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Multiday corticosteroids in cancer chemotherapy delay the diagnosis of and antimicrobial administration for febrile neutropenia: a double-center retrospective study.

Uda H, Suga Y, Toriba E, Staub AY, Shimada T, Sai Y, Kawahara M, Matsusita R.

J Pharm Health Care Sci. 2019 Feb 4;5:3. doi: 10.1186/s40780-018-0130-2. eCollection 2019.


Rapid Estimate of Adult Literacy in Medicine and Dentistry-20 and oral health status among adolescents, India: A cross-sectional study.

Neelima M, Chandrashekar BR, Thetakala RK, Sai Y, Arzu F, Mohd Sali MN.

J Educ Health Promot. 2018 Dec 28;7:159. doi: 10.4103/jehp.jehp_57_18. eCollection 2018.


Effect of coadministration of rifampicin on the pharmacokinetics of linezolid: clinical and animal studies.

Hashimoto S, Honda K, Fujita K, Miyachi Y, Isoda K, Misaka K, Suga Y, Kato S, Tsuchiya H, Kato Y, Okajima M, Taniguchi T, Shimada T, Sai Y.

J Pharm Health Care Sci. 2018 Nov 12;4:27. doi: 10.1186/s40780-018-0123-1. eCollection 2018.


Mutual Antagonism of PINK1/Parkin and PGC-1α Contributes to Maintenance of Mitochondrial Homeostasis in Rotenone-Induced Neurotoxicity.

Peng K, Xiao J, Yang L, Ye F, Cao J, Sai Y.

Neurotox Res. 2019 Feb;35(2):331-343. doi: 10.1007/s12640-018-9957-4. Epub 2018 Sep 21.


Erratum: Protective effect of astragalosides from Radix Astragali on adriamycin-induced podocyte injury.

Sai YP, Song YC, Chen XX, Luo X, Liu J, Cui WJ.

Exp Ther Med. 2018 Sep;16(3):2168. doi: 10.3892/etm.2018.6361. Epub 2018 Jun 27.


Correction to: Evaluation of Generic Methods to Predict Human Pharmacokinetics Using Physiologically Based Pharmacokinetic Model for Early Drug Discovery of Tyrosine Kinase Inhibitors.

Ren HC, Sai Y, Chen T.

Eur J Drug Metab Pharmacokinet. 2018 Sep 11. doi: 10.1007/s13318-018-0511-9. [Epub ahead of print]


Do Mandibular Third Molars Play a Role in Fractures of the Mandibular Angle and Condyle?

Nogami S, Yamauchi K, Bottini GB, Kouketsu A, Otake Y, Sai Y, Kataoka Y, Miyashita H, Takahashi T.

J Craniofac Surg. 2018 Oct;29(7):e713-e717. doi: 10.1097/SCS.0000000000004961.


Clinical diagnosis and treatment of pediatric anti-N-methyl-D-aspartate receptor encephalitis: A single center retrospective study.

Sai Y, Zhang X, Feng M, Tang J, Liao H, Tan L.

Exp Ther Med. 2018 Aug;16(2):1442-1448. doi: 10.3892/etm.2018.6329. Epub 2018 Jun 20.


Risk factors for oxaliplatin-induced vascular pain in patients with colorectal cancer and comparison of the efficacy of preventive methods.

Suga Y, Ikeda N, Maeda M, Staub AY, Shimada T, Yonezawa M, Kitade H, Katsura H, Okada M, Ishizaki J, Sai Y, Matsushita R.

J Pharm Health Care Sci. 2018 Aug 7;4:18. doi: 10.1186/s40780-018-0117-z. eCollection 2018.


Protective effect of astragalosides from Radix Astragali on adriamycin-induced podocyte injury.

Sai YP, Sun YC, Chen XX, Luo X, Liu J, Cui WJ.

Exp Ther Med. 2018 May;15(5):4485-4490. doi: 10.3892/etm.2018.5933. Epub 2018 Mar 6. Erratum in: Exp Ther Med. 2018 Sep;16(3):2168.


Contribution of equilibrative nucleoside transporters 1 and 2 to gemcitabine uptake in pancreatic cancer cells.

Hioki M, Shimada T, Yuan T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Sawamoto K, Akashita G, Miyamoto KI, Ohta T, Tamai I, Shimada T, Sai Y.

