge R, Balschun D, Saido TC, De Strooper B, Dotti CG.

Neurobiol Dis. 2018 May;113:82-96. doi: 10.1016/j.nbd.2018.02.001. Epub 2018 Feb 7.

PMID:
29427755
34.

Correction for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival".

Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.

Mol Cell Biol. 2018 Jan 29;38(4). pii: e00614-17. doi: 10.1128/MCB.00614-17. Print 2018 Feb 15. No abstract available.

35.

DNA methylation level of the neprilysin promoter in Alzheimer's disease brains.

Nagata K, Mano T, Murayama S, Saido TC, Iwata A.

Neurosci Lett. 2018 Mar 23;670:8-13. doi: 10.1016/j.neulet.2018.01.003. Epub 2018 Jan 12.

PMID:
29339171
36.

Loss of kallikrein-related peptidase 7 exacerbates amyloid pathology in Alzheimer's disease model mice.

Kidana K, Tatebe T, Ito K, Hara N, Kakita A, Saito T, Takatori S, Ouchi Y, Ikeuchi T, Makino M, Saido TC, Akishita M, Iwatsubo T, Hori Y, Tomita T.

EMBO Mol Med. 2018 Mar;10(3). pii: e8184. doi: 10.15252/emmm.201708184.

37.

Endoplasmic reticulum stress responses in mouse models of Alzheimer's disease: Overexpression paradigm versus knockin paradigm.

Hashimoto S, Ishii A, Kamano N, Watamura N, Saito T, Ohshima T, Yokosuka M, Saido TC.

J Biol Chem. 2018 Mar 2;293(9):3118-3125. doi: 10.1074/jbc.M117.811315. Epub 2018 Jan 3.

38.

Reduced expression of Na+/Ca2+ exchangers is associated with cognitive deficits seen in Alzheimer's disease model mice.

Moriguchi S, Kita S, Fukaya M, Osanai M, Inagaki R, Sasaki Y, Izumi H, Horie K, Takeda J, Saito T, Sakagami H, Saido TC, Iwamoto T, Fukunaga K.

Neuropharmacology. 2018 Mar 15;131:291-303. doi: 10.1016/j.neuropharm.2017.12.037. Epub 2017 Dec 22.

PMID:
29274751
39.

Expression of Concern for Takano et al., "Vital Role of the Calpain-Calpastatin System for Placental-Integrity-Dependent Embryonic Survival".

Takano J, Mihira N, Fujioka R, Hosoki E, Chishti AH, Saido TC.

Mol Cell Biol. 2017 Nov 13;37(23). pii: e00530-17. doi: 10.1128/MCB.00530-17. Print 2017 Dec 1. No abstract available.

40.

Distinct functional consequences of ECEL1/DINE missense mutations in the pathogenesis of congenital contracture disorders.

Nagata K, Takahashi M, Kiryu-Seo S, Kiyama H, Saido TC.

Acta Neuropathol Commun. 2017 Nov 13;5(1):83. doi: 10.1186/s40478-017-0486-9.

41.

Istradefylline reduces memory deficits in aging mice with amyloid pathology.

Orr AG, Lo I, Schumacher H, Ho K, Gill M, Guo W, Kim DH, Knox A, Saito T, Saido TC, Simms J, Toddes C, Wang X, Yu GQ, Mucke L.

Neurobiol Dis. 2018 Feb;110:29-36. doi: 10.1016/j.nbd.2017.10.014. Epub 2017 Oct 31.

42.

Neuron-specific methylome analysis reveals epigenetic regulation and tau-related dysfunction of BRCA1 in Alzheimer's disease.

Mano T, Nagata K, Nonaka T, Tarutani A, Imamura T, Hashimoto T, Bannai T, Koshi-Mano K, Tsuchida T, Ohtomo R, Takahashi-Fujigasaki J, Yamashita S, Ohyagi Y, Yamasaki R, Tsuji S, Tamaoka A, Ikeuchi T, Saido TC, Iwatsubo T, Ushijima T, Murayama S, Hasegawa M, Iwata A.

Proc Natl Acad Sci U S A. 2017 Nov 7;114(45):E9645-E9654. doi: 10.1073/pnas.1707151114. Epub 2017 Oct 17.

43.

Reduction in open field activity in the absence of memory deficits in the AppNL-G-F knock-in mouse model of Alzheimer's disease.

Whyte LS, Hemsley KM, Lau AA, Hassiotis S, Saito T, Saido TC, Hopwood JJ, Sargeant TJ.

Behav Brain Res. 2018 Jan 15;336:177-181. doi: 10.1016/j.bbr.2017.09.006. Epub 2017 Sep 5.

PMID:
28887197
44.

Time-course global proteome analyses reveal an inverse correlation between Aβ burden and immunoglobulin M levels in the APPNL-F mouse model of Alzheimer disease.

Wang H, Williams D, Griffin J, Saito T, Saido TC, Fraser PE, Rogaeva E, Schmitt-Ulms G.

PLoS One. 2017 Aug 23;12(8):e0182844. doi: 10.1371/journal.pone.0182844. eCollection 2017.

45.

APP mouse models for Alzheimer's disease preclinical studies.

Sasaguri H, Nilsson P, Hashimoto S, Nagata K, Saito T, De Strooper B, Hardy J, Vassar R, Winblad B, Saido TC.

EMBO J. 2017 Sep 1;36(17):2473-2487. doi: 10.15252/embj.201797397. Epub 2017 Aug 1. Review.

46.

Alzheimer's-Causing Mutations Shift Aβ Length by Destabilizing γ-Secretase-Aβn Interactions.

Szaruga M, Munteanu B, Lismont S, Veugelen S, Horré K, Mercken M, Saido TC, Ryan NS, De Vos T, Savvides SN, Gallardo R, Schymkowitz J, Rousseau F, Fox NC, Hopf C, De Strooper B, Chávez-Gutiérrez L.

Cell. 2017 Jul 27;170(3):443-456.e14. doi: 10.1016/j.cell.2017.07.004.

47.

Impaired In Vivo Gamma Oscillations in the Medial Entorhinal Cortex of Knock-in Alzheimer Model.

Nakazono T, Lam TN, Patel AY, Kitazawa M, Saito T, Saido TC, Igarashi KM.

Front Syst Neurosci. 2017 Jun 30;11:48. doi: 10.3389/fnsys.2017.00048. eCollection 2017.

48.

PLD3 gene and processing of APP.

Fazzari P, Horre K, Arranz AM, Frigerio CS, Saito T, Saido TC, De Strooper B.

Nature. 2017 Jan 25;541(7638):E1-E2. doi: 10.1038/nature21030. No abstract available.

PMID:
28128235
49.

Calpain research for drug discovery: challenges and potential.

Ono Y, Saido TC, Sorimachi H.

Nat Rev Drug Discov. 2016 Dec;15(12):854-876. doi: 10.1038/nrd.2016.212. Epub 2016 Nov 11. Review.

PMID:
27833121
50.

Calpain Activation in Alzheimer's Model Mice Is an Artifact of APP and Presenilin Overexpression.

Saito T, Matsuba Y, Yamazaki N, Hashimoto S, Saido TC.

J Neurosci. 2016 Sep 21;36(38):9933-6. doi: 10.1523/JNEUROSCI.1907-16.2016.

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