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Items: 1 to 50 of 126

1.

Two-Step Activation Mechanism of the ClpB Disaggregase for Sequential Substrate Threading by the Main ATPase Motor.

Deville C, Franke K, Mogk A, Bukau B, Saibil HR.

Cell Rep. 2019 Jun 18;27(12):3433-3446.e4. doi: 10.1016/j.celrep.2019.05.075.

2.

Cryo-EM of amyloid fibrils and cellular aggregates.

Fitzpatrick AW, Saibil HR.

Curr Opin Struct Biol. 2019 Oct;58:34-42. doi: 10.1016/j.sbi.2019.05.003. Epub 2019 Jun 12. Review.

3.

Structural features distinguishing infectious ex vivo mammalian prions from non-infectious fibrillar assemblies generated in vitro.

Terry C, Harniman RL, Sells J, Wenborn A, Joiner S, Saibil HR, Miles MJ, Collinge J, Wadsworth JDF.

Sci Rep. 2019 Jan 23;9(1):376. doi: 10.1038/s41598-018-36700-w.

4.

A two-domain folding intermediate of RuBisCO in complex with the GroEL chaperonin.

Natesh R, Clare DK, Farr GW, Horwich AL, Saibil HR.

Int J Biol Macromol. 2018 Oct 15;118(Pt A):671-675. doi: 10.1016/j.ijbiomac.2018.06.120. Epub 2018 Jun 27.

5.

A Liquid to Solid Phase Transition Underlying Pathological Huntingtin Exon1 Aggregation.

Peskett TR, Rau F, O'Driscoll J, Patani R, Lowe AR, Saibil HR.

Mol Cell. 2018 May 17;70(4):588-601.e6. doi: 10.1016/j.molcel.2018.04.007. Epub 2018 May 10.

6.

Publisher Correction: A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):523. doi: 10.1038/s41564-018-0134-6.

PMID:
29511275
7.

A protease cascade regulates release of the human malaria parasite Plasmodium falciparum from host red blood cells.

Thomas JA, Tan MSY, Bisson C, Borg A, Umrekar TR, Hackett F, Hale VL, Vizcay-Barrena G, Fleck RA, Snijders AP, Saibil HR, Blackman MJ.

Nat Microbiol. 2018 Apr;3(4):447-455. doi: 10.1038/s41564-018-0111-0. Epub 2018 Feb 19. Erratum in: Nat Microbiol. 2018 Mar 6;:.

8.

Blob-ology and biology of cryo-EM: an interview with Helen Saibil.

Saibil HR.

BMC Biol. 2017 Aug 31;15(1):77. doi: 10.1186/s12915-017-0417-z.

9.

Structural pathway of regulated substrate transfer and threading through an Hsp100 disaggregase.

Deville C, Carroni M, Franke KB, Topf M, Bukau B, Mogk A, Saibil HR.

Sci Adv. 2017 Aug 4;3(8):e1701726. doi: 10.1126/sciadv.1701726. eCollection 2017 Aug.

10.

Building bridges between cellular and molecular structural biology.

Patwardhan A, Brandt R, Butcher SJ, Collinson L, Gault D, Grünewald K, Hecksel C, Huiskonen JT, Iudin A, Jones ML, Korir PK, Koster AJ, Lagerstedt I, Lawson CL, Mastronarde D, McCormick M, Parkinson H, Rosenthal PB, Saalfeld S, Saibil HR, Sarntivijai S, Solanes Valero I, Subramaniam S, Swedlow JR, Tudose I, Winn M, Kleywegt GJ.

Elife. 2017 Jul 6;6. pii: e25835. doi: 10.7554/eLife.25835.

11.

Electron Bio-Imaging Centre (eBIC): the UK national research facility for biological electron microscopy.

Clare DK, Siebert CA, Hecksel C, Hagen C, Mordhorst V, Grange M, Ashton AW, Walsh MA, Grünewald K, Saibil HR, Stuart DI, Zhang P.