Biopharm Drug Dispos. 2018 May;39(5):256-264. doi: 10.1002/bdd.2131.


Nonhistone targets of KAT2A and KAT2B implicated in cancer biology 1.

Bondy-Chorney E, Denoncourt A, Sai Y, Downey M.

Biochem Cell Biol. 2019 Feb;97(1):30-45. doi: 10.1139/bcb-2017-0297. Epub 2018 Apr 19.


A Screen for Candidate Targets of Lysine Polyphosphorylation Uncovers a Conserved Network Implicated in Ribosome Biogenesis.

Bentley-DeSousa A, Holinier C, Moteshareie H, Tseng YC, Kajjo S, Nwosu C, Amodeo GF, Bondy-Chorney E, Sai Y, Rudner A, Golshani A, Davey NE, Downey M.

Cell Rep. 2018 Mar 27;22(13):3427-3439. doi: 10.1016/j.celrep.2018.02.104.


Volumetric comparison of maxillofacial soft tissue morphology: computed tomography in the supine position versus three-dimensional optical scanning in the sitting position.

Yamaguchi Y, Yamauchi K, Suzuki H, Sai Y, Nogami S, Takahashi T.

Oral Surg Oral Med Oral Pathol Oral Radiol. 2018 Apr;125(4):351-357. doi: 10.1016/j.oooo.2017.12.018. Epub 2018 Jan 8.


Capacity of octacalcium phosphate to promote osteoblastic differentiation toward osteocytes in vitro.

Sai Y, Shiwaku Y, Anada T, Tsuchiya K, Takahashi T, Suzuki O.

Acta Biomater. 2018 Mar 15;69:362-371. doi: 10.1016/j.actbio.2018.01.026. Epub 2018 Feb 4.


Mitochondrial ATP-sensitive potassium channel regulates mitochondrial dynamics to participate in neurodegeneration of Parkinson's disease.

Peng K, Hu J, Xiao J, Dan G, Yang L, Ye F, Zou Z, Cao J, Sai Y.

Biochim Biophys Acta Mol Basis Dis. 2018 Apr;1864(4 Pt A):1086-1103. doi: 10.1016/j.bbadis.2018.01.013. Epub 2018 Jan 17.


The combination of indocyanine green clearance test and model for end-stage liver disease score predicts early graft outcome after liver transplantation.

Yunhua T, Weiqiang J, Maogen C, Sai Y, Zhiheng Z, Dongping W, Zhiyong G, Xiaoshun H.

J Clin Monit Comput. 2018 Jun;32(3):471-479. doi: 10.1007/s10877-017-0051-x. Epub 2017 Aug 22.


miR-17-92 promotes leukemogenesis in chronic myeloid leukemia via targeting A20 and activation of NF-κB signaling.

Jia Q, Sun H, Xiao F, Sai Y, Li Q, Zhang X, Yang S, Wang H, Wang H, Yang Y, Wu CT, Wang L.

Biochem Biophys Res Commun. 2017 Jun 10;487(4):868-874. doi: 10.1016/j.bbrc.2017.04.144. Epub 2017 Apr 28.


Sulfatinib, a novel kinase inhibitor, in patients with advanced solid tumors: results from a phase I study.

Xu JM, Wang Y, Chen YL, Jia R, Li J, Gong JF, Li J, Qi C, Hua Y, Tan CR, Wang J, Li K, Sai Y, Zhou F, Ren YX, Qing WG, Jia H, Su WG, Shen L.

Oncotarget. 2017 Jun 27;8(26):42076-42086. doi: 10.18632/oncotarget.14942.


Drug interaction between methotrexate and salazosulfapyridine in Japanese patients with rheumatoid arthritis.

Okada M, Fujii H, Suga Y, Morito S, Okada M, Nishigami J, Kawano M, Shimada T, Sai Y.

J Pharm Health Care Sci. 2017 Jan 19;3:7. doi: 10.1186/s40780-017-0073-z. eCollection 2017.


Co-administration of dexamethasone increases severity and accelerates onset day of neutropenia in bladder cancer patients on methotrexate, vinblastine, adriamycin and cisplatin chemotherapy: a retrospective cohort study.

