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Items: 1 to 50 of 203

1.

Docking on Lipid II-A Widespread Mechanism for Potent Bactericidal Activities of Antibiotic Peptides.

Grein F, Schneider T, Sahl HG.

J Mol Biol. 2019 May 14. pii: S0022-2836(19)30281-5. doi: 10.1016/j.jmb.2019.05.014. [Epub ahead of print] Review.

PMID:
31100388
2.

Coordination of capsule assembly and cell wall biosynthesis in Staphylococcus aureus.

Rausch M, Deisinger JP, Ulm H, Müller A, Li W, Hardt P, Wang X, Li X, Sylvester M, Engeser M, Vollmer W, Müller CE, Sahl HG, Lee JC, Schneider T.

Nat Commun. 2019 Mar 29;10(1):1404. doi: 10.1038/s41467-019-09356-x.

3.

The pentaglycine bridges of Staphylococcus aureus peptidoglycan are essential for cell integrity.

Monteiro JM, Covas G, Rausch D, Filipe SR, Schneider T, Sahl HG, Pinho MG.

Sci Rep. 2019 Mar 21;9(1):5010. doi: 10.1038/s41598-019-41461-1.

4.

Discovery of the Cyclic Lipopeptide Gacamide A by Genome Mining and Repair of the Defective GacA Regulator in Pseudomonas fluorescens Pf0-1.

Jahanshah G, Yan Q, Gerhardt H, Pataj Z, Lämmerhofer M, Pianet I, Josten M, Sahl HG, Silby MW, Loper JE, Gross H.

J Nat Prod. 2019 Feb 22;82(2):301-308. doi: 10.1021/acs.jnatprod.8b00747. Epub 2019 Jan 22.

PMID:
30666877
5.

Sulfide Protects Staphylococcus aureus from Aminoglycoside Antibiotics but Cannot Be Regarded as a General Defense Mechanism against Antibiotics.

Weikum J, Ritzmann N, Jelden N, Klöckner A, Herkersdorf S, Josten M, Sahl HG, Grein F.

Antimicrob Agents Chemother. 2018 Sep 24;62(10). pii: e00602-18. doi: 10.1128/AAC.00602-18. Print 2018 Oct.

6.

Deficient Lipid A Remodeling by the arnB Gene Promotes Biofilm Formation in Antimicrobial Peptide Susceptible Pseudomonas aeruginosa.

Segev-Zarko LA, Kapach G, Josten M, Klug YA, Sahl HG, Shai Y.

Biochemistry. 2018 Apr 3;57(13):2024-2034. doi: 10.1021/acs.biochem.8b00149. Epub 2018 Mar 19.

PMID:
29518324
7.

Differential daptomycin resistance development in Staphylococcus aureus strains with active and mutated gra regulatory systems.

Müller A, Grein F, Otto A, Gries K, Orlov D, Zarubaev V, Girard M, Sher X, Shamova O, Roemer T, François P, Becher D, Schneider T, Sahl HG.

Int J Med Microbiol. 2018 Apr;308(3):335-348. doi: 10.1016/j.ijmm.2017.12.002. Epub 2017 Dec 21.

PMID:
29429584
8.

A quinolinol-based small molecule with anti-MRSA activity that targets bacterial membrane and promotes fermentative metabolism.

Nair DR, Chen J, Monteiro JM, Josten M, Pinho MG, Sahl HG, Wu J, Cheung A.

J Antibiot (Tokyo). 2017 Oct;70(10):1009-1019. doi: 10.1038/ja.2017.79. Epub 2017 Jul 12.

9.

Antibacterial Nucleoside-Analog Inhibitor of Bacterial RNA Polymerase.

Maffioli SI, Zhang Y, Degen D, Carzaniga T, Del Gatto G, Serina S, Monciardini P, Mazzetti C, Guglierame P, Candiani G, Chiriac AI, Facchetti G, Kaltofen P, Sahl HG, Dehò G, Donadio S, Ebright RH.

Cell. 2017 Jun 15;169(7):1240-1248.e23. doi: 10.1016/j.cell.2017.05.042.

10.

The cell wall precursor lipid II acts as a molecular signal for the Ser/Thr kinase PknB of Staphylococcus aureus.

