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Items: 1 to 50 of 150

1.

Endoscopic sphincterotoMy for delayIng choLecystectomy in mild acute biliarY pancreatitis (EMILY study): protocol of a multicentre randomised clinical trial.

Kucserik LP, Márta K, Vincze Á, Lázár G, Czakó L, Szentkereszty Z, Papp M, Palatka K, Izbéki F, Altorjay Á, Török I, Barbu S, Tantau M, Vereczkei A, Bogár L, Dénes M, Németh I, Szentesi A, Zádori N, Antal J, Lerch MM, Neoptolemos J, Sahin-Tóth M, Petersen OH, Kelemen D, Hegyi P.

BMJ Open. 2019 Jul 9;9(7):e025551. doi: 10.1136/bmjopen-2018-025551.

2.

Engineering mouse cationic trypsinogen for rapid and selective activation by cathepsin B.

Demcsák A, Geisz A, Sahin-Tóth M.

Sci Rep. 2019 Jun 24;9(1):9188. doi: 10.1038/s41598-019-45631-z.

3.

Natural single-nucleotide deletion in chymotrypsinogen C gene increases severity of secretagogue-induced pancreatitis in C57BL/6 mice.

Geisz A, Jancsó Z, Németh BC, Hegyi E, Sahin-Tóth M.

JCI Insight. 2019 Jun 18;5. pii: 129717. doi: 10.1172/jci.insight.129717.

4.

Novel Pathogenic PRSS1 Variant p.Glu190Lys in a Case of Chronic Pancreatitis.

Jancsó Z, Oracz G, Kujko AA, Kolodziejczyk E, Radisky ES, Rygiel AM, Sahin-Tóth M.

Front Genet. 2019 Feb 6;10:46. doi: 10.3389/fgene.2019.00046. eCollection 2019.

5.

Protease-Sensitive Pancreatic Lipase Variants Are Associated With Early Onset Chronic Pancreatitis.

Lasher D, Szabó A, Masamune A, Chen JM, Xiao X, Whitcomb DC, Barmada MM, Ewers M, Ruffert C, Paliwal S, Issarapu P, Bhaskar S, Mani KR, Chandak GR, Laumen H, Masson E, Kume K, Hamada S, Nakano E, Seltsam K, Bugert P, Müller T, Groneberg DA, Shimosegawa T, Rosendahl J, Férec C, Lowe ME, Witt H, Sahin-Tóth M.

Am J Gastroenterol. 2019 Jun;114(6):974-983. doi: 10.14309/ajg.0000000000000051.

6.

Genetics, Cell Biology, and Pathophysiology of Pancreatitis.

Mayerle J, Sendler M, Hegyi E, Beyer G, Lerch MM, Sahin-Tóth M.

Gastroenterology. 2019 May;156(7):1951-1968.e1. doi: 10.1053/j.gastro.2018.11.081. Epub 2019 Jan 18. Review.

PMID:
30660731
7.

A preclinical model of chronic pancreatitis driven by trypsinogen autoactivation.

Geisz A, Sahin-Tóth M.

Nat Commun. 2018 Nov 28;9(1):5033. doi: 10.1038/s41467-018-07347-y.

8.

The common truncation variant in pancreatic lipase related protein 2 (PNLIPRP2) is expressed poorly and does not alter risk for chronic pancreatitis.

Németh BC, Pesei ZG, Hegyi E, Szücs Á, Szentesi A, Hegyi P, Lowe ME, Sahin-Tóth M.

PLoS One. 2018 Nov 8;13(11):e0206869. doi: 10.1371/journal.pone.0206869. eCollection 2018.

9.

Trypsinogen isoforms in the ferret pancreas.

Hegyi E, Sahin-Tóth M.

Sci Rep. 2018 Oct 10;8(1):15094. doi: 10.1038/s41598-018-33423-w.

10.

Pancreatitis-Associated Genes and Pancreatic Cancer Risk: A Systematic Review and Meta-analysis.

Cazacu IM, Farkas N, Garami A, Balaskó M, Mosdósi B, Alizadeh H, Gyöngyi Z, Rakonczay Z Jr, Vigh É, Habon T, Czopf L, Lazarescu MA, Erőss B, Sahin-Tóth M, Hegyi P.

