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Items: 1 to 50 of 77

1.

Cardiovascular magnetic resonance in immune checkpoint inhibitor-associated myocarditis.

Zhang L, Awadalla M, Mahmood SS, Nohria A, Hassan MZO, Thuny F, Zlotoff DA, Murphy SP, Stone JR, Golden DLA, Alvi RM, Rokicki A, Jones-O'Connor M, Cohen JV, Heinzerling LM, Mulligan C, Armanious M, Barac A, Forrestal BJ, Sullivan RJ, Kwong RY, Yang EH, Damrongwatanasuk R, Chen CL, Gupta D, Kirchberger MC, Moslehi JJ, Coelho-Filho OR, Ganatra S, Rizvi MA, Sahni G, Tocchetti CG, Mercurio V, Mahmoudi M, Lawrence DP, Reynolds KL, Weinsaft JW, Baksi AJ, Ederhy S, Groarke JD, Lyon AR, Fradley MG, Thavendiranathan P, Neilan TG.

Eur Heart J. 2020 Feb 29. pii: ehaa051. doi: 10.1093/eurheartj/ehaa051. [Epub ahead of print]

PMID:
32112560
2.

Kringles of substrate plasminogen provide a 'catalytic switch' in plasminogen to plasmin turnover by Streptokinase.

Sharma V, Kumar S, Sahni G.

Biochem J. 2020 Mar 13;477(5):953-970. doi: 10.1042/BCJ20190909.

PMID:
32069359
3.

Global Longitudinal Strain and Cardiac Events in Patients With Immune Checkpoint Inhibitor-Related Myocarditis.

Awadalla M, Mahmood SS, Groarke JD, Hassan MZO, Nohria A, Rokicki A, Murphy SP, Mercaldo ND, Zhang L, Zlotoff DA, Reynolds KL, Alvi RM, Banerji D, Liu S, Heinzerling LM, Jones-O'Connor M, Bakar RB, Cohen JV, Kirchberger MC, Sullivan RJ, Gupta D, Mulligan CP, Shah SP, Ganatra S, Rizvi MA, Sahni G, Tocchetti CG, Lawrence DP, Mahmoudi M, Devereux RB, Forrestal BJ, Mandawat A, Lyon AR, Chen CL, Barac A, Hung J, Thavendiranathan P, Picard MH, Thuny F, Ederhy S, Fradley MG, Neilan TG.

J Am Coll Cardiol. 2020 Feb 11;75(5):467-478. doi: 10.1016/j.jacc.2019.11.049.

PMID:
32029128
4.

Design of a thrombin inhibitory staphylokinase based plasminogen activator with anti-reocclusion potential.

Arora K, Maheshwari N, Sahni G.

Int J Biol Macromol. 2020 Feb 1;144:791-800. doi: 10.1016/j.ijbiomac.2019.11.121. Epub 2019 Nov 16.

PMID:
31739007
5.

Corrigendum to 'Cloning and purification of an anti-thrombotic, chimeric Staphylokinase in Pichia pastoris' [Protein Expr. Purif. 162 (2019) 1-8].

Vandana, Kantipudi S, Maheshwari N, Sharma S, Sahni G.

Protein Expr Purif. 2020 Mar;167:105488. doi: 10.1016/j.pep.2019.105488. Epub 2019 Sep 11. No abstract available.

PMID:
31519453
6.

Site-specific PEGylation of micro-plasmin for improved thrombolytic therapy through engineering enhanced resistance against serpin mediated inhibition.

Kaur N, Sinha PK, Sahni G.

PLoS One. 2019 May 29;14(5):e0217234. doi: 10.1371/journal.pone.0217234. eCollection 2019.

7.

Cloning and purification of an anti-thrombotic, chimeric Staphylokinase in Pichia pastoris.

Vandana, Kantipudi S, Maheshwari N, Sharma S, Sahni G.