Itai S, Suga Y, Hara Y, Izumi K, Maeda Y, Kitagawa Y, Ishizaki J, Shimada T, Mizokami A, Sai Y.

J Pharm Health Care Sci. 2017 Jan 11;3:3. doi: 10.1186/s40780-016-0072-5. eCollection 2017.


Development of an FBG Sensor Array for Multi-Impact Source Localization on CFRP Structures.

Jiang M, Sai Y, Geng X, Sui Q, Liu X, Jia L.

Sensors (Basel). 2016 Oct 24;16(10). pii: E1770.


Bifunctional alkylating agent-mediated MGMT-DNA cross-linking and its proteolytic cleavage in 16HBE cells.

Cheng J, Ye F, Dan G, Zhao Y, Wang B, Zhao J, Sai Y, Zou Z.

Toxicol Appl Pharmacol. 2016 Aug 15;305:267-273. doi: 10.1016/j.taap.2016.06.022. Epub 2016 Jun 21.


Tunable Lamb wave band gaps in two-dimensional magnetoelastic phononic crystal slabs by an applied external magnetostatic field.

Zhou C, Sai Y, Chen J.

Ultrasonics. 2016 Sep;71:69-74. doi: 10.1016/j.ultras.2016.05.023. Epub 2016 May 28.


The Interaction of Mitochondrial Biogenesis and Fission/Fusion Mediated by PGC-1α Regulates Rotenone-Induced Dopaminergic Neurotoxicity.

Peng K, Yang L, Wang J, Ye F, Dan G, Zhao Y, Cai Y, Cui Z, Ao L, Liu J, Zou Z, Sai Y, Cao J.

Mol Neurobiol. 2017 Jul;54(5):3783-3797. doi: 10.1007/s12035-016-9944-9. Epub 2016 Jun 7.


Relationship between genotypes and clinical manifestation, pathology, and cccDNA in Chinese children with hepatitis B virus-associated glomerulonephritis.

Sun YH, Lei XY, Sai YP, Chen JH, Sun YC, Gao X.

World J Pediatr. 2016 Aug;12(3):347-352. doi: 10.1007/s12519-016-0015-0. Epub 2016 Apr 8.


Oxytocin for Male Subjects with Autism Spectrum Disorder and Comorbid Intellectual Disabilities: A Randomized Pilot Study.

Munesue T, Nakamura H, Kikuchi M, Miura Y, Takeuchi N, Anme T, Nanba E, Adachi K, Tsubouchi K, Sai Y, Miyamoto K, Horike S, Yokoyama S, Nakatani H, Niida Y, Kosaka H, Minabe Y, Higashida H.

Front Psychiatry. 2016 Jan 21;7:2. doi: 10.3389/fpsyt.2016.00002. eCollection 2016.


PK/PD analysis of biapenem in patients undergoing continuous hemodiafiltration.

Akashita G, Hosaka Y, Noda T, Isoda K, Shimada T, Sawamoto K, Miyamoto K, Taniguchi T, Sai Y.

J Pharm Health Care Sci. 2015 Nov 14;1:31. doi: 10.1186/s40780-015-0031-6. eCollection 2015.


Effect of switching basal insulin regimen to degludec on quality of life in Japanese patients with type 1 and type 2 diabetes mellitus.

Okada M, Okada M, Nishigami J, Yamaaki N, Furukawa K, Ohyama K, Shimada T, Sai Y.

J Pharm Health Care Sci. 2015 Sep 30;1:26. doi: 10.1186/s40780-015-0027-2. eCollection 2015.


Resveratrol Regulates Mitochondrial Biogenesis and Fission/Fusion to Attenuate Rotenone-Induced Neurotoxicity.

Peng K, Tao Y, Zhang J, Wang J, Ye F, Dan G, Zhao Y, Cai Y, Zhao J, Wu Q, Zou Z, Cao J, Sai Y.

Oxid Med Cell Longev. 2016;2016:6705621. doi: 10.1155/2016/6705621. Epub 2015 Dec 6.


Saturable Hepatic Extraction of Gemcitabine Involves Biphasic Uptake Mediated by Nucleoside Transporters Equilibrative Nucleoside Transporter 1 and 2.

Shimada T, Nakanishi T, Tajima H, Yamazaki M, Yokono R, Takabayashi M, Shimada T, Sawamoto K, Miyamoto K, Kitagawa H, Ohta T, Tamai I, Sai Y.

