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Items: 50

1.

Rapid Bioavailability and Disposition protocol: A novel higher throughput approach to assess pharmacokinetics and steady-state brain distribution with reduced animal usage.

Fu T, Gao R, Scott-Stevens P, Chen Y, Zhang C, Wang J, Summerfield S, Liu H, Sahi J.

Eur J Pharm Sci. 2018 Sep 15;122:13-21. doi: 10.1016/j.ejps.2018.05.027. Epub 2018 May 29.

PMID:
29857045
2.

Correlation between Membrane Protein Expression Levels and Transcellular Transport Activity for Breast Cancer Resistance Protein.

Liu H, Huang L, Li Y, Fu T, Sun X, Zhang YY, Gao R, Chen Q, Zhang W, Sahi J, Summerfield S, Dong K.

Drug Metab Dispos. 2017 May;45(5):449-456. doi: 10.1124/dmd.116.074245. Epub 2017 Feb 16.

PMID:
28209803
3.

Role of Hepatic Drug Transporters in Drug Development.

Liu H, Sahi J.

J Clin Pharmacol. 2016 Jul;56 Suppl 7:S11-22. doi: 10.1002/jcph.703. Review.

PMID:
27385168
4.

Integrating in Silico and in Vitro Approaches To Predict Drug Accessibility to the Central Nervous System.

Zhang YY, Liu H, Summerfield SG, Luscombe CN, Sahi J.

Mol Pharm. 2016 May 2;13(5):1540-50. doi: 10.1021/acs.molpharmaceut.6b00031. Epub 2016 Apr 4.

PMID:
27015243
5.

Solute Carrier Family of the Organic Anion-Transporting Polypeptides 1A2- Madin-Darby Canine Kidney II: A Promising In Vitro System to Understand the Role of Organic Anion-Transporting Polypeptide 1A2 in Blood-Brain Barrier Drug Penetration.

Liu H, Yu N, Lu S, Ito S, Zhang X, Prasad B, He E, Lu X, Li Y, Wang F, Xu H, An G, Unadkat JD, Kusuhara H, Sugiyama Y, Sahi J.

Drug Metab Dispos. 2015 Jul;43(7):1008-18. doi: 10.1124/dmd.115.064170. Epub 2015 Apr 23.

PMID:
25908246
6.

Temporal expression of transporters and receptors in a rat primary co-culture blood-brain barrier model.

Liu H, Li Y, Lu S, Wu Y, Sahi J.

Xenobiotica. 2014 Oct;44(10):941-51. doi: 10.3109/00498254.2014.919430. Epub 2014 May 14.

PMID:
24827375
7.

A comprehensive evaluation of metabolic activity and intrinsic clearance in suspensions and monolayer cultures of cryopreserved primary human hepatocytes.

Smith CM, Nolan CK, Edwards MA, Hatfield JB, Stewart TW, Ferguson SS, Lecluyse EL, Sahi J.

J Pharm Sci. 2012 Oct;101(10):3989-4002. doi: 10.1002/jps.23262. Epub 2012 Jul 17.

PMID:
22806329
8.

Determination of OATP-, NTCP- and OCT-mediated substrate uptake activities in individual and pooled batches of cryopreserved human hepatocytes.

De Bruyn T, Ye ZW, Peeters A, Sahi J, Baes M, Augustijns PF, Annaert PP.

Eur J Pharm Sci. 2011 Jul 17;43(4):297-307. doi: 10.1016/j.ejps.2011.05.002. Epub 2011 May 14.

PMID:
21605667
9.

Hepatocytes as a tool in drug metabolism, transport and safety evaluations in drug discovery.

Sahi J, Grepper S, Smith C.

Curr Drug Discov Technol. 2010 Sep;7(3):188-98. Review.

PMID:
20843293
10.
11.

Regulation of cytochrome P450 2C9 expression in primary cultures of human hepatocytes.

Sahi J, Shord SS, Lindley C, Ferguson S, LeCluyse EL.