Protein Expr Purif. 2019 Oct;162:1-8. doi: 10.1016/j.pep.2019.05.004. Epub 2019 May 17. Erratum in: Protein Expr Purif. 2020 Mar;167:105488.

PMID:
31108209
8.

Influenza vaccination and myocarditis among patients receiving immune checkpoint inhibitors.

Awadalla M, Golden DLA, Mahmood SS, Alvi RM, Mercaldo ND, Hassan MZO, Banerji D, Rokicki A, Mulligan C, Murphy SPT, Jones-O'Connor M, Cohen JV, Heinzerling LM, Armanious M, Sullivan RJ, Damrongwatanasuk R, Chen CL, Gupta D, Kirchberger MC, Moslehi JJ, Shah SP, Ganatra S, Thavendiranathan P, Rizvi MA, Sahni G, Lyon AR, Tocchetti CG, Mercurio V, Thuny F, Ederhy S, Mahmoudi M, Lawrence DP, Groarke JD, Nohria A, Fradley MG, Reynolds KL, Neilan TG.

J Immunother Cancer. 2019 Feb 22;7(1):53. doi: 10.1186/s40425-019-0535-y.

9.

Production, Purification, and Characterization of Thermostable Alkaline Xylanase From Anoxybacillus kamchatkensis NASTPD13.

Yadav P, Maharjan J, Korpole S, Prasad GS, Sahni G, Bhattarai T, Sreerama L.

Front Bioeng Biotechnol. 2018 May 15;6:65. doi: 10.3389/fbioe.2018.00065. eCollection 2018.

10.

Production, purification and characterization of raw starch hydrolyzing thermostable acidic α-amylase from hot springs, India.

Sudan SK, Kumar N, Kaur I, Sahni G.

Int J Biol Macromol. 2018 Oct 1;117:831-839. doi: 10.1016/j.ijbiomac.2018.05.231. Epub 2018 Jun 1.

PMID:
29864538
11.

Worldwide Protein Data Bank biocuration supporting open access to high-quality 3D structural biology data.

Young JY, Westbrook JD, Feng Z, Peisach E, Persikova I, Sala R, Sen S, Berrisford JM, Swaminathan GJ, Oldfield TJ, Gutmanas A, Igarashi R, Armstrong DR, Baskaran K, Chen L, Chen M, Clark AR, Di Costanzo L, Dimitropoulos D, Gao G, Ghosh S, Gore S, Guranovic V, Hendrickx PMS, Hudson BP, Ikegawa Y, Kengaku Y, Lawson CL, Liang Y, Mak L, Mukhopadhyay A, Narayanan B, Nishiyama K, Patwardhan A, Sahni G, Sanz-García E, Sato J, Sekharan MR, Shao C, Smart OS, Tan L, van Ginkel G, Yang H, Zhuravleva MA, Markley JL, Nakamura H, Kurisu G, Kleywegt GJ, Velankar S, Berman HM, Burley SK.

Database (Oxford). 2018 Jan 1;2018. doi: 10.1093/database/bay002.

12.

Molecular Imaging of Apoptosis in Cancer Therapy-Related Cardiac Dysfunction Before LVEF Reduction.

Nakahara T, Petrov A, Tanimoto T, Chaudhry F, Narula N, Seshan SV, Mattis JA, Pak KY, Sahni G, Bhardwaj A, Sengupta PP, Tiersten A, Strauss HW, Narula J.

JACC Cardiovasc Imaging. 2018 Aug;11(8):1203-1205. doi: 10.1016/j.jcmg.2017.12.012. Epub 2018 Feb 14. No abstract available.

13.

Pseudomonas fluvialis sp. nov., a novel member of the genus Pseudomonas isolated from the river Ganges, India.

Sudan SK, Pal D, Bisht B, Kumar N, Chaudhry V, Patil P, Sahni G, Mayilraj S, Krishnamurthi S.