Pancreas. 2018 Oct;47(9):1078-1086. doi: 10.1097/MPA.0000000000001145.

11.

Chymotrypsin Reduces the Severity of Secretagogue-Induced Pancreatitis in Mice.

Jancsó Z, Hegyi E, Sahin-Tóth M.

Gastroenterology. 2018 Oct;155(4):1017-1021. doi: 10.1053/j.gastro.2018.06.041. Epub 2018 Aug 1.

PMID:
30076839
12.

Human CPA1 mutation causes digestive enzyme misfolding and chronic pancreatitis in mice.

Hegyi E, Sahin-Tóth M.

Gut. 2019 Feb;68(2):301-312. doi: 10.1136/gutjnl-2018-315994. Epub 2018 Jul 25.

PMID:
30045879
13.

EPC/HPSG evidence-based guidelines for the management of pediatric pancreatitis.

Párniczky A, Abu-El-Haija M, Husain S, Lowe M, Oracz G, Sahin-Tóth M, Szabó FK, Uc A, Wilschanski M, Witt H, Czakó L, Grammatikopoulos T, Rasmussen IC, Sutton R, Hegyi P.

Pancreatology. 2018 Mar;18(2):146-160. doi: 10.1016/j.pan.2018.01.001. Epub 2018 Jan 4. Review.

PMID:
29398347
14.

Novel PRSS1 Mutation p.P17T Validates Pathogenic Relevance of CTRC-Mediated Processing of the Trypsinogen Activation Peptide in Chronic Pancreatitis.

Németh BC, Szücs Á, Hegyi P, Sahin-Tóth M.

Am J Gastroenterol. 2017 Dec;112(12):1896-1898. doi: 10.1038/ajg.2017.393. No abstract available.

15.

Smoking and Drinking Synergize in Pancreatitis: Multiple Hits on Multiple Targets.

Sahin-Tóth M, Hegyi P.

Gastroenterology. 2017 Dec;153(6):1479-1481. doi: 10.1053/j.gastro.2017.10.031. Epub 2017 Oct 31. No abstract available.

PMID:
29100845
16.

Partial and complete SPINK1 deficiency cause distinct pancreatic phenotypes.

Sahin-Tóth M.

Hum Mutat. 2017 Dec;38(12):1619. doi: 10.1002/humu.23352. No abstract available.

PMID:
29091332
17.

High versus low energy administration in the early phase of acute pancreatitis (GOULASH trial): protocol of a multicentre randomised double-blind clinical trial.

Márta K, Szabó AN, Pécsi D, Varjú P, Bajor J, Gódi S, Sarlós P, Mikó A, Szemes K, Papp M, Tornai T, Vincze Á, Márton Z, Vincze PA, Lankó E, Szentesi A, Molnár T, Hágendorn R, Faluhelyi N, Battyáni I, Kelemen D, Papp R, Miseta A, Verzár Z, Lerch MM, Neoptolemos JP, Sahin-Tóth M, Petersen OH, Hegyi P; Hungarian Pancreatic Study Group.

BMJ Open. 2017 Sep 14;7(9):e015874. doi: 10.1136/bmjopen-2017-015874.

18.

Genome-wide association study identifies inversion in the CTRB1-CTRB2 locus to modify risk for alcoholic and non-alcoholic chronic pancreatitis.