J Biochem Mol Toxicol. 2009 Jan-Feb;23(1):43-58. doi: 10.1002/jbt.20264.

PMID:
19202563
12.

The state of in vitro science for use in bioaccumulation assessments for fish.

Weisbrod AV, Sahi J, Segner H, James MO, Nichols J, Schultz I, Erhardt S, Cowan-Ellsberry C, Bonnell M, Hoeger B.

Environ Toxicol Chem. 2009 Jan;28(1):86-96. doi: 10.1897/08-015.1. Review.

PMID:
18717614
13.

Current industrial practices in assessing CYP450 enzyme induction: preclinical and clinical.

Sinz M, Wallace G, Sahi J.

AAPS J. 2008 Jun;10(2):391-400. doi: 10.1208/s12248-008-9037-4. Epub 2008 Aug 7. Review.

14.

Use of in vitro transporter assays to understand hepatic and renal disposition of new drug candidates.

Sahi J.

Expert Opin Drug Metab Toxicol. 2005 Oct;1(3):409-27. Review.

PMID:
16863453
15.

Hepatobiliary disposition in primary cultures of dog and monkey hepatocytes.

Rose KA, Kostrubsky V, Sahi J.

Mol Pharm. 2006 May-Jun;3(3):266-74.

PMID:
16749858
16.

Metabolism and transporter-mediated drug-drug interactions of the endothelin-A receptor antagonist CI-1034.

Sahi J, Sinz MW, Campbell S, Mireles R, Zheng X, Rose KA, Raeissi S, Hashim MF, Ye Y, de Morais SM, Black C, Tugnait M, Keller LH.

Chem Biol Interact. 2006 Feb 1;159(2):156-68. Epub 2005 Dec 13.

PMID:
16356485
17.

In vitro ADME phenotyping in drug discovery: current challenges and future solutions.

Williams JA, Bauman J, Cai H, Conlon K, Hansel S, Hurst S, Sadagopan N, Tugnait M, Zhang L, Sahi J.

Curr Opin Drug Discov Devel. 2005 Jan;8(1):78-88. Review.

PMID:
15679175
18.

Effects of avasimibe on cytochrome P450 2C9 expression in vitro and in vivo.

Sahi J, Stern RH, Milad MA, Rose KA, Gibson G, Zheng X, Stilgenbauer L, Sadagopan N, Jolley S, Gilbert D, LeCluyse EL.

Drug Metab Dispos. 2004 Dec;32(12):1370-6. Epub 2004 Aug 27.

PMID:
15333513
19.

Induction of drug metabolism enzymes and MDR1 using a novel human hepatocyte cell line.

Mills JB, Rose KA, Sadagopan N, Sahi J, de Morais SM.

J Pharmacol Exp Ther. 2004 Apr;309(1):303-9. Epub 2004 Jan 13.

PMID:
14722322
20.

Evaluation of hepatotoxic potential of drugs by inhibition of bile-acid transport in cultured primary human hepatocytes and intact rats.

Kostrubsky VE, Strom SC, Hanson J, Urda E, Rose K, Burliegh J, Zocharski P, Cai H, Sinclair JF, Sahi J.

Toxicol Sci. 2003 Nov;76(1):220-8. Epub 2003 Aug 27.

PMID:
12944587
21.

Avasimibe induces CYP3A4 and multiple drug resistance protein 1 gene expression through activation of the pregnane X receptor.

Sahi J, Milad MA, Zheng X, Rose KA, Wang H, Stilgenbauer L, Gilbert D, Jolley S, Stern RH, LeCluyse EL.

J Pharmacol Exp Ther. 2003 Sep;306(3):1027-34. Epub 2003 May 23.

PMID:
12766253
22.

Comparative effects of thiazolidinediones on in vitro P450 enzyme induction and inhibition.

Sahi J, Black CB, Hamilton GA, Zheng X, Jolley S, Rose KA, Gilbert D, LeCluyse EL, Sinz MW.

