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Inorganic polyphosphate in mammals: where's Wally?

Desfougères Y, Saiardi A, Azevedo C.

Biochem Soc Trans. 2020 Feb 12. pii: BST20190328. doi: 10.1042/BST20190328. [Epub ahead of print]


Cellular IP6 Levels Limit HIV Production while Viruses that Cannot Efficiently Package IP6 Are Attenuated for Infection and Replication.

Mallery DL, Faysal KMR, Kleinpeter A, Wilson MSC, Vaysburd M, Fletcher AJ, Novikova M, Böcking T, Freed EO, Saiardi A, James LC.

Cell Rep. 2019 Dec 17;29(12):3983-3996.e4. doi: 10.1016/j.celrep.2019.11.050.


Development of a yeast model to study the contribution of vacuolar polyphosphate metabolism to lysine polyphosphorylation.

Azevedo C, Desfougères Y, Jiramongkol Y, Partington H, Trakansuebkul S, Singh J, Steck N, Jessen HJ, Saiardi A.

J Biol Chem. 2020 Feb 7;295(6):1439-1451. doi: 10.1074/jbc.RA119.011680. Epub 2019 Dec 16.


Dictyostelium discoideum as a Model to Study Inositol Polyphosphates and Inorganic Polyphosphate.

Desfougères Y, Saiardi A.

Methods Mol Biol. 2020;2091:59-71. doi: 10.1007/978-1-0716-0167-9_5.


ITPK1 mediates the lipid-independent synthesis of inositol phosphates controlled by metabolism.

Desfougères Y, Wilson MSC, Laha D, Miller GJ, Saiardi A.

Proc Natl Acad Sci U S A. 2019 Dec 3;116(49):24551-24561. doi: 10.1073/pnas.1911431116. Epub 2019 Nov 21.


Arabidopsis ITPK1 and ITPK2 Have an Evolutionarily Conserved Phytic Acid Kinase Activity.

Laha D, Parvin N, Hofer A, Giehl RFH, Fernandez-Rebollo N, von Wirén N, Saiardi A, Jessen HJ, Schaaf G.

ACS Chem Biol. 2019 Oct 18;14(10):2127-2133. doi: 10.1021/acschembio.9b00423. Epub 2019 Sep 24.


Fungal Kinases With a Sweet Tooth: Pleiotropic Roles of Their Phosphorylated Inositol Sugar Products in the Pathogenicity of Cryptococcus neoformans Present Novel Drug Targeting Opportunities.

Lev S, Li C, Desmarini D, Sorrell TC, Saiardi A, Djordjevic JT.

Front Cell Infect Microbiol. 2019 Jul 15;9:248. doi: 10.3389/fcimb.2019.00248. eCollection 2019. Review.


Harnessing 13C-labeled myo-inositol to interrogate inositol phosphate messengers by NMR.

Harmel RK, Puschmann R, Nguyen Trung M, Saiardi A, Schmieder P, Fiedler D.

Chem Sci. 2019 Apr 23;10(20):5267-5274. doi: 10.1039/c9sc00151d. eCollection 2019 May 28.


The inositol hexakisphosphate kinases IP6K1 and -2 regulate human cellular phosphate homeostasis, including XPR1-mediated phosphate export.

Wilson MS, Jessen HJ, Saiardi A.

J Biol Chem. 2019 Jul 26;294(30):11597-11608. doi: 10.1074/jbc.RA119.007848. Epub 2019 Jun 11.


FEDRO: a software tool for the automatic discovery of candidate ORFs in plants with c →u RNA editing.

Fassetti F, Giallombardo C, Leone O, Palopoli L, Rombo SE, Saiardi A.

BMC Bioinformatics. 2019 Apr 18;20(Suppl 4):124. doi: 10.1186/s12859-019-2696-6.


Inositol Polyphosphate Multikinase (IPMK), a Gene Coding for a Potential Moonlighting Protein, Contributes to Human Female Longevity.

De Rango F, Crocco P, Iannone F, Saiardi A, Passarino G, Dato S, Rose G.

Genes (Basel). 2019 Feb 8;10(2). pii: E125. doi: 10.3390/genes10020125.