Rosendahl J, Kirsten H, Hegyi E, Kovacs P, Weiss FU, Laumen H, Lichtner P, Ruffert C, Chen JM, Masson E, Beer S, Zimmer C, Seltsam K, Algül H, Bühler F, Bruno MJ, Bugert P, Burkhardt R, Cavestro GM, Cichoz-Lach H, Farré A, Frank J, Gambaro G, Gimpfl S, Grallert H, Griesmann H, Grützmann R, Hellerbrand C, Hegyi P, Hollenbach M, Iordache S, Jurkowska G, Keim V, Kiefer F, Krug S, Landt O, Leo MD, Lerch MM, Lévy P, Löffler M, Löhr M, Ludwig M, Macek M, Malats N, Malecka-Panas E, Malerba G, Mann K, Mayerle J, Mohr S, Te Morsche RHM, Motyka M, Mueller S, Müller T, Nöthen MM, Pedrazzoli S, Pereira SP, Peters A, Pfützer R, Real FX, Rebours V, Ridinger M, Rietschel M, Rösmann E, Saftoiu A, Schneider A, Schulz HU, Soranzo N, Soyka M, Simon P, Skipworth J, Stickel F, Strauch K, Stumvoll M, Testoni PA, Tönjes A, Werner L, Werner J, Wodarz N, Ziegler M, Masamune A, Mössner J, Férec C, Michl P, P H Drenth J, Witt H, Scholz M, Sahin-Tóth M; all members of the PanEuropean Working group on ACP.

Gut. 2018 Oct;67(10):1855-1863. doi: 10.1136/gutjnl-2017-314454. Epub 2017 Jul 28.

19.

Genetic risk in chronic pancreatitis: the misfolding-dependent pathway.

Sahin-Tóth M.

Curr Opin Gastroenterol. 2017 Sep;33(5):390-395. doi: 10.1097/MOG.0000000000000380. Review.

20.

Pancreatic Cancer Cell Lines Heterozygous for the SPINK1 p.N34S Haplotype Exhibit Diminished Expression of the Variant Allele.

Kereszturi É, Sahin-Tóth M.

Pancreas. 2017 Jul;46(6):e54-e55. doi: 10.1097/MPA.0000000000000817. No abstract available.

21.

Genetic Risk in Chronic Pancreatitis: The Trypsin-Dependent Pathway.

Hegyi E, Sahin-Tóth M.

Dig Dis Sci. 2017 Jul;62(7):1692-1701. doi: 10.1007/s10620-017-4601-3. Epub 2017 May 23. Review.

22.

No significant enrichment of rare functionally defective CPA1 variants in a large Chinese idiopathic chronic pancreatitis cohort.

Wu H, Zhou DZ, Berki D, Geisz A, Zou WB, Sun XT, Hu LH, Zhao ZH, Zhao AJ, He L, Cooper DN, Férec C, Chen JM, Li ZS, Sahin-Tóth M, Liao Z.

Hum Mutat. 2017 Aug;38(8):959-963. doi: 10.1002/humu.23254. Epub 2017 May 30.

23.

Detection of human elastase isoforms by the ScheBo Pancreatic Elastase 1 Test.

Tóth AZ, Szabó A, Hegyi E, Hegyi P, Sahin-Tóth M.

Am J Physiol Gastrointest Liver Physiol. 2017 Jun 1;312(6):G606-G614. doi: 10.1152/ajpgi.00060.2017. Epub 2017 Mar 30.

24.

A novel p.Ser282Pro CPA1 variant is associated with autosomal dominant hereditary pancreatitis.

Kujko AA, Berki DM, Oracz G, Wejnarska K, Antoniuk J, Wertheim-Tysarowska K, Kołodziejczyk E, Bal J, Sahin-Tóth M, Rygiel AM.

Gut. 2017 Sep;66(9):1728-1730. doi: 10.1136/gutjnl-2017-313816. Epub 2017 Mar 3. No abstract available.

25.

Chronic pancreatitis: Multicentre prospective data collection and analysis by the Hungarian Pancreatic Study Group.

Szücs Á, Marjai T, Szentesi A, Farkas N, Párniczky A, Nagy G, Kui B, Takács T, Czakó L, Szepes Z, Németh BC, Vincze Á, Pár G, Szabó I, Sarlós P, Illés A, Gódi S, Izbéki F, Gervain J, Halász A, Farkas G, Leindler L, Kelemen D, Papp R, Szmola R, Varga M, Hamvas J, Novák J, Bod B, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group.

PLoS One. 2017 Feb 16;12(2):e0171420. doi: 10.1371/journal.pone.0171420. eCollection 2017.

26.

Overlapping Specificity of Duplicated Human Pancreatic Elastase 3 Isoforms and Archetypal Porcine Elastase 1 Provides Clues to Evolution of Digestive Enzymes.