Hardt P, Engels I, Rausch M, Gajdiss M, Ulm H, Sass P, Ohlsen K, Sahl HG, Bierbaum G, Schneider T, Grein F.

Int J Med Microbiol. 2017 Jan;307(1):1-10. doi: 10.1016/j.ijmm.2016.12.001. Epub 2016 Dec 12.

PMID:
27989665
11.

Development of in vitro resistance to chitosan is related to changes in cell envelope structure of Staphylococcus aureus.

Raafat D, Leib N, Wilmes M, François P, Schrenzel J, Sahl HG.

Carbohydr Polym. 2017 Feb 10;157:146-155. doi: 10.1016/j.carbpol.2016.09.075. Epub 2016 Sep 26.

PMID:
27987856
12.

Differentiation of Staphylococcus argenteus (formerly: Staphylococcus aureus clonal complex 75) by mass spectrometry from S. aureus using the first strain isolated from a wild African great ape.

Schuster D, Rickmeyer J, Gajdiss M, Thye T, Lorenzen S, Reif M, Josten M, Szekat C, Melo LDR, Schmithausen RM, Liégeois F, Sahl HG, Gonzalez JJ, Nagel M, Bierbaum G.

Int J Med Microbiol. 2017 Jan;307(1):57-63. doi: 10.1016/j.ijmm.2016.11.003. Epub 2016 Nov 30.

PMID:
27931949
13.

Determination of Bacterial Membrane Impairment by Antimicrobial Agents.

Wilmes M, Sahl HG.

Methods Mol Biol. 2017;1520:133-143. doi: 10.1007/978-1-4939-6634-9_8.

PMID:
27873250
14.

Daptomycin inhibits cell envelope synthesis by interfering with fluid membrane microdomains.

Müller A, Wenzel M, Strahl H, Grein F, Saaki TNV, Kohl B, Siersma T, Bandow JE, Sahl HG, Schneider T, Hamoen LW.

Proc Natl Acad Sci U S A. 2016 Nov 8;113(45):E7077-E7086. doi: 10.1073/pnas.1611173113. Epub 2016 Oct 24.

15.

Identification of antibacterial peptides from endophytic microbiome.

Tejesvi MV, Picart P, Kajula M, Hautajärvi H, Ruddock L, Kristensen HH, Tossi A, Sahl HG, Ek S, Mattila S, Pirttilä AM.

Appl Microbiol Biotechnol. 2016 Nov;100(21):9283-9293. Epub 2016 Aug 19.

PMID:
27541748
16.

Bridged Epipolythiodiketopiperazines from Penicillium raciborskii, an Endophytic Fungus of Rhododendron tomentosum Harmaja.

Kajula M, Ward JM, Turpeinen A, Tejesvi MV, Hokkanen J, Tolonen A, Häkkänen H, Picart P, Ihalainen J, Sahl HG, Pirttilä AM, Mattila S.

J Nat Prod. 2016 Apr 22;79(4):685-90. doi: 10.1021/np500822k. Epub 2016 Apr 8.

PMID:
27057690
17.

Investigations to the Antibacterial Mechanism of Action of Kendomycin.

Elnakady YA, Chatterjee I, Bischoff M, Rohde M, Josten M, Sahl HG, Herrmann M, Müller R.

PLoS One. 2016 Jan 21;11(1):e0146165. doi: 10.1371/journal.pone.0146165. eCollection 2016.

18.

Lipid Requirements for the Enzymatic Activity of MraY Translocases and in Vitro Reconstitution of the Lipid II Synthesis Pathway.

Henrich E, Ma Y, Engels I, Münch D, Otten C, Schneider T, Henrichfreise B, Sahl HG, Dötsch V, Bernhard F.

J Biol Chem. 2016 Jan 29;291(5):2535-46. doi: 10.1074/jbc.M115.664292. Epub 2015 Nov 30.

19.

Biosynthetic Origin of the Antibiotic Pseudopyronines A and B in Pseudomonas putida BW11M1.

Bauer JS, Ghequire MG, Nett M, Josten M, Sahl HG, De Mot R, Gross H.

Chembiochem. 2015 Nov;16(17):2491-7. doi: 10.1002/cbic.201500413. Epub 2015 Oct 28.