Crosstalk between Ras and inositol phosphate signaling revealed by lithium action on inositol monophosphatase in Schizophyllum commune.

Murry R, Kniemeyer O, Krause K, Saiardi A, Kothe E.

Adv Biol Regul. 2019 May;72:78-88. doi: 10.1016/j.jbior.2019.01.001. Epub 2019 Jan 3.


Hydrophilic interaction liquid chromatography-tandem mass spectrometry for the quantitative analysis of mammalian-derived inositol poly/pyrophosphates.

Ito M, Fujii N, Wittwer C, Sasaki A, Tanaka M, Bittner T, Jessen HJ, Saiardi A, Takizawa S, Nagata E.

J Chromatogr A. 2018 Oct 26;1573:87-97. doi: 10.1016/j.chroma.2018.08.061. Epub 2018 Aug 31.


Rab4A organizes endosomal domains for sorting cargo to lysosome-related organelles.

Nag S, Rani S, Mahanty S, Bissig C, Arora P, Azevedo C, Saiardi A, van der Sluijs P, Delevoye C, van Niel G, Raposo G, Setty SRG.

J Cell Sci. 2018 Sep 20;131(18). pii: jcs216226. doi: 10.1242/jcs.216226.


Inositol Phosphates Purification Using Titanium Dioxide Beads.

Wilson MS, Saiardi A.

Bio Protoc. 2018 Aug 5;8(15). pii: e2959. doi: 10.21769/BioProtoc.2959.


Screening a Protein Array with Synthetic Biotinylated Inorganic Polyphosphate To Define the Human PolyP-ome.

Azevedo C, Singh J, Steck N, Hofer A, Ruiz FA, Singh T, Jessen HJ, Saiardi A.

ACS Chem Biol. 2018 Aug 17;13(8):1958-1963. doi: 10.1021/acschembio.8b00357. Epub 2018 Jul 8.


IP6 is an HIV pocket factor that prevents capsid collapse and promotes DNA synthesis.

Mallery DL, Márquez CL, McEwan WA, Dickson CF, Jacques DA, Anandapadamanaban M, Bichel K, Towers GJ, Saiardi A, Böcking T, James LC.

Elife. 2018 May 31;7. pii: e35335. doi: 10.7554/eLife.35335.


Asp1 Bifunctional Activity Modulates Spindle Function via Controlling Cellular Inositol Pyrophosphate Levels in Schizosaccharomyces pombe.

Pascual-Ortiz M, Saiardi A, Walla E, Jakopec V, Künzel NA, Span I, Vangala A, Fleig U.

Mol Cell Biol. 2018 Apr 16;38(9). pii: e00047-18. doi: 10.1128/MCB.00047-18. Print 2018 May 1.


IP3-4 kinase Arg1 regulates cell wall homeostasis and surface architecture to promote clearance of Cryptococcus neoformans infection in a mouse model.

Li C, Lev S, Desmarini D, Kaufman-Francis K, Saiardi A, Silva APG, Mackay JP, Thompson PE, Sorrell TC, Djordjevic JT.

Virulence. 2017 Nov 17;8(8):1833-1848. doi: 10.1080/21505594.2017.1385692. Epub 2017 Dec 8.


Microbial inositol polyphosphate metabolic pathway as drug development target.

Saiardi A, Azevedo C, Desfougères Y, Portela-Torres P, Wilson MSC.

Adv Biol Regul. 2018 Jan;67:74-83. doi: 10.1016/j.jbior.2017.09.007. Epub 2017 Sep 22. Review.


The inositol pyrophosphate synthesis pathway in Trypanosoma brucei is linked to polyphosphate synthesis in acidocalcisomes.

Cordeiro CD, Saiardi A, Docampo R.

Mol Microbiol. 2017 Oct;106(2):319-333. doi: 10.1111/mmi.13766. Epub 2017 Aug 22.


Has Inositol Played Any Role in the Origin of Life?

Saiardi A.

Life (Basel). 2017 Jun 5;7(2). pii: E24. doi: 10.3390/life7020024.


Importance of Radioactive Labelling to Elucidate Inositol Polyphosphate Signalling.

Wilson MSC, Saiardi A.