Boros E, Szabó A, Zboray K, Héja D, Pál G, Sahin-Tóth M.

J Biol Chem. 2017 Feb 17;292(7):2690-2702. doi: 10.1074/jbc.M116.770560. Epub 2017 Jan 6.

27.

Misfolding cationic trypsinogen variant p.L104P causes hereditary pancreatitis.

Németh BC, Patai ÁV, Sahin-Tóth M, Hegyi P.

Gut. 2017 Sep;66(9):1727-1728. doi: 10.1136/gutjnl-2016-313451. Epub 2016 Dec 23. No abstract available.

28.

Genetic Analysis of Human Chymotrypsin-Like Elastases 3A and 3B (CELA3A and CELA3B) to Assess the Role of Complex Formation between Proelastases and Procarboxypeptidases in Chronic Pancreatitis.

Párniczky A, Hegyi E, Tóth AZ, Szücs Á, Szentesi A, Vincze Á, Izbéki F, Németh BC, Hegyi P, Sahin-Tóth M.

Int J Mol Sci. 2016 Dec 20;17(12):2148. doi: 10.3390/ijms17122148.

29.

Prospective, Multicentre, Nationwide Clinical Data from 600 Cases of Acute Pancreatitis.

Párniczky A, Kui B, Szentesi A, Balázs A, Szűcs Á, Mosztbacher D, Czimmer J, Sarlós P, Bajor J, Gódi S, Vincze Á, Illés A, Szabó I, Pár G, Takács T, Czakó L, Szepes Z, Rakonczay Z, Izbéki F, Gervain J, Halász A, Novák J, Crai S, Hritz I, Góg C, Sümegi J, Golovics P, Varga M, Bod B, Hamvas J, Varga-Müller M, Papp Z, Sahin-Tóth M, Hegyi P; Hungarian Pancreatic Study Group.

PLoS One. 2016 Oct 31;11(10):e0165309. doi: 10.1371/journal.pone.0165309. eCollection 2016.

30.

Complex Formation of Human Proelastases with Procarboxypeptidases A1 and A2.

Szabó A, Pilsak C, Bence M, Witt H, Sahin-Tóth M.

J Biol Chem. 2016 Aug 19;291(34):17706-16. doi: 10.1074/jbc.M116.743237. Epub 2016 Jun 29.

31.

Tighter Control by Chymotrypsin C (CTRC) Explains Lack of Association between Human Anionic Trypsinogen and Hereditary Pancreatitis.

Jancsó Z, Sahin-Tóth M.

J Biol Chem. 2016 Jun 17;291(25):12897-905. doi: 10.1074/jbc.M116.725374. Epub 2016 Apr 18.

32.

CFTR: A New Horizon in the Pathomechanism and Treatment of Pancreatitis.

Hegyi P, Wilschanski M, Muallem S, Lukacs GL, Sahin-Tóth M, Uc A, Gray MA, Rakonczay Z Jr, Maléth J.

Rev Physiol Biochem Pharmacol. 2016;170:37-66. doi: 10.1007/112_2015_5002. Review.

33.

Pathogenic cellular role of the p.L104P human cationic trypsinogen variant in chronic pancreatitis.

Balázs A, Hegyi P, Sahin-Tóth M.

Am J Physiol Gastrointest Liver Physiol. 2016 Apr 1;310(7):G477-86. doi: 10.1152/ajpgi.00444.2015. Epub 2016 Jan 28.

34.

A Common CCK-B Receptor Intronic Variant in Pancreatic Adenocarcinoma in a Hungarian Cohort.

Balázs A, Németh BC, Ördög B, Hegyi E, Hritz I, Czakó L, Czimmer J, Gódi S, Csiszkó A, Rakonczay Z Jr, Párniczky A, Izbéki F, Halász A, Kahán Z, Hegyi P, Sahin-Tóth M; Hungarian Pancreatic Study Group.

Pancreas. 2016 Apr;45(4):541-5. doi: 10.1097/MPA.0000000000000539.

35.

Serine protease inhibitor Kazal type 1 (SPINK1) drives proliferation and anoikis resistance in a subset of ovarian cancers.