Acta Crystallogr D Struct Biol. 2017 Jun 1;73(Pt 6):488-495. doi: 10.1107/S2059798317007756. Epub 2017 May 31.

12.

Parasitophorous vacuole poration precedes its rupture and rapid host erythrocyte cytoskeleton collapse in Plasmodium falciparum egress.

Hale VL, Watermeyer JM, Hackett F, Vizcay-Barrena G, van Ooij C, Thomas JA, Spink MC, Harkiolaki M, Duke E, Fleck RA, Blackman MJ, Saibil HR.

Proc Natl Acad Sci U S A. 2017 Mar 28;114(13):3439-3444. doi: 10.1073/pnas.1619441114. Epub 2017 Mar 14.

13.

Real-time visualization of perforin nanopore assembly.

Leung C, Hodel AW, Brennan AJ, Lukoyanova N, Tran S, House CM, Kondos SC, Whisstock JC, Dunstone MA, Trapani JA, Voskoboinik I, Saibil HR, Hoogenboom BW.

Nat Nanotechnol. 2017 May;12(5):467-473. doi: 10.1038/nnano.2016.303. Epub 2017 Feb 6.

PMID:
28166206
14.

Ex vivo mammalian prions are formed of paired double helical prion protein fibrils.

Terry C, Wenborn A, Gros N, Sells J, Joiner S, Hosszu LL, Tattum MH, Panico S, Clare DK, Collinge J, Saibil HR, Wadsworth JD.

Open Biol. 2016 May;6(5). pii: 160035. doi: 10.1098/rsob.160035. Epub 2016 May 4.

15.

The membrane attack complex, perforin and cholesterol-dependent cytolysin superfamily of pore-forming proteins.

Lukoyanova N, Hoogenboom BW, Saibil HR.

J Cell Sci. 2016 Jun 1;129(11):2125-33. doi: 10.1242/jcs.182741. Epub 2016 May 13. Review.

16.

Atomic force microscopy of membrane pore formation by cholesterol dependent cytolysins.

Hodel AW, Leung C, Dudkina NV, Saibil HR, Hoogenboom BW.

Curr Opin Struct Biol. 2016 Aug;39:8-15. doi: 10.1016/j.sbi.2016.03.005. Epub 2016 Apr 7. Review. No abstract available.

PMID:
27062575
17.

Structure of the poly-C9 component of the complement membrane attack complex.

Dudkina NV, Spicer BA, Reboul CF, Conroy PJ, Lukoyanova N, Elmlund H, Law RH, Ekkel SM, Kondos SC, Goode RJ, Ramm G, Whisstock JC, Saibil HR, Dunstone MA.

Nat Commun. 2016 Feb 4;7:10588. doi: 10.1038/ncomms10588.

18.

Structure of a bacterial type III secretion system in contact with a host membrane in situ.

Nans A, Kudryashev M, Saibil HR, Hayward RD.

Nat Commun. 2015 Dec 11;6:10114. doi: 10.1038/ncomms10114.

19.

Cryo electron microscopy to determine the structure of macromolecular complexes.

Carroni M, Saibil HR.

Methods. 2016 Feb 15;95:78-85. doi: 10.1016/j.ymeth.2015.11.023. Epub 2015 Nov 27. Review.

20.

A spiral scaffold underlies cytoadherent knobs in Plasmodium falciparum-infected erythrocytes.

Watermeyer JM, Hale VL, Hackett F, Clare DK, Cutts EE, Vakonakis I, Fleck RA, Blackman MJ, Saibil HR.

Blood. 2016 Jan 21;127(3):343-51. doi: 10.1182/blood-2015-10-674002. Epub 2015 Dec 4.

21.

Processing of Plasmodium falciparum Merozoite Surface Protein MSP1 Activates a Spectrin-Binding Function Enabling Parasite Egress from RBCs.

Das S, Hertrich N, Perrin AJ, Withers-Martinez C, Collins CR, Jones ML, Watermeyer JM, Fobes ET, Martin SR, Saibil HR, Wright GJ, Treeck M, Epp C, Blackman MJ.