PMID:
26507104
20.

Bacterial resistance to antimicrobial peptides.

Sahl HG, Shai Y.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3019-20. doi: 10.1016/j.bbamem.2015.08.009. Epub 2015 Sep 3. No abstract available.

21.

Mode of action of closthioamide: the first member of the polythioamide class of bacterial DNA gyrase inhibitors.

Chiriac AI, Kloss F, Krämer J, Vuong C, Hertweck C, Sahl HG.

J Antimicrob Chemother. 2015 Sep;70(9):2576-88. doi: 10.1093/jac/dkv161. Epub 2015 Jul 14.

PMID:
26174721
22.

Structural variations of the cell wall precursor lipid II in Gram-positive bacteria - Impact on binding and efficacy of antimicrobial peptides.

Münch D, Sahl HG.

Biochim Biophys Acta. 2015 Nov;1848(11 Pt B):3062-71. doi: 10.1016/j.bbamem.2015.04.014. Epub 2015 Apr 29. Review.

23.

Co-solvents as stabilizing agents during heterologous overexpression in Escherichia coli - application to chlamydial penicillin-binding protein 6.

Otten C, De Benedetti S, Gaballah A, Bühl H, Klöckner A, Brauner J, Sahl HG, Henrichfreise B.

PLoS One. 2015 Apr 7;10(4):e0122110. doi: 10.1371/journal.pone.0122110. eCollection 2015.

24.

Antimicrobial Peptides from the Aurein Family Form Ion-Selective Pores in Bacillus subtilis.

Wenzel M, Senges CH, Zhang J, Suleman S, Nguyen M, Kumar P, Chiriac AI, Stepanek JJ, Raatschen N, May C, Krämer U, Sahl HG, Straus SK, Bandow JE.

Chembiochem. 2015 May 4;16(7):1101-8. doi: 10.1002/cbic.201500020. Epub 2015 Mar 27.

PMID:
25821129
25.

Pseudomycoicidin, a Class II Lantibiotic from Bacillus pseudomycoides.

Basi-Chipalu S, Dischinger J, Josten M, Szekat C, Zweynert A, Sahl HG, Bierbaum G.

Appl Environ Microbiol. 2015 May 15;81(10):3419-29. doi: 10.1128/AEM.00299-15. Epub 2015 Mar 13.

26.

The lantibiotic nisin induces lipid II aggregation, causing membrane instability and vesicle budding.

Scherer KM, Spille JH, Sahl HG, Grein F, Kubitscheck U.

Biophys J. 2015 Mar 10;108(5):1114-24. doi: 10.1016/j.bpj.2015.01.020.

27.

Killing of staphylococci by θ-defensins involves membrane impairment and activation of autolytic enzymes.

Wilmes M, Stockem M, Bierbaum G, Schlag M, Götz F, Tran DQ, Schaal JB, Ouellette AJ, Selsted ME, Sahl HG.

Antibiotics (Basel). 2014;3(4):617-31. doi: 10.3390/antibiotics3040617.

28.

Family of class I lantibiotics from actinomycetes and improvement of their antibacterial activities.

Maffioli SI, Monciardini P, Catacchio B, Mazzetti C, Münch D, Brunati C, Sahl HG, Donadio S.

ACS Chem Biol. 2015 Apr 17;10(4):1034-42. doi: 10.1021/cb500878h. Epub 2015 Jan 23.

PMID:
25574687
29.

Structural variations of the cell wall precursor lipid II and their influence on binding and activity of the lipoglycopeptide antibiotic oritavancin.

Münch D, Engels I, Müller A, Reder-Christ K, Falkenstein-Paul H, Bierbaum G, Grein F, Bendas G, Sahl HG, Schneider T.

Antimicrob Agents Chemother. 2015 Feb;59(2):772-81. doi: 10.1128/AAC.02663-14. Epub 2014 Nov 17.

30.

Copsin, a novel peptide-based fungal antibiotic interfering with the peptidoglycan synthesis.

Essig A, Hofmann D, Münch D, Gayathri S, Künzler M, Kallio PT, Sahl HG, Wider G, Schneider T, Aebi M.

J Biol Chem. 2014 Dec 12;289(50):34953-64. doi: 10.1074/jbc.M114.599878. Epub 2014 Oct 23.