Mehner C, Oberg AL, Kalli KR, Nassar A, Hockla A, Pendlebury D, Cichon MA, Goergen KM, Maurer MJ, Goode EL, Keeney GL, Jatoi A, Sahin-Tóth M, Copland JA, Radisky DC, Radisky ES.

Oncotarget. 2015 Nov 3;6(34):35737-54. doi: 10.18632/oncotarget.5927.

36.

Genetic analysis of the bicarbonate secreting anion exchanger SLC26A6 in chronic pancreatitis.

Balázs A, Ruffert C, Hegyi E, Hritz I, Czakó L, Takács T, Szepes Z, Németh BC, Gervain J, Izbéki F, Halász A, Kelemen D, Szmola R, Novák J, Crai S, Illés A, Vincze Á, Molnár Z, Varga M, Bod B, Farkas G Jr, Sümegi J, Szepes A, Dubravcsik Z, Lásztity N, Párniczky A, Hamvas J, Andorka C, Veres G, Szentkereszty Z, Rakonczay Z Jr, Maléth J, Sahin-Tóth M, Rosendahl J, Hegyi P; Hungarian Pancreatic Study Group.

Pancreatology. 2015 Sep-Oct;15(5):508-513. doi: 10.1016/j.pan.2015.08.008. Epub 2015 Sep 1.

PMID:
26372434
37.

SPINK1 Promoter Variants in Chronic Pancreatitis.

Hegyi E, Geisz A, Sahin-Tóth M, Derikx MH, Németh BC, Balázs A, Hritz I, Izbéki F, Halász A, Párniczky A, Takács T, Kelemen D, Sarlós P, Hegyi P, Czakó L; Hungarian Pancreatic Study Group.

Pancreas. 2016 Jan;45(1):148-53. doi: 10.1097/MPA.0000000000000412.

PMID:
26348468
38.

Variants in pancreatic carboxypeptidase genes CPA2 and CPB1 are not associated with chronic pancreatitis.

Nakano E, Geisz A, Masamune A, Niihori T, Hamada S, Kume K, Kakuta Y, Aoki Y, Matsubara Y, Ebert K, Ludwig M, Braun M, Groneberg DA, Shimosegawa T, Sahin-Tóth M, Witt H.

Am J Physiol Gastrointest Liver Physiol. 2015 Oct 15;309(8):G688-94. doi: 10.1152/ajpgi.00241.2015. Epub 2015 Aug 27.

39.

Mesotrypsin Signature Mutation in a Chymotrypsin C (CTRC) Variant Associated with Chronic Pancreatitis.

Szabó A, Ludwig M, Hegyi E, Szépeová R, Witt H, Sahin-Tóth M.

J Biol Chem. 2015 Jul 10;290(28):17282-92. doi: 10.1074/jbc.M114.618439. Epub 2015 May 26.

40.

A novel mutation in PNLIP causes pancreatic triglyceride lipase deficiency through protein misfolding.

Szabó A, Xiao X, Haughney M, Spector A, Sahin-Tóth M, Lowe ME.

Biochim Biophys Acta. 2015 Jul;1852(7):1372-9. doi: 10.1016/j.bbadis.2015.04.002. Epub 2015 Apr 7.

41.

Functional significance of SPINK1 promoter variants in chronic pancreatitis.

Derikx MH, Geisz A, Kereszturi É, Sahin-Tóth M.

Am J Physiol Gastrointest Liver Physiol. 2015 May 1;308(9):G779-84. doi: 10.1152/ajpgi.00022.2015. Epub 2015 Mar 19.

42.

[Pancreatic cancer. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

Szmola R, Farkas G, Hegyi P, Czakó L, Dubravcsik Z, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Párniczky A, Rubovszky G, Sahin-Tóth M, Szentkereszti Z, Szücs Á, Takács T, Tiszlavicz L, Pap Á; Magyar Hasnyálmirigy Munkacsoport, Hungarian Pancreatic Study Group.

Orv Hetil. 2015 Feb 22;156(8):326-39. doi: 10.1556/OH.2015.30063. Review. Hungarian.

PMID:
25662149
43.