Cell Host Microbe. 2015 Oct 14;18(4):433-44. doi: 10.1016/j.chom.2015.09.007.

22.

Human Hsp70 Disaggregase Reverses Parkinson's-Linked α-Synuclein Amyloid Fibrils.

Gao X, Carroni M, Nussbaum-Krammer C, Mogk A, Nillegoda NB, Szlachcic A, Guilbride DL, Saibil HR, Mayer MP, Bukau B.

Mol Cell. 2015 Sep 3;59(5):781-93. doi: 10.1016/j.molcel.2015.07.012. Epub 2015 Aug 20.

23.

A novel and rapid method for obtaining high titre intact prion strains from mammalian brain.

Wenborn A, Terry C, Gros N, Joiner S, D'Castro L, Panico S, Sells J, Cronier S, Linehan JM, Brandner S, Saibil HR, Collinge J, Wadsworth JD.

Sci Rep. 2015 May 7;5:10062. doi: 10.1038/srep10062.

24.

Conformational changes during pore formation by the perforin-related protein pleurotolysin.

Lukoyanova N, Kondos SC, Farabella I, Law RH, Reboul CF, Caradoc-Davies TT, Spicer BA, Kleifeld O, Traore DA, Ekkel SM, Voskoboinik I, Trapani JA, Hatfaludi T, Oliver K, Hotze EM, Tweten RK, Whisstock JC, Topf M, Saibil HR, Dunstone MA.

PLoS Biol. 2015 Feb 5;13(2):e1002049. doi: 10.1371/journal.pbio.1002049. eCollection 2015 Feb.

25.

A national facility for biological cryo-electron microscopy.

Saibil HR, Grünewald K, Stuart DI.

Acta Crystallogr D Biol Crystallogr. 2015 Jan 1;71(Pt 1):127-35. doi: 10.1107/S1399004714025280. Epub 2015 Jan 1.

26.

Making connections: snapshots of chlamydial type III secretion systems in contact with host membranes.

Dumoux M, Nans A, Saibil HR, Hayward RD.

Curr Opin Microbiol. 2015 Feb;23:1-7. doi: 10.1016/j.mib.2014.09.019. Epub 2014 Oct 24. Review.

PMID:
25461566
27.

Stepwise visualization of membrane pore formation by suilysin, a bacterial cholesterol-dependent cytolysin.

Leung C, Dudkina NV, Lukoyanova N, Hodel AW, Farabella I, Pandurangan AP, Jahan N, Pires Damaso M, Osmanović D, Reboul CF, Dunstone MA, Andrew PW, Lonnen R, Topf M, Saibil HR, Hoogenboom BW.

Elife. 2014 Dec 2;3:e04247. doi: 10.7554/eLife.04247. Erratum in: Elife. 2014;4:e06740.

28.

A 3D cellular context for the macromolecular world.

Patwardhan A, Ashton A, Brandt R, Butcher S, Carzaniga R, Chiu W, Collinson L, Doux P, Duke E, Ellisman MH, Franken E, Grünewald K, Heriche JK, Koster A, Kühlbrandt W, Lagerstedt I, Larabell C, Lawson CL, Saibil HR, Sanz-García E, Subramaniam S, Verkade P, Swedlow JR, Kleywegt GJ.

Nat Struct Mol Biol. 2014 Oct;21(10):841-5. doi: 10.1038/nsmb.2897. No abstract available.

29.

N-terminal domain of prion protein directs its oligomeric association.

Trevitt CR, Hosszu LL, Batchelor M, Panico S, Terry C, Nicoll AJ, Risse E, Taylor WA, Sandberg MK, Al-Doujaily H, Linehan JM, Saibil HR, Scott DJ, Collinge J, Waltho JP, Clarke AR.

J Biol Chem. 2014 Sep 12;289(37):25497-508. doi: 10.1074/jbc.M114.566588. Epub 2014 Jul 29.