Top Curr Chem (Cham). 2017 Feb;375(1):14. doi: 10.1007/s41061-016-0099-y. Epub 2017 Jan 18. Review.


Eukaryotic Phosphate Homeostasis: The Inositol Pyrophosphate Perspective.

Azevedo C, Saiardi A.

Trends Biochem Sci. 2017 Mar;42(3):219-231. doi: 10.1016/j.tibs.2016.10.008. Epub 2016 Nov 19. Review.


Protein pyrophosphorylation: moving forward.

Saiardi A.

Biochem J. 2016 Nov 1;473(21):3765-3768.


Inositol Pyrophosphate Profiling of Two HCT116 Cell Lines Uncovers Variation in InsP8 Levels.

Gu C, Wilson MS, Jessen HJ, Saiardi A, Shears SB.

PLoS One. 2016 Oct 27;11(10):e0165286. doi: 10.1371/journal.pone.0165286. eCollection 2016.


Inositol Polyphosphate Kinases, Fungal Virulence and Drug Discovery.

Li C, Lev S, Saiardi A, Desmarini D, Sorrell TC, Djordjevic JT.

J Fungi (Basel). 2016 Sep 6;2(3). pii: E24. doi: 10.3390/jof2030024. Review.


Correction: The new world of inorganic polyphosphates.

Azevedo C, Saiardi A.

Biochem Soc Trans. 2016 Aug 15;44(4):1183. doi: 10.1042/BST0441183a. No abstract available.


Contribution of polymorphic variation of inositol hexakisphosphate kinase 3 (IP6K3) gene promoter to the susceptibility to late onset Alzheimer's disease.

Crocco P, Saiardi A, Wilson MS, Maletta R, Bruni AC, Passarino G, Rose G.

Biochim Biophys Acta. 2016 Sep;1862(9):1766-73. doi: 10.1016/j.bbadis.2016.06.014. Epub 2016 Jun 21.


Control of eukaryotic phosphate homeostasis by inositol polyphosphate sensor domains.

Wild R, Gerasimaite R, Jung JY, Truffault V, Pavlovic I, Schmidt A, Saiardi A, Jessen HJ, Poirier Y, Hothorn M, Mayer A.

Science. 2016 May 20;352(6288):986-90. doi: 10.1126/science.aad9858. Epub 2016 Apr 14.


Identification of a major IP5 kinase in Cryptococcus neoformans confirms that PP-IP5/IP7, not IP6, is essential for virulence.

Li C, Lev S, Saiardi A, Desmarini D, Sorrell TC, Djordjevic JT.

Sci Rep. 2016 Apr 1;6:23927. doi: 10.1038/srep23927.


Phosphate, inositol and polyphosphates.

Livermore TM, Azevedo C, Kolozsvari B, Wilson MS, Saiardi A.

Biochem Soc Trans. 2016 Feb;44(1):253-9. doi: 10.1042/BST20150215. Review.


The new world of inorganic polyphosphates.

Azevedo C, Saiardi A.

Biochem Soc Trans. 2016 Feb;44(1):13-7. doi: 10.1042/BST20150210. Review. Erratum in: Biochem Soc Trans. 2016 Aug 15;44(4):1183.


Developmental accumulation of inorganic polyphosphate affects germination and energetic metabolism in Dictyostelium discoideum.

Livermore TM, Chubb JR, Saiardi A.

Proc Natl Acad Sci U S A. 2016 Jan 26;113(4):996-1001. doi: 10.1073/pnas.1519440113. Epub 2016 Jan 11.


There is no 'Conundrum' of InsP6.

Irvine RF, Bulley SJ, Wilson MS, Saiardi A.

Open Biol. 2015 Nov;5(11). pii: 150181. doi: 10.1098/rsob.150181.


Why always lysine? The ongoing tale of one of the most modified amino acids.

Azevedo C, Saiardi A.

Adv Biol Regul. 2016 Jan;60:144-150. doi: 10.1016/j.jbior.2015.09.008. Epub 2015 Oct 16. Review.


Quantitative imaging of inositol distribution in yeast using multi-isotope imaging mass spectrometry (MIMS).

Saiardi A, Guillermier C, Loss O, Poczatek JC, Lechene C.