[Pediatric pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

Párniczky A, Czakó L, Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Morvay Z, Oláh A, Pap Á, Sahin-Tóth M, Szabó F, Szentkereszti Z, Szmola R, Takács T, Tiszlavicz L, Veres G, Szücs Á, Lásztity N; Magyar Hasnyálmirigy Munkacsoport, Hungarian Pancreatic Study Group.

Orv Hetil. 2015 Feb 22;156(8):308-25. doi: 10.1556/OH.2015.30062. Review. Hungarian.

PMID:
25662148
44.

[Autoimmune pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Sahin-Tóth M, Szentkereszti Z, Szmola R, Takács T, Tiszlavicz L, Szücs Á, Czakó L; Magyar Hasnyálmirigy Munkacsoport, Hungarian Pancreatic Study Group.

Orv Hetil. 2015 Feb 22;156(8):292-307. doi: 10.1556/OH.2015.30061. Review. Hungarian.

PMID:
25662147
45.

[Chronic pancreatitis. Evidence based management guidelines of the Hungarian Pancreatic Study Group].

Takács T, Czakó L, Dubravcsik Z, Farkas G, Hegyi P, Hritz I, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Patai Á, Sahin-Tóth M, Szentkereszti Z, Szmola R, Tiszlavicz L, Szücs Á; Magyar Hasnyálmirigy Munkacsoport.

Orv Hetil. 2015 Feb 15;156(7):262-88. doi: 10.1556/OH.2015.30060. Review. Hungarian.

PMID:
25661971
46.

[Acute pancreatitis. Evidence-based practice guidelines, prepared by the Hungarian Pancreatic Study Group].

Hritz I, Czakó L, Dubravcsik Z, Farkas G, Kelemen D, Lásztity N, Morvay Z, Oláh A, Pap Á, Párniczky A, Sahin-Tóth M, Szentkereszti Z, Szmola R, Szücs Á, Takács T, Tiszlavicz L, Hegyi P; Magyar Hasnyálmirigy Munkacsoport, Hungarian Pancreatic Study Group.

Orv Hetil. 2015 Feb 15;156(7):244-61. doi: 10.1556/OH.2015.30059. Review. Hungarian.

PMID:
25661970
47.

Gene conversion between cationic trypsinogen (PRSS1) and the pseudogene trypsinogen 6 (PRSS3P2) in patients with chronic pancreatitis.

Rygiel AM, Beer S, Simon P, Wertheim-Tysarowska K, Oracz G, Kucharzik T, Tysarowski A, Niepokój K, Kierkus J, Jurek M, Gawliński P, Poznański J, Bal J, Lerch MM, Sahin-Tóth M, Weiss FU.

Hum Mutat. 2015 Mar;36(3):350-6. doi: 10.1002/humu.22747.

48.

Alcohol disrupts levels and function of the cystic fibrosis transmembrane conductance regulator to promote development of pancreatitis.

Maléth J, Balázs A, Pallagi P, Balla Z, Kui B, Katona M, Judák L, Németh I, Kemény LV, Rakonczay Z Jr, Venglovecz V, Földesi I, Pető Z, Somorácz Á, Borka K, Perdomo D, Lukacs GL, Gray MA, Monterisi S, Zaccolo M, Sendler M, Mayerle J, Kühn JP, Lerch MM, Sahin-Tóth M, Hegyi P.

Gastroenterology. 2015 Feb;148(2):427-39.e16. doi: 10.1053/j.gastro.2014.11.002. Epub 2014 Nov 7.

49.

Tyrosine sulfation of human trypsin steers S2' subsite selectivity towards basic amino acids.

Szabó A, Salameh MA, Ludwig M, Radisky ES, Sahin-Tóth M.

PLoS One. 2014 Jul 10;9(7):e102063. doi: 10.1371/journal.pone.0102063. eCollection 2014.

50.

Human cationic trypsinogen (PRSS1) variants and chronic pancreatitis.

Németh BC, Sahin-Tóth M.

Am J Physiol Gastrointest Liver Physiol. 2014 Mar;306(6):G466-73. doi: 10.1152/ajpgi.00419.2013. Epub 2014 Jan 23. Review.

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