Int J Syst Evol Microbiol. 2018 Jan;68(1):402-408. doi: 10.1099/ijsem.0.002520. Epub 2017 Dec 14.

PMID:
29239716
14.

Validation of Structures in the Protein Data Bank.

Gore S, Sanz García E, Hendrickx PMS, Gutmanas A, Westbrook JD, Yang H, Feng Z, Baskaran K, Berrisford JM, Hudson BP, Ikegawa Y, Kobayashi N, Lawson CL, Mading S, Mak L, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Peisach E, Sahni G, Sekharan MR, Sen S, Shao C, Smart OS, Ulrich EL, Yamashita R, Quesada M, Young JY, Nakamura H, Markley JL, Berman HM, Burley SK, Velankar S, Kleywegt GJ.

Structure. 2017 Dec 5;25(12):1916-1927. doi: 10.1016/j.str.2017.10.009. Epub 2017 Nov 22.

15.

Clinical Benefit from Trametinib in a Patient with Appendiceal Adenocarcinoma with a GNAS R201H Mutation.

Ang C, Stollman A, Zhu H, Sarpel U, Scarborough B, Sahni G, Millis SZ.

Case Rep Oncol. 2017 Jun 22;10(2):548-552. doi: 10.1159/000477562. eCollection 2017 May-Aug.

16.

Spasmogenic Effects of the Proteasome Inhibitor Carfilzomib on Coronary Resistance, Vascular Tone and Reactivity.

Chen-Scarabelli C, Corsetti G, Pasini E, Dioguardi FS, Sahni G, Narula J, Gavazzoni M, Patel H, Saravolatz L, Knight R, Raddino R, Scarabelli TM.

EBioMedicine. 2017 Jul;21:206-212. doi: 10.1016/j.ebiom.2017.05.024. Epub 2017 May 23.

17.

Mechanism of plasmin generation by S100A10.

Miller VA, Madureira PA, Kamaludin AA, Komar J, Sharma V, Sahni G, Thelwell C, Longstaff C, Waisman DM.

Thromb Haemost. 2017 Jun 2;117(6):1058-1071. doi: 10.1160/TH16-12-0936. Epub 2017 Apr 6.

PMID:
28382372
18.

Incidence and Risk of Cardiac Events in Patients With Previously Treated Multiple Myeloma Versus Matched Patients Without Multiple Myeloma: An Observational, Retrospective, Cohort Study.

Kistler KD, Kalman J, Sahni G, Murphy B, Werther W, Rajangam K, Chari A.

Clin Lymphoma Myeloma Leuk. 2017 Feb;17(2):89-96.e3. doi: 10.1016/j.clml.2016.11.009. Epub 2016 Nov 22.

19.

Biochemical and structural characterization of a novel halotolerant cellulase from soil metagenome.

Garg R, Srivastava R, Brahma V, Verma L, Karthikeyan S, Sahni G.

Sci Rep. 2016 Dec 23;6:39634. doi: 10.1038/srep39634.

20.

18F-Sodium Fluoride PET/MR for the Assessment of Cardiac Amyloidosis.

Trivieri MG, Dweck MR, Abgral R, Robson PM, Karakatsanis NA, Lala A, Contreras J, Sahni G, Gopalan R, Gorevic P, Fuster V, Narula J, Fayad ZA.

J Am Coll Cardiol. 2016 Dec 20;68(24):2712-2714. doi: 10.1016/j.jacc.2016.09.953. No abstract available.

21.
22.

PEGylation of Truncated Streptokinase Leads to Formulation of a Useful Drug with Ameliorated Attributes.

Sawhney P, Katare K, Sahni G.

PLoS One. 2016 May 18;11(5):e0155831. doi: 10.1371/journal.pone.0155831. eCollection 2016.

23.

Stencil Micropatterning for Spatial Control of Human Pluripotent Stem Cell Fate Heterogeneity.

Yuan J, Sahni G, Toh YC.