31.

Structural dynamics of the cell wall precursor lipid II in the presence and absence of the lantibiotic nisin.

Koch DC, Schmidt TH, Sahl HG, Kubitscheck U, Kandt C.

Biochim Biophys Acta. 2014 Dec;1838(12):3061-8. doi: 10.1016/j.bbamem.2014.07.024. Epub 2014 Aug 12.

32.

Thiosulfate transfer mediated by DsrE/TusA homologs from acidothermophilic sulfur-oxidizing archaeon Metallosphaera cuprina.

Liu LJ, Stockdreher Y, Koch T, Sun ST, Fan Z, Josten M, Sahl HG, Wang Q, Luo YM, Liu SJ, Dahl C, Jiang CY.

J Biol Chem. 2014 Sep 26;289(39):26949-59. doi: 10.1074/jbc.M114.591669. Epub 2014 Aug 13.

33.

Identification of agr-positive methicillin-resistant Staphylococcus aureus harbouring the class A mec complex by MALDI-TOF mass spectrometry.

Josten M, Dischinger J, Szekat C, Reif M, Al-Sabti N, Sahl HG, Parcina M, Bekeredjian-Ding I, Bierbaum G.

Int J Med Microbiol. 2014 Nov;304(8):1018-23. doi: 10.1016/j.ijmm.2014.07.005. Epub 2014 Jul 25.

PMID:
25116838
34.

AmiA is a penicillin target enzyme with dual activity in the intracellular pathogen Chlamydia pneumoniae.

Klöckner A, Otten C, Derouaux A, Vollmer W, Bühl H, De Benedetti S, Münch D, Josten M, Mölleken K, Sahl HG, Henrichfreise B.

Nat Commun. 2014 Jun 23;5:4201. doi: 10.1038/ncomms5201.

35.

Bactericidal activity of the human skin fatty acid cis-6-hexadecanoic acid on Staphylococcus aureus.

Cartron ML, England SR, Chiriac AI, Josten M, Turner R, Rauter Y, Hurd A, Sahl HG, Jones S, Foster SJ.

Antimicrob Agents Chemother. 2014 Jul;58(7):3599-609. doi: 10.1128/AAC.01043-13. Epub 2014 Apr 7.

36.

Small cationic antimicrobial peptides delocalize peripheral membrane proteins.

Wenzel M, Chiriac AI, Otto A, Zweytick D, May C, Schumacher C, Gust R, Albada HB, Penkova M, Krämer U, Erdmann R, Metzler-Nolte N, Straus SK, Bremer E, Becher D, Brötz-Oesterhelt H, Sahl HG, Bandow JE.

Proc Natl Acad Sci U S A. 2014 Apr 8;111(14):E1409-18. doi: 10.1073/pnas.1319900111. Epub 2014 Mar 24.

37.

New proteins involved in sulfur trafficking in the cytoplasm of Allochromatium vinosum.

Stockdreher Y, Sturm M, Josten M, Sahl HG, Dobler N, Zigann R, Dahl C.

J Biol Chem. 2014 May 2;289(18):12390-403. doi: 10.1074/jbc.M113.536425. Epub 2014 Mar 19.

38.

The lantibiotic NAI-107 binds to bactoprenol-bound cell wall precursors and impairs membrane functions.

Münch D, Müller A, Schneider T, Kohl B, Wenzel M, Bandow JE, Maffioli S, Sosio M, Donadio S, Wimmer R, Sahl HG.

J Biol Chem. 2014 Apr 25;289(17):12063-76. doi: 10.1074/jbc.M113.537449. Epub 2014 Mar 13.

39.

Characterization of serine hydroxymethyltransferase GlyA as a potential source of D-alanine in Chlamydia pneumoniae.

De Benedetti S, Bühl H, Gaballah A, Klöckner A, Otten C, Schneider T, Sahl HG, Henrichfreise B.

Front Cell Infect Microbiol. 2014 Feb 26;4:19. doi: 10.3389/fcimb.2014.00019. eCollection 2014.

40.

Biosynthetic origin of the antibiotic cyclocarbamate brabantamide A (SB-253514) in plant-associated Pseudomonas.

