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Items: 12

1.

Phase II clinical trial of adoptive cell therapy for patients with metastatic melanoma with autologous tumor-infiltrating lymphocytes and low-dose interleukin-2.

Nguyen LT, Saibil SD, Sotov V, Le MX, Khoja L, Ghazarian D, Bonilla L, Majeed H, Hogg D, Joshua AM, Crump M, Franke N, Spreafico A, Hansen A, Al-Habeeb A, Leong W, Easson A, Reedijk M, Goldstein DP, McCready D, Yasufuku K, Waddell T, Cypel M, Pierre A, Zhang B, Boross-Harmer S, Cipollone J, Nelles M, Scheid E, Fyrsta M, Lo CS, Nie J, Yam JY, Yen PH, Gray D, Motta V, Elford AR, DeLuca S, Wang L, Effendi S, Ellenchery R, Hirano N, Ohashi PS, Butler MO.

Cancer Immunol Immunother. 2019 Feb 11. doi: 10.1007/s00262-019-02307-x. [Epub ahead of print]

PMID:
30747243
2.

Activation of Peroxisome Proliferator-Activated Receptors α and δ Synergizes with Inflammatory Signals to Enhance Adoptive Cell Therapy.

Saibil SD, St Paul M, Laister RC, Garcia-Batres CR, Israni-Winger K, Elford AR, Grimshaw N, Robert-Tissot C, Roy DG, Jones RG, Nguyen LT, Ohashi PS.

Cancer Res. 2019 Feb 1;79(3):445-451. doi: 10.1158/0008-5472.CAN-17-3053. Epub 2018 Dec 20.

PMID:
30573521
3.

Glycogen Synthase Kinase-3 Modulates Cbl-b and Constrains T Cell Activation.

Tran CW, Saibil SD, Le Bihan T, Hamilton SR, Lang KS, You H, Lin AE, Garza KM, Elford AR, Tai K, Parsons ME, Wigmore K, Vainberg MG, Penninger JM, Woodgett JR, Mak TW, Ohashi PS.

J Immunol. 2017 Dec 15;199(12):4056-4065. doi: 10.4049/jimmunol.1600396. Epub 2017 Nov 6.

4.

ARIH2 is essential for embryogenesis, and its hematopoietic deficiency causes lethal activation of the immune system.

Lin AE, Ebert G, Ow Y, Preston SP, Toe JG, Cooney JP, Scott HW, Sasaki M, Saibil SD, Dissanayake D, Kim RH, Wakeham A, You-Ten A, Shahinian A, Duncan G, Silvester J, Ohashi PS, Mak TW, Pellegrini M.

Nat Immunol. 2013 Jan;14(1):27-33. doi: 10.1038/ni.2478. Epub 2012 Nov 25.

PMID:
23179078
5.

c-Rel phenocopies PKCtheta but not Bcl-10 in regulating CD8+ T-cell activation versus tolerance.

Deenick EK, Po L, Chapatte L, Murakami K, Lu YC, Elford AR, Saibil SD, Ruland J, Gerondakis S, Mak TW, Ohashi PS.

Eur J Immunol. 2010 Mar;40(3):867-77. doi: 10.1002/eji.200939445.

6.

DNA damage- and stress-induced apoptosis occurs independently of PIDD.

Kim IR, Murakami K, Chen NJ, Saibil SD, Matysiak-Zablocki E, Elford AR, Bonnard M, Benchimol S, Jurisicova A, Yeh WC, Ohashi PS.

Apoptosis. 2009 Sep;14(9):1039-49. doi: 10.1007/s10495-009-0375-1.

PMID:
19575295
7.

RIP2 contributes to Nod signaling but is not essential for T cell proliferation, T helper differentiation or TLR responses.

Hall HT, Wilhelm MT, Saibil SD, Mak TW, Flavell RA, Ohashi PS.

Eur J Immunol. 2008 Jan;38(1):64-72.

8.

The sound of silence: modulating anergy in T lymphocytes.

Saibil SD, Deenick EK, Ohashi PS.

Curr Opin Immunol. 2007 Dec;19(6):658-64. Epub 2007 Oct 18. Review.

PMID:
17949964
9.

CD4+ and CD8+ T cell survival is regulated differentially by protein kinase Ctheta, c-Rel, and protein kinase B.

Saibil SD, Jones RG, Deenick EK, Liadis N, Elford AR, Vainberg MG, Baerg H, Woodgett JR, Gerondakis S, Ohashi PS.

J Immunol. 2007 Mar 1;178(5):2932-9.

10.

NF-kappaB couples protein kinase B/Akt signaling to distinct survival pathways and the regulation of lymphocyte homeostasis in vivo.

Jones RG, Saibil SD, Pun JM, Elford AR, Bonnard M, Pellegrini M, Arya S, Parsons ME, Krawczyk CM, Gerondakis S, Yeh WC, Woodgett JR, Boothby MR, Ohashi PS.

J Immunol. 2005 Sep 15;175(6):3790-9.

11.

Weak agonist self-peptides promote selection and tuning of virus-specific T cells.

Saibil SD, Ohteki T, White FM, Luscher M, Zakarian A, Elford A, Shabanowitz J, Nishina H, Hugo P, Penninger J, Barber B, Hunt DF, Ohashi PS.

Eur J Immunol. 2003 Mar;33(3):685-96.

12.

Marked induction of the IAP family antiapoptotic proteins survivin and XIAP by VEGF in vascular endothelial cells.

Tran J, Rak J, Sheehan C, Saibil SD, LaCasse E, Korneluk RG, Kerbel RS.

Biochem Biophys Res Commun. 1999 Nov 2;264(3):781-8.

PMID:
10544009

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