J Pharm Sci. 2015 Sep;104(9):3162-9. doi: 10.1002/jps.24498. Epub 2015 Jun 2.


Pharmacokinetics of docetaxel during hyperthermic intraperitoneal chemotherapy for peritoneal metastasis.

Yonemura Y, Canbay E, Sako S, Ishibashi H, Hirano M, Mizumoto A, Takeshita K, Takao N, Ichinose M, Liu Y, Li Y, Ikeda S, Noguchi A, Sai Y.

Gan To Kagaku Ryoho. 2014 Nov;41(12):2496-9.


Molecular Genetics and Metabolism Report Long-term follow-up of post hematopoietic stem cell transplantation for Hurler syndrome: clinical, biochemical, and pathological improvements.

Yasuda E, Mackenzie W, Ruhnke K, Shimada T, Mason RW, Zustin J, Martin PL, Thacker M, Orii T, Sai Y, Tomatsu S.

Mol Genet Metab Rep. 2015 Mar;2:65-76.


Glycogen synthase kinase 3β sustains invasion of glioblastoma via the focal adhesion kinase, Rac1, and c-Jun N-terminal kinase-mediated pathway.

Chikano Y, Domoto T, Furuta T, Sabit H, Kitano-Tamura A, Pyko IV, Takino T, Sai Y, Hayashi Y, Sato H, Miyamoto K, Nakada M, Minamoto T.

Mol Cancer Ther. 2015 Feb;14(2):564-74. doi: 10.1158/1535-7163.MCT-14-0479. Epub 2014 Dec 10.


Discovery of fruquintinib, a potent and highly selective small molecule inhibitor of VEGFR 1, 2, 3 tyrosine kinases for cancer therapy.

Sun Q, Zhou J, Zhang Z, Guo M, Liang J, Zhou F, Long J, Zhang W, Yin F, Cai H, Yang H, Zhang W, Gu Y, Ni L, Sai Y, Cui Y, Zhang M, Hong M, Sun J, Yang Z, Qing W, Su W, Ren Y.

Cancer Biol Ther. 2014;15(12):1635-45. doi: 10.4161/15384047.2014.964087.


Discovery of (S)-1-(1-(Imidazo[1,2-a]pyridin-6-yl)ethyl)-6-(1-methyl-1H-pyrazol-4-yl)-1H-[1,2,3]triazolo[4,5-b]pyrazine (volitinib) as a highly potent and selective mesenchymal-epithelial transition factor (c-Met) inhibitor in clinical development for treatment of cancer.

Jia H, Dai G, Weng J, Zhang Z, Wang Q, Zhou F, Jiao L, Cui Y, Ren Y, Fan S, Zhou J, Qing W, Gu Y, Wang J, Sai Y, Su W.

J Med Chem. 2014 Sep 25;57(18):7577-89. doi: 10.1021/jm500510f. Epub 2014 Sep 15.


Fetal growth retardation and lack of hypotaurine in ezrin knockout mice.

Nishimura T, Higuchi K, Sai Y, Sugita Y, Yoshida Y, Tomi M, Wada M, Wakayama T, Tamura A, Tsukita S, Soga T, Nakashima E.

PLoS One. 2014 Aug 21;9(8):e105423. doi: 10.1371/journal.pone.0105423. eCollection 2014.


Salacia reticulata has therapeutic effects on obesity.

Shimada T, Nakayama Y, Harasawa Y, Matsui H, Kobayashi H, Sai Y, Miyamoto K, Tomatsu S, Aburada M.

J Nat Med. 2014 Oct;68(4):668-76. doi: 10.1007/s11418-014-0845-9. Epub 2014 May 18.


Preclinical pharmacokinetics and disposition of a novel selective VEGFR inhibitor fruquintinib (HMPL-013) and the prediction of its human pharmacokinetics.

Gu Y, Wang J, Li K, Zhang L, Ren H, Guo L, Sai Y, Zhang W, Su W.

Cancer Chemother Pharmacol. 2014 Jul;74(1):95-115. doi: 10.1007/s00280-014-2471-3. Epub 2014 May 11.


Basic fibroblast growth factor is essential to maintain endothelial progenitor cell phenotype in TR-BME2 cells.