Methods Mol Biol. 2016;1516:171-181. doi: 10.1007/7651_2016_325.

PMID:
27032943
24.

Amino-Terminal Fusion of Epidermal Growth Factor 4,5,6 Domains of Human Thrombomodulin on Streptokinase Confers Anti-Reocclusion Characteristics along with Plasmin-Mediated Clot Specificity.

Maheshwari N, Kantipudi S, Maheshwari A, Arora K, Vandana, Kwatra N, Sahni G.

PLoS One. 2016 Mar 14;11(3):e0150315. doi: 10.1371/journal.pone.0150315. eCollection 2016.

25.

Site-Specific Thiol-mediated PEGylation of Streptokinase Leads to Improved Properties with Clinical Potential.

Sawhney P, Kumar S, Maheshwari N, Guleria SS, Dhar N, Kashyap R, Sahni G.

Curr Pharm Des. 2016;22(38):5868-5878.

PMID:
26845325
26.

PDBe: improved accessibility of macromolecular structure data from PDB and EMDB.

Velankar S, van Ginkel G, Alhroub Y, Battle GM, Berrisford JM, Conroy MJ, Dana JM, Gore SP, Gutmanas A, Haslam P, Hendrickx PM, Lagerstedt I, Mir S, Fernandez Montecelo MA, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Sanz-García E, Sen S, Slowley RA, Wainwright ME, Deshpande MS, Iudin A, Sahni G, Salavert Torres J, Hirshberg M, Mak L, Nadzirin N, Armstrong DR, Clark AR, Smart OS, Korir PK, Kleywegt GJ.

Nucleic Acids Res. 2016 Jan 4;44(D1):D385-95. doi: 10.1093/nar/gkv1047. Epub 2015 Oct 17.

27.

Penta-L-lysine Potentiates Fibrin-Independent Activity of Human Tissue Plasminogen Activator.

Rehan M, Sagar A, Sharma V, Mishra S, Ashish, Sahni G.

J Phys Chem B. 2015 Oct 22;119(42):13271-7. doi: 10.1021/acs.jpcb.5b07735. Epub 2015 Oct 8.

PMID:
26447340
28.

Outcome of patients with multiple myeloma and hypotension during high-dose chemotherapy.

Biran N, Sehgal P, Sahni G, Doucette J, Chari A.

Am J Hematol. 2015 Jun;90(6):E125-7. doi: 10.1002/ajh.23991. Epub 2015 Apr 29. No abstract available.

29.

Small molecule annotation for the Protein Data Bank.

Sen S, Young J, Berrisford JM, Chen M, Conroy MJ, Dutta S, Di Costanzo L, Gao G, Ghosh S, Hudson BP, Igarashi R, Kengaku Y, Liang Y, Peisach E, Persikova I, Mukhopadhyay A, Narayanan BC, Sahni G, Sato J, Sekharan M, Shao C, Tan L, Zhuravleva MA.

Database (Oxford). 2014 Nov 25;2014:bau116. doi: 10.1093/database/bau116. Print 2014.

30.

Latex agglutination test (LAT) for the diagnosis of typhoid fever.

Sahni GS.

J Indian Med Assoc. 2013 Jun;111(6):395-7, 403.

PMID:
24761498
31.

PDBe: Protein Data Bank in Europe.

Gutmanas A, Alhroub Y, Battle GM, Berrisford JM, Bochet E, Conroy MJ, Dana JM, Fernandez Montecelo MA, van Ginkel G, Gore SP, Haslam P, Hatherley R, Hendrickx PM, Hirshberg M, Lagerstedt I, Mir S, Mukhopadhyay A, Oldfield TJ, Patwardhan A, Rinaldi L, Sahni G, Sanz-García E, Sen S, Slowley RA, Velankar S, Wainwright ME, Kleywegt GJ.

Nucleic Acids Res. 2014 Jan;42(Database issue):D285-91. doi: 10.1093/nar/gkt1180. Epub 2013 Nov 27.