30.

Head-to-tail interactions of the coiled-coil domains regulate ClpB activity and cooperation with Hsp70 in protein disaggregation.

Carroni M, Kummer E, Oguchi Y, Wendler P, Clare DK, Sinning I, Kopp J, Mogk A, Bukau B, Saibil HR.

Elife. 2014 Apr 30;3:e02481. doi: 10.7554/eLife.02481.

31.

Pathogen-host reorganization during Chlamydia invasion revealed by cryo-electron tomography.

Nans A, Saibil HR, Hayward RD.

Cell Microbiol. 2014 Oct;16(10):1457-72. doi: 10.1111/cmi.12310. Epub 2014 Jun 3.

32.

Amyloid-β nanotubes are associated with prion protein-dependent synaptotoxicity.

Nicoll AJ, Panico S, Freir DB, Wright D, Terry C, Risse E, Herron CE, O'Malley T, Wadsworth JD, Farrow MA, Walsh DM, Saibil HR, Collinge J.

Nat Commun. 2013;4:2416. doi: 10.1038/ncomms3416.

33.

ATP-driven molecular chaperone machines.

Clare DK, Saibil HR.

Biopolymers. 2013 Nov;99(11):846-59. doi: 10.1002/bip.22361. Review.

34.

Intrinsically disordered protein threads through the bacterial outer-membrane porin OmpF.

Housden NG, Hopper JT, Lukoyanova N, Rodriguez-Larrea D, Wojdyla JA, Klein A, Kaminska R, Bayley H, Saibil HR, Robinson CV, Kleanthous C.

Science. 2013 Jun 28;340(6140):1570-4. doi: 10.1126/science.1237864.

35.

Atomic structure and hierarchical assembly of a cross-β amyloid fibril.

Fitzpatrick AW, Debelouchina GT, Bayro MJ, Clare DK, Caporini MA, Bajaj VS, Jaroniec CP, Wang L, Ladizhansky V, Müller SA, MacPhee CE, Waudby CA, Mott HR, De Simone A, Knowles TP, Saibil HR, Vendruscolo M, Orlova EV, Griffin RG, Dobson CM.

Proc Natl Acad Sci U S A. 2013 Apr 2;110(14):5468-73. doi: 10.1073/pnas.1219476110. Epub 2013 Mar 19.

36.

Biochemistry. Machinery to reverse irreversible aggregates.

Saibil HR.

Science. 2013 Mar 1;339(6123):1040-1. doi: 10.1126/science.1236012. No abstract available.

PMID:
23449583
37.

Perforin forms transient pores on the target cell plasma membrane to facilitate rapid access of granzymes during killer cell attack.

Lopez JA, Susanto O, Jenkins MR, Lukoyanova N, Sutton VR, Law RH, Johnston A, Bird CH, Bird PI, Whisstock JC, Trapani JA, Saibil HR, Voskoboinik I.

Blood. 2013 Apr 4;121(14):2659-68. doi: 10.1182/blood-2012-07-446146. Epub 2013 Feb 1.

PMID:
23377437
38.

Direct three-dimensional visualization of membrane disruption by amyloid fibrils.

Milanesi L, Sheynis T, Xue WF, Orlova EV, Hellewell AL, Jelinek R, Hewitt EW, Radford SE, Saibil HR.

Proc Natl Acad Sci U S A. 2012 Dec 11;109(50):20455-60. doi: 10.1073/pnas.1206325109. Epub 2012 Nov 26.

39.

Structure and allostery of the chaperonin GroEL.

Saibil HR, Fenton WA, Clare DK, Horwich AL.

J Mol Biol. 2013 May 13;425(9):1476-87. doi: 10.1016/j.jmb.2012.11.028. Epub 2012 Nov 24. Review.

PMID:
23183375
40.

Heritable yeast prions have a highly organized three-dimensional architecture with interfiber structures.