Sai Y, Nishimura T, Muta M, Iizasa H, Miyata T, Nakashima E.

Biol Pharm Bull. 2014;37(4):688-93.


Mechanisms of lower maintenance dose of tacrolimus in obese patients.

Sawamoto K, Huong TT, Sugimoto N, Mizutani Y, Sai Y, Miyamoto K.

Drug Metab Pharmacokinet. 2014;29(4):341-7. Epub 2014 Mar 25.


Hepatic arterial infusion chemotherapy with gemcitabine and 5-fluorouracil or oral S-1 improves the prognosis of patients with postoperative liver metastases from pancreatic cancer.

Tajima H, Kitagawa H, Tsukada T, Okamoto K, Nakanuma SI, Sakai S, Makino I, Furukawa H, Hayashi H, Oyama K, Inokuchi M, Nakagawara H, Miyashita T, Itoh H, Fujita H, Takamura H, Ninomiya I, Fushida S, Fujimura T, Ohta T, Koda W, Minami T, Ryu Y, Sanada J, Gabata T, Matsui O, Sai Y.

Mol Clin Oncol. 2013 Sep;1(5):869-874. Epub 2013 Jul 23.


Determination of six components of Andrographis paniculata extract and one major metabolite of andrographolide in rat plasma by liquid chromatography-tandem mass spectrometry.

Wang J, Yang W, Wang G, Tang P, Sai Y.

J Chromatogr B Analyt Technol Biomed Life Sci. 2014 Mar 1;951-952:78-88. doi: 10.1016/j.jchromb.2014.01.028. Epub 2014 Jan 28.


System A amino acid transporter SNAT2 shows subtype-specific affinity for betaine and hyperosmotic inducibility in placental trophoblasts.

Nishimura T, Yagi R, Usuda M, Oda K, Yamazaki M, Suda S, Takahashi Y, Okazaki F, Sai Y, Higuchi K, Maruyama T, Tomi M, Nakashima E.

Biochim Biophys Acta. 2014 May;1838(5):1306-12. doi: 10.1016/j.bbamem.2014.01.004. Epub 2014 Jan 14.


[Hepatic arterial infusion chemotherapy with gemcitabine for patients with postoperative liver metastases from pancreatic cancer].

Tajima H, Kitagawa H, Shoji M, Okamoto K, Nakanuma S, Sakai S, Kinoshita J, Makino I, Hayashi H, Nakamura K, Oyama K, Nakagawara H, Miyashita T, Takamura H, Ohta T, Minami T, Koda W, Sanada J, Gabata T, Sai Y.

Gan To Kagaku Ryoho. 2013 Nov;40(12):1668-71. Japanese.


Enantioselective disposition of clenbuterol in rats.

Hirosawa I, Ishikawa M, Ogino M, Ito H, Hirao T, Yamada H, Asahi M, Kotaki H, Sai Y, Miyamoto K.

Biopharm Drug Dispos. 2014 May;35(4):207-17. doi: 10.1002/bdd.1885. Epub 2013 Dec 26.


Ligand-dependent EphB1 signaling suppresses glioma invasion and correlates with patient survival.

Teng L, Nakada M, Furuyama N, Sabit H, Furuta T, Hayashi Y, Takino T, Dong Y, Sato H, Sai Y, Miyamoto K, Berens ME, Zhao SG, Hamada J.

Neuro Oncol. 2013 Dec;15(12):1710-20. doi: 10.1093/neuonc/not128. Epub 2013 Oct 11.


14-3-3 Proteins in the regulation of rotenone-induced neurotoxicity might be via its isoform 14-3-3epsilon's involvement in autophagy.

Sai Y, Peng K, Ye F, Zhao X, Zhao Y, Zou Z, Cao J, Dong Z.

Cell Mol Neurobiol. 2013 Nov;33(8):1109-21. doi: 10.1007/s10571-013-9977-9. Epub 2013 Sep 4.


The genotype C could play a key role in hepatitis B virus associated nephritis among the northwest Chinese children.

Lei X, Gao X, Yang J, Sun Y, Sai Y, You W, Yuan H.

Eur J Intern Med. 2013 Dec;24(8):835-8. doi: 10.1016/j.ejim.2013.07.009. Epub 2013 Aug 26.


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