32.

Multiple exosites distributed across the three domains of streptokinase co-operate to generate high catalytic rates in the streptokinase-plasmin activator complex.

Aneja R, Datt M, Yadav S, Sahni G.

Biochemistry. 2013 Dec 10;52(49):8957-68. doi: 10.1021/bi400142s. Epub 2013 Nov 25.

PMID:
23919427
33.

A novel thermal decomposition approach to synthesize hydroxyapatite-silver nanocomposites and their antibacterial action against GFP-expressing antibiotic resistant E. coli.

Sahni G, Gopinath P, Jeevanandam P.

Colloids Surf B Biointerfaces. 2013 Mar 1;103:441-7. doi: 10.1016/j.colsurfb.2012.10.050. Epub 2012 Nov 17.

PMID:
23261564
34.

Visceral leishmaniasis (Kala-azar) without splenomegaly.

Sahni GS.

Indian Pediatr. 2012 Jul;49(7):590-1. No abstract available.

35.

Cardiovascular disease in pregnancy. Preface.

Sahni G, Elkayam U.

Cardiol Clin. 2012 Aug;30(3):xi-xii. doi: 10.1016/j.ccl.2012.05.005. Epub 2012 Jun 6. No abstract available.

PMID:
22813373
36.

Chest pain syndromes in pregnancy.

Sahni G.

Cardiol Clin. 2012 Aug;30(3):343-67. doi: 10.1016/j.ccl.2012.04.008. Review.

PMID:
22813362
37.

Recurring epidemics of acute encephalopathy in children in Muzaffarpur, Bihar.

Sahni GS.

Indian Pediatr. 2012 Jun;49(6):502-3. No abstract available.

38.

Impact of geographic range on genetic and chemical diversity of Indian valerian (Valeriana jatamansi) from northwestern Himalaya.

Sundaresan V, Sahni G, Verma RS, Padalia RC, Mehrotra S, Thul ST.

Biochem Genet. 2012 Oct;50(9-10):797-808. doi: 10.1007/s10528-012-9521-5. Epub 2012 Jun 23.

PMID:
22729695
39.

First structural model of full-length human tissue-plasminogen activator: a SAXS data-based modeling study.

Rathore YS, Rehan M, Pandey K, Sahni G, Ashish.

J Phys Chem B. 2012 Jan 12;116(1):496-502. doi: 10.1021/jp207243n. Epub 2011 Dec 19.

PMID:
22128869
40.

PDBe: Protein Data Bank in Europe.

Velankar S, Alhroub Y, Best C, Caboche S, Conroy MJ, Dana JM, Fernandez Montecelo MA, van Ginkel G, Golovin A, Gore SP, Gutmanas A, Haslam P, Hendrickx PM, Heuson E, Hirshberg M, John M, Lagerstedt I, Mir S, Newman LE, Oldfield TJ, Patwardhan A, Rinaldi L, Sahni G, Sanz-García E, Sen S, Slowley R, Suarez-Uruena A, Swaminathan GJ, Symmons MF, Vranken WF, Wainwright M, Kleywegt GJ.

Nucleic Acids Res. 2012 Jan;40(Database issue):D445-52. doi: 10.1093/nar/gkr998. Epub 2011 Nov 21.

41.

Substrate kringle-mediated catalysis by the streptokinase-plasmin activator complex: critical contribution of kringle-4 revealed by the mutagenesis approaches.

Joshi KK, Nanda JS, Kumar P, Sahni G.

Biochim Biophys Acta. 2012 Feb;1824(2):326-33. doi: 10.1016/j.bbapap.2011.10.010. Epub 2011 Oct 25.

PMID:
22056293
42.

Large interventricular septal aneurysm with thrombo-embolism in a healthy woman.

Sy A, Sahni G.

Eur Heart J. 2011 Jul;32(13):1613. doi: 10.1093/eurheartj/ehr087. Epub 2011 Mar 30. No abstract available.