Surf Interface Anal. 2014 Nov 1;46(Suppl 1):169-172.


Fungal Inositol Pyrophosphate IP7 Is Crucial for Metabolic Adaptation to the Host Environment and Pathogenicity.

Lev S, Li C, Desmarini D, Saiardi A, Fewings NL, Schibeci SD, Sharma R, Sorrell TC, Djordjevic JT.

mBio. 2015 Jun 2;6(3):e00531-15. doi: 10.1128/mBio.00531-15.


Prometabolites of 5-Diphospho-myo-inositol Pentakisphosphate.

Pavlovic I, Thakor DT, Bigler L, Wilson MS, Laha D, Schaaf G, Saiardi A, Jessen HJ.

Angew Chem Int Ed Engl. 2015 Aug 10;54(33):9622-6. doi: 10.1002/anie.201503094. Epub 2015 May 27.


VIH2 Regulates the Synthesis of Inositol Pyrophosphate InsP8 and Jasmonate-Dependent Defenses in Arabidopsis.

Laha D, Johnen P, Azevedo C, Dynowski M, Weiß M, Capolicchio S, Mao H, Iven T, Steenbergen M, Freyer M, Gaugler P, de Campos MK, Zheng N, Feussner I, Jessen HJ, Van Wees SC, Saiardi A, Schaaf G.

Plant Cell. 2015 Apr;27(4):1082-97. doi: 10.1105/tpc.114.135160. Epub 2015 Apr 21.


A novel method for the purification of inositol phosphates from biological samples reveals that no phytate is present in human plasma or urine.

Wilson MS, Bulley SJ, Pisani F, Irvine RF, Saiardi A.

Open Biol. 2015 Mar;5(3):150014. doi: 10.1098/rsob.150014.


Protein polyphosphorylation of lysine residues by inorganic polyphosphate.

Azevedo C, Livermore T, Saiardi A.

Mol Cell. 2015 Apr 2;58(1):71-82. doi: 10.1016/j.molcel.2015.02.010. Epub 2015 Mar 12.


Raman spectroscopy detection of phytic acid in plant seeds reveals the absence of inorganic polyphosphate.

Kolozsvari B, Firth S, Saiardi A.

Mol Plant. 2015 May;8(5):826-8. doi: 10.1016/j.molp.2015.01.015. Epub 2015 Jan 22. No abstract available.


Inositol phosphates induce DAPI fluorescence shift.

Kolozsvari B, Parisi F, Saiardi A.

Biochem J. 2014 Jun 15;460(3):377-85. doi: 10.1042/BJ20140237.


Molecular and biochemical identification of inositol 1,3,4,5,6-pentakisphosphate 2-kinase encoding mRNA variants in castor bean (Ricinus communis L.) seeds.

Yu J, Saiardi A, Greenwood JS, Bewley JD.

Planta. 2014 May;239(5):965-77. doi: 10.1007/s00425-014-2028-z. Epub 2014 Jan 25.


Functions of inorganic polyphosphates in eukaryotic cells: a coat of many colours.

Azevedo C, Saiardi A.

Biochem Soc Trans. 2014 Feb;42(1):98-102. doi: 10.1042/BST20130111. Review.


Analysis of Dictyostelium discoideum inositol pyrophosphate metabolism by gel electrophoresis.

Pisani F, Livermore T, Rose G, Chubb JR, Gaspari M, Saiardi A.

PLoS One. 2014 Jan 9;9(1):e85533. doi: 10.1371/journal.pone.0085533. eCollection 2014.


Inositol pyrophosphates regulate JMJD2C-dependent histone demethylation.

Burton A, Azevedo C, Andreassi C, Riccio A, Saiardi A.

Proc Natl Acad Sci U S A. 2013 Nov 19;110(47):18970-5. doi: 10.1073/pnas.1309699110. Epub 2013 Nov 4.


Modulation of inositol polyphosphate levels regulates neuronal differentiation.

Loss O, Wu CT, Riccio A, Saiardi A.

Mol Biol Cell. 2013 Sep;24(18):2981-9. doi: 10.1091/mbc.E13-04-0198. Epub 2013 Jul 17.

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