Saibil HR, Seybert A, Habermann A, Winkler J, Eltsov M, Perkovic M, Castaño-Diez D, Scheffer MP, Haselmann U, Chlanda P, Lindquist S, Tyedmers J, Frangakis AS.

Proc Natl Acad Sci U S A. 2012 Sep 11;109(37):14906-11. doi: 10.1073/pnas.1211976109. Epub 2012 Aug 27.

41.

Chlamydiae assemble a pathogen synapse to hijack the host endoplasmic reticulum.

Dumoux M, Clare DK, Saibil HR, Hayward RD.

Traffic. 2012 Dec;13(12):1612-27. doi: 10.1111/tra.12002. Epub 2012 Sep 11.

42.

Go hybrid: EM, crystallography, and beyond.

Lander GC, Saibil HR, Nogales E.

Curr Opin Struct Biol. 2012 Oct;22(5):627-35. doi: 10.1016/j.sbi.2012.07.006. Epub 2012 Jul 24. Review.

43.

ATP-triggered conformational changes delineate substrate-binding and -folding mechanics of the GroEL chaperonin.

Clare DK, Vasishtan D, Stagg S, Quispe J, Farr GW, Topf M, Horwich AL, Saibil HR.

Cell. 2012 Mar 30;149(1):113-23. doi: 10.1016/j.cell.2012.02.047. Epub 2012 Mar 22.

44.

Newly folded substrates inside the molecular cage of the HtrA chaperone DegQ.

Malet H, Canellas F, Sawa J, Yan J, Thalassinos K, Ehrmann M, Clausen T, Saibil HR.

Nat Struct Mol Biol. 2012 Jan 15;19(2):152-7. doi: 10.1038/nsmb.2210.

45.

Structural analysis of macromolecular assemblies by electron microscopy.

Orlova EV, Saibil HR.

Chem Rev. 2011 Dec 14;111(12):7710-48. doi: 10.1021/cr100353t. Epub 2011 Sep 16. Review. No abstract available.

46.

Interaction between prion protein and toxic amyloid β assemblies can be therapeutically targeted at multiple sites.

Freir DB, Nicoll AJ, Klyubin I, Panico S, Mc Donald JM, Risse E, Asante EA, Farrow MA, Sessions RB, Saibil HR, Clarke AR, Rowan MJ, Walsh DM, Collinge J.

Nat Commun. 2011 Jun 7;2:336. doi: 10.1038/ncomms1341.

47.

RNA channelling by the eukaryotic exosome.

Malet H, Topf M, Clare DK, Ebert J, Bonneau F, Basquin J, Drazkowska K, Tomecki R, Dziembowski A, Conti E, Saibil HR, Lorentzen E.

EMBO Rep. 2010 Dec;11(12):936-42. doi: 10.1038/embor.2010.164. Epub 2010 Nov 12.

48.

The structural basis for membrane binding and pore formation by lymphocyte perforin.

Law RH, Lukoyanova N, Voskoboinik I, Caradoc-Davies TT, Baran K, Dunstone MA, D'Angelo ME, Orlova EV, Coulibaly F, Verschoor S, Browne KA, Ciccone A, Kuiper MJ, Bird PI, Trapani JA, Saibil HR, Whisstock JC.

Nature. 2010 Nov 18;468(7322):447-51. doi: 10.1038/nature09518. Epub 2010 Oct 31.

PMID:
21037563
49.

Methods for three-dimensional reconstruction of heterogeneous assemblies.

Orlova EV, Saibil HR.

Methods Enzymol. 2010;482:321-41. doi: 10.1016/S0076-6879(10)82013-0.

PMID:
20888967
50.

Visualization of macromolecular structures.

O'Donoghue SI, Goodsell DS, Frangakis AS, Jossinet F, Laskowski RA, Nilges M, Saibil HR, Schafferhans A, Wade RC, Westhof E, Olson AJ.

Nat Methods. 2010 Mar;7(3 Suppl):S42-55. doi: 10.1038/nmeth.1427. Epub 2010 Mar 1. Review.

PMID:
20195256

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