PMID:
21450720
43.

Identification through combinatorial random and rational mutagenesis of a substrate-interacting exosite in the gamma domain of streptokinase.

Yadav S, Aneja R, Kumar P, Datt M, Sinha S, Sahni G.

J Biol Chem. 2011 Feb 25;286(8):6458-69. doi: 10.1074/jbc.M110.152355. Epub 2010 Dec 17.

44.

PDBe: Protein Data Bank in Europe.

Velankar S, Alhroub Y, Alili A, Best C, Boutselakis HC, Caboche S, Conroy MJ, Dana JM, van Ginkel G, Golovin A, Gore SP, Gutmanas A, Haslam P, Hirshberg M, John M, Lagerstedt I, Mir S, Newman LE, Oldfield TJ, Penkett CJ, Pineda-Castillo J, Rinaldi L, Sahni G, Sawka G, Sen S, Slowley R, Sousa da Silva AW, Suarez-Uruena A, Swaminathan GJ, Symmons MF, Vranken WF, Wainwright M, Kleywegt GJ.

Nucleic Acids Res. 2011 Jan;39(Database issue):D402-10. doi: 10.1093/nar/gkq985. Epub 2010 Nov 2.

45.

EMDataBank.org: unified data resource for CryoEM.

Lawson CL, Baker ML, Best C, Bi C, Dougherty M, Feng P, van Ginkel G, Devkota B, Lagerstedt I, Ludtke SJ, Newman RH, Oldfield TJ, Rees I, Sahni G, Sala R, Velankar S, Warren J, Westbrook JD, Henrick K, Kleywegt GJ, Berman HM, Chiu W.

Nucleic Acids Res. 2011 Jan;39(Database issue):D456-64. doi: 10.1093/nar/gkq880. Epub 2010 Oct 8.

46.

Probing the primary structural determinants of streptokinase inter-domain linkers by site-specific substitution and deletion mutagenesis.

Yadav S, Sahni G.

Biochim Biophys Acta. 2010 Sep;1804(9):1730-7. doi: 10.1016/j.bbapap.2010.04.003. Epub 2010 Apr 24.

PMID:
20417732
47.

PDBe: Protein Data Bank in Europe.

Velankar S, Best C, Beuth B, Boutselakis CH, Cobley N, Sousa Da Silva AW, Dimitropoulos D, Golovin A, Hirshberg M, John M, Krissinel EB, Newman R, Oldfield T, Pajon A, Penkett CJ, Pineda-Castillo J, Sahni G, Sen S, Slowley R, Suarez-Uruena A, Swaminathan J, van Ginkel G, Vranken WF, Henrick K, Kleywegt GJ.

Nucleic Acids Res. 2010 Jan;38(Database issue):D308-17. doi: 10.1093/nar/gkp916. Epub 2009 Oct 25.

48.

Identification of a new exosite involved in catalytic turnover by the streptokinase-plasmin activator complex during human plasminogen activation.

Aneja R, Datt M, Singh B, Kumar S, Sahni G.

J Biol Chem. 2009 Nov 20;284(47):32642-50. doi: 10.1074/jbc.M109.046573. Epub 2009 Sep 30.

49.

Enhanced production of recombinant streptokinase in Escherichia coli using fed-batch culture.

Goyal D, Sahni G, Sahoo DK.

Bioresour Technol. 2009 Oct;100(19):4468-74. doi: 10.1016/j.biortech.2009.04.008. Epub 2009 May 9.

PMID:
19428239
50.

Role of the 88-97 loop in plasminogen activation by streptokinase probed through site-specific mutagenesis.

Yadav S, Datt M, Singh B, Sahni G.

Biochim Biophys Acta. 2008 Sep;1784(9):1310-8. doi: 10.1016/j.bbapap.2008.05.013. Epub 2008 Jun 6.

PMID:
18590837

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