Schmidt Y, van der Voort M, Crüsemann M, Piel J, Josten M, Sahl HG, Miess H, Raaijmakers JM, Gross H.

Chembiochem. 2014 Jan 24;15(2):259-66.

PMID:
24436210
41.

The search for new anti-infective drugs: untapped resources and strategies.

Bierbaum G, Sahl HG.

Int J Med Microbiol. 2014 Jan;304(1):1-2. doi: 10.1016/j.ijmm.2013.10.003. Epub 2013 Oct 11. No abstract available.

PMID:
24183099
42.

Defensin-based anti-infective strategies.

Wilmes M, Sahl HG.

Int J Med Microbiol. 2014 Jan;304(1):93-9. doi: 10.1016/j.ijmm.2013.08.007. Epub 2013 Sep 4. Review.

PMID:
24119539
43.

Antibiotic-induced autoactivation of IS256 in Staphylococcus aureus.

Schreiber F, Szekat C, Josten M, Sahl HG, Bierbaum G.

Antimicrob Agents Chemother. 2013 Dec;57(12):6381-4. doi: 10.1128/AAC.01585-13. Epub 2013 Sep 30.

44.

New strategies and compounds for anti-infective treatment.

Hancock RE, Sahl HG.

Curr Opin Microbiol. 2013 Oct;16(5):519-21. doi: 10.1016/j.mib.2013.08.004. Epub 2013 Aug 30. No abstract available.

PMID:
23998895
45.

On the antibiotic and antifungal activity of pestalone, pestalachloride A, and structurally related compounds.

Augner D, Krut O, Slavov N, Gerbino DC, Sahl HG, Benting J, Nising CF, Hillebrand S, Krönke M, Schmalz HG.

J Nat Prod. 2013 Aug 23;76(8):1519-22. doi: 10.1021/np400301d. Epub 2013 Aug 1.

PMID:
23905700
46.

Aggregates of nisin with various bactoprenol-containing cell wall precursors differ in size and membrane permeation capacity.

Scherer K, Wiedemann I, Ciobanasu C, Sahl HG, Kubitscheck U.

Biochim Biophys Acta. 2013 Nov;1828(11):2628-36. doi: 10.1016/j.bbamem.2013.07.014. Epub 2013 Jul 18.

47.

Analysis of the matrix-assisted laser desorption ionization-time of flight mass spectrum of Staphylococcus aureus identifies mutations that allow differentiation of the main clonal lineages.

Josten M, Reif M, Szekat C, Al-Sabti N, Roemer T, Sparbier K, Kostrzewa M, Rohde H, Sahl HG, Bierbaum G.

J Clin Microbiol. 2013 Jun;51(6):1809-17. doi: 10.1128/JCM.00518-13. Epub 2013 Apr 3.

48.

Requirement of lipid II biosynthesis for cell division in cell wall-less Wolbachia, endobacteria of arthropods and filarial nematodes.

Vollmer J, Schiefer A, Schneider T, Jülicher K, Johnston KL, Taylor MJ, Sahl HG, Hoerauf A, Pfarr K.

Int J Med Microbiol. 2013 Apr;303(3):140-9. doi: 10.1016/j.ijmm.2013.01.002. Epub 2013 Mar 19.

PMID:
23517690
49.

Lahorenoic acids A-C, ortho-dialkyl-substituted aromatic acids from the biocontrol strain Pseudomonas aurantiaca PB-St2.

Mehnaz S, Saleem RS, Yameen B, Pianet I, Schnakenburg G, Pietraszkiewicz H, Valeriote F, Josten M, Sahl HG, Franzblau SG, Gross H.

J Nat Prod. 2013 Feb 22;76(2):135-41. doi: 10.1021/np3005166. Epub 2013 Feb 12.

PMID:
23402329
50.

The Staphylococcus aureus Membrane Protein SA2056 Interacts with Peptidoglycan Synthesis Enzymes.

Quiblier C, Luczak-Kadlubowska A, Holdener E, Alborn D, Schneider T, Wiedemann I, Pinho MG, Sahl HG, Rohrer S, Berger-Bächi B, Senn MM.

Antibiotics (Basel). 2013 Jan 22;2(1):11-27. doi: 10.3390/antibiotics2010011.

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