Drug Metab Dispos. 2003 Apr;31(4):439-46.

PMID:
12642470
23.

Effects of bergamottin on human and monkey drug-metabolizing enzymes in primary cultured hepatocytes.

Wen YH, Sahi J, Urda E, Kulkarni S, Rose K, Zheng X, Sinclair JF, Cai H, Strom SC, Kostrubsky VE.

Drug Metab Dispos. 2002 Sep;30(9):977-84.

PMID:
12167562
24.

The effect of bergamottin on diazepam plasma levels and P450 enzymes in beagle dogs.

Sahi J, Reyner EL, Bauman JN, Gueneva-Boucheva K, Burleigh JE, Thomas VH.

Drug Metab Dispos. 2002 Feb;30(2):135-40.

PMID:
11792681
25.

Human intestinal anion exchanger isoforms: expression, distribution, and membrane localization.

Alrefai WA, Tyagi S, Nazir TM, Barakat J, Anwar SS, Hadjiagapiou C, Bavishi D, Sahi J, Malik P, Goldstein J, Layden TJ, Ramaswamy K, Dudeja PK.

Biochim Biophys Acta. 2001 Mar 9;1511(1):17-27.

26.

Ion transport during growth and differentiation.

Venkatasubramanian J, Sahi J, Rao MC.

Ann N Y Acad Sci. 2000;915:357-72. Review.

PMID:
11193599
27.

Effect of troglitazone on cytochrome P450 enzymes in primary cultures of human and rat hepatocytes.

Sahi J, Hamilton G, Sinz M, Barros S, Huang SM, Lesko LJ, LeCluyse EL.

Xenobiotica. 2000 Mar;30(3):273-84.

PMID:
10752642
28.

Cl- transport in an immortalized human epithelial cell line (NCM460) derived from the normal transverse colon.

Sahi J, Nataraja SG, Layden TJ, Goldstein JL, Moyer MP, Rao MC.

Am J Physiol. 1998 Oct;275(4):C1048-57. doi: 10.1152/ajpcell.1998.275.4.C1048.

PMID:
9755058
29.

Chloride transport in primary cultures of rabbit colonocytes at different stages of development.

Desai GN, Sahi J, Reddy PM, Venkatasubramanian J, Vidyasagar D, Rao MC.

Gastroenterology. 1996 Dec;111(6):1541-50.

PMID:
8942733
30.

Calcium regulated chloride permeabilities in primary cultures of rabbit colonocytes.

Sahi J, Wiggins MP, Gibori GB, Layden TJ, Rao MC.

J Cell Physiol. 1996 Aug;168(2):276-83.

PMID:
8707863
31.

Altered growth and attachment of rabbit crypt colonocytes isolated from different developmental stages.

Reddy PM, Sahi J, Desai G, Vidyasagar D, Rao MC.

Pediatr Res. 1996 Feb;39(2):287-94.

PMID:
8825802
32.

Escherichia coli heat-stable enterotoxin-mediated colonic Cl- secretion is absent in cystic fibrosis.

Goldstein JL, Sahi J, Bhuva M, Layden TJ, Rao MC.

Gastroenterology. 1994 Oct;107(4):950-6.

PMID:
7926485
33.

Cyclic AMP- and phorbol ester-regulated Cl- permeabilities in primary cultures of human and rabbit colonocytes.

Sahi J, Goldstein JL, Layden TJ, Rao MC.

Am J Physiol. 1994 May;266(5 Pt 1):G846-55.

PMID:
8203530
34.

Isolation, characterization, and attachment of rabbit distal colon epithelial cells.

Benya RV, Schmidt LN, Sahi J, Layden TJ, Rao MC.

Gastroenterology. 1991 Sep;101(3):692-702.

PMID:
1650317
35.

[Combination of Noleptan and oxyethyltheophylline for the oral therapy in "multilocal trial"].

Sahi J, Tschakert H.

Med Monatsschr. 1976 Sep;30(9):408-13. German. No abstract available.

PMID:
790142
36.

[Calcitonin and treatment of osteoporosis with reference to the therapeutic possibilities in senile osteoporosis. I].

Klatt R, Sahi JS, Schmidt UJ, Kalbe I, Hähnel H.

Z Alternsforsch. 1973;27(3):283-8. German. No abstract available.

PMID:
4771229
37.

The azurophilic granules of lymphocytes in the aged.

Sahi J, Stobbe H, Klatt R.

Z Alternsforsch. 1972;26(1):49-50 passim. No abstract available.

PMID:
4651463
38.

[Case report on intestinal lipodystrophy (Whipple's disease)].

Sahi J, Knappe G, Lüning M, Werner W.

Dtsch Gesundheitsw. 1971 Dec 16;26(51):2396-8. German. No abstract available.

PMID:
4112626
39.

[Abdominal lymphogranulomatosis. Case report].

Richter R, Sahi J, Künzel A, Herrmann H.

Z Arztl Fortbild (Jena). 1971 Jun 15;65(12):591-5. German. No abstract available.

PMID:
5112869
40.

Lymphocyte function in the aged.

Heine KM, Stobbe H, Klatt R, Sahi J, Herrmann H.

Helv Med Acta. 1971 May;35(6):484-9. No abstract available.

PMID:
5112187
41.

[Hemoglobin F in old age and in different heart diseases].

Klatt R, Friedrich J, Herrmann K, Presber W, Sahi JS.

Z Alternsforsch. 1971;24(1):79. German. No abstract available.

PMID:
5578043
42.

[Disturbances of lymphocyte function in the aged].

Heine KM, Stobbe H, Klatt R, Sahi J, Herrmann H, Kupke J.

Z Alternsforsch. 1971;24(1):23-30. German. No abstract available.

PMID:
5578035
43.

[Effect of morphine sulfate on the respiratory function in the aged].

Klatt R, Brüschke G, Sahi JS, Demmig J, Mehls E.

Z Alternsforsch. 1971;24(2):151-4. German. No abstract available.

PMID:
5110510
44.

[Reactivity of lymphocytes in the aged].

Heine KM, Hofer E, Klatt R, Kupke J, Reitzig P, Sahi J, Schmidt U, Stobbe H.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1971;96(1):29-33. German. No abstract available.

PMID:
4110781
45.

[Azurophilic granulation in lymphocytes. 3. Behavior of lymphocytes with azurophilic granulation in various hematologic diseases].

Sahi J, Stobbe H, Klatt R, Heine KM, Hofer E.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1971;95(4):385-8. German. No abstract available.

PMID:
4107573
46.

[Azurophilic granulation in lymphocytes. II. Behavior of azurophilic granula of transformed lymphocytes in various age groups in short germ lymphocyte cultures].

Sahi J, Stobbe H, Klatt R, Heine KM, Hofer E.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1971;95(4):379-84. German. No abstract available.

PMID:
4107572
47.

[Azurophilic granulation of lymphocytes. I. Review of the literature and determination of normal values].

Sahi J, Stobbe H, Klatt R, Heine KM, Hofer E.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1971;95(4):372-8. German. No abstract available.

PMID:
4107571
48.

[The incidence of hemoglobin abnormalities in the aged].

Klatt R, Sahi J, Haase J, Rühland W, Künzel A, Herrmann H.

Folia Haematol Int Mag Klin Morphol Blutforsch. 1970;94(4):346-9. German. No abstract available.

PMID:
4101125
49.

[Clinical aspects of hemoglobin C anomaly].

Klatt R, Sahi J, Haase J, Reitzig P.

Dtsch Gesundheitsw. 1969 Nov 20;24(47):2252-4. German. No abstract available.

PMID:
5376426
50.

[Leukocyte changes in the blood following administration of adrenaline with special regard to lymphocyte mobilization].

Sahi J, Stobbe H, Klatt R.

Z Gesamte Inn Med. 1969 Nov 15;24(22):817-21. German. No abstract available.

PMID